Amino acid dipepetide frequency for Bosea sp. LC85

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.549AlaAla: 18.549 ± 0.152
1.138AlaCys: 1.138 ± 0.024
6.334AlaAsp: 6.334 ± 0.067
7.736AlaGlu: 7.736 ± 0.074
4.828AlaPhe: 4.828 ± 0.055
11.797AlaGly: 11.797 ± 0.106
2.261AlaHis: 2.261 ± 0.035
7.061AlaIle: 7.061 ± 0.072
4.071AlaLys: 4.071 ± 0.054
14.88AlaLeu: 14.88 ± 0.095
3.705AlaMet: 3.705 ± 0.054
2.796AlaAsn: 2.796 ± 0.041
5.972AlaPro: 5.972 ± 0.072
4.188AlaGln: 4.188 ± 0.059
9.568AlaArg: 9.568 ± 0.078
6.889AlaSer: 6.889 ± 0.059
6.413AlaThr: 6.413 ± 0.064
9.122AlaVal: 9.122 ± 0.071
1.546AlaTrp: 1.546 ± 0.031
2.52AlaTyr: 2.52 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.972CysAla: 0.972 ± 0.027
0.102CysCys: 0.102 ± 0.008
0.482CysAsp: 0.482 ± 0.017
0.444CysGlu: 0.444 ± 0.015
0.327CysPhe: 0.327 ± 0.013
0.926CysGly: 0.926 ± 0.026
0.21CysHis: 0.21 ± 0.011
0.402CysIle: 0.402 ± 0.016
0.18CysLys: 0.18 ± 0.008
0.787CysLeu: 0.787 ± 0.021
0.134CysMet: 0.134 ± 0.008
0.183CysAsn: 0.183 ± 0.01
0.418CysPro: 0.418 ± 0.015
0.21CysGln: 0.21 ± 0.012
0.611CysArg: 0.611 ± 0.018
0.429CysSer: 0.429 ± 0.016
0.39CysThr: 0.39 ± 0.014
0.608CysVal: 0.608 ± 0.017
0.112CysTrp: 0.112 ± 0.008
0.192CysTyr: 0.192 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.469AspAla: 6.469 ± 0.064
0.455AspCys: 0.455 ± 0.017
2.735AspAsp: 2.735 ± 0.071
3.276AspGlu: 3.276 ± 0.045
2.019AspPhe: 2.019 ± 0.04
5.117AspGly: 5.117 ± 0.075
1.131AspHis: 1.131 ± 0.028
2.85AspIle: 2.85 ± 0.04
1.535AspLys: 1.535 ± 0.034
5.731AspLeu: 5.731 ± 0.056
1.16AspMet: 1.16 ± 0.025
1.038AspAsn: 1.038 ± 0.027
3.415AspPro: 3.415 ± 0.047
1.524AspGln: 1.524 ± 0.028
4.06AspArg: 4.06 ± 0.051
1.995AspSer: 1.995 ± 0.032
2.272AspThr: 2.272 ± 0.054
3.876AspVal: 3.876 ± 0.043
0.888AspTrp: 0.888 ± 0.024
1.331AspTyr: 1.331 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
8.097GluAla: 8.097 ± 0.083
0.336GluCys: 0.336 ± 0.012
2.305GluAsp: 2.305 ± 0.033
2.735GluGlu: 2.735 ± 0.044
1.678GluPhe: 1.678 ± 0.032
4.042GluGly: 4.042 ± 0.05
1.073GluHis: 1.073 ± 0.027
3.598GluIle: 3.598 ± 0.047
1.909GluLys: 1.909 ± 0.034
5.291GluLeu: 5.291 ± 0.058
1.398GluMet: 1.398 ± 0.028
1.328GluAsn: 1.328 ± 0.03
2.917GluPro: 2.917 ± 0.042
1.973GluGln: 1.973 ± 0.032
5.239GluArg: 5.239 ± 0.061
2.25GluSer: 2.25 ± 0.034
3.354GluThr: 3.354 ± 0.041
3.471GluVal: 3.471 ± 0.039
0.609GluTrp: 0.609 ± 0.019
0.795GluTyr: 0.795 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
4.958PheAla: 4.958 ± 0.06
0.371PheCys: 0.371 ± 0.013
2.461PheAsp: 2.461 ± 0.038
2.083PheGlu: 2.083 ± 0.037
1.361PhePhe: 1.361 ± 0.032
3.85PheGly: 3.85 ± 0.057
0.749PheHis: 0.749 ± 0.021
1.674PheIle: 1.674 ± 0.031
1.008PheLys: 1.008 ± 0.023
3.392PheLeu: 3.392 ± 0.045
0.838PheMet: 0.838 ± 0.022
0.985PheAsn: 0.985 ± 0.028
1.629PhePro: 1.629 ± 0.029
1.018PheGln: 1.018 ± 0.025
2.361PheArg: 2.361 ± 0.033
2.211PheSer: 2.211 ± 0.036
1.95PheThr: 1.95 ± 0.032
3.011PheVal: 3.011 ± 0.043
0.568PheTrp: 0.568 ± 0.021
0.806PheTyr: 0.806 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
9.922GlyAla: 9.922 ± 0.091
0.862GlyCys: 0.862 ± 0.021
4.394GlyAsp: 4.394 ± 0.09
4.889GlyGlu: 4.889 ± 0.051
3.845GlyPhe: 3.845 ± 0.049
7.758GlyGly: 7.758 ± 0.128
1.927GlyHis: 1.927 ± 0.031
4.641GlyIle: 4.641 ± 0.062
3.245GlyLys: 3.245 ± 0.054
9.857GlyLeu: 9.857 ± 0.08
2.167GlyMet: 2.167 ± 0.033
2.138GlyAsn: 2.138 ± 0.058
3.815GlyPro: 3.815 ± 0.049
2.995GlyGln: 2.995 ± 0.043
6.621GlyArg: 6.621 ± 0.057
4.923GlySer: 4.923 ± 0.064
4.66GlyThr: 4.66 ± 0.072
6.13GlyVal: 6.13 ± 0.056
1.423GlyTrp: 1.423 ± 0.027
2.342GlyTyr: 2.342 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.371HisAla: 2.371 ± 0.037
0.213HisCys: 0.213 ± 0.012
1.186HisAsp: 1.186 ± 0.028
1.038HisGlu: 1.038 ± 0.023
0.812HisPhe: 0.812 ± 0.021
1.96HisGly: 1.96 ± 0.035
0.53HisHis: 0.53 ± 0.017
0.815HisIle: 0.815 ± 0.023
0.43HisLys: 0.43 ± 0.015
2.078HisLeu: 2.078 ± 0.032
0.434HisMet: 0.434 ± 0.015
0.389HisAsn: 0.389 ± 0.014
1.305HisPro: 1.305 ± 0.024
0.568HisGln: 0.568 ± 0.016
1.45HisArg: 1.45 ± 0.026
0.887HisSer: 0.887 ± 0.024
0.698HisThr: 0.698 ± 0.02
1.53HisVal: 1.53 ± 0.029
0.34HisTrp: 0.34 ± 0.012
0.489HisTyr: 0.489 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
8.071IleAla: 8.071 ± 0.065
0.511IleCys: 0.511 ± 0.018
3.337IleAsp: 3.337 ± 0.045
3.431IleGlu: 3.431 ± 0.048
1.687IlePhe: 1.687 ± 0.032
5.282IleGly: 5.282 ± 0.063
0.875IleHis: 0.875 ± 0.024
2.255IleIle: 2.255 ± 0.041
1.376IleLys: 1.376 ± 0.028
4.627IleLeu: 4.627 ± 0.05
0.982IleMet: 0.982 ± 0.024
1.242IleAsn: 1.242 ± 0.029
2.374IlePro: 2.374 ± 0.038
1.183IleGln: 1.183 ± 0.022
3.269IleArg: 3.269 ± 0.039
2.886IleSer: 2.886 ± 0.045
2.629IleThr: 2.629 ± 0.042
4.532IleVal: 4.532 ± 0.055
0.603IleTrp: 0.603 ± 0.02
1.05IleTyr: 1.05 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
4.4LysAla: 4.4 ± 0.064
0.132LysCys: 0.132 ± 0.009
1.531LysAsp: 1.531 ± 0.035
1.372LysGlu: 1.372 ± 0.03
0.831LysPhe: 0.831 ± 0.021
2.624LysGly: 2.624 ± 0.046
0.535LysHis: 0.535 ± 0.017
1.453LysIle: 1.453 ± 0.034
0.982LysLys: 0.982 ± 0.025
3.358LysLeu: 3.358 ± 0.045
0.617LysMet: 0.617 ± 0.018
0.734LysAsn: 0.734 ± 0.021
2.22LysPro: 2.22 ± 0.039
0.972LysGln: 0.972 ± 0.024
2.312LysArg: 2.312 ± 0.039
1.669LysSer: 1.669 ± 0.035
1.776LysThr: 1.776 ± 0.029
2.396LysVal: 2.396 ± 0.042
0.309LysTrp: 0.309 ± 0.013
0.481LysTyr: 0.481 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
15.478LeuAla: 15.478 ± 0.108
0.839LeuCys: 0.839 ± 0.023
6.035LeuAsp: 6.035 ± 0.063
4.902LeuGlu: 4.902 ± 0.053
3.642LeuPhe: 3.642 ± 0.053
9.217LeuGly: 9.217 ± 0.082
1.867LeuHis: 1.867 ± 0.034
5.321LeuIle: 5.321 ± 0.063
3.599LeuLys: 3.599 ± 0.054
10.064LeuLeu: 10.064 ± 0.094
2.348LeuMet: 2.348 ± 0.037
2.46LeuAsn: 2.46 ± 0.038
5.931LeuPro: 5.931 ± 0.053
2.729LeuGln: 2.729 ± 0.038
7.212LeuArg: 7.212 ± 0.068
6.643LeuSer: 6.643 ± 0.062
5.647LeuThr: 5.647 ± 0.056
8.16LeuVal: 8.16 ± 0.076
1.202LeuTrp: 1.202 ± 0.026
1.892LeuTyr: 1.892 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
3.065MetAla: 3.065 ± 0.037
0.147MetCys: 0.147 ± 0.009
0.953MetAsp: 0.953 ± 0.022
0.881MetGlu: 0.881 ± 0.023
0.643MetPhe: 0.643 ± 0.019
1.623MetGly: 1.623 ± 0.029
0.388MetHis: 0.388 ± 0.014
1.343MetIle: 1.343 ± 0.027
0.924MetLys: 0.924 ± 0.023
2.607MetLeu: 2.607 ± 0.034
0.614MetMet: 0.614 ± 0.02
0.687MetAsn: 0.687 ± 0.02
1.536MetPro: 1.536 ± 0.024
0.783MetGln: 0.783 ± 0.02
1.879MetArg: 1.879 ± 0.03
1.683MetSer: 1.683 ± 0.03
1.87MetThr: 1.87 ± 0.032
1.659MetVal: 1.659 ± 0.031
0.169MetTrp: 0.169 ± 0.01
0.266MetTyr: 0.266 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.018AsnAla: 3.018 ± 0.04
0.189AsnCys: 0.189 ± 0.01
1.238AsnAsp: 1.238 ± 0.043
1.129AsnGlu: 1.129 ± 0.024
0.873AsnPhe: 0.873 ± 0.022
2.282AsnGly: 2.282 ± 0.048
0.443AsnHis: 0.443 ± 0.016
1.157AsnIle: 1.157 ± 0.024
0.593AsnLys: 0.593 ± 0.019
2.517AsnLeu: 2.517 ± 0.039
0.51AsnMet: 0.51 ± 0.016
0.608AsnAsn: 0.608 ± 0.023
1.753AsnPro: 1.753 ± 0.026
0.692AsnGln: 0.692 ± 0.022
1.694AsnArg: 1.694 ± 0.03
1.152AsnSer: 1.152 ± 0.024
1.175AsnThr: 1.175 ± 0.027
1.725AsnVal: 1.725 ± 0.034
0.433AsnTrp: 0.433 ± 0.017
0.579AsnTyr: 0.579 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
6.925ProAla: 6.925 ± 0.073
0.317ProCys: 0.317 ± 0.014
3.39ProAsp: 3.39 ± 0.047
3.543ProGlu: 3.543 ± 0.049
2.132ProPhe: 2.132 ± 0.037
4.93ProGly: 4.93 ± 0.057
1.112ProHis: 1.112 ± 0.023
2.427ProIle: 2.427 ± 0.038
1.617ProLys: 1.617 ± 0.03
5.064ProLeu: 5.064 ± 0.051
1.242ProMet: 1.242 ± 0.029
1.363ProAsn: 1.363 ± 0.029
2.785ProPro: 2.785 ± 0.048
1.692ProGln: 1.692 ± 0.031
3.303ProArg: 3.303 ± 0.043
3.004ProSer: 3.004 ± 0.041
2.518ProThr: 2.518 ± 0.037
4.389ProVal: 4.389 ± 0.052
0.692ProTrp: 0.692 ± 0.022
1.171ProTyr: 1.171 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
4.445GlnAla: 4.445 ± 0.061
0.187GlnCys: 0.187 ± 0.009
1.417GlnAsp: 1.417 ± 0.026
1.374GlnGlu: 1.374 ± 0.026
1.003GlnPhe: 1.003 ± 0.023
2.503GlnGly: 2.503 ± 0.034
0.598GlnHis: 0.598 ± 0.018
1.796GlnIle: 1.796 ± 0.034
0.908GlnLys: 0.908 ± 0.022
2.778GlnLeu: 2.778 ± 0.038
0.762GlnMet: 0.762 ± 0.019
0.798GlnAsn: 0.798 ± 0.023
1.815GlnPro: 1.815 ± 0.031
1.183GlnGln: 1.183 ± 0.031
2.624GlnArg: 2.624 ± 0.044
1.698GlnSer: 1.698 ± 0.028
1.546GlnThr: 1.546 ± 0.034
2.23GlnVal: 2.23 ± 0.037
0.359GlnTrp: 0.359 ± 0.013
0.531GlnTyr: 0.531 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
8.281ArgAla: 8.281 ± 0.069
0.555ArgCys: 0.555 ± 0.018
4.139ArgAsp: 4.139 ± 0.049
4.28ArgGlu: 4.28 ± 0.061
3.083ArgPhe: 3.083 ± 0.046
5.097ArgGly: 5.097 ± 0.056
1.758ArgHis: 1.758 ± 0.037
4.17ArgIle: 4.17 ± 0.051
2.223ArgLys: 2.223 ± 0.038
8.426ArgLeu: 8.426 ± 0.068
1.887ArgMet: 1.887 ± 0.035
1.852ArgAsn: 1.852 ± 0.033
3.856ArgPro: 3.856 ± 0.053
2.593ArgGln: 2.593 ± 0.043
6.036ArgArg: 6.036 ± 0.075
4.139ArgSer: 4.139 ± 0.047
3.33ArgThr: 3.33 ± 0.04
4.838ArgVal: 4.838 ± 0.052
0.995ArgTrp: 0.995 ± 0.024
1.694ArgTyr: 1.694 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.518SerAla: 6.518 ± 0.059
0.421SerCys: 0.421 ± 0.017
2.786SerAsp: 2.786 ± 0.039
2.835SerGlu: 2.835 ± 0.043
2.439SerPhe: 2.439 ± 0.033
5.785SerGly: 5.785 ± 0.069
1.117SerHis: 1.117 ± 0.025
2.691SerIle: 2.691 ± 0.039
1.456SerLys: 1.456 ± 0.028
5.915SerLeu: 5.915 ± 0.058
1.198SerMet: 1.198 ± 0.025
1.254SerAsn: 1.254 ± 0.027
2.882SerPro: 2.882 ± 0.038
1.615SerGln: 1.615 ± 0.032
3.821SerArg: 3.821 ± 0.042
3.008SerSer: 3.008 ± 0.038
2.628SerThr: 2.628 ± 0.041
4.018SerVal: 4.018 ± 0.046
0.831SerTrp: 0.831 ± 0.02
1.327SerTyr: 1.327 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
6.239ThrAla: 6.239 ± 0.062
0.405ThrCys: 0.405 ± 0.015
2.439ThrAsp: 2.439 ± 0.036
2.478ThrGlu: 2.478 ± 0.036
1.905ThrPhe: 1.905 ± 0.036
5.119ThrGly: 5.119 ± 0.066
0.965ThrHis: 0.965 ± 0.024
3.083ThrIle: 3.083 ± 0.047
1.353ThrLys: 1.353 ± 0.03
6.05ThrLeu: 6.05 ± 0.067
1.18ThrMet: 1.18 ± 0.024
1.167ThrAsn: 1.167 ± 0.029
3.236ThrPro: 3.236 ± 0.048
1.446ThrGln: 1.446 ± 0.032
3.451ThrArg: 3.451 ± 0.041
2.724ThrSer: 2.724 ± 0.039
2.858ThrThr: 2.858 ± 0.045
4.272ThrVal: 4.272 ± 0.051
0.671ThrTrp: 0.671 ± 0.019
1.104ThrTyr: 1.104 ± 0.024
0.0ThrXaa: 0.0 ± 0.0
Val
9.889ValAla: 9.889 ± 0.084
0.576ValCys: 0.576 ± 0.016
3.816ValAsp: 3.816 ± 0.05
4.353ValGlu: 4.353 ± 0.053
2.784ValPhe: 2.784 ± 0.041
5.687ValGly: 5.687 ± 0.064
1.25ValHis: 1.25 ± 0.028
4.042ValIle: 4.042 ± 0.052
2.313ValLys: 2.313 ± 0.046
7.787ValLeu: 7.787 ± 0.077
1.871ValMet: 1.871 ± 0.033
1.813ValAsn: 1.813 ± 0.036
3.91ValPro: 3.91 ± 0.047
2.037ValGln: 2.037 ± 0.033
4.813ValArg: 4.813 ± 0.051
4.426ValSer: 4.426 ± 0.05
4.678ValThr: 4.678 ± 0.05
6.09ValVal: 6.09 ± 0.059
0.818ValTrp: 0.818 ± 0.022
1.363ValTyr: 1.363 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.222TrpAla: 1.222 ± 0.029
0.143TrpCys: 0.143 ± 0.009
0.57TrpAsp: 0.57 ± 0.018
0.516TrpGlu: 0.516 ± 0.018
0.569TrpPhe: 0.569 ± 0.017
0.922TrpGly: 0.922 ± 0.025
0.3TrpHis: 0.3 ± 0.013
0.646TrpIle: 0.646 ± 0.02
0.419TrpLys: 0.419 ± 0.014
1.75TrpLeu: 1.75 ± 0.039
0.307TrpMet: 0.307 ± 0.012
0.438TrpAsn: 0.438 ± 0.014
0.744TrpPro: 0.744 ± 0.022
0.534TrpGln: 0.534 ± 0.018
1.174TrpArg: 1.174 ± 0.026
0.851TrpSer: 0.851 ± 0.02
0.798TrpThr: 0.798 ± 0.023
0.739TrpVal: 0.739 ± 0.022
0.237TrpTrp: 0.237 ± 0.012
0.272TrpTyr: 0.272 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.485TyrAla: 2.485 ± 0.034
0.221TyrCys: 0.221 ± 0.012
1.328TyrAsp: 1.328 ± 0.028
1.104TyrGlu: 1.104 ± 0.027
0.823TyrPhe: 0.823 ± 0.019
2.034TyrGly: 2.034 ± 0.033
0.434TyrHis: 0.434 ± 0.014
0.775TyrIle: 0.775 ± 0.02
0.562TyrLys: 0.562 ± 0.018
2.232TyrLeu: 2.232 ± 0.037
0.366TyrMet: 0.366 ± 0.015
0.486TyrAsn: 0.486 ± 0.016
1.106TyrPro: 1.106 ± 0.022
0.62TyrGln: 0.62 ± 0.02
1.73TyrArg: 1.73 ± 0.027
1.077TyrSer: 1.077 ± 0.022
0.953TyrThr: 0.953 ± 0.024
1.523TyrVal: 1.523 ± 0.028
0.347TyrTrp: 0.347 ± 0.013
0.532TyrTyr: 0.532 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6190 proteins (1918328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski