Amino acid dipepetide frequency for Methylobrevis pamukkalensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.176AlaAla: 21.176 ± 0.203	1.238AlaCys: 1.238 ± 0.033	8.297AlaAsp: 8.297 ± 0.08	8.223AlaGlu: 8.223 ± 0.094	4.649AlaPhe: 4.649 ± 0.068	13.291AlaGly: 13.291 ± 0.125	2.268AlaHis: 2.268 ± 0.052	6.465AlaIle: 6.465 ± 0.077	3.011AlaLys: 3.011 ± 0.063	13.502AlaLeu: 13.502 ± 0.132	3.689AlaMet: 3.689 ± 0.058	2.422AlaAsn: 2.422 ± 0.045	6.695AlaPro: 6.695 ± 0.099	2.998AlaGln: 2.998 ± 0.054	11.046AlaArg: 11.046 ± 0.124	6.92AlaSer: 6.92 ± 0.084	6.816AlaThr: 6.816 ± 0.07	9.994AlaVal: 9.994 ± 0.097	1.457AlaTrp: 1.457 ± 0.034	2.285AlaTyr: 2.285 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.041CysAla: 1.041 ± 0.027	0.18CysCys: 0.18 ± 0.014	0.522CysAsp: 0.522 ± 0.023	0.391CysGlu: 0.391 ± 0.019	0.278CysPhe: 0.278 ± 0.016	0.933CysGly: 0.933 ± 0.027	0.229CysHis: 0.229 ± 0.013	0.285CysIle: 0.285 ± 0.014	0.153CysLys: 0.153 ± 0.012	0.773CysLeu: 0.773 ± 0.029	0.185CysMet: 0.185 ± 0.014	0.173CysAsn: 0.173 ± 0.012	0.522CysPro: 0.522 ± 0.02	0.18CysGln: 0.18 ± 0.01	0.989CysArg: 0.989 ± 0.032	0.578CysSer: 0.578 ± 0.023	0.395CysThr: 0.395 ± 0.018	0.566CysVal: 0.566 ± 0.021	0.166CysTrp: 0.166 ± 0.012	0.166CysTyr: 0.166 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.668AspAla: 7.668 ± 0.09	0.491AspCys: 0.491 ± 0.019	3.751AspAsp: 3.751 ± 0.074	3.542AspGlu: 3.542 ± 0.058	2.237AspPhe: 2.237 ± 0.045	6.074AspGly: 6.074 ± 0.083	1.407AspHis: 1.407 ± 0.036	2.945AspIle: 2.945 ± 0.057	1.324AspLys: 1.324 ± 0.036	7.081AspLeu: 7.081 ± 0.088	1.325AspMet: 1.325 ± 0.035	1.106AspAsn: 1.106 ± 0.034	4.024AspPro: 4.024 ± 0.059	1.373AspGln: 1.373 ± 0.038	5.031AspArg: 5.031 ± 0.075	1.939AspSer: 1.939 ± 0.041	2.796AspThr: 2.796 ± 0.06	4.639AspVal: 4.639 ± 0.063	0.894AspTrp: 0.894 ± 0.029	1.349AspTyr: 1.349 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.354GluAla: 8.354 ± 0.105	0.298GluCys: 0.298 ± 0.015	2.951GluAsp: 2.951 ± 0.061	3.009GluGlu: 3.009 ± 0.057	1.566GluPhe: 1.566 ± 0.037	4.594GluGly: 4.594 ± 0.066	1.024GluHis: 1.024 ± 0.034	3.681GluIle: 3.681 ± 0.062	1.752GluLys: 1.752 ± 0.045	4.562GluLeu: 4.562 ± 0.073	1.466GluMet: 1.466 ± 0.034	1.171GluAsn: 1.171 ± 0.033	2.645GluPro: 2.645 ± 0.045	1.573GluGln: 1.573 ± 0.045	4.758GluArg: 4.758 ± 0.077	2.073GluSer: 2.073 ± 0.037	3.903GluThr: 3.903 ± 0.071	4.189GluVal: 4.189 ± 0.067	0.554GluTrp: 0.554 ± 0.024	0.735GluTyr: 0.735 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.698PheAla: 4.698 ± 0.069	0.352PheCys: 0.352 ± 0.017	2.661PheAsp: 2.661 ± 0.055	2.037PheGlu: 2.037 ± 0.037	1.268PhePhe: 1.268 ± 0.037	3.635PheGly: 3.635 ± 0.063	0.746PheHis: 0.746 ± 0.027	1.32PheIle: 1.32 ± 0.036	0.749PheLys: 0.749 ± 0.026	3.291PheLeu: 3.291 ± 0.063	0.717PheMet: 0.717 ± 0.025	0.84PheAsn: 0.84 ± 0.027	1.546PhePro: 1.546 ± 0.039	0.867PheGln: 0.867 ± 0.029	2.502PheArg: 2.502 ± 0.049	2.06PheSer: 2.06 ± 0.045	1.831PheThr: 1.831 ± 0.037	2.941PheVal: 2.941 ± 0.051	0.475PheTrp: 0.475 ± 0.019	0.764PheTyr: 0.764 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.449GlyAla: 10.449 ± 0.103	0.87GlyCys: 0.87 ± 0.028	5.247GlyAsp: 5.247 ± 0.082	5.28GlyGlu: 5.28 ± 0.074	3.595GlyPhe: 3.595 ± 0.059	8.308GlyGly: 8.308 ± 0.118	2.067GlyHis: 2.067 ± 0.051	4.483GlyIle: 4.483 ± 0.063	2.633GlyLys: 2.633 ± 0.054	9.641GlyLeu: 9.641 ± 0.102	2.234GlyMet: 2.234 ± 0.043	2.149GlyAsn: 2.149 ± 0.061	4.071GlyPro: 4.071 ± 0.062	2.379GlyGln: 2.379 ± 0.052	7.823GlyArg: 7.823 ± 0.098	4.764GlySer: 4.764 ± 0.066	5.091GlyThr: 5.091 ± 0.071	6.457GlyVal: 6.457 ± 0.078	1.413GlyTrp: 1.413 ± 0.037	2.131GlyTyr: 2.131 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.407HisAla: 2.407 ± 0.047	0.194HisCys: 0.194 ± 0.012	1.383HisAsp: 1.383 ± 0.033	0.988HisGlu: 0.988 ± 0.031	0.754HisPhe: 0.754 ± 0.027	2.158HisGly: 2.158 ± 0.052	0.605HisHis: 0.605 ± 0.026	0.759HisIle: 0.759 ± 0.024	0.358HisLys: 0.358 ± 0.019	2.139HisLeu: 2.139 ± 0.041	0.457HisMet: 0.457 ± 0.02	0.343HisAsn: 0.343 ± 0.016	1.416HisPro: 1.416 ± 0.034	0.484HisGln: 0.484 ± 0.022	1.546HisArg: 1.546 ± 0.042	0.741HisSer: 0.741 ± 0.025	0.735HisThr: 0.735 ± 0.028	1.674HisVal: 1.674 ± 0.039	0.258HisTrp: 0.258 ± 0.014	0.448HisTyr: 0.448 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.391IleAla: 7.391 ± 0.088	0.445IleCys: 0.445 ± 0.02	3.77IleAsp: 3.77 ± 0.057	3.416IleGlu: 3.416 ± 0.052	1.529IlePhe: 1.529 ± 0.039	4.967IleGly: 4.967 ± 0.074	0.882IleHis: 0.882 ± 0.027	1.669IleIle: 1.669 ± 0.051	0.95IleLys: 0.95 ± 0.031	4.209IleLeu: 4.209 ± 0.066	0.807IleMet: 0.807 ± 0.026	1.055IleAsn: 1.055 ± 0.033	2.113IlePro: 2.113 ± 0.049	0.936IleGln: 0.936 ± 0.028	3.4IleArg: 3.4 ± 0.056	2.465IleSer: 2.465 ± 0.047	2.368IleThr: 2.368 ± 0.043	4.205IleVal: 4.205 ± 0.059	0.561IleTrp: 0.561 ± 0.021	0.91IleTyr: 0.91 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.683LysAla: 3.683 ± 0.064	0.128LysCys: 0.128 ± 0.012	1.388LysAsp: 1.388 ± 0.042	1.076LysGlu: 1.076 ± 0.031	0.698LysPhe: 0.698 ± 0.02	2.167LysGly: 2.167 ± 0.052	0.395LysHis: 0.395 ± 0.019	1.413LysIle: 1.413 ± 0.035	0.829LysLys: 0.829 ± 0.03	2.414LysLeu: 2.414 ± 0.048	0.597LysMet: 0.597 ± 0.023	0.55LysAsn: 0.55 ± 0.023	1.556LysPro: 1.556 ± 0.036	0.563LysGln: 0.563 ± 0.023	1.847LysArg: 1.847 ± 0.041	1.337LysSer: 1.337 ± 0.037	1.622LysThr: 1.622 ± 0.039	2.23LysVal: 2.23 ± 0.044	0.283LysTrp: 0.283 ± 0.015	0.414LysTyr: 0.414 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.34LeuAla: 15.34 ± 0.151	0.828LeuCys: 0.828 ± 0.025	6.491LeuAsp: 6.491 ± 0.087	4.798LeuGlu: 4.798 ± 0.068	3.398LeuPhe: 3.398 ± 0.063	8.673LeuGly: 8.673 ± 0.093	1.828LeuHis: 1.828 ± 0.045	4.164LeuIle: 4.164 ± 0.066	2.893LeuLys: 2.893 ± 0.049	9.303LeuLeu: 9.303 ± 0.114	2.187LeuMet: 2.187 ± 0.047	1.901LeuAsn: 1.901 ± 0.043	5.788LeuPro: 5.788 ± 0.086	2.124LeuGln: 2.124 ± 0.04	6.993LeuArg: 6.993 ± 0.08	5.69LeuSer: 5.69 ± 0.075	5.37LeuThr: 5.37 ± 0.069	8.384LeuVal: 8.384 ± 0.086	1.059LeuTrp: 1.059 ± 0.03	1.829LeuTyr: 1.829 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.18MetAla: 3.18 ± 0.046	0.126MetCys: 0.126 ± 0.009	1.132MetAsp: 1.132 ± 0.027	1.045MetGlu: 1.045 ± 0.03	0.669MetPhe: 0.669 ± 0.027	1.582MetGly: 1.582 ± 0.039	0.36MetHis: 0.36 ± 0.017	1.401MetIle: 1.401 ± 0.033	0.82MetLys: 0.82 ± 0.029	2.408MetLeu: 2.408 ± 0.048	0.675MetMet: 0.675 ± 0.023	0.647MetAsn: 0.647 ± 0.024	1.661MetPro: 1.661 ± 0.043	0.667MetGln: 0.667 ± 0.021	1.957MetArg: 1.957 ± 0.039	1.623MetSer: 1.623 ± 0.037	2.095MetThr: 2.095 ± 0.04	1.718MetVal: 1.718 ± 0.037	0.207MetTrp: 0.207 ± 0.015	0.251MetTyr: 0.251 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.603AsnAla: 2.603 ± 0.047	0.189AsnCys: 0.189 ± 0.014	1.269AsnAsp: 1.269 ± 0.045	0.924AsnGlu: 0.924 ± 0.029	0.741AsnPhe: 0.741 ± 0.025	1.967AsnGly: 1.967 ± 0.051	0.434AsnHis: 0.434 ± 0.02	1.03AsnIle: 1.03 ± 0.029	0.443AsnLys: 0.443 ± 0.019	1.997AsnLeu: 1.997 ± 0.048	0.468AsnMet: 0.468 ± 0.021	0.472AsnAsn: 0.472 ± 0.019	1.493AsnPro: 1.493 ± 0.037	0.493AsnGln: 0.493 ± 0.022	1.583AsnArg: 1.583 ± 0.035	0.941AsnSer: 0.941 ± 0.032	1.026AsnThr: 1.026 ± 0.032	1.705AsnVal: 1.705 ± 0.04	0.353AsnTrp: 0.353 ± 0.017	0.474AsnTyr: 0.474 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.157ProAla: 8.157 ± 0.107	0.425ProCys: 0.425 ± 0.022	4.014ProAsp: 4.014 ± 0.059	3.637ProGlu: 3.637 ± 0.057	1.981ProPhe: 1.981 ± 0.042	5.187ProGly: 5.187 ± 0.078	1.097ProHis: 1.097 ± 0.032	2.068ProIle: 2.068 ± 0.044	1.435ProLys: 1.435 ± 0.034	4.808ProLeu: 4.808 ± 0.069	1.358ProMet: 1.358 ± 0.033	1.041ProAsn: 1.041 ± 0.033	3.222ProPro: 3.222 ± 0.078	1.388ProGln: 1.388 ± 0.033	3.768ProArg: 3.768 ± 0.066	2.968ProSer: 2.968 ± 0.056	2.688ProThr: 2.688 ± 0.049	4.762ProVal: 4.762 ± 0.07	0.695ProTrp: 0.695 ± 0.023	1.041ProTyr: 1.041 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.185GlnAla: 3.185 ± 0.059	0.14GlnCys: 0.14 ± 0.011	1.194GlnAsp: 1.194 ± 0.034	1.148GlnGlu: 1.148 ± 0.037	0.822GlnPhe: 0.822 ± 0.023	1.831GlnGly: 1.831 ± 0.044	0.505GlnHis: 0.505 ± 0.023	1.563GlnIle: 1.563 ± 0.038	0.755GlnLys: 0.755 ± 0.026	2.126GlnLeu: 2.126 ± 0.045	0.689GlnMet: 0.689 ± 0.026	0.538GlnAsn: 0.538 ± 0.023	1.443GlnPro: 1.443 ± 0.039	0.81GlnGln: 0.81 ± 0.031	2.11GlnArg: 2.11 ± 0.05	1.29GlnSer: 1.29 ± 0.04	1.401GlnThr: 1.401 ± 0.037	1.883GlnVal: 1.883 ± 0.044	0.25GlnTrp: 0.25 ± 0.015	0.403GlnTyr: 0.403 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.306ArgAla: 9.306 ± 0.112	0.796ArgCys: 0.796 ± 0.029	4.35ArgAsp: 4.35 ± 0.064	4.119ArgGlu: 4.119 ± 0.05	2.977ArgPhe: 2.977 ± 0.057	5.594ArgGly: 5.594 ± 0.084	2.006ArgHis: 2.006 ± 0.042	4.463ArgIle: 4.463 ± 0.065	1.957ArgLys: 1.957 ± 0.044	9.124ArgLeu: 9.124 ± 0.125	2.122ArgMet: 2.122 ± 0.046	1.642ArgAsn: 1.642 ± 0.037	5.024ArgPro: 5.024 ± 0.082	2.357ArgGln: 2.357 ± 0.051	8.265ArgArg: 8.265 ± 0.117	4.339ArgSer: 4.339 ± 0.075	3.83ArgThr: 3.83 ± 0.056	4.989ArgVal: 4.989 ± 0.071	1.157ArgTrp: 1.157 ± 0.033	1.469ArgTyr: 1.469 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.738SerAla: 6.738 ± 0.088	0.483SerCys: 0.483 ± 0.021	2.79SerAsp: 2.79 ± 0.054	2.422SerGlu: 2.422 ± 0.045	2.056SerPhe: 2.056 ± 0.046	5.699SerGly: 5.699 ± 0.089	0.95SerHis: 0.95 ± 0.031	2.353SerIle: 2.353 ± 0.047	1.176SerLys: 1.176 ± 0.03	5.065SerLeu: 5.065 ± 0.066	1.27SerMet: 1.27 ± 0.032	1.019SerAsn: 1.019 ± 0.032	3.127SerPro: 3.127 ± 0.068	1.237SerGln: 1.237 ± 0.031	4.167SerArg: 4.167 ± 0.069	3.1SerSer: 3.1 ± 0.068	2.743SerThr: 2.743 ± 0.054	3.735SerVal: 3.735 ± 0.06	0.653SerTrp: 0.653 ± 0.023	1.054SerTyr: 1.054 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.042ThrAla: 7.042 ± 0.085	0.502ThrCys: 0.502 ± 0.022	3.088ThrAsp: 3.088 ± 0.052	2.613ThrGlu: 2.613 ± 0.043	1.969ThrPhe: 1.969 ± 0.042	5.597ThrGly: 5.597 ± 0.07	0.91ThrHis: 0.91 ± 0.025	2.697ThrIle: 2.697 ± 0.052	1.151ThrLys: 1.151 ± 0.032	5.81ThrLeu: 5.81 ± 0.077	1.276ThrMet: 1.276 ± 0.037	1.053ThrAsn: 1.053 ± 0.034	3.428ThrPro: 3.428 ± 0.054	1.078ThrGln: 1.078 ± 0.032	3.874ThrArg: 3.874 ± 0.058	3.063ThrSer: 3.063 ± 0.058	3.169ThrThr: 3.169 ± 0.058	4.565ThrVal: 4.565 ± 0.064	0.696ThrTrp: 0.696 ± 0.028	1.073ThrTyr: 1.073 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.62ValAla: 10.62 ± 0.113	0.653ValCys: 0.653 ± 0.024	4.798ValAsp: 4.798 ± 0.06	4.714ValGlu: 4.714 ± 0.073	2.884ValPhe: 2.884 ± 0.056	6.002ValGly: 6.002 ± 0.074	1.443ValHis: 1.443 ± 0.035	3.972ValIle: 3.972 ± 0.065	1.971ValLys: 1.971 ± 0.042	7.424ValLeu: 7.424 ± 0.088	1.941ValMet: 1.941 ± 0.039	1.706ValAsn: 1.706 ± 0.045	4.217ValPro: 4.217 ± 0.067	1.619ValGln: 1.619 ± 0.041	5.362ValArg: 5.362 ± 0.07	4.187ValSer: 4.187 ± 0.055	4.975ValThr: 4.975 ± 0.063	6.936ValVal: 6.936 ± 0.092	0.954ValTrp: 0.954 ± 0.03	1.49ValTyr: 1.49 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.125TrpAla: 1.125 ± 0.034	0.182TrpCys: 0.182 ± 0.014	0.568TrpAsp: 0.568 ± 0.024	0.448TrpGlu: 0.448 ± 0.021	0.483TrpPhe: 0.483 ± 0.024	0.802TrpGly: 0.802 ± 0.025	0.295TrpHis: 0.295 ± 0.015	0.602TrpIle: 0.602 ± 0.026	0.379TrpLys: 0.379 ± 0.017	1.43TrpLeu: 1.43 ± 0.035	0.372TrpMet: 0.372 ± 0.018	0.377TrpAsn: 0.377 ± 0.018	0.783TrpPro: 0.783 ± 0.029	0.47TrpGln: 0.47 ± 0.02	1.32TrpArg: 1.32 ± 0.035	0.863TrpSer: 0.863 ± 0.033	0.858TrpThr: 0.858 ± 0.031	0.727TrpVal: 0.727 ± 0.023	0.242TrpTrp: 0.242 ± 0.014	0.266TrpTyr: 0.266 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.281TyrAla: 2.281 ± 0.044	0.189TyrCys: 0.189 ± 0.013	1.331TyrAsp: 1.331 ± 0.029	1.024TyrGlu: 1.024 ± 0.027	0.747TyrPhe: 0.747 ± 0.022	2.025TyrGly: 2.025 ± 0.044	0.395TyrHis: 0.395 ± 0.018	0.715TyrIle: 0.715 ± 0.025	0.453TyrLys: 0.453 ± 0.022	1.936TyrLeu: 1.936 ± 0.044	0.388TyrMet: 0.388 ± 0.018	0.4TyrAsn: 0.4 ± 0.019	0.967TyrPro: 0.967 ± 0.027	0.491TyrGln: 0.491 ± 0.021	1.546TyrArg: 1.546 ± 0.036	0.893TyrSer: 0.893 ± 0.027	0.943TyrThr: 0.943 ± 0.027	1.568TyrVal: 1.568 ± 0.038	0.261TyrTrp: 0.261 ± 0.014	0.437TyrTyr: 0.437 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4503 proteins (1213789 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---