Amino acid dipepetide frequency for Proteiniborus ethanoligenes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.918AlaAla: 3.918 ± 0.093	0.556AlaCys: 0.556 ± 0.028	2.676AlaAsp: 2.676 ± 0.056	3.7AlaGlu: 3.7 ± 0.077	2.586AlaPhe: 2.586 ± 0.056	4.149AlaGly: 4.149 ± 0.086	0.909AlaHis: 0.909 ± 0.032	6.084AlaIle: 6.084 ± 0.101	4.577AlaLys: 4.577 ± 0.081	6.04AlaLeu: 6.04 ± 0.093	1.777AlaMet: 1.777 ± 0.047	2.692AlaAsn: 2.692 ± 0.055	1.518AlaPro: 1.518 ± 0.044	1.586AlaGln: 1.586 ± 0.043	2.232AlaArg: 2.232 ± 0.054	3.422AlaSer: 3.422 ± 0.067	2.956AlaThr: 2.956 ± 0.069	4.128AlaVal: 4.128 ± 0.077	0.376AlaTrp: 0.376 ± 0.021	2.255AlaTyr: 2.255 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.45CysAla: 0.45 ± 0.022	0.12CysCys: 0.12 ± 0.012	0.501CysAsp: 0.501 ± 0.026	0.531CysGlu: 0.531 ± 0.024	0.359CysPhe: 0.359 ± 0.02	0.887CysGly: 0.887 ± 0.04	0.182CysHis: 0.182 ± 0.015	0.895CysIle: 0.895 ± 0.036	0.645CysLys: 0.645 ± 0.029	0.668CysLeu: 0.668 ± 0.028	0.217CysMet: 0.217 ± 0.016	0.494CysAsn: 0.494 ± 0.023	0.426CysPro: 0.426 ± 0.03	0.236CysGln: 0.236 ± 0.015	0.317CysArg: 0.317 ± 0.019	0.616CysSer: 0.616 ± 0.028	0.477CysThr: 0.477 ± 0.027	0.469CysVal: 0.469 ± 0.022	0.06CysTrp: 0.06 ± 0.008	0.34CysTyr: 0.34 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.74AspAla: 2.74 ± 0.051	0.506AspCys: 0.506 ± 0.024	2.665AspAsp: 2.665 ± 0.073	4.666AspGlu: 4.666 ± 0.08	2.646AspPhe: 2.646 ± 0.052	3.347AspGly: 3.347 ± 0.077	0.61AspHis: 0.61 ± 0.03	6.568AspIle: 6.568 ± 0.1	5.047AspLys: 5.047 ± 0.081	4.831AspLeu: 4.831 ± 0.075	1.608AspMet: 1.608 ± 0.04	3.367AspAsn: 3.367 ± 0.067	1.429AspPro: 1.429 ± 0.039	0.875AspGln: 0.875 ± 0.035	2.073AspArg: 2.073 ± 0.048	3.137AspSer: 3.137 ± 0.063	2.62AspThr: 2.62 ± 0.057	3.472AspVal: 3.472 ± 0.065	0.472AspTrp: 0.472 ± 0.021	2.753AspTyr: 2.753 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.689GluAla: 4.689 ± 0.076	0.513GluCys: 0.513 ± 0.025	4.377GluAsp: 4.377 ± 0.065	7.732GluGlu: 7.732 ± 0.131	2.715GluPhe: 2.715 ± 0.059	4.688GluGly: 4.688 ± 0.086	1.055GluHis: 1.055 ± 0.037	8.106GluIle: 8.106 ± 0.11	7.66GluLys: 7.66 ± 0.119	7.29GluLeu: 7.29 ± 0.103	2.0GluMet: 2.0 ± 0.047	4.904GluAsn: 4.904 ± 0.076	1.757GluPro: 1.757 ± 0.052	1.981GluGln: 1.981 ± 0.054	3.132GluArg: 3.132 ± 0.067	3.636GluSer: 3.636 ± 0.071	2.97GluThr: 2.97 ± 0.059	4.855GluVal: 4.855 ± 0.081	0.48GluTrp: 0.48 ± 0.024	3.332GluTyr: 3.332 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.286PheAla: 2.286 ± 0.058	0.423PheCys: 0.423 ± 0.021	2.392PheAsp: 2.392 ± 0.056	2.687PheGlu: 2.687 ± 0.059	1.928PhePhe: 1.928 ± 0.055	2.797PheGly: 2.797 ± 0.064	0.619PheHis: 0.619 ± 0.025	4.401PheIle: 4.401 ± 0.085	3.289PheLys: 3.289 ± 0.065	3.659PheLeu: 3.659 ± 0.071	1.05PheMet: 1.05 ± 0.038	2.53PheAsn: 2.53 ± 0.051	1.278PhePro: 1.278 ± 0.034	1.02PheGln: 1.02 ± 0.031	1.389PheArg: 1.389 ± 0.036	2.916PheSer: 2.916 ± 0.064	2.312PheThr: 2.312 ± 0.055	2.603PheVal: 2.603 ± 0.052	0.299PheTrp: 0.299 ± 0.019	1.62PheTyr: 1.62 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.242GlyAla: 4.242 ± 0.106	0.773GlyCys: 0.773 ± 0.033	3.312GlyAsp: 3.312 ± 0.063	4.721GlyGlu: 4.721 ± 0.085	3.204GlyPhe: 3.204 ± 0.07	4.609GlyGly: 4.609 ± 0.095	1.145GlyHis: 1.145 ± 0.039	7.138GlyIle: 7.138 ± 0.1	5.545GlyLys: 5.545 ± 0.08	6.257GlyLeu: 6.257 ± 0.094	1.775GlyMet: 1.775 ± 0.049	3.264GlyAsn: 3.264 ± 0.067	1.428GlyPro: 1.428 ± 0.049	1.753GlyGln: 1.753 ± 0.04	2.565GlyArg: 2.565 ± 0.057	3.736GlySer: 3.736 ± 0.065	3.651GlyThr: 3.651 ± 0.077	4.586GlyVal: 4.586 ± 0.083	0.508GlyTrp: 0.508 ± 0.025	3.048GlyTyr: 3.048 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.766HisAla: 0.766 ± 0.028	0.17HisCys: 0.17 ± 0.013	0.741HisAsp: 0.741 ± 0.03	0.98HisGlu: 0.98 ± 0.031	0.628HisPhe: 0.628 ± 0.026	1.086HisGly: 1.086 ± 0.037	0.297HisHis: 0.297 ± 0.018	1.666HisIle: 1.666 ± 0.045	1.11HisLys: 1.11 ± 0.036	1.287HisLeu: 1.287 ± 0.036	0.424HisMet: 0.424 ± 0.02	0.823HisAsn: 0.823 ± 0.032	0.702HisPro: 0.702 ± 0.025	0.41HisGln: 0.41 ± 0.02	0.659HisArg: 0.659 ± 0.026	0.956HisSer: 0.956 ± 0.036	0.764HisThr: 0.764 ± 0.03	0.877HisVal: 0.877 ± 0.03	0.129HisTrp: 0.129 ± 0.011	0.617HisTyr: 0.617 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.072IleAla: 6.072 ± 0.084	0.891IleCys: 0.891 ± 0.032	6.353IleAsp: 6.353 ± 0.087	7.932IleGlu: 7.932 ± 0.107	4.093IlePhe: 4.093 ± 0.077	6.823IleGly: 6.823 ± 0.124	1.427IleHis: 1.427 ± 0.04	10.274IleIle: 10.274 ± 0.151	8.363IleLys: 8.363 ± 0.111	9.457IleLeu: 9.457 ± 0.118	2.459IleMet: 2.459 ± 0.054	5.698IleAsn: 5.698 ± 0.086	3.525IlePro: 3.525 ± 0.07	2.481IleGln: 2.481 ± 0.051	3.616IleArg: 3.616 ± 0.06	7.093IleSer: 7.093 ± 0.101	4.872IleThr: 4.872 ± 0.069	6.676IleVal: 6.676 ± 0.095	0.585IleTrp: 0.585 ± 0.026	3.44IleTyr: 3.44 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.174LysAla: 5.174 ± 0.084	0.635LysCys: 0.635 ± 0.033	5.712LysAsp: 5.712 ± 0.084	8.609LysGlu: 8.609 ± 0.118	2.414LysPhe: 2.414 ± 0.054	5.37LysGly: 5.37 ± 0.079	1.24LysHis: 1.24 ± 0.031	7.583LysIle: 7.583 ± 0.102	7.004LysLys: 7.004 ± 0.101	7.024LysLeu: 7.024 ± 0.084	2.126LysMet: 2.126 ± 0.048	5.016LysAsn: 5.016 ± 0.088	2.248LysPro: 2.248 ± 0.052	2.03LysGln: 2.03 ± 0.057	3.175LysArg: 3.175 ± 0.054	4.698LysSer: 4.698 ± 0.075	4.047LysThr: 4.047 ± 0.069	5.22LysVal: 5.22 ± 0.079	0.572LysTrp: 0.572 ± 0.023	3.633LysTyr: 3.633 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	5.486LeuAla: 5.486 ± 0.088	0.848LeuCys: 0.848 ± 0.03	5.389LeuAsp: 5.389 ± 0.087	6.988LeuGlu: 6.988 ± 0.116	3.785LeuPhe: 3.785 ± 0.08	6.644LeuGly: 6.644 ± 0.103	1.185LeuHis: 1.185 ± 0.037	8.4LeuIle: 8.4 ± 0.122	7.902LeuLys: 7.902 ± 0.096	8.482LeuLeu: 8.482 ± 0.136	2.334LeuMet: 2.334 ± 0.056	5.411LeuAsn: 5.411 ± 0.083	2.984LeuPro: 2.984 ± 0.06	2.154LeuGln: 2.154 ± 0.047	3.436LeuArg: 3.436 ± 0.061	6.669LeuSer: 6.669 ± 0.095	4.518LeuThr: 4.518 ± 0.07	5.631LeuVal: 5.631 ± 0.091	0.611LeuTrp: 0.611 ± 0.031	3.287LeuTyr: 3.287 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.729MetAla: 1.729 ± 0.047	0.189MetCys: 0.189 ± 0.015	1.523MetAsp: 1.523 ± 0.042	2.033MetGlu: 2.033 ± 0.046	0.939MetPhe: 0.939 ± 0.038	1.773MetGly: 1.773 ± 0.049	0.344MetHis: 0.344 ± 0.017	2.282MetIle: 2.282 ± 0.052	2.428MetLys: 2.428 ± 0.055	2.444MetLeu: 2.444 ± 0.053	0.674MetMet: 0.674 ± 0.03	1.536MetAsn: 1.536 ± 0.043	0.882MetPro: 0.882 ± 0.033	0.628MetGln: 0.628 ± 0.027	0.958MetArg: 0.958 ± 0.032	1.674MetSer: 1.674 ± 0.047	1.34MetThr: 1.34 ± 0.037	1.674MetVal: 1.674 ± 0.043	0.14MetTrp: 0.14 ± 0.013	0.827MetTyr: 0.827 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.704AsnAla: 2.704 ± 0.053	0.515AsnCys: 0.515 ± 0.029	2.514AsnAsp: 2.514 ± 0.045	4.048AsnGlu: 4.048 ± 0.071	1.986AsnPhe: 1.986 ± 0.047	3.484AsnGly: 3.484 ± 0.064	0.979AsnHis: 0.979 ± 0.033	6.878AsnIle: 6.878 ± 0.091	5.249AsnLys: 5.249 ± 0.091	4.923AsnLeu: 4.923 ± 0.074	1.566AsnMet: 1.566 ± 0.043	3.779AsnAsn: 3.779 ± 0.068	2.237AsnPro: 2.237 ± 0.048	1.504AsnGln: 1.504 ± 0.047	2.284AsnArg: 2.284 ± 0.053	3.524AsnSer: 3.524 ± 0.068	2.906AsnThr: 2.906 ± 0.053	3.257AsnVal: 3.257 ± 0.063	0.438AsnTrp: 0.438 ± 0.022	2.283AsnTyr: 2.283 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.589ProAla: 1.589 ± 0.042	0.255ProCys: 0.255 ± 0.018	1.747ProAsp: 1.747 ± 0.043	2.512ProGlu: 2.512 ± 0.053	1.394ProPhe: 1.394 ± 0.042	1.937ProGly: 1.937 ± 0.053	0.567ProHis: 0.567 ± 0.025	3.006ProIle: 3.006 ± 0.064	2.195ProLys: 2.195 ± 0.053	2.612ProLeu: 2.612 ± 0.057	0.779ProMet: 0.779 ± 0.032	1.623ProAsn: 1.623 ± 0.041	0.804ProPro: 0.804 ± 0.036	0.89ProGln: 0.89 ± 0.034	0.973ProArg: 0.973 ± 0.032	1.918ProSer: 1.918 ± 0.047	1.642ProThr: 1.642 ± 0.043	2.319ProVal: 2.319 ± 0.059	0.21ProTrp: 0.21 ± 0.016	1.388ProTyr: 1.388 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.554GlnAla: 1.554 ± 0.046	0.192GlnCys: 0.192 ± 0.016	1.295GlnAsp: 1.295 ± 0.04	1.862GlnGlu: 1.862 ± 0.045	0.933GlnPhe: 0.933 ± 0.035	1.698GlnGly: 1.698 ± 0.04	0.389GlnHis: 0.389 ± 0.019	2.477GlnIle: 2.477 ± 0.059	2.065GlnLys: 2.065 ± 0.045	2.331GlnLeu: 2.331 ± 0.048	0.771GlnMet: 0.771 ± 0.026	1.433GlnAsn: 1.433 ± 0.038	0.687GlnPro: 0.687 ± 0.03	0.73GlnGln: 0.73 ± 0.031	1.097GlnArg: 1.097 ± 0.029	1.486GlnSer: 1.486 ± 0.045	1.071GlnThr: 1.071 ± 0.035	1.598GlnVal: 1.598 ± 0.039	0.23GlnTrp: 0.23 ± 0.013	1.01GlnTyr: 1.01 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.169ArgAla: 2.169 ± 0.047	0.338ArgCys: 0.338 ± 0.021	2.075ArgAsp: 2.075 ± 0.048	3.407ArgGlu: 3.407 ± 0.064	1.643ArgPhe: 1.643 ± 0.049	2.254ArgGly: 2.254 ± 0.053	0.521ArgHis: 0.521 ± 0.025	3.807ArgIle: 3.807 ± 0.066	3.177ArgLys: 3.177 ± 0.061	3.686ArgLeu: 3.686 ± 0.062	0.996ArgMet: 0.996 ± 0.031	2.065ArgAsn: 2.065 ± 0.045	1.061ArgPro: 1.061 ± 0.038	1.145ArgGln: 1.145 ± 0.035	1.694ArgArg: 1.694 ± 0.049	1.683ArgSer: 1.683 ± 0.041	1.775ArgThr: 1.775 ± 0.046	2.519ArgVal: 2.519 ± 0.058	0.254ArgTrp: 0.254 ± 0.015	1.629ArgTyr: 1.629 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.082SerAla: 3.082 ± 0.069	0.531SerCys: 0.531 ± 0.027	2.888SerAsp: 2.888 ± 0.06	3.859SerGlu: 3.859 ± 0.057	3.057SerPhe: 3.057 ± 0.058	4.17SerGly: 4.17 ± 0.078	1.03SerHis: 1.03 ± 0.034	6.821SerIle: 6.821 ± 0.108	5.08SerLys: 5.08 ± 0.071	6.189SerLeu: 6.189 ± 0.09	1.716SerMet: 1.716 ± 0.046	3.429SerAsn: 3.429 ± 0.071	1.837SerPro: 1.837 ± 0.047	1.806SerGln: 1.806 ± 0.041	2.348SerArg: 2.348 ± 0.048	4.266SerSer: 4.266 ± 0.083	3.159SerThr: 3.159 ± 0.068	3.485SerVal: 3.485 ± 0.062	0.396SerTrp: 0.396 ± 0.021	2.511SerTyr: 2.511 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.082ThrAla: 3.082 ± 0.072	0.38ThrCys: 0.38 ± 0.017	2.526ThrAsp: 2.526 ± 0.053	3.326ThrGlu: 3.326 ± 0.06	2.064ThrPhe: 2.064 ± 0.048	3.995ThrGly: 3.995 ± 0.068	0.849ThrHis: 0.849 ± 0.033	5.152ThrIle: 5.152 ± 0.091	3.484ThrLys: 3.484 ± 0.057	4.691ThrLeu: 4.691 ± 0.067	1.134ThrMet: 1.134 ± 0.035	2.55ThrAsn: 2.55 ± 0.054	1.898ThrPro: 1.898 ± 0.048	1.182ThrGln: 1.182 ± 0.04	1.788ThrArg: 1.788 ± 0.044	2.999ThrSer: 2.999 ± 0.062	2.721ThrThr: 2.721 ± 0.06	3.333ThrVal: 3.333 ± 0.076	0.356ThrTrp: 0.356 ± 0.019	1.84ThrTyr: 1.84 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.022ValAla: 4.022 ± 0.087	0.563ValCys: 0.563 ± 0.022	3.96ValAsp: 3.96 ± 0.068	4.762ValGlu: 4.762 ± 0.08	2.892ValPhe: 2.892 ± 0.062	4.327ValGly: 4.327 ± 0.082	0.972ValHis: 0.972 ± 0.034	5.906ValIle: 5.906 ± 0.092	5.033ValLys: 5.033 ± 0.073	6.024ValLeu: 6.024 ± 0.088	1.517ValMet: 1.517 ± 0.042	3.474ValAsn: 3.474 ± 0.057	2.143ValPro: 2.143 ± 0.053	1.446ValGln: 1.446 ± 0.04	2.271ValArg: 2.271 ± 0.048	4.125ValSer: 4.125 ± 0.07	3.165ValThr: 3.165 ± 0.082	4.441ValVal: 4.441 ± 0.091	0.379ValTrp: 0.379 ± 0.022	2.274ValTyr: 2.274 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.414TrpAla: 0.414 ± 0.021	0.055TrpCys: 0.055 ± 0.008	0.453TrpAsp: 0.453 ± 0.025	0.528TrpGlu: 0.528 ± 0.027	0.288TrpPhe: 0.288 ± 0.018	0.541TrpGly: 0.541 ± 0.026	0.126TrpHis: 0.126 ± 0.012	0.605TrpIle: 0.605 ± 0.026	0.517TrpLys: 0.517 ± 0.027	0.623TrpLeu: 0.623 ± 0.027	0.181TrpMet: 0.181 ± 0.016	0.414TrpAsn: 0.414 ± 0.021	0.173TrpPro: 0.173 ± 0.014	0.176TrpGln: 0.176 ± 0.015	0.272TrpArg: 0.272 ± 0.018	0.415TrpSer: 0.415 ± 0.024	0.345TrpThr: 0.345 ± 0.023	0.377TrpVal: 0.377 ± 0.022	0.083TrpTrp: 0.083 ± 0.009	0.274TrpTyr: 0.274 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.967TyrAla: 1.967 ± 0.057	0.437TyrCys: 0.437 ± 0.021	2.333TyrAsp: 2.333 ± 0.056	2.992TyrGlu: 2.992 ± 0.066	1.941TyrPhe: 1.941 ± 0.052	2.68TyrGly: 2.68 ± 0.064	0.647TyrHis: 0.647 ± 0.028	4.081TyrIle: 4.081 ± 0.082	3.16TyrLys: 3.16 ± 0.064	3.628TyrLeu: 3.628 ± 0.072	0.913TyrMet: 0.913 ± 0.031	2.556TyrAsn: 2.556 ± 0.061	1.341TyrPro: 1.341 ± 0.037	0.879TyrGln: 0.879 ± 0.028	1.621TyrArg: 1.621 ± 0.038	2.689TyrSer: 2.689 ± 0.059	2.037TyrThr: 2.037 ± 0.047	2.175TyrVal: 2.175 ± 0.044	0.283TyrTrp: 0.283 ± 0.018	1.843TyrTyr: 1.843 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2950 proteins (922494 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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