Amino acid dipepetide frequency for Nocardia sp. SYP-A9097

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.436AlaAla: 20.436 ± 0.142	0.942AlaCys: 0.942 ± 0.019	8.49AlaAsp: 8.49 ± 0.066	8.407AlaGlu: 8.407 ± 0.079	3.443AlaPhe: 3.443 ± 0.036	11.762AlaGly: 11.762 ± 0.08	2.799AlaHis: 2.799 ± 0.035	5.261AlaIle: 5.261 ± 0.054	2.805AlaLys: 2.805 ± 0.042	13.391AlaLeu: 13.391 ± 0.09	2.722AlaMet: 2.722 ± 0.033	2.573AlaAsn: 2.573 ± 0.029	6.133AlaPro: 6.133 ± 0.062	4.174AlaGln: 4.174 ± 0.049	8.929AlaArg: 8.929 ± 0.074	5.403AlaSer: 5.403 ± 0.043	7.387AlaThr: 7.387 ± 0.057	11.347AlaVal: 11.347 ± 0.083	1.72AlaTrp: 1.72 ± 0.026	2.405AlaTyr: 2.405 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.032CysAla: 1.032 ± 0.023	0.091CysCys: 0.091 ± 0.007	0.478CysAsp: 0.478 ± 0.014	0.403CysGlu: 0.403 ± 0.014	0.212CysPhe: 0.212 ± 0.009	0.89CysGly: 0.89 ± 0.021	0.19CysHis: 0.19 ± 0.008	0.237CysIle: 0.237 ± 0.01	0.132CysLys: 0.132 ± 0.008	0.665CysLeu: 0.665 ± 0.018	0.115CysMet: 0.115 ± 0.007	0.144CysAsn: 0.144 ± 0.007	0.455CysPro: 0.455 ± 0.015	0.17CysGln: 0.17 ± 0.009	0.527CysArg: 0.527 ± 0.017	0.452CysSer: 0.452 ± 0.015	0.502CysThr: 0.502 ± 0.014	0.581CysVal: 0.581 ± 0.015	0.124CysTrp: 0.124 ± 0.006	0.174CysTyr: 0.174 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.214AspAla: 7.214 ± 0.056	0.448AspCys: 0.448 ± 0.013	3.361AspAsp: 3.361 ± 0.043	3.517AspGlu: 3.517 ± 0.034	1.87AspPhe: 1.87 ± 0.028	5.343AspGly: 5.343 ± 0.051	1.467AspHis: 1.467 ± 0.025	2.7AspIle: 2.7 ± 0.032	1.306AspLys: 1.306 ± 0.03	6.317AspLeu: 6.317 ± 0.066	0.989AspMet: 0.989 ± 0.019	1.243AspAsn: 1.243 ± 0.023	4.544AspPro: 4.544 ± 0.062	1.86AspGln: 1.86 ± 0.027	4.931AspArg: 4.931 ± 0.054	3.345AspSer: 3.345 ± 0.049	3.399AspThr: 3.399 ± 0.035	4.131AspVal: 4.131 ± 0.049	1.051AspTrp: 1.051 ± 0.022	1.383AspTyr: 1.383 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	5.939GluAla: 5.939 ± 0.067	0.388GluCys: 0.388 ± 0.011	2.268GluAsp: 2.268 ± 0.029	2.384GluGlu: 2.384 ± 0.034	2.077GluPhe: 2.077 ± 0.034	3.266GluGly: 3.266 ± 0.044	1.639GluHis: 1.639 ± 0.026	2.946GluIle: 2.946 ± 0.031	1.261GluLys: 1.261 ± 0.027	7.467GluLeu: 7.467 ± 0.075	1.043GluMet: 1.043 ± 0.021	1.271GluAsn: 1.271 ± 0.027	3.176GluPro: 3.176 ± 0.044	2.488GluGln: 2.488 ± 0.031	4.756GluArg: 4.756 ± 0.045	3.173GluSer: 3.173 ± 0.037	2.986GluThr: 2.986 ± 0.037	4.403GluVal: 4.403 ± 0.044	0.879GluTrp: 0.879 ± 0.018	1.312GluTyr: 1.312 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.127PheAla: 4.127 ± 0.043	0.257PheCys: 0.257 ± 0.012	2.512PheAsp: 2.512 ± 0.038	1.78PheGlu: 1.78 ± 0.031	0.915PhePhe: 0.915 ± 0.019	3.516PheGly: 3.516 ± 0.045	0.659PheHis: 0.659 ± 0.018	1.004PheIle: 1.004 ± 0.02	0.474PheLys: 0.474 ± 0.015	2.603PheLeu: 2.603 ± 0.036	0.481PheMet: 0.481 ± 0.015	0.632PheAsn: 0.632 ± 0.016	1.455PhePro: 1.455 ± 0.023	0.778PheGln: 0.778 ± 0.021	1.838PheArg: 1.838 ± 0.025	1.592PheSer: 1.592 ± 0.024	2.153PheThr: 2.153 ± 0.034	2.34PheVal: 2.34 ± 0.037	0.415PheTrp: 0.415 ± 0.013	0.618PheTyr: 0.618 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	9.98GlyAla: 9.98 ± 0.08	0.771GlyCys: 0.771 ± 0.017	4.768GlyAsp: 4.768 ± 0.048	4.629GlyGlu: 4.629 ± 0.051	3.045GlyPhe: 3.045 ± 0.039	7.606GlyGly: 7.606 ± 0.076	2.088GlyHis: 2.088 ± 0.036	4.382GlyIle: 4.382 ± 0.046	2.378GlyLys: 2.378 ± 0.036	8.644GlyLeu: 8.644 ± 0.067	2.084GlyMet: 2.084 ± 0.03	2.02GlyAsn: 2.02 ± 0.028	4.422GlyPro: 4.422 ± 0.053	2.636GlyGln: 2.636 ± 0.042	6.315GlyArg: 6.315 ± 0.048	5.279GlySer: 5.279 ± 0.059	5.615GlyThr: 5.615 ± 0.06	7.198GlyVal: 7.198 ± 0.055	1.629GlyTrp: 1.629 ± 0.025	2.361GlyTyr: 2.361 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.64HisAla: 2.64 ± 0.035	0.212HisCys: 0.212 ± 0.011	1.303HisAsp: 1.303 ± 0.026	1.157HisGlu: 1.157 ± 0.024	0.675HisPhe: 0.675 ± 0.015	2.174HisGly: 2.174 ± 0.028	0.666HisHis: 0.666 ± 0.018	0.918HisIle: 0.918 ± 0.02	0.365HisLys: 0.365 ± 0.013	2.257HisLeu: 2.257 ± 0.031	0.426HisMet: 0.426 ± 0.012	0.524HisAsn: 0.524 ± 0.016	1.788HisPro: 1.788 ± 0.032	0.648HisGln: 0.648 ± 0.018	1.992HisArg: 1.992 ± 0.029	1.202HisSer: 1.202 ± 0.021	1.372HisThr: 1.372 ± 0.024	1.484HisVal: 1.484 ± 0.025	0.385HisTrp: 0.385 ± 0.014	0.558HisTyr: 0.558 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	6.825IleAla: 6.825 ± 0.055	0.348IleCys: 0.348 ± 0.013	3.429IleAsp: 3.429 ± 0.034	2.811IleGlu: 2.811 ± 0.037	1.052IlePhe: 1.052 ± 0.021	4.649IleGly: 4.649 ± 0.05	0.846IleHis: 0.846 ± 0.02	1.497IleIle: 1.497 ± 0.029	0.78IleLys: 0.78 ± 0.02	3.377IleLeu: 3.377 ± 0.047	0.656IleMet: 0.656 ± 0.015	0.972IleAsn: 0.972 ± 0.023	2.566IlePro: 2.566 ± 0.034	0.974IleGln: 0.974 ± 0.02	2.877IleArg: 2.877 ± 0.033	2.44IleSer: 2.44 ± 0.032	3.0IleThr: 3.0 ± 0.042	3.586IleVal: 3.586 ± 0.042	0.467IleTrp: 0.467 ± 0.014	0.755IleTyr: 0.755 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.483LysAla: 2.483 ± 0.037	0.121LysCys: 0.121 ± 0.008	1.066LysAsp: 1.066 ± 0.026	0.89LysGlu: 0.89 ± 0.023	0.652LysPhe: 0.652 ± 0.016	1.448LysGly: 1.448 ± 0.024	0.468LysHis: 0.468 ± 0.016	0.992LysIle: 0.992 ± 0.02	0.625LysLys: 0.625 ± 0.02	2.258LysLeu: 2.258 ± 0.034	0.488LysMet: 0.488 ± 0.017	0.514LysAsn: 0.514 ± 0.015	1.386LysPro: 1.386 ± 0.027	0.746LysGln: 0.746 ± 0.02	1.436LysArg: 1.436 ± 0.026	1.313LysSer: 1.313 ± 0.025	1.306LysThr: 1.306 ± 0.022	1.782LysVal: 1.782 ± 0.032	0.297LysTrp: 0.297 ± 0.01	0.486LysTyr: 0.486 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.254LeuAla: 14.254 ± 0.095	0.797LeuCys: 0.797 ± 0.02	6.777LeuAsp: 6.777 ± 0.068	5.044LeuGlu: 5.044 ± 0.048	2.792LeuPhe: 2.792 ± 0.039	8.846LeuGly: 8.846 ± 0.071	2.224LeuHis: 2.224 ± 0.032	4.458LeuIle: 4.458 ± 0.048	1.589LeuLys: 1.589 ± 0.028	10.334LeuLeu: 10.334 ± 0.072	1.662LeuMet: 1.662 ± 0.03	2.101LeuAsn: 2.101 ± 0.033	6.293LeuPro: 6.293 ± 0.058	2.4LeuGln: 2.4 ± 0.033	8.408LeuArg: 8.408 ± 0.066	5.695LeuSer: 5.695 ± 0.054	6.976LeuThr: 6.976 ± 0.062	8.128LeuVal: 8.128 ± 0.074	1.255LeuTrp: 1.255 ± 0.023	1.713LeuTyr: 1.713 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.362MetAla: 2.362 ± 0.03	0.155MetCys: 0.155 ± 0.009	0.908MetAsp: 0.908 ± 0.021	0.718MetGlu: 0.718 ± 0.019	0.614MetPhe: 0.614 ± 0.016	1.371MetGly: 1.371 ± 0.026	0.417MetHis: 0.417 ± 0.014	0.897MetIle: 0.897 ± 0.018	0.418MetLys: 0.418 ± 0.012	2.058MetLeu: 2.058 ± 0.03	0.371MetMet: 0.371 ± 0.012	0.549MetAsn: 0.549 ± 0.015	1.239MetPro: 1.239 ± 0.023	0.526MetGln: 0.526 ± 0.014	1.574MetArg: 1.574 ± 0.027	1.498MetSer: 1.498 ± 0.028	1.606MetThr: 1.606 ± 0.028	1.609MetVal: 1.609 ± 0.024	0.23MetTrp: 0.23 ± 0.011	0.365MetTyr: 0.365 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.6AsnAla: 2.6 ± 0.032	0.174AsnCys: 0.174 ± 0.009	1.143AsnAsp: 1.143 ± 0.02	0.982AsnGlu: 0.982 ± 0.021	0.627AsnPhe: 0.627 ± 0.017	2.174AsnGly: 2.174 ± 0.03	0.476AsnHis: 0.476 ± 0.014	0.939AsnIle: 0.939 ± 0.021	0.452AsnLys: 0.452 ± 0.014	2.103AsnLeu: 2.103 ± 0.032	0.436AsnMet: 0.436 ± 0.013	0.537AsnAsn: 0.537 ± 0.017	1.834AsnPro: 1.834 ± 0.031	0.678AsnGln: 0.678 ± 0.017	1.563AsnArg: 1.563 ± 0.028	1.348AsnSer: 1.348 ± 0.023	1.379AsnThr: 1.379 ± 0.025	1.53AsnVal: 1.53 ± 0.026	0.406AsnTrp: 0.406 ± 0.012	0.526AsnTyr: 0.526 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.781ProAla: 7.781 ± 0.085	0.278ProCys: 0.278 ± 0.012	4.227ProAsp: 4.227 ± 0.046	4.257ProGlu: 4.257 ± 0.05	1.582ProPhe: 1.582 ± 0.024	5.841ProGly: 5.841 ± 0.055	1.27ProHis: 1.27 ± 0.026	2.416ProIle: 2.416 ± 0.032	1.29ProLys: 1.29 ± 0.027	4.971ProLeu: 4.971 ± 0.05	1.141ProMet: 1.141 ± 0.023	1.416ProAsn: 1.416 ± 0.025	3.05ProPro: 3.05 ± 0.057	1.875ProGln: 1.875 ± 0.032	3.522ProArg: 3.522 ± 0.041	2.878ProSer: 2.878 ± 0.036	3.458ProThr: 3.458 ± 0.042	5.066ProVal: 5.066 ± 0.06	0.827ProTrp: 0.827 ± 0.019	1.088ProTyr: 1.088 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.623GlnAla: 3.623 ± 0.043	0.192GlnCys: 0.192 ± 0.009	1.369GlnAsp: 1.369 ± 0.027	1.224GlnGlu: 1.224 ± 0.021	0.896GlnPhe: 0.896 ± 0.017	2.057GlnGly: 2.057 ± 0.034	0.764GlnHis: 0.764 ± 0.016	1.412GlnIle: 1.412 ± 0.028	0.517GlnLys: 0.517 ± 0.016	3.749GlnLeu: 3.749 ± 0.045	0.555GlnMet: 0.555 ± 0.015	0.562GlnAsn: 0.562 ± 0.013	2.01GlnPro: 2.01 ± 0.035	1.435GlnGln: 1.435 ± 0.032	2.834GlnArg: 2.834 ± 0.033	1.506GlnSer: 1.506 ± 0.025	1.412GlnThr: 1.412 ± 0.026	2.721GlnVal: 2.721 ± 0.043	0.562GlnTrp: 0.562 ± 0.015	0.678GlnTyr: 0.678 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	8.95ArgAla: 8.95 ± 0.079	0.56ArgCys: 0.56 ± 0.015	4.209ArgAsp: 4.209 ± 0.047	4.316ArgGlu: 4.316 ± 0.049	2.488ArgPhe: 2.488 ± 0.034	5.258ArgGly: 5.258 ± 0.045	1.79ArgHis: 1.79 ± 0.026	3.917ArgIle: 3.917 ± 0.037	1.731ArgLys: 1.731 ± 0.025	7.795ArgLeu: 7.795 ± 0.072	1.903ArgMet: 1.903 ± 0.026	1.717ArgAsn: 1.717 ± 0.029	4.093ArgPro: 4.093 ± 0.049	2.263ArgGln: 2.263 ± 0.034	6.425ArgArg: 6.425 ± 0.065	4.032ArgSer: 4.032 ± 0.039	4.936ArgThr: 4.936 ± 0.051	5.515ArgVal: 5.515 ± 0.044	1.372ArgTrp: 1.372 ± 0.025	1.838ArgTyr: 1.838 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.127SerAla: 7.127 ± 0.05	0.417SerCys: 0.417 ± 0.014	3.159SerAsp: 3.159 ± 0.043	2.761SerGlu: 2.761 ± 0.036	1.676SerPhe: 1.676 ± 0.026	6.019SerGly: 6.019 ± 0.058	1.047SerHis: 1.047 ± 0.023	2.29SerIle: 2.29 ± 0.031	1.179SerLys: 1.179 ± 0.023	4.655SerLeu: 4.655 ± 0.041	1.281SerMet: 1.281 ± 0.023	1.209SerAsn: 1.209 ± 0.024	2.981SerPro: 2.981 ± 0.039	1.396SerGln: 1.396 ± 0.023	3.668SerArg: 3.668 ± 0.045	3.053SerSer: 3.053 ± 0.043	3.507SerThr: 3.507 ± 0.04	4.332SerVal: 4.332 ± 0.046	0.942SerTrp: 0.942 ± 0.021	1.254SerTyr: 1.254 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.737ThrAla: 8.737 ± 0.07	0.403ThrCys: 0.403 ± 0.013	3.807ThrAsp: 3.807 ± 0.043	3.554ThrGlu: 3.554 ± 0.036	1.743ThrPhe: 1.743 ± 0.024	6.356ThrGly: 6.356 ± 0.054	1.269ThrHis: 1.269 ± 0.022	2.597ThrIle: 2.597 ± 0.037	1.232ThrLys: 1.232 ± 0.025	5.827ThrLeu: 5.827 ± 0.052	1.108ThrMet: 1.108 ± 0.019	1.194ThrAsn: 1.194 ± 0.021	4.068ThrPro: 4.068 ± 0.054	1.521ThrGln: 1.521 ± 0.026	3.965ThrArg: 3.965 ± 0.04	3.086ThrSer: 3.086 ± 0.035	4.049ThrThr: 4.049 ± 0.058	5.966ThrVal: 5.966 ± 0.06	0.807ThrTrp: 0.807 ± 0.02	1.236ThrTyr: 1.236 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.479ValAla: 10.479 ± 0.085	0.667ValCys: 0.667 ± 0.017	5.068ValAsp: 5.068 ± 0.047	4.508ValGlu: 4.508 ± 0.043	2.528ValPhe: 2.528 ± 0.032	6.23ValGly: 6.23 ± 0.056	1.845ValHis: 1.845 ± 0.029	3.702ValIle: 3.702 ± 0.036	1.513ValLys: 1.513 ± 0.028	9.146ValLeu: 9.146 ± 0.075	1.383ValMet: 1.383 ± 0.02	1.853ValAsn: 1.853 ± 0.029	4.726ValPro: 4.726 ± 0.049	2.166ValGln: 2.166 ± 0.03	6.273ValArg: 6.273 ± 0.06	4.456ValSer: 4.456 ± 0.045	5.288ValThr: 5.288 ± 0.053	7.389ValVal: 7.389 ± 0.069	1.053ValTrp: 1.053 ± 0.021	1.467ValTyr: 1.467 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.519TrpAla: 1.519 ± 0.027	0.151TrpCys: 0.151 ± 0.008	0.797TrpAsp: 0.797 ± 0.022	0.741TrpGlu: 0.741 ± 0.018	0.553TrpPhe: 0.553 ± 0.016	0.992TrpGly: 0.992 ± 0.023	0.367TrpHis: 0.367 ± 0.012	0.657TrpIle: 0.657 ± 0.019	0.351TrpLys: 0.351 ± 0.011	1.723TrpLeu: 1.723 ± 0.029	0.32TrpMet: 0.32 ± 0.011	0.434TrpAsn: 0.434 ± 0.013	0.802TrpPro: 0.802 ± 0.019	0.665TrpGln: 0.665 ± 0.015	1.319TrpArg: 1.319 ± 0.024	1.005TrpSer: 1.005 ± 0.02	0.973TrpThr: 0.973 ± 0.021	1.111TrpVal: 1.111 ± 0.022	0.346TrpTrp: 0.346 ± 0.012	0.334TrpTyr: 0.334 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.423TyrAla: 2.423 ± 0.03	0.199TyrCys: 0.199 ± 0.009	1.279TyrAsp: 1.279 ± 0.022	1.04TyrGlu: 1.04 ± 0.023	0.706TyrPhe: 0.706 ± 0.018	2.053TyrGly: 2.053 ± 0.029	0.457TyrHis: 0.457 ± 0.014	0.685TyrIle: 0.685 ± 0.018	0.358TyrLys: 0.358 ± 0.012	2.405TyrLeu: 2.405 ± 0.036	0.321TyrMet: 0.321 ± 0.013	0.443TyrAsn: 0.443 ± 0.013	1.213TyrPro: 1.213 ± 0.023	0.677TyrGln: 0.677 ± 0.018	1.956TyrArg: 1.956 ± 0.031	1.197TyrSer: 1.197 ± 0.023	1.221TyrThr: 1.221 ± 0.026	1.522TyrVal: 1.522 ± 0.03	0.395TyrTrp: 0.395 ± 0.013	0.469TyrTyr: 0.469 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7799 proteins (2561633 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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