Amino acid dipepetide frequency for Paracoccidioides brasiliensis (strain Pb18)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.912AlaAla: 7.912 ± 0.071
0.915AlaCys: 0.915 ± 0.016
3.813AlaAsp: 3.813 ± 0.034
4.768AlaGlu: 4.768 ± 0.047
2.756AlaPhe: 2.756 ± 0.031
5.323AlaGly: 5.323 ± 0.04
1.658AlaHis: 1.658 ± 0.021
3.99AlaIle: 3.99 ± 0.034
3.964AlaLys: 3.964 ± 0.04
6.918AlaLeu: 6.918 ± 0.049
1.703AlaMet: 1.703 ± 0.021
2.971AlaAsn: 2.971 ± 0.029
4.156AlaPro: 4.156 ± 0.04
3.001AlaGln: 3.001 ± 0.037
4.562AlaArg: 4.562 ± 0.034
6.857AlaSer: 6.857 ± 0.054
4.852AlaThr: 4.852 ± 0.04
4.959AlaVal: 4.959 ± 0.041
0.919AlaTrp: 0.919 ± 0.017
1.835AlaTyr: 1.835 ± 0.023
0.0AlaXaa: 0.0 ± 0.0
Cys
0.858CysAla: 0.858 ± 0.014
0.245CysCys: 0.245 ± 0.009
0.61CysAsp: 0.61 ± 0.014
0.61CysGlu: 0.61 ± 0.012
0.509CysPhe: 0.509 ± 0.011
0.92CysGly: 0.92 ± 0.019
0.348CysHis: 0.348 ± 0.01
0.696CysIle: 0.696 ± 0.014
0.544CysLys: 0.544 ± 0.012
1.263CysLeu: 1.263 ± 0.023
0.261CysMet: 0.261 ± 0.008
0.446CysAsn: 0.446 ± 0.011
0.693CysPro: 0.693 ± 0.014
0.491CysGln: 0.491 ± 0.01
0.781CysArg: 0.781 ± 0.015
0.998CysSer: 0.998 ± 0.017
0.645CysThr: 0.645 ± 0.012
0.727CysVal: 0.727 ± 0.013
0.187CysTrp: 0.187 ± 0.007
0.344CysTyr: 0.344 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.126AspAla: 4.126 ± 0.035
0.606AspCys: 0.606 ± 0.014
4.214AspAsp: 4.214 ± 0.055
4.299AspGlu: 4.299 ± 0.046
2.078AspPhe: 2.078 ± 0.027
4.097AspGly: 4.097 ± 0.034
1.185AspHis: 1.185 ± 0.018
3.299AspIle: 3.299 ± 0.026
2.38AspLys: 2.38 ± 0.026
4.801AspLeu: 4.801 ± 0.042
1.26AspMet: 1.26 ± 0.018
2.011AspAsn: 2.011 ± 0.021
3.254AspPro: 3.254 ± 0.034
1.757AspGln: 1.757 ± 0.022
3.124AspArg: 3.124 ± 0.042
4.209AspSer: 4.209 ± 0.038
2.829AspThr: 2.829 ± 0.029
3.571AspVal: 3.571 ± 0.034
0.735AspTrp: 0.735 ± 0.014
1.469AspTyr: 1.469 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
4.835GluAla: 4.835 ± 0.04
0.654GluCys: 0.654 ± 0.012
4.006GluAsp: 4.006 ± 0.043
5.63GluGlu: 5.63 ± 0.058
1.987GluPhe: 1.987 ± 0.022
3.797GluGly: 3.797 ± 0.038
1.361GluHis: 1.361 ± 0.021
3.282GluIle: 3.282 ± 0.037
3.908GluLys: 3.908 ± 0.042
5.306GluLeu: 5.306 ± 0.049
1.506GluMet: 1.506 ± 0.019
2.661GluAsn: 2.661 ± 0.028
2.683GluPro: 2.683 ± 0.036
2.458GluGln: 2.458 ± 0.028
4.17GluArg: 4.17 ± 0.039
4.474GluSer: 4.474 ± 0.038
3.367GluThr: 3.367 ± 0.032
3.454GluVal: 3.454 ± 0.037
0.836GluTrp: 0.836 ± 0.015
1.647GluTyr: 1.647 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
2.71PheAla: 2.71 ± 0.031
0.562PheCys: 0.562 ± 0.012
2.178PheAsp: 2.178 ± 0.024
2.162PheGlu: 2.162 ± 0.024
1.477PhePhe: 1.477 ± 0.023
2.626PheGly: 2.626 ± 0.032
0.923PheHis: 0.923 ± 0.017
1.821PheIle: 1.821 ± 0.023
1.562PheLys: 1.562 ± 0.022
3.42PheLeu: 3.42 ± 0.035
0.715PheMet: 0.715 ± 0.014
1.469PheAsn: 1.469 ± 0.02
2.095PhePro: 2.095 ± 0.027
1.402PheGln: 1.402 ± 0.019
2.053PheArg: 2.053 ± 0.026
3.255PheSer: 3.255 ± 0.031
2.032PheThr: 2.032 ± 0.023
2.267PheVal: 2.267 ± 0.026
0.556PheTrp: 0.556 ± 0.013
1.05PheTyr: 1.05 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
4.726GlyAla: 4.726 ± 0.047
0.837GlyCys: 0.837 ± 0.015
3.756GlyAsp: 3.756 ± 0.037
3.916GlyGlu: 3.916 ± 0.032
2.586GlyPhe: 2.586 ± 0.025
6.013GlyGly: 6.013 ± 0.065
1.598GlyHis: 1.598 ± 0.025
3.584GlyIle: 3.584 ± 0.037
3.655GlyLys: 3.655 ± 0.039
5.503GlyLeu: 5.503 ± 0.043
1.607GlyMet: 1.607 ± 0.022
2.794GlyAsn: 2.794 ± 0.031
3.144GlyPro: 3.144 ± 0.037
2.448GlyGln: 2.448 ± 0.031
4.259GlyArg: 4.259 ± 0.043
5.797GlySer: 5.797 ± 0.05
3.728GlyThr: 3.728 ± 0.034
4.212GlyVal: 4.212 ± 0.035
1.052GlyTrp: 1.052 ± 0.017
1.984GlyTyr: 1.984 ± 0.024
0.0GlyXaa: 0.0 ± 0.0
His
1.718HisAla: 1.718 ± 0.022
0.328HisCys: 0.328 ± 0.011
1.274HisAsp: 1.274 ± 0.018
1.287HisGlu: 1.287 ± 0.02
0.94HisPhe: 0.94 ± 0.016
1.672HisGly: 1.672 ± 0.021
0.995HisHis: 0.995 ± 0.023
1.344HisIle: 1.344 ± 0.018
0.977HisLys: 0.977 ± 0.017
2.3HisLeu: 2.3 ± 0.03
0.485HisMet: 0.485 ± 0.012
0.955HisAsn: 0.955 ± 0.017
1.912HisPro: 1.912 ± 0.029
1.159HisGln: 1.159 ± 0.019
1.631HisArg: 1.631 ± 0.024
2.16HisSer: 2.16 ± 0.029
1.32HisThr: 1.32 ± 0.019
1.408HisVal: 1.408 ± 0.02
0.3HisTrp: 0.3 ± 0.009
0.667HisTyr: 0.667 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
3.928IleAla: 3.928 ± 0.037
0.786IleCys: 0.786 ± 0.015
2.906IleAsp: 2.906 ± 0.028
2.931IleGlu: 2.931 ± 0.035
2.109IlePhe: 2.109 ± 0.028
3.034IleGly: 3.034 ± 0.031
1.322IleHis: 1.322 ± 0.019
2.695IleIle: 2.695 ± 0.03
2.311IleLys: 2.311 ± 0.026
4.84IleLeu: 4.84 ± 0.044
0.983IleMet: 0.983 ± 0.018
1.958IleAsn: 1.958 ± 0.024
3.476IlePro: 3.476 ± 0.035
2.011IleGln: 2.011 ± 0.024
3.045IleArg: 3.045 ± 0.028
4.644IleSer: 4.644 ± 0.03
2.904IleThr: 2.904 ± 0.028
3.079IleVal: 3.079 ± 0.033
0.674IleTrp: 0.674 ± 0.013
1.484IleTyr: 1.484 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
3.974LysAla: 3.974 ± 0.04
0.556LysCys: 0.556 ± 0.012
2.691LysAsp: 2.691 ± 0.028
3.579LysGlu: 3.579 ± 0.038
1.63LysPhe: 1.63 ± 0.021
3.187LysGly: 3.187 ± 0.034
1.213LysHis: 1.213 ± 0.019
2.534LysIle: 2.534 ± 0.026
3.464LysLys: 3.464 ± 0.056
4.458LysLeu: 4.458 ± 0.039
1.077LysMet: 1.077 ± 0.017
1.931LysAsn: 1.931 ± 0.026
2.947LysPro: 2.947 ± 0.036
2.007LysGln: 2.007 ± 0.026
3.825LysArg: 3.825 ± 0.038
4.027LysSer: 4.027 ± 0.038
2.787LysThr: 2.787 ± 0.029
2.812LysVal: 2.812 ± 0.031
0.657LysTrp: 0.657 ± 0.014
1.433LysTyr: 1.433 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
7.046LeuAla: 7.046 ± 0.053
1.179LeuCys: 1.179 ± 0.018
4.969LeuAsp: 4.969 ± 0.039
5.574LeuGlu: 5.574 ± 0.054
3.279LeuPhe: 3.279 ± 0.037
5.518LeuGly: 5.518 ± 0.044
2.288LeuHis: 2.288 ± 0.025
4.049LeuIle: 4.049 ± 0.035
4.538LeuLys: 4.538 ± 0.037
8.373LeuLeu: 8.373 ± 0.068
1.672LeuMet: 1.672 ± 0.023
3.366LeuAsn: 3.366 ± 0.031
5.657LeuPro: 5.657 ± 0.046
3.896LeuGln: 3.896 ± 0.038
5.893LeuArg: 5.893 ± 0.044
7.932LeuSer: 7.932 ± 0.051
4.754LeuThr: 4.754 ± 0.037
5.101LeuVal: 5.101 ± 0.043
1.071LeuTrp: 1.071 ± 0.018
2.269LeuTyr: 2.269 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
1.986MetAla: 1.986 ± 0.025
0.227MetCys: 0.227 ± 0.008
1.229MetAsp: 1.229 ± 0.02
1.394MetGlu: 1.394 ± 0.018
0.713MetPhe: 0.713 ± 0.014
1.432MetGly: 1.432 ± 0.021
0.444MetHis: 0.444 ± 0.011
0.977MetIle: 0.977 ± 0.019
1.106MetLys: 1.106 ± 0.019
1.756MetLeu: 1.756 ± 0.022
0.514MetMet: 0.514 ± 0.012
0.827MetAsn: 0.827 ± 0.016
1.185MetPro: 1.185 ± 0.018
0.813MetGln: 0.813 ± 0.014
1.248MetArg: 1.248 ± 0.017
1.845MetSer: 1.845 ± 0.023
1.218MetThr: 1.218 ± 0.017
1.25MetVal: 1.25 ± 0.02
0.244MetTrp: 0.244 ± 0.008
0.459MetTyr: 0.459 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.041AsnAla: 3.041 ± 0.028
0.493AsnCys: 0.493 ± 0.011
2.16AsnAsp: 2.16 ± 0.023
2.214AsnGlu: 2.214 ± 0.028
1.426AsnPhe: 1.426 ± 0.02
3.169AsnGly: 3.169 ± 0.033
1.028AsnHis: 1.028 ± 0.02
2.302AsnIle: 2.302 ± 0.024
1.771AsnLys: 1.771 ± 0.02
3.477AsnLeu: 3.477 ± 0.036
0.848AsnMet: 0.848 ± 0.015
1.965AsnAsn: 1.965 ± 0.03
2.825AsnPro: 2.825 ± 0.03
1.493AsnGln: 1.493 ± 0.02
2.258AsnArg: 2.258 ± 0.028
3.314AsnSer: 3.314 ± 0.03
2.36AsnThr: 2.36 ± 0.025
2.398AsnVal: 2.398 ± 0.025
0.503AsnTrp: 0.503 ± 0.012
1.049AsnTyr: 1.049 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
4.789ProAla: 4.789 ± 0.045
0.559ProCys: 0.559 ± 0.014
3.111ProAsp: 3.111 ± 0.03
3.663ProGlu: 3.663 ± 0.035
2.128ProPhe: 2.128 ± 0.025
3.771ProGly: 3.771 ± 0.034
1.551ProHis: 1.551 ± 0.022
2.789ProIle: 2.789 ± 0.027
2.821ProLys: 2.821 ± 0.032
5.084ProLeu: 5.084 ± 0.037
1.022ProMet: 1.022 ± 0.019
2.481ProAsn: 2.481 ± 0.026
5.857ProPro: 5.857 ± 0.087
2.742ProGln: 2.742 ± 0.039
3.521ProArg: 3.521 ± 0.038
6.815ProSer: 6.815 ± 0.066
4.23ProThr: 4.23 ± 0.044
3.521ProVal: 3.521 ± 0.032
0.648ProTrp: 0.648 ± 0.013
1.524ProTyr: 1.524 ± 0.02
0.0ProXaa: 0.0 ± 0.0
Gln
3.011GlnAla: 3.011 ± 0.036
0.446GlnCys: 0.446 ± 0.009
1.919GlnAsp: 1.919 ± 0.026
2.368GlnGlu: 2.368 ± 0.03
1.318GlnPhe: 1.318 ± 0.02
2.312GlnGly: 2.312 ± 0.03
1.222GlnHis: 1.222 ± 0.024
1.995GlnIle: 1.995 ± 0.021
2.122GlnLys: 2.122 ± 0.028
3.536GlnLeu: 3.536 ± 0.033
0.865GlnMet: 0.865 ± 0.017
1.768GlnAsn: 1.768 ± 0.023
2.776GlnPro: 2.776 ± 0.037
3.174GlnGln: 3.174 ± 0.069
2.861GlnArg: 2.861 ± 0.028
3.408GlnSer: 3.408 ± 0.039
2.38GlnThr: 2.38 ± 0.021
2.062GlnVal: 2.062 ± 0.021
0.482GlnTrp: 0.482 ± 0.012
1.098GlnTyr: 1.098 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
4.497ArgAla: 4.497 ± 0.035
0.783ArgCys: 0.783 ± 0.014
3.427ArgAsp: 3.427 ± 0.04
4.133ArgGlu: 4.133 ± 0.039
2.167ArgPhe: 2.167 ± 0.027
3.999ArgGly: 3.999 ± 0.04
1.647ArgHis: 1.647 ± 0.022
3.195ArgIle: 3.195 ± 0.032
3.853ArgLys: 3.853 ± 0.04
5.472ArgLeu: 5.472 ± 0.042
1.361ArgMet: 1.361 ± 0.02
2.665ArgAsn: 2.665 ± 0.032
3.544ArgPro: 3.544 ± 0.037
2.745ArgGln: 2.745 ± 0.03
5.49ArgArg: 5.49 ± 0.058
5.334ArgSer: 5.334 ± 0.052
3.375ArgThr: 3.375 ± 0.031
3.421ArgVal: 3.421 ± 0.026
0.855ArgTrp: 0.855 ± 0.016
1.661ArgTyr: 1.661 ± 0.022
0.0ArgXaa: 0.0 ± 0.0
Ser
6.437SerAla: 6.437 ± 0.046
0.968SerCys: 0.968 ± 0.017
4.219SerAsp: 4.219 ± 0.038
4.28SerGlu: 4.28 ± 0.042
3.229SerPhe: 3.229 ± 0.033
5.817SerGly: 5.817 ± 0.048
2.295SerHis: 2.295 ± 0.026
4.363SerIle: 4.363 ± 0.035
4.246SerLys: 4.246 ± 0.037
7.754SerLeu: 7.754 ± 0.052
1.74SerMet: 1.74 ± 0.022
3.622SerAsn: 3.622 ± 0.031
6.428SerPro: 6.428 ± 0.071
3.738SerGln: 3.738 ± 0.04
5.701SerArg: 5.701 ± 0.05
10.454SerSer: 10.454 ± 0.101
6.047SerThr: 6.047 ± 0.051
4.642SerVal: 4.642 ± 0.043
1.066SerTrp: 1.066 ± 0.018
2.081SerTyr: 2.081 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
4.829ThrAla: 4.829 ± 0.041
0.714ThrCys: 0.714 ± 0.016
2.811ThrAsp: 2.811 ± 0.029
3.013ThrGlu: 3.013 ± 0.026
2.113ThrPhe: 2.113 ± 0.026
3.971ThrGly: 3.971 ± 0.039
1.347ThrHis: 1.347 ± 0.02
3.053ThrIle: 3.053 ± 0.027
2.686ThrLys: 2.686 ± 0.026
5.152ThrLeu: 5.152 ± 0.041
1.097ThrMet: 1.097 ± 0.017
2.281ThrAsn: 2.281 ± 0.025
4.507ThrPro: 4.507 ± 0.04
2.05ThrGln: 2.05 ± 0.023
3.2ThrArg: 3.2 ± 0.033
5.848ThrSer: 5.848 ± 0.054
4.485ThrThr: 4.485 ± 0.049
3.479ThrVal: 3.479 ± 0.032
0.681ThrTrp: 0.681 ± 0.015
1.48ThrTyr: 1.48 ± 0.022
0.0ThrXaa: 0.0 ± 0.0
Val
4.605ValAla: 4.605 ± 0.032
0.767ValCys: 0.767 ± 0.014
3.668ValAsp: 3.668 ± 0.034
3.927ValGlu: 3.927 ± 0.036
2.274ValPhe: 2.274 ± 0.025
3.899ValGly: 3.899 ± 0.036
1.343ValHis: 1.343 ± 0.021
2.994ValIle: 2.994 ± 0.031
3.01ValLys: 3.01 ± 0.029
5.271ValLeu: 5.271 ± 0.042
1.263ValMet: 1.263 ± 0.019
2.278ValAsn: 2.278 ± 0.025
3.433ValPro: 3.433 ± 0.032
2.2ValGln: 2.2 ± 0.021
3.451ValArg: 3.451 ± 0.031
4.753ValSer: 4.753 ± 0.034
3.28ValThr: 3.28 ± 0.03
4.016ValVal: 4.016 ± 0.035
0.745ValTrp: 0.745 ± 0.015
1.504ValTyr: 1.504 ± 0.02
0.0ValXaa: 0.0 ± 0.0
Trp
0.951TrpAla: 0.951 ± 0.016
0.167TrpCys: 0.167 ± 0.007
0.794TrpAsp: 0.794 ± 0.015
0.804TrpGlu: 0.804 ± 0.016
0.455TrpPhe: 0.455 ± 0.013
0.791TrpGly: 0.791 ± 0.016
0.309TrpHis: 0.309 ± 0.01
0.695TrpIle: 0.695 ± 0.015
0.786TrpLys: 0.786 ± 0.015
1.171TrpLeu: 1.171 ± 0.019
0.336TrpMet: 0.336 ± 0.01
0.587TrpAsn: 0.587 ± 0.012
0.501TrpPro: 0.501 ± 0.013
0.479TrpGln: 0.479 ± 0.01
0.934TrpArg: 0.934 ± 0.016
0.917TrpSer: 0.917 ± 0.018
0.743TrpThr: 0.743 ± 0.016
0.781TrpVal: 0.781 ± 0.014
0.241TrpTrp: 0.241 ± 0.009
0.344TrpTyr: 0.344 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.857TyrAla: 1.857 ± 0.022
0.385TyrCys: 0.385 ± 0.011
1.55TyrAsp: 1.55 ± 0.021
1.467TyrGlu: 1.467 ± 0.02
1.158TyrPhe: 1.158 ± 0.017
1.849TyrGly: 1.849 ± 0.024
0.755TyrHis: 0.755 ± 0.014
1.462TyrIle: 1.462 ± 0.023
1.083TyrLys: 1.083 ± 0.019
2.569TyrLeu: 2.569 ± 0.03
0.55TyrMet: 0.55 ± 0.011
1.057TyrAsn: 1.057 ± 0.016
1.555TyrPro: 1.555 ± 0.026
1.059TyrGln: 1.059 ± 0.018
1.618TyrArg: 1.618 ± 0.02
2.086TyrSer: 2.086 ± 0.023
1.46TyrThr: 1.46 ± 0.018
1.522TyrVal: 1.522 ± 0.022
0.335TyrTrp: 0.335 ± 0.009
0.862TyrTyr: 0.862 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8399 proteins (3885900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski