Amino acid dipepetide frequency for Mycobacterium asiaticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.95AlaAla: 19.95 ± 0.191	0.97AlaCys: 0.97 ± 0.023	7.896AlaAsp: 7.896 ± 0.072	7.647AlaGlu: 7.647 ± 0.091	3.312AlaPhe: 3.312 ± 0.046	12.487AlaGly: 12.487 ± 0.351	2.482AlaHis: 2.482 ± 0.042	5.203AlaIle: 5.203 ± 0.057	3.101AlaLys: 3.101 ± 0.048	12.49AlaLeu: 12.49 ± 0.114	2.82AlaMet: 2.82 ± 0.045	2.947AlaAsn: 2.947 ± 0.055	6.233AlaPro: 6.233 ± 0.096	4.214AlaGln: 4.214 ± 0.058	8.333AlaArg: 8.333 ± 0.09	6.084AlaSer: 6.084 ± 0.07	7.038AlaThr: 7.038 ± 0.064	11.109AlaVal: 11.109 ± 0.111	1.604AlaTrp: 1.604 ± 0.032	2.312AlaTyr: 2.312 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.03	0.093CysCys: 0.093 ± 0.012	0.547CysAsp: 0.547 ± 0.02	0.407CysGlu: 0.407 ± 0.016	0.239CysPhe: 0.239 ± 0.01	0.915CysGly: 0.915 ± 0.026	0.173CysHis: 0.173 ± 0.011	0.288CysIle: 0.288 ± 0.012	0.124CysLys: 0.124 ± 0.01	0.654CysLeu: 0.654 ± 0.02	0.132CysMet: 0.132 ± 0.009	0.187CysAsn: 0.187 ± 0.01	0.483CysPro: 0.483 ± 0.022	0.238CysGln: 0.238 ± 0.013	0.584CysArg: 0.584 ± 0.018	0.466CysSer: 0.466 ± 0.017	0.463CysThr: 0.463 ± 0.018	0.644CysVal: 0.644 ± 0.019	0.128CysTrp: 0.128 ± 0.011	0.197CysTyr: 0.197 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.403AspAla: 7.403 ± 0.081	0.456AspCys: 0.456 ± 0.017	4.111AspAsp: 4.111 ± 0.074	4.014AspGlu: 4.014 ± 0.06	1.857AspPhe: 1.857 ± 0.033	5.794AspGly: 5.794 ± 0.115	1.385AspHis: 1.385 ± 0.033	2.652AspIle: 2.652 ± 0.045	1.341AspLys: 1.341 ± 0.037	5.904AspLeu: 5.904 ± 0.072	0.989AspMet: 0.989 ± 0.026	1.268AspAsn: 1.268 ± 0.028	4.241AspPro: 4.241 ± 0.059	1.856AspGln: 1.856 ± 0.028	4.361AspArg: 4.361 ± 0.062	2.937AspSer: 2.937 ± 0.043	2.962AspThr: 2.962 ± 0.045	5.128AspVal: 5.128 ± 0.061	0.974AspTrp: 0.974 ± 0.026	1.43AspTyr: 1.43 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.017GluAla: 6.017 ± 0.086	0.361GluCys: 0.361 ± 0.015	2.478GluAsp: 2.478 ± 0.044	2.547GluGlu: 2.547 ± 0.052	1.866GluPhe: 1.866 ± 0.033	3.33GluGly: 3.33 ± 0.049	1.546GluHis: 1.546 ± 0.035	2.664GluIle: 2.664 ± 0.048	1.279GluLys: 1.279 ± 0.033	6.562GluLeu: 6.562 ± 0.083	1.101GluMet: 1.101 ± 0.026	1.164GluAsn: 1.164 ± 0.03	2.99GluPro: 2.99 ± 0.079	2.261GluGln: 2.261 ± 0.043	4.333GluArg: 4.333 ± 0.059	2.792GluSer: 2.792 ± 0.048	2.607GluThr: 2.607 ± 0.042	4.397GluVal: 4.397 ± 0.067	0.753GluTrp: 0.753 ± 0.023	1.142GluTyr: 1.142 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.922PheAla: 3.922 ± 0.056	0.333PheCys: 0.333 ± 0.014	2.407PheAsp: 2.407 ± 0.038	1.596PheGlu: 1.596 ± 0.034	1.033PhePhe: 1.033 ± 0.033	3.625PheGly: 3.625 ± 0.06	0.684PheHis: 0.684 ± 0.021	1.086PheIle: 1.086 ± 0.027	0.544PheLys: 0.544 ± 0.021	2.528PheLeu: 2.528 ± 0.043	0.512PheMet: 0.512 ± 0.016	0.875PheAsn: 0.875 ± 0.039	1.54PhePro: 1.54 ± 0.034	0.773PheGln: 0.773 ± 0.026	1.715PheArg: 1.715 ± 0.037	1.805PheSer: 1.805 ± 0.035	1.995PheThr: 1.995 ± 0.037	2.514PheVal: 2.514 ± 0.044	0.442PheTrp: 0.442 ± 0.017	0.74PheTyr: 0.74 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.71GlyAla: 10.71 ± 0.311	0.809GlyCys: 0.809 ± 0.024	4.962GlyAsp: 4.962 ± 0.089	4.271GlyGlu: 4.271 ± 0.063	3.135GlyPhe: 3.135 ± 0.064	10.073GlyGly: 10.073 ± 0.761	2.091GlyHis: 2.091 ± 0.041	4.29GlyIle: 4.29 ± 0.058	2.485GlyLys: 2.485 ± 0.069	8.651GlyLeu: 8.651 ± 0.081	2.215GlyMet: 2.215 ± 0.043	2.845GlyAsn: 2.845 ± 0.263	4.62GlyPro: 4.62 ± 0.067	3.074GlyGln: 3.074 ± 0.057	6.184GlyArg: 6.184 ± 0.068	5.698GlySer: 5.698 ± 0.125	5.478GlyThr: 5.478 ± 0.188	7.496GlyVal: 7.496 ± 0.1	1.669GlyTrp: 1.669 ± 0.038	2.441GlyTyr: 2.441 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.397HisAla: 2.397 ± 0.04	0.232HisCys: 0.232 ± 0.014	1.361HisAsp: 1.361 ± 0.031	1.071HisGlu: 1.071 ± 0.03	0.688HisPhe: 0.688 ± 0.021	2.172HisGly: 2.172 ± 0.042	0.642HisHis: 0.642 ± 0.023	0.875HisIle: 0.875 ± 0.024	0.388HisLys: 0.388 ± 0.017	2.158HisLeu: 2.158 ± 0.042	0.363HisMet: 0.363 ± 0.016	0.517HisAsn: 0.517 ± 0.019	1.657HisPro: 1.657 ± 0.033	0.754HisGln: 0.754 ± 0.023	1.864HisArg: 1.864 ± 0.038	1.141HisSer: 1.141 ± 0.025	1.238HisThr: 1.238 ± 0.031	1.695HisVal: 1.695 ± 0.039	0.394HisTrp: 0.394 ± 0.018	0.586HisTyr: 0.586 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.052IleAla: 6.052 ± 0.06	0.408IleCys: 0.408 ± 0.017	3.36IleAsp: 3.36 ± 0.054	2.664IleGlu: 2.664 ± 0.056	1.099IlePhe: 1.099 ± 0.027	4.443IleGly: 4.443 ± 0.063	0.842IleHis: 0.842 ± 0.023	1.42IleIle: 1.42 ± 0.031	0.957IleLys: 0.957 ± 0.027	3.018IleLeu: 3.018 ± 0.048	0.63IleMet: 0.63 ± 0.021	1.26IleAsn: 1.26 ± 0.026	2.511IlePro: 2.511 ± 0.05	1.008IleGln: 1.008 ± 0.028	2.705IleArg: 2.705 ± 0.044	2.417IleSer: 2.417 ± 0.041	2.806IleThr: 2.806 ± 0.041	3.522IleVal: 3.522 ± 0.065	0.507IleTrp: 0.507 ± 0.017	0.84IleTyr: 0.84 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.624LysAla: 2.624 ± 0.043	0.118LysCys: 0.118 ± 0.009	1.199LysAsp: 1.199 ± 0.029	0.967LysGlu: 0.967 ± 0.03	0.665LysPhe: 0.665 ± 0.019	1.645LysGly: 1.645 ± 0.066	0.515LysHis: 0.515 ± 0.018	0.996LysIle: 0.996 ± 0.025	0.688LysLys: 0.688 ± 0.03	2.342LysLeu: 2.342 ± 0.043	0.483LysMet: 0.483 ± 0.018	0.538LysAsn: 0.538 ± 0.019	1.522LysPro: 1.522 ± 0.035	0.742LysGln: 0.742 ± 0.021	1.664LysArg: 1.664 ± 0.037	1.291LysSer: 1.291 ± 0.031	1.363LysThr: 1.363 ± 0.033	1.961LysVal: 1.961 ± 0.04	0.35LysTrp: 0.35 ± 0.016	0.508LysTyr: 0.508 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.664LeuAla: 13.664 ± 0.111	0.806LeuCys: 0.806 ± 0.025	6.338LeuAsp: 6.338 ± 0.071	4.309LeuGlu: 4.309 ± 0.061	2.785LeuPhe: 2.785 ± 0.047	8.685LeuGly: 8.685 ± 0.083	2.055LeuHis: 2.055 ± 0.041	4.133LeuIle: 4.133 ± 0.06	1.849LeuLys: 1.849 ± 0.035	9.701LeuLeu: 9.701 ± 0.102	1.778LeuMet: 1.778 ± 0.035	2.338LeuAsn: 2.338 ± 0.046	5.975LeuPro: 5.975 ± 0.072	2.767LeuGln: 2.767 ± 0.043	7.537LeuArg: 7.537 ± 0.086	5.769LeuSer: 5.769 ± 0.061	6.188LeuThr: 6.188 ± 0.072	8.267LeuVal: 8.267 ± 0.09	1.199LeuTrp: 1.199 ± 0.029	1.674LeuTyr: 1.674 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.613MetAla: 2.613 ± 0.041	0.178MetCys: 0.178 ± 0.011	0.884MetAsp: 0.884 ± 0.022	0.698MetGlu: 0.698 ± 0.023	0.661MetPhe: 0.661 ± 0.022	1.532MetGly: 1.532 ± 0.032	0.448MetHis: 0.448 ± 0.017	0.864MetIle: 0.864 ± 0.021	0.468MetLys: 0.468 ± 0.018	2.08MetLeu: 2.08 ± 0.039	0.429MetMet: 0.429 ± 0.018	0.511MetAsn: 0.511 ± 0.019	1.243MetPro: 1.243 ± 0.031	0.61MetGln: 0.61 ± 0.019	1.556MetArg: 1.556 ± 0.032	1.566MetSer: 1.566 ± 0.032	1.751MetThr: 1.751 ± 0.033	1.599MetVal: 1.599 ± 0.032	0.29MetTrp: 0.29 ± 0.012	0.36MetTyr: 0.36 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.977AsnAla: 2.977 ± 0.067	0.201AsnCys: 0.201 ± 0.011	1.255AsnAsp: 1.255 ± 0.03	1.087AsnGlu: 1.087 ± 0.026	0.854AsnPhe: 0.854 ± 0.032	2.769AsnGly: 2.769 ± 0.259	0.514AsnHis: 0.514 ± 0.019	1.079AsnIle: 1.079 ± 0.029	0.508AsnLys: 0.508 ± 0.017	2.319AsnLeu: 2.319 ± 0.051	0.464AsnMet: 0.464 ± 0.019	0.722AsnAsn: 0.722 ± 0.033	1.833AsnPro: 1.833 ± 0.037	0.759AsnGln: 0.759 ± 0.023	1.646AsnArg: 1.646 ± 0.036	1.422AsnSer: 1.422 ± 0.059	1.493AsnThr: 1.493 ± 0.053	1.879AsnVal: 1.879 ± 0.038	0.429AsnTrp: 0.429 ± 0.015	0.604AsnTyr: 0.604 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.163ProAla: 7.163 ± 0.096	0.274ProCys: 0.274 ± 0.013	4.231ProAsp: 4.231 ± 0.054	3.757ProGlu: 3.757 ± 0.07	1.693ProPhe: 1.693 ± 0.034	5.852ProGly: 5.852 ± 0.069	1.212ProHis: 1.212 ± 0.029	2.195ProIle: 2.195 ± 0.043	1.336ProLys: 1.336 ± 0.029	4.993ProLeu: 4.993 ± 0.07	1.202ProMet: 1.202 ± 0.025	1.402ProAsn: 1.402 ± 0.028	3.85ProPro: 3.85 ± 0.078	1.935ProGln: 1.935 ± 0.041	3.394ProArg: 3.394 ± 0.054	3.105ProSer: 3.105 ± 0.046	3.427ProThr: 3.427 ± 0.057	5.026ProVal: 5.026 ± 0.068	0.84ProTrp: 0.84 ± 0.022	1.194ProTyr: 1.194 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.85GlnAla: 3.85 ± 0.056	0.234GlnCys: 0.234 ± 0.013	1.336GlnAsp: 1.336 ± 0.03	1.28GlnGlu: 1.28 ± 0.029	1.044GlnPhe: 1.044 ± 0.025	2.207GlnGly: 2.207 ± 0.051	0.869GlnHis: 0.869 ± 0.024	1.554GlnIle: 1.554 ± 0.032	0.608GlnLys: 0.608 ± 0.022	3.784GlnLeu: 3.784 ± 0.053	0.739GlnMet: 0.739 ± 0.024	0.683GlnAsn: 0.683 ± 0.023	1.992GlnPro: 1.992 ± 0.042	1.504GlnGln: 1.504 ± 0.038	2.906GlnArg: 2.906 ± 0.044	1.586GlnSer: 1.586 ± 0.027	1.711GlnThr: 1.711 ± 0.033	2.681GlnVal: 2.681 ± 0.043	0.592GlnTrp: 0.592 ± 0.02	0.674GlnTyr: 0.674 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.082ArgAla: 8.082 ± 0.087	0.573ArgCys: 0.573 ± 0.02	4.258ArgAsp: 4.258 ± 0.058	3.733ArgGlu: 3.733 ± 0.042	2.419ArgPhe: 2.419 ± 0.041	5.126ArgGly: 5.126 ± 0.056	1.755ArgHis: 1.755 ± 0.037	3.341ArgIle: 3.341 ± 0.046	1.601ArgLys: 1.601 ± 0.029	7.417ArgLeu: 7.417 ± 0.087	1.764ArgMet: 1.764 ± 0.03	1.743ArgAsn: 1.743 ± 0.034	3.967ArgPro: 3.967 ± 0.052	2.416ArgGln: 2.416 ± 0.038	6.403ArgArg: 6.403 ± 0.091	4.045ArgSer: 4.045 ± 0.059	3.964ArgThr: 3.964 ± 0.048	5.52ArgVal: 5.52 ± 0.061	1.347ArgTrp: 1.347 ± 0.03	1.921ArgTyr: 1.921 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.154SerAla: 7.154 ± 0.076	0.425SerCys: 0.425 ± 0.015	3.274SerAsp: 3.274 ± 0.046	2.676SerGlu: 2.676 ± 0.045	1.721SerPhe: 1.721 ± 0.032	6.172SerGly: 6.172 ± 0.157	1.07SerHis: 1.07 ± 0.023	2.182SerIle: 2.182 ± 0.043	1.246SerLys: 1.246 ± 0.028	4.903SerLeu: 4.903 ± 0.064	1.337SerMet: 1.337 ± 0.026	1.28SerAsn: 1.28 ± 0.029	3.077SerPro: 3.077 ± 0.048	1.599SerGln: 1.599 ± 0.027	3.722SerArg: 3.722 ± 0.057	3.228SerSer: 3.228 ± 0.055	3.371SerThr: 3.371 ± 0.053	4.588SerVal: 4.588 ± 0.057	0.96SerTrp: 0.96 ± 0.025	1.335SerTyr: 1.335 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	7.575ThrAla: 7.575 ± 0.073	0.412ThrCys: 0.412 ± 0.018	3.545ThrAsp: 3.545 ± 0.049	3.114ThrGlu: 3.114 ± 0.047	1.81ThrPhe: 1.81 ± 0.036	6.194ThrGly: 6.194 ± 0.148	1.179ThrHis: 1.179 ± 0.027	2.406ThrIle: 2.406 ± 0.041	1.302ThrLys: 1.302 ± 0.029	5.491ThrLeu: 5.491 ± 0.066	1.193ThrMet: 1.193 ± 0.027	1.373ThrAsn: 1.373 ± 0.036	3.671ThrPro: 3.671 ± 0.058	1.574ThrGln: 1.574 ± 0.035	3.588ThrArg: 3.588 ± 0.046	3.177ThrSer: 3.177 ± 0.043	3.684ThrThr: 3.684 ± 0.057	5.55ThrVal: 5.55 ± 0.065	0.816ThrTrp: 0.816 ± 0.025	1.285ThrTyr: 1.285 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	11.009ValAla: 11.009 ± 0.093	0.745ValCys: 0.745 ± 0.022	5.458ValAsp: 5.458 ± 0.069	4.503ValGlu: 4.503 ± 0.067	2.498ValPhe: 2.498 ± 0.041	7.087ValGly: 7.087 ± 0.081	1.845ValHis: 1.845 ± 0.036	3.859ValIle: 3.859 ± 0.053	1.679ValLys: 1.679 ± 0.037	8.764ValLeu: 8.764 ± 0.097	1.557ValMet: 1.557 ± 0.032	2.217ValAsn: 2.217 ± 0.037	4.583ValPro: 4.583 ± 0.061	2.29ValGln: 2.29 ± 0.041	5.759ValArg: 5.759 ± 0.072	4.648ValSer: 4.648 ± 0.06	5.31ValThr: 5.31 ± 0.068	8.172ValVal: 8.172 ± 0.103	1.002ValTrp: 1.002 ± 0.03	1.556ValTyr: 1.556 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.51TrpAla: 1.51 ± 0.031	0.155TrpCys: 0.155 ± 0.01	0.815TrpAsp: 0.815 ± 0.023	0.682TrpGlu: 0.682 ± 0.025	0.533TrpPhe: 0.533 ± 0.02	1.023TrpGly: 1.023 ± 0.025	0.365TrpHis: 0.365 ± 0.017	0.681TrpIle: 0.681 ± 0.024	0.327TrpLys: 0.327 ± 0.015	1.763TrpLeu: 1.763 ± 0.041	0.332TrpMet: 0.332 ± 0.014	0.419TrpAsn: 0.419 ± 0.016	0.837TrpPro: 0.837 ± 0.024	0.664TrpGln: 0.664 ± 0.018	1.246TrpArg: 1.246 ± 0.028	0.943TrpSer: 0.943 ± 0.027	0.928TrpThr: 0.928 ± 0.025	1.123TrpVal: 1.123 ± 0.029	0.344TrpTrp: 0.344 ± 0.015	0.331TrpTyr: 0.331 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.487TyrAla: 2.487 ± 0.04	0.255TyrCys: 0.255 ± 0.012	1.348TyrAsp: 1.348 ± 0.031	1.165TyrGlu: 1.165 ± 0.03	0.76TyrPhe: 0.76 ± 0.02	2.063TyrGly: 2.063 ± 0.04	0.521TyrHis: 0.521 ± 0.019	0.7TyrIle: 0.7 ± 0.019	0.346TyrLys: 0.346 ± 0.016	2.298TyrLeu: 2.298 ± 0.037	0.305TyrMet: 0.305 ± 0.013	0.524TyrAsn: 0.524 ± 0.02	1.26TyrPro: 1.26 ± 0.033	0.794TyrGln: 0.794 ± 0.024	1.893TyrArg: 1.893 ± 0.034	1.201TyrSer: 1.201 ± 0.025	1.162TyrThr: 1.162 ± 0.029	1.671TyrVal: 1.671 ± 0.035	0.38TyrTrp: 0.38 ± 0.017	0.53TyrTyr: 0.53 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4763 proteins (1590993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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