Amino acid dipepetide frequency for Mannheimia phage vB_MhM_3927AP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.168AlaAla: 6.168 ± 1.226
1.328AlaCys: 1.328 ± 0.441
5.029AlaAsp: 5.029 ± 0.664
6.832AlaGlu: 6.832 ± 0.879
3.416AlaPhe: 3.416 ± 0.46
6.357AlaGly: 6.357 ± 0.89
1.139AlaHis: 1.139 ± 0.26
5.598AlaIle: 5.598 ± 0.703
7.211AlaLys: 7.211 ± 0.903
8.919AlaLeu: 8.919 ± 1.379
2.087AlaMet: 2.087 ± 0.385
4.08AlaAsn: 4.08 ± 0.669
1.708AlaPro: 1.708 ± 0.434
3.606AlaGln: 3.606 ± 0.704
3.795AlaArg: 3.795 ± 0.562
4.649AlaSer: 4.649 ± 1.106
5.693AlaThr: 5.693 ± 0.484
6.452AlaVal: 6.452 ± 0.688
0.854AlaTrp: 0.854 ± 0.249
2.847AlaTyr: 2.847 ± 0.432
0.0AlaXaa: 0.0 ± 0.0
Cys
0.285CysAla: 0.285 ± 0.186
0.19CysCys: 0.19 ± 0.135
0.569CysAsp: 0.569 ± 0.235
1.044CysGlu: 1.044 ± 0.357
0.285CysPhe: 0.285 ± 0.17
0.854CysGly: 0.854 ± 0.29
0.38CysHis: 0.38 ± 0.148
0.38CysIle: 0.38 ± 0.218
0.759CysLys: 0.759 ± 0.243
0.759CysLeu: 0.759 ± 0.244
0.19CysMet: 0.19 ± 0.134
0.285CysAsn: 0.285 ± 0.163
0.285CysPro: 0.285 ± 0.139
0.285CysGln: 0.285 ± 0.207
0.285CysArg: 0.285 ± 0.167
0.474CysSer: 0.474 ± 0.187
0.854CysThr: 0.854 ± 0.301
0.569CysVal: 0.569 ± 0.185
0.095CysTrp: 0.095 ± 0.086
0.19CysTyr: 0.19 ± 0.127
0.0CysXaa: 0.0 ± 0.0
Asp
3.511AspAla: 3.511 ± 0.516
0.474AspCys: 0.474 ± 0.186
3.985AspAsp: 3.985 ± 0.747
3.985AspGlu: 3.985 ± 0.695
2.277AspPhe: 2.277 ± 0.487
5.788AspGly: 5.788 ± 0.751
0.759AspHis: 0.759 ± 0.26
2.847AspIle: 2.847 ± 0.457
4.175AspLys: 4.175 ± 0.721
5.788AspLeu: 5.788 ± 0.958
1.328AspMet: 1.328 ± 0.343
2.847AspAsn: 2.847 ± 0.74
2.372AspPro: 2.372 ± 0.516
0.854AspGln: 0.854 ± 0.338
2.087AspArg: 2.087 ± 0.402
4.175AspSer: 4.175 ± 0.893
1.993AspThr: 1.993 ± 0.485
4.46AspVal: 4.46 ± 0.477
0.949AspTrp: 0.949 ± 0.349
1.898AspTyr: 1.898 ± 0.386
0.0AspXaa: 0.0 ± 0.0
Glu
6.357GluAla: 6.357 ± 0.677
0.569GluCys: 0.569 ± 0.224
2.372GluAsp: 2.372 ± 0.433
4.555GluGlu: 4.555 ± 0.612
3.416GluPhe: 3.416 ± 0.605
2.657GluGly: 2.657 ± 0.386
1.044GluHis: 1.044 ± 0.258
5.029GluIle: 5.029 ± 0.816
4.649GluLys: 4.649 ± 0.654
8.824GluLeu: 8.824 ± 1.046
3.036GluMet: 3.036 ± 0.684
3.985GluAsn: 3.985 ± 0.601
1.898GluPro: 1.898 ± 0.404
3.606GluGln: 3.606 ± 0.536
3.795GluArg: 3.795 ± 0.488
4.46GluSer: 4.46 ± 0.673
3.795GluThr: 3.795 ± 0.652
4.649GluVal: 4.649 ± 0.747
0.664GluTrp: 0.664 ± 0.234
2.277GluTyr: 2.277 ± 0.495
0.0GluXaa: 0.0 ± 0.0
Phe
2.562PheAla: 2.562 ± 0.516
0.285PheCys: 0.285 ± 0.177
3.416PheAsp: 3.416 ± 0.548
2.941PheGlu: 2.941 ± 0.483
0.854PhePhe: 0.854 ± 0.27
3.036PheGly: 3.036 ± 0.472
0.285PheHis: 0.285 ± 0.14
2.182PheIle: 2.182 ± 0.601
3.131PheLys: 3.131 ± 0.537
2.847PheLeu: 2.847 ± 0.512
0.854PheMet: 0.854 ± 0.236
3.036PheAsn: 3.036 ± 0.533
1.328PhePro: 1.328 ± 0.513
0.759PheGln: 0.759 ± 0.304
1.423PheArg: 1.423 ± 0.371
1.898PheSer: 1.898 ± 0.438
1.423PheThr: 1.423 ± 0.346
2.182PheVal: 2.182 ± 0.431
0.664PheTrp: 0.664 ± 0.234
1.234PheTyr: 1.234 ± 0.288
0.0PheXaa: 0.0 ± 0.0
Gly
4.649GlyAla: 4.649 ± 0.847
0.19GlyCys: 0.19 ± 0.131
4.08GlyAsp: 4.08 ± 0.664
4.08GlyGlu: 4.08 ± 0.668
2.467GlyPhe: 2.467 ± 0.495
5.314GlyGly: 5.314 ± 0.796
1.044GlyHis: 1.044 ± 0.287
4.555GlyIle: 4.555 ± 0.651
5.788GlyLys: 5.788 ± 0.824
4.839GlyLeu: 4.839 ± 0.834
1.613GlyMet: 1.613 ± 0.393
3.795GlyAsn: 3.795 ± 0.639
0.095GlyPro: 0.095 ± 0.099
2.182GlyGln: 2.182 ± 0.4
5.029GlyArg: 5.029 ± 0.732
4.27GlySer: 4.27 ± 0.724
3.985GlyThr: 3.985 ± 0.835
6.357GlyVal: 6.357 ± 0.827
1.803GlyTrp: 1.803 ± 0.472
1.518GlyTyr: 1.518 ± 0.441
0.0GlyXaa: 0.0 ± 0.0
His
0.949HisAla: 0.949 ± 0.252
0.19HisCys: 0.19 ± 0.117
1.328HisAsp: 1.328 ± 0.345
0.664HisGlu: 0.664 ± 0.236
0.569HisPhe: 0.569 ± 0.235
1.613HisGly: 1.613 ± 0.337
0.38HisHis: 0.38 ± 0.204
1.139HisIle: 1.139 ± 0.377
1.234HisLys: 1.234 ± 0.323
0.949HisLeu: 0.949 ± 0.346
0.19HisMet: 0.19 ± 0.149
1.423HisAsn: 1.423 ± 0.471
0.854HisPro: 0.854 ± 0.247
0.854HisGln: 0.854 ± 0.275
1.328HisArg: 1.328 ± 0.423
0.949HisSer: 0.949 ± 0.318
0.664HisThr: 0.664 ± 0.247
0.474HisVal: 0.474 ± 0.183
0.19HisTrp: 0.19 ± 0.134
1.423HisTyr: 1.423 ± 0.355
0.0HisXaa: 0.0 ± 0.0
Ile
4.934IleAla: 4.934 ± 0.781
1.044IleCys: 1.044 ± 0.326
3.89IleAsp: 3.89 ± 0.606
6.073IleGlu: 6.073 ± 0.712
1.708IlePhe: 1.708 ± 0.37
3.036IleGly: 3.036 ± 0.575
1.518IleHis: 1.518 ± 0.37
2.372IleIle: 2.372 ± 0.434
3.511IleLys: 3.511 ± 0.605
3.321IleLeu: 3.321 ± 0.604
0.854IleMet: 0.854 ± 0.251
3.795IleAsn: 3.795 ± 1.137
1.044IlePro: 1.044 ± 0.322
2.752IleGln: 2.752 ± 0.479
3.226IleArg: 3.226 ± 0.551
3.89IleSer: 3.89 ± 0.536
3.89IleThr: 3.89 ± 0.66
3.701IleVal: 3.701 ± 0.693
0.759IleTrp: 0.759 ± 0.242
1.803IleTyr: 1.803 ± 0.429
0.0IleXaa: 0.0 ± 0.0
Lys
6.262LysAla: 6.262 ± 0.73
0.285LysCys: 0.285 ± 0.173
2.657LysAsp: 2.657 ± 0.43
5.029LysGlu: 5.029 ± 0.786
1.328LysPhe: 1.328 ± 0.386
5.503LysGly: 5.503 ± 0.728
2.087LysHis: 2.087 ± 0.426
3.036LysIle: 3.036 ± 0.555
5.029LysLys: 5.029 ± 0.834
7.97LysLeu: 7.97 ± 0.995
1.993LysMet: 1.993 ± 0.388
4.744LysAsn: 4.744 ± 0.614
3.416LysPro: 3.416 ± 0.596
4.934LysGln: 4.934 ± 1.022
3.89LysArg: 3.89 ± 0.649
4.08LysSer: 4.08 ± 0.549
4.46LysThr: 4.46 ± 0.625
5.408LysVal: 5.408 ± 0.56
0.664LysTrp: 0.664 ± 0.241
1.803LysTyr: 1.803 ± 0.327
0.0LysXaa: 0.0 ± 0.0
Leu
7.401LeuAla: 7.401 ± 0.98
0.759LeuCys: 0.759 ± 0.272
5.029LeuAsp: 5.029 ± 0.702
6.547LeuGlu: 6.547 ± 0.95
3.036LeuPhe: 3.036 ± 0.557
6.547LeuGly: 6.547 ± 1.0
2.277LeuHis: 2.277 ± 0.522
5.503LeuIle: 5.503 ± 0.583
6.737LeuLys: 6.737 ± 0.759
8.919LeuLeu: 8.919 ± 1.114
2.182LeuMet: 2.182 ± 0.479
5.029LeuAsn: 5.029 ± 0.808
3.226LeuPro: 3.226 ± 0.602
2.847LeuGln: 2.847 ± 0.427
4.555LeuArg: 4.555 ± 0.611
7.211LeuSer: 7.211 ± 1.105
5.408LeuThr: 5.408 ± 0.822
5.788LeuVal: 5.788 ± 0.672
0.949LeuTrp: 0.949 ± 0.374
2.277LeuTyr: 2.277 ± 0.429
0.0LeuXaa: 0.0 ± 0.0
Met
2.467MetAla: 2.467 ± 0.722
0.0MetCys: 0.0 ± 0.0
1.328MetAsp: 1.328 ± 0.468
1.139MetGlu: 1.139 ± 0.321
0.474MetPhe: 0.474 ± 0.195
1.423MetGly: 1.423 ± 0.332
0.19MetHis: 0.19 ± 0.128
1.328MetIle: 1.328 ± 0.32
2.372MetLys: 2.372 ± 0.419
2.087MetLeu: 2.087 ± 0.452
0.759MetMet: 0.759 ± 0.291
0.474MetAsn: 0.474 ± 0.212
1.139MetPro: 1.139 ± 0.374
1.234MetGln: 1.234 ± 0.421
1.044MetArg: 1.044 ± 0.312
1.993MetSer: 1.993 ± 0.31
1.708MetThr: 1.708 ± 0.464
1.234MetVal: 1.234 ± 0.252
0.095MetTrp: 0.095 ± 0.099
0.474MetTyr: 0.474 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
6.073AsnAla: 6.073 ± 0.843
0.664AsnCys: 0.664 ± 0.229
1.898AsnAsp: 1.898 ± 0.466
4.08AsnGlu: 4.08 ± 0.756
2.087AsnPhe: 2.087 ± 0.454
4.555AsnGly: 4.555 ± 0.673
0.759AsnHis: 0.759 ± 0.254
3.606AsnIle: 3.606 ± 0.661
2.941AsnLys: 2.941 ± 0.405
4.175AsnLeu: 4.175 ± 0.53
0.759AsnMet: 0.759 ± 0.206
3.226AsnAsn: 3.226 ± 1.083
2.847AsnPro: 2.847 ± 0.666
2.847AsnGln: 2.847 ± 0.59
1.993AsnArg: 1.993 ± 0.436
2.752AsnSer: 2.752 ± 0.584
2.941AsnThr: 2.941 ± 0.521
2.752AsnVal: 2.752 ± 0.595
0.474AsnTrp: 0.474 ± 0.203
0.854AsnTyr: 0.854 ± 0.227
0.0AsnXaa: 0.0 ± 0.0
Pro
3.226ProAla: 3.226 ± 0.586
0.095ProCys: 0.095 ± 0.09
2.467ProAsp: 2.467 ± 0.46
2.182ProGlu: 2.182 ± 0.441
1.613ProPhe: 1.613 ± 0.326
0.19ProGly: 0.19 ± 0.144
0.759ProHis: 0.759 ± 0.267
2.941ProIle: 2.941 ± 0.495
2.467ProLys: 2.467 ± 0.391
2.752ProLeu: 2.752 ± 0.493
0.474ProMet: 0.474 ± 0.214
1.803ProAsn: 1.803 ± 0.416
1.234ProPro: 1.234 ± 0.301
1.803ProGln: 1.803 ± 0.424
1.044ProArg: 1.044 ± 0.226
2.087ProSer: 2.087 ± 0.424
2.182ProThr: 2.182 ± 0.485
2.087ProVal: 2.087 ± 0.424
0.095ProTrp: 0.095 ± 0.095
0.759ProTyr: 0.759 ± 0.255
0.0ProXaa: 0.0 ± 0.0
Gln
6.452GlnAla: 6.452 ± 1.268
0.285GlnCys: 0.285 ± 0.157
1.803GlnAsp: 1.803 ± 0.439
3.036GlnGlu: 3.036 ± 0.451
2.657GlnPhe: 2.657 ± 0.431
2.467GlnGly: 2.467 ± 0.481
0.759GlnHis: 0.759 ± 0.305
2.467GlnIle: 2.467 ± 0.462
4.08GlnLys: 4.08 ± 0.663
4.08GlnLeu: 4.08 ± 0.509
1.044GlnMet: 1.044 ± 0.298
1.898GlnAsn: 1.898 ± 0.441
1.518GlnPro: 1.518 ± 0.385
3.416GlnGln: 3.416 ± 0.647
2.467GlnArg: 2.467 ± 0.527
1.993GlnSer: 1.993 ± 0.369
2.752GlnThr: 2.752 ± 0.643
2.467GlnVal: 2.467 ± 0.522
0.569GlnTrp: 0.569 ± 0.212
1.234GlnTyr: 1.234 ± 0.286
0.0GlnXaa: 0.0 ± 0.0
Arg
4.555ArgAla: 4.555 ± 0.75
0.759ArgCys: 0.759 ± 0.267
3.226ArgAsp: 3.226 ± 0.374
3.131ArgGlu: 3.131 ± 0.581
2.277ArgPhe: 2.277 ± 0.399
2.657ArgGly: 2.657 ± 0.437
0.854ArgHis: 0.854 ± 0.4
2.752ArgIle: 2.752 ± 0.518
4.175ArgLys: 4.175 ± 0.724
5.503ArgLeu: 5.503 ± 0.772
1.044ArgMet: 1.044 ± 0.296
2.752ArgAsn: 2.752 ± 0.455
1.993ArgPro: 1.993 ± 0.397
2.372ArgGln: 2.372 ± 0.514
3.131ArgArg: 3.131 ± 0.635
2.277ArgSer: 2.277 ± 0.559
1.993ArgThr: 1.993 ± 0.558
2.941ArgVal: 2.941 ± 0.547
0.854ArgTrp: 0.854 ± 0.283
2.182ArgTyr: 2.182 ± 0.576
0.0ArgXaa: 0.0 ± 0.0
Ser
4.934SerAla: 4.934 ± 0.531
0.569SerCys: 0.569 ± 0.206
4.175SerAsp: 4.175 ± 0.656
4.649SerGlu: 4.649 ± 0.652
3.226SerPhe: 3.226 ± 0.677
4.839SerGly: 4.839 ± 0.772
0.664SerHis: 0.664 ± 0.287
2.277SerIle: 2.277 ± 0.475
4.839SerLys: 4.839 ± 0.915
5.124SerLeu: 5.124 ± 0.753
1.898SerMet: 1.898 ± 0.439
1.898SerAsn: 1.898 ± 0.56
1.708SerPro: 1.708 ± 0.459
2.847SerGln: 2.847 ± 0.469
2.752SerArg: 2.752 ± 0.409
3.131SerSer: 3.131 ± 0.514
1.898SerThr: 1.898 ± 0.406
4.744SerVal: 4.744 ± 0.664
0.759SerTrp: 0.759 ± 0.227
2.182SerTyr: 2.182 ± 0.476
0.0SerXaa: 0.0 ± 0.0
Thr
6.547ThrAla: 6.547 ± 0.841
0.0ThrCys: 0.0 ± 0.0
2.941ThrAsp: 2.941 ± 0.636
3.985ThrGlu: 3.985 ± 0.558
1.139ThrPhe: 1.139 ± 0.337
3.701ThrGly: 3.701 ± 0.674
0.664ThrHis: 0.664 ± 0.254
3.511ThrIle: 3.511 ± 0.494
3.226ThrLys: 3.226 ± 0.428
5.978ThrLeu: 5.978 ± 0.89
0.949ThrMet: 0.949 ± 0.265
2.467ThrAsn: 2.467 ± 0.455
2.847ThrPro: 2.847 ± 0.419
2.467ThrGln: 2.467 ± 0.473
2.277ThrArg: 2.277 ± 0.489
2.182ThrSer: 2.182 ± 0.387
2.941ThrThr: 2.941 ± 0.759
4.27ThrVal: 4.27 ± 0.652
0.19ThrTrp: 0.19 ± 0.121
1.234ThrTyr: 1.234 ± 0.427
0.0ThrXaa: 0.0 ± 0.0
Val
6.642ValAla: 6.642 ± 0.909
0.474ValCys: 0.474 ± 0.208
4.365ValAsp: 4.365 ± 0.626
5.314ValGlu: 5.314 ± 0.675
1.613ValPhe: 1.613 ± 0.45
5.029ValGly: 5.029 ± 0.454
1.139ValHis: 1.139 ± 0.405
3.606ValIle: 3.606 ± 0.616
5.598ValLys: 5.598 ± 0.857
5.314ValLeu: 5.314 ± 0.697
1.234ValMet: 1.234 ± 0.299
3.131ValAsn: 3.131 ± 0.618
1.234ValPro: 1.234 ± 0.319
3.511ValGln: 3.511 ± 0.545
5.029ValArg: 5.029 ± 0.673
4.365ValSer: 4.365 ± 0.489
3.416ValThr: 3.416 ± 0.689
5.883ValVal: 5.883 ± 0.672
0.854ValTrp: 0.854 ± 0.332
1.708ValTyr: 1.708 ± 0.415
0.0ValXaa: 0.0 ± 0.0
Trp
1.139TrpAla: 1.139 ± 0.334
0.19TrpCys: 0.19 ± 0.131
0.664TrpAsp: 0.664 ± 0.267
0.949TrpGlu: 0.949 ± 0.372
0.854TrpPhe: 0.854 ± 0.268
0.569TrpGly: 0.569 ± 0.268
0.19TrpHis: 0.19 ± 0.155
0.759TrpIle: 0.759 ± 0.272
0.664TrpLys: 0.664 ± 0.234
1.234TrpLeu: 1.234 ± 0.252
0.095TrpMet: 0.095 ± 0.086
0.38TrpAsn: 0.38 ± 0.217
0.095TrpPro: 0.095 ± 0.108
1.328TrpGln: 1.328 ± 0.323
0.664TrpArg: 0.664 ± 0.416
0.285TrpSer: 0.285 ± 0.197
0.474TrpThr: 0.474 ± 0.194
1.234TrpVal: 1.234 ± 0.32
0.285TrpTrp: 0.285 ± 0.149
0.38TrpTyr: 0.38 ± 0.159
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.657TyrAla: 2.657 ± 0.542
0.664TyrCys: 0.664 ± 0.234
1.328TyrAsp: 1.328 ± 0.382
1.423TyrGlu: 1.423 ± 0.284
1.139TyrPhe: 1.139 ± 0.397
1.518TyrGly: 1.518 ± 0.408
0.474TyrHis: 0.474 ± 0.193
1.234TyrIle: 1.234 ± 0.373
1.993TyrLys: 1.993 ± 0.397
2.847TyrLeu: 2.847 ± 0.526
0.285TyrMet: 0.285 ± 0.141
1.234TyrAsn: 1.234 ± 0.31
1.423TyrPro: 1.423 ± 0.273
2.941TyrGln: 2.941 ± 0.425
1.613TyrArg: 1.613 ± 0.413
1.993TyrSer: 1.993 ± 0.4
1.044TyrThr: 1.044 ± 0.461
1.803TyrVal: 1.803 ± 0.398
0.664TyrTrp: 0.664 ± 0.221
0.569TyrTyr: 0.569 ± 0.227
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (10540 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski