Amino acid dipepetide frequency for Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling s disease fungus) (Histoplasma capsulatum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.962AlaAla: 7.962 ± 0.061
0.972AlaCys: 0.972 ± 0.017
3.833AlaAsp: 3.833 ± 0.033
4.827AlaGlu: 4.827 ± 0.041
2.831AlaPhe: 2.831 ± 0.031
5.483AlaGly: 5.483 ± 0.042
1.696AlaHis: 1.696 ± 0.019
4.079AlaIle: 4.079 ± 0.031
3.938AlaLys: 3.938 ± 0.041
7.069AlaLeu: 7.069 ± 0.046
1.715AlaMet: 1.715 ± 0.022
2.921AlaAsn: 2.921 ± 0.027
4.269AlaPro: 4.269 ± 0.041
3.04AlaGln: 3.04 ± 0.034
4.811AlaArg: 4.811 ± 0.037
6.943AlaSer: 6.943 ± 0.045
4.909AlaThr: 4.909 ± 0.039
4.894AlaVal: 4.894 ± 0.042
0.96AlaTrp: 0.96 ± 0.014
1.852AlaTyr: 1.852 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
0.885CysAla: 0.885 ± 0.016
0.273CysCys: 0.273 ± 0.01
0.646CysAsp: 0.646 ± 0.015
0.649CysGlu: 0.649 ± 0.012
0.54CysPhe: 0.54 ± 0.011
0.939CysGly: 0.939 ± 0.017
0.362CysHis: 0.362 ± 0.01
0.71CysIle: 0.71 ± 0.014
0.552CysLys: 0.552 ± 0.012
1.279CysLeu: 1.279 ± 0.018
0.273CysMet: 0.273 ± 0.007
0.451CysAsn: 0.451 ± 0.011
0.745CysPro: 0.745 ± 0.015
0.495CysGln: 0.495 ± 0.013
0.837CysArg: 0.837 ± 0.016
1.015CysSer: 1.015 ± 0.018
0.661CysThr: 0.661 ± 0.014
0.771CysVal: 0.771 ± 0.015
0.209CysTrp: 0.209 ± 0.007
0.359CysTyr: 0.359 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
4.147AspAla: 4.147 ± 0.037
0.643AspCys: 0.643 ± 0.015
4.181AspAsp: 4.181 ± 0.049
4.29AspGlu: 4.29 ± 0.039
2.1AspPhe: 2.1 ± 0.025
4.108AspGly: 4.108 ± 0.032
1.23AspHis: 1.23 ± 0.018
3.376AspIle: 3.376 ± 0.034
2.372AspLys: 2.372 ± 0.026
4.806AspLeu: 4.806 ± 0.037
1.238AspMet: 1.238 ± 0.018
2.05AspAsn: 2.05 ± 0.025
3.261AspPro: 3.261 ± 0.032
1.776AspGln: 1.776 ± 0.022
3.108AspArg: 3.108 ± 0.032
4.198AspSer: 4.198 ± 0.036
2.829AspThr: 2.829 ± 0.029
3.474AspVal: 3.474 ± 0.033
0.785AspTrp: 0.785 ± 0.013
1.475AspTyr: 1.475 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
4.859GluAla: 4.859 ± 0.039
0.661GluCys: 0.661 ± 0.012
3.974GluAsp: 3.974 ± 0.041
5.298GluGlu: 5.298 ± 0.068
1.993GluPhe: 1.993 ± 0.022
3.733GluGly: 3.733 ± 0.033
1.359GluHis: 1.359 ± 0.018
3.259GluIle: 3.259 ± 0.033
3.801GluLys: 3.801 ± 0.039
5.193GluLeu: 5.193 ± 0.048
1.457GluMet: 1.457 ± 0.018
2.659GluAsn: 2.659 ± 0.027
2.785GluPro: 2.785 ± 0.037
2.424GluGln: 2.424 ± 0.027
4.15GluArg: 4.15 ± 0.036
4.46GluSer: 4.46 ± 0.034
3.387GluThr: 3.387 ± 0.029
3.344GluVal: 3.344 ± 0.035
0.823GluTrp: 0.823 ± 0.014
1.673GluTyr: 1.673 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.757PheAla: 2.757 ± 0.025
0.559PheCys: 0.559 ± 0.012
2.187PheAsp: 2.187 ± 0.024
2.131PheGlu: 2.131 ± 0.021
1.492PhePhe: 1.492 ± 0.023
2.656PheGly: 2.656 ± 0.032
0.964PheHis: 0.964 ± 0.015
1.768PheIle: 1.768 ± 0.022
1.532PheLys: 1.532 ± 0.02
3.457PheLeu: 3.457 ± 0.036
0.721PheMet: 0.721 ± 0.013
1.405PheAsn: 1.405 ± 0.016
2.141PhePro: 2.141 ± 0.026
1.411PheGln: 1.411 ± 0.018
2.092PheArg: 2.092 ± 0.021
3.22PheSer: 3.22 ± 0.032
2.036PheThr: 2.036 ± 0.022
2.274PheVal: 2.274 ± 0.026
0.563PheTrp: 0.563 ± 0.011
1.026PheTyr: 1.026 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
4.799GlyAla: 4.799 ± 0.042
0.89GlyCys: 0.89 ± 0.019
3.754GlyAsp: 3.754 ± 0.033
3.86GlyGlu: 3.86 ± 0.034
2.613GlyPhe: 2.613 ± 0.026
5.973GlyGly: 5.973 ± 0.067
1.625GlyHis: 1.625 ± 0.023
3.552GlyIle: 3.552 ± 0.026
3.631GlyLys: 3.631 ± 0.034
5.613GlyLeu: 5.613 ± 0.038
1.589GlyMet: 1.589 ± 0.022
2.784GlyAsn: 2.784 ± 0.029
3.233GlyPro: 3.233 ± 0.03
2.436GlyGln: 2.436 ± 0.025
4.353GlyArg: 4.353 ± 0.036
5.822GlySer: 5.822 ± 0.046
3.741GlyThr: 3.741 ± 0.034
4.178GlyVal: 4.178 ± 0.033
1.097GlyTrp: 1.097 ± 0.019
1.999GlyTyr: 1.999 ± 0.022
0.0GlyXaa: 0.0 ± 0.0
His
1.792HisAla: 1.792 ± 0.02
0.349HisCys: 0.349 ± 0.009
1.324HisAsp: 1.324 ± 0.019
1.315HisGlu: 1.315 ± 0.019
0.935HisPhe: 0.935 ± 0.015
1.722HisGly: 1.722 ± 0.025
0.944HisHis: 0.944 ± 0.019
1.338HisIle: 1.338 ± 0.018
0.949HisLys: 0.949 ± 0.017
2.317HisLeu: 2.317 ± 0.024
0.488HisMet: 0.488 ± 0.011
0.938HisAsn: 0.938 ± 0.015
1.918HisPro: 1.918 ± 0.024
1.141HisGln: 1.141 ± 0.02
1.666HisArg: 1.666 ± 0.021
2.193HisSer: 2.193 ± 0.027
1.327HisThr: 1.327 ± 0.02
1.379HisVal: 1.379 ± 0.019
0.308HisTrp: 0.308 ± 0.01
0.663HisTyr: 0.663 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.924IleAla: 3.924 ± 0.034
0.817IleCys: 0.817 ± 0.015
2.95IleAsp: 2.95 ± 0.026
2.928IleGlu: 2.928 ± 0.029
2.103IlePhe: 2.103 ± 0.025
3.096IleGly: 3.096 ± 0.03
1.35IleHis: 1.35 ± 0.019
2.645IleIle: 2.645 ± 0.03
2.285IleLys: 2.285 ± 0.027
4.879IleLeu: 4.879 ± 0.043
0.991IleMet: 0.991 ± 0.016
1.887IleAsn: 1.887 ± 0.023
3.472IlePro: 3.472 ± 0.031
2.003IleGln: 2.003 ± 0.025
3.044IleArg: 3.044 ± 0.033
4.586IleSer: 4.586 ± 0.034
2.874IleThr: 2.874 ± 0.027
3.062IleVal: 3.062 ± 0.029
0.687IleTrp: 0.687 ± 0.014
1.467IleTyr: 1.467 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
3.938LysAla: 3.938 ± 0.04
0.578LysCys: 0.578 ± 0.012
2.648LysAsp: 2.648 ± 0.028
3.443LysGlu: 3.443 ± 0.043
1.61LysPhe: 1.61 ± 0.02
3.051LysGly: 3.051 ± 0.034
1.217LysHis: 1.217 ± 0.016
2.531LysIle: 2.531 ± 0.027
3.382LysLys: 3.382 ± 0.049
4.345LysLeu: 4.345 ± 0.04
1.061LysMet: 1.061 ± 0.017
1.916LysAsn: 1.916 ± 0.025
2.925LysPro: 2.925 ± 0.035
2.04LysGln: 2.04 ± 0.026
3.787LysArg: 3.787 ± 0.033
3.88LysSer: 3.88 ± 0.035
2.793LysThr: 2.793 ± 0.029
2.765LysVal: 2.765 ± 0.03
0.663LysTrp: 0.663 ± 0.014
1.445LysTyr: 1.445 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
7.249LeuAla: 7.249 ± 0.05
1.221LeuCys: 1.221 ± 0.016
5.018LeuAsp: 5.018 ± 0.039
5.519LeuGlu: 5.519 ± 0.048
3.276LeuPhe: 3.276 ± 0.033
5.671LeuGly: 5.671 ± 0.038
2.296LeuHis: 2.296 ± 0.025
4.002LeuIle: 4.002 ± 0.037
4.466LeuLys: 4.466 ± 0.038
8.466LeuLeu: 8.466 ± 0.061
1.668LeuMet: 1.668 ± 0.02
3.314LeuAsn: 3.314 ± 0.034
5.637LeuPro: 5.637 ± 0.039
3.855LeuGln: 3.855 ± 0.039
6.01LeuArg: 6.01 ± 0.038
7.82LeuSer: 7.82 ± 0.046
4.64LeuThr: 4.64 ± 0.035
5.12LeuVal: 5.12 ± 0.04
1.13LeuTrp: 1.13 ± 0.019
2.263LeuTyr: 2.263 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
2.091MetAla: 2.091 ± 0.021
0.24MetCys: 0.24 ± 0.007
1.238MetAsp: 1.238 ± 0.017
1.372MetGlu: 1.372 ± 0.021
0.703MetPhe: 0.703 ± 0.013
1.422MetGly: 1.422 ± 0.019
0.446MetHis: 0.446 ± 0.011
0.992MetIle: 0.992 ± 0.016
1.066MetLys: 1.066 ± 0.016
1.757MetLeu: 1.757 ± 0.021
0.507MetMet: 0.507 ± 0.012
0.821MetAsn: 0.821 ± 0.016
1.191MetPro: 1.191 ± 0.018
0.828MetGln: 0.828 ± 0.016
1.225MetArg: 1.225 ± 0.016
1.815MetSer: 1.815 ± 0.022
1.198MetThr: 1.198 ± 0.017
1.23MetVal: 1.23 ± 0.019
0.247MetTrp: 0.247 ± 0.009
0.484MetTyr: 0.484 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.043AsnAla: 3.043 ± 0.029
0.494AsnCys: 0.494 ± 0.011
2.153AsnAsp: 2.153 ± 0.026
2.201AsnGlu: 2.201 ± 0.021
1.403AsnPhe: 1.403 ± 0.019
3.118AsnGly: 3.118 ± 0.033
0.995AsnHis: 0.995 ± 0.017
2.317AsnIle: 2.317 ± 0.023
1.728AsnLys: 1.728 ± 0.022
3.398AsnLeu: 3.398 ± 0.032
0.835AsnMet: 0.835 ± 0.017
1.934AsnAsn: 1.934 ± 0.029
2.746AsnPro: 2.746 ± 0.026
1.467AsnGln: 1.467 ± 0.02
2.273AsnArg: 2.273 ± 0.022
3.278AsnSer: 3.278 ± 0.029
2.282AsnThr: 2.282 ± 0.024
2.329AsnVal: 2.329 ± 0.026
0.503AsnTrp: 0.503 ± 0.009
1.039AsnTyr: 1.039 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
4.954ProAla: 4.954 ± 0.043
0.602ProCys: 0.602 ± 0.012
3.173ProAsp: 3.173 ± 0.027
3.645ProGlu: 3.645 ± 0.037
2.139ProPhe: 2.139 ± 0.027
3.878ProGly: 3.878 ± 0.032
1.54ProHis: 1.54 ± 0.02
2.814ProIle: 2.814 ± 0.026
2.792ProLys: 2.792 ± 0.027
5.077ProLeu: 5.077 ± 0.04
1.028ProMet: 1.028 ± 0.017
2.468ProAsn: 2.468 ± 0.028
5.876ProPro: 5.876 ± 0.087
2.728ProGln: 2.728 ± 0.036
3.624ProArg: 3.624 ± 0.031
6.709ProSer: 6.709 ± 0.063
4.282ProThr: 4.282 ± 0.046
3.436ProVal: 3.436 ± 0.032
0.691ProTrp: 0.691 ± 0.014
1.503ProTyr: 1.503 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
3.078GlnAla: 3.078 ± 0.03
0.451GlnCys: 0.451 ± 0.011
1.929GlnAsp: 1.929 ± 0.023
2.383GlnGlu: 2.383 ± 0.03
1.299GlnPhe: 1.299 ± 0.016
2.322GlnGly: 2.322 ± 0.023
1.209GlnHis: 1.209 ± 0.021
1.987GlnIle: 1.987 ± 0.02
2.118GlnLys: 2.118 ± 0.022
3.554GlnLeu: 3.554 ± 0.031
0.867GlnMet: 0.867 ± 0.015
1.745GlnAsn: 1.745 ± 0.021
2.798GlnPro: 2.798 ± 0.037
2.828GlnGln: 2.828 ± 0.059
2.878GlnArg: 2.878 ± 0.027
3.337GlnSer: 3.337 ± 0.032
2.331GlnThr: 2.331 ± 0.026
2.03GlnVal: 2.03 ± 0.023
0.493GlnTrp: 0.493 ± 0.011
1.091GlnTyr: 1.091 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
4.603ArgAla: 4.603 ± 0.036
0.821ArgCys: 0.821 ± 0.014
3.479ArgAsp: 3.479 ± 0.03
4.058ArgGlu: 4.058 ± 0.042
2.195ArgPhe: 2.195 ± 0.024
4.089ArgGly: 4.089 ± 0.039
1.692ArgHis: 1.692 ± 0.022
3.183ArgIle: 3.183 ± 0.03
3.9ArgLys: 3.9 ± 0.035
5.612ArgLeu: 5.612 ± 0.039
1.399ArgMet: 1.399 ± 0.016
2.633ArgAsn: 2.633 ± 0.022
3.582ArgPro: 3.582 ± 0.037
2.78ArgGln: 2.78 ± 0.03
5.606ArgArg: 5.606 ± 0.051
5.323ArgSer: 5.323 ± 0.056
3.428ArgThr: 3.428 ± 0.037
3.454ArgVal: 3.454 ± 0.029
0.92ArgTrp: 0.92 ± 0.014
1.702ArgTyr: 1.702 ± 0.02
0.0ArgXaa: 0.0 ± 0.0
Ser
6.565SerAla: 6.565 ± 0.039
0.989SerCys: 0.989 ± 0.016
4.221SerAsp: 4.221 ± 0.036
4.257SerGlu: 4.257 ± 0.035
3.147SerPhe: 3.147 ± 0.028
5.715SerGly: 5.715 ± 0.042
2.32SerHis: 2.32 ± 0.028
4.339SerIle: 4.339 ± 0.036
4.073SerLys: 4.073 ± 0.039
7.679SerLeu: 7.679 ± 0.047
1.757SerMet: 1.757 ± 0.019
3.55SerAsn: 3.55 ± 0.033
6.399SerPro: 6.399 ± 0.062
3.634SerGln: 3.634 ± 0.041
5.762SerArg: 5.762 ± 0.046
10.134SerSer: 10.134 ± 0.094
5.98SerThr: 5.98 ± 0.046
4.555SerVal: 4.555 ± 0.039
1.091SerTrp: 1.091 ± 0.017
2.055SerTyr: 2.055 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
4.843ThrAla: 4.843 ± 0.038
0.729ThrCys: 0.729 ± 0.012
2.768ThrAsp: 2.768 ± 0.03
3.006ThrGlu: 3.006 ± 0.028
2.145ThrPhe: 2.145 ± 0.027
3.991ThrGly: 3.991 ± 0.038
1.357ThrHis: 1.357 ± 0.017
3.068ThrIle: 3.068 ± 0.029
2.672ThrLys: 2.672 ± 0.032
5.077ThrLeu: 5.077 ± 0.036
1.123ThrMet: 1.123 ± 0.018
2.242ThrAsn: 2.242 ± 0.024
4.442ThrPro: 4.442 ± 0.049
2.087ThrGln: 2.087 ± 0.025
3.244ThrArg: 3.244 ± 0.029
5.782ThrSer: 5.782 ± 0.046
4.409ThrThr: 4.409 ± 0.051
3.411ThrVal: 3.411 ± 0.033
0.713ThrTrp: 0.713 ± 0.015
1.462ThrTyr: 1.462 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
4.674ValAla: 4.674 ± 0.037
0.789ValCys: 0.789 ± 0.013
3.619ValAsp: 3.619 ± 0.03
3.821ValGlu: 3.821 ± 0.034
2.256ValPhe: 2.256 ± 0.023
3.868ValGly: 3.868 ± 0.036
1.334ValHis: 1.334 ± 0.017
2.929ValIle: 2.929 ± 0.032
2.877ValLys: 2.877 ± 0.028
5.21ValLeu: 5.21 ± 0.043
1.236ValMet: 1.236 ± 0.014
2.18ValAsn: 2.18 ± 0.024
3.388ValPro: 3.388 ± 0.029
2.181ValGln: 2.181 ± 0.022
3.397ValArg: 3.397 ± 0.029
4.664ValSer: 4.664 ± 0.04
3.255ValThr: 3.255 ± 0.031
4.015ValVal: 4.015 ± 0.039
0.789ValTrp: 0.789 ± 0.016
1.534ValTyr: 1.534 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
1.002TrpAla: 1.002 ± 0.017
0.171TrpCys: 0.171 ± 0.006
0.818TrpAsp: 0.818 ± 0.016
0.845TrpGlu: 0.845 ± 0.013
0.458TrpPhe: 0.458 ± 0.01
0.824TrpGly: 0.824 ± 0.016
0.325TrpHis: 0.325 ± 0.01
0.706TrpIle: 0.706 ± 0.014
0.809TrpLys: 0.809 ± 0.014
1.254TrpLeu: 1.254 ± 0.02
0.34TrpMet: 0.34 ± 0.009
0.597TrpAsn: 0.597 ± 0.011
0.546TrpPro: 0.546 ± 0.013
0.503TrpGln: 0.503 ± 0.011
0.976TrpArg: 0.976 ± 0.015
0.951TrpSer: 0.951 ± 0.016
0.752TrpThr: 0.752 ± 0.012
0.802TrpVal: 0.802 ± 0.013
0.247TrpTrp: 0.247 ± 0.008
0.358TrpTyr: 0.358 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.841TyrAla: 1.841 ± 0.022
0.402TyrCys: 0.402 ± 0.01
1.531TyrAsp: 1.531 ± 0.019
1.445TyrGlu: 1.445 ± 0.016
1.156TyrPhe: 1.156 ± 0.017
1.884TyrGly: 1.884 ± 0.024
0.743TyrHis: 0.743 ± 0.014
1.455TyrIle: 1.455 ± 0.019
1.075TyrLys: 1.075 ± 0.018
2.599TyrLeu: 2.599 ± 0.028
0.582TyrMet: 0.582 ± 0.012
1.04TyrAsn: 1.04 ± 0.017
1.604TyrPro: 1.604 ± 0.029
1.072TyrGln: 1.072 ± 0.015
1.617TyrArg: 1.617 ± 0.02
2.091TyrSer: 2.091 ± 0.027
1.459TyrThr: 1.459 ± 0.02
1.493TyrVal: 1.493 ± 0.02
0.362TyrTrp: 0.362 ± 0.01
0.853TyrTyr: 0.853 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9214 proteins (4155681 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski