Amino acid dipepetide frequency for Sphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.571AlaAla: 5.571 ± 0.085	1.125AlaCys: 1.125 ± 0.041	3.434AlaAsp: 3.434 ± 0.058	4.058AlaGlu: 4.058 ± 0.07	3.778AlaPhe: 3.778 ± 0.064	5.218AlaGly: 5.218 ± 0.083	1.138AlaHis: 1.138 ± 0.034	5.968AlaIle: 5.968 ± 0.084	5.129AlaLys: 5.129 ± 0.069	8.97AlaLeu: 8.97 ± 0.1	2.59AlaMet: 2.59 ± 0.056	3.027AlaAsn: 3.027 ± 0.058	2.218AlaPro: 2.218 ± 0.056	2.561AlaGln: 2.561 ± 0.058	3.019AlaArg: 3.019 ± 0.05	5.639AlaSer: 5.639 ± 0.082	4.2AlaThr: 4.2 ± 0.071	5.286AlaVal: 5.286 ± 0.073	0.743AlaTrp: 0.743 ± 0.025	2.646AlaTyr: 2.646 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.961CysAla: 0.961 ± 0.029	0.247CysCys: 0.247 ± 0.017	0.778CysAsp: 0.778 ± 0.028	0.779CysGlu: 0.779 ± 0.028	0.673CysPhe: 0.673 ± 0.022	1.227CysGly: 1.227 ± 0.038	0.306CysHis: 0.306 ± 0.018	1.031CysIle: 1.031 ± 0.033	0.775CysLys: 0.775 ± 0.034	1.275CysLeu: 1.275 ± 0.036	0.377CysMet: 0.377 ± 0.018	0.616CysAsn: 0.616 ± 0.027	0.664CysPro: 0.664 ± 0.029	0.387CysGln: 0.387 ± 0.019	0.538CysArg: 0.538 ± 0.026	1.041CysSer: 1.041 ± 0.036	0.859CysThr: 0.859 ± 0.032	0.754CysVal: 0.754 ± 0.025	0.121CysTrp: 0.121 ± 0.011	0.468CysTyr: 0.468 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.889AspAla: 3.889 ± 0.07	0.706AspCys: 0.706 ± 0.025	2.377AspAsp: 2.377 ± 0.047	3.408AspGlu: 3.408 ± 0.062	2.748AspPhe: 2.748 ± 0.058	3.616AspGly: 3.616 ± 0.071	0.966AspHis: 0.966 ± 0.027	3.892AspIle: 3.892 ± 0.06	2.825AspLys: 2.825 ± 0.048	5.245AspLeu: 5.245 ± 0.078	1.347AspMet: 1.347 ± 0.033	1.908AspAsn: 1.908 ± 0.042	2.122AspPro: 2.122 ± 0.044	1.531AspGln: 1.531 ± 0.035	2.434AspArg: 2.434 ± 0.066	3.636AspSer: 3.636 ± 0.058	2.88AspThr: 2.88 ± 0.058	3.045AspVal: 3.045 ± 0.057	0.66AspTrp: 0.66 ± 0.03	2.006AspTyr: 2.006 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.949GluAla: 4.949 ± 0.068	0.555GluCys: 0.555 ± 0.021	3.039GluAsp: 3.039 ± 0.058	4.415GluGlu: 4.415 ± 0.079	2.146GluPhe: 2.146 ± 0.045	4.344GluGly: 4.344 ± 0.071	1.14GluHis: 1.14 ± 0.029	4.512GluIle: 4.512 ± 0.069	5.204GluLys: 5.204 ± 0.073	5.586GluLeu: 5.586 ± 0.072	1.787GluMet: 1.787 ± 0.041	3.31GluAsn: 3.31 ± 0.062	1.807GluPro: 1.807 ± 0.072	2.728GluGln: 2.728 ± 0.052	2.883GluArg: 2.883 ± 0.064	3.486GluSer: 3.486 ± 0.05	3.538GluThr: 3.538 ± 0.062	3.758GluVal: 3.758 ± 0.062	0.458GluTrp: 0.458 ± 0.022	1.971GluTyr: 1.971 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.838PheAla: 3.838 ± 0.065	0.844PheCys: 0.844 ± 0.026	2.716PheAsp: 2.716 ± 0.053	2.56PheGlu: 2.56 ± 0.055	2.624PhePhe: 2.624 ± 0.059	3.567PheGly: 3.567 ± 0.058	0.859PheHis: 0.859 ± 0.033	3.087PheIle: 3.087 ± 0.06	2.144PheLys: 2.144 ± 0.046	5.304PheLeu: 5.304 ± 0.085	1.086PheMet: 1.086 ± 0.033	1.825PheAsn: 1.825 ± 0.043	2.064PhePro: 2.064 ± 0.043	1.374PheGln: 1.374 ± 0.041	1.665PheArg: 1.665 ± 0.04	4.745PheSer: 4.745 ± 0.068	2.731PheThr: 2.731 ± 0.052	3.016PheVal: 3.016 ± 0.052	0.561PheTrp: 0.561 ± 0.023	1.555PheTyr: 1.555 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.803GlyAla: 4.803 ± 0.074	1.194GlyCys: 1.194 ± 0.036	3.175GlyAsp: 3.175 ± 0.071	4.043GlyGlu: 4.043 ± 0.068	3.78GlyPhe: 3.78 ± 0.06	5.032GlyGly: 5.032 ± 0.079	1.199GlyHis: 1.199 ± 0.035	6.184GlyIle: 6.184 ± 0.087	5.312GlyLys: 5.312 ± 0.07	6.783GlyLeu: 6.783 ± 0.081	2.286GlyMet: 2.286 ± 0.048	3.133GlyAsn: 3.133 ± 0.067	1.99GlyPro: 1.99 ± 0.044	2.069GlyGln: 2.069 ± 0.05	2.872GlyArg: 2.872 ± 0.05	4.978GlySer: 4.978 ± 0.073	4.467GlyThr: 4.467 ± 0.064	4.84GlyVal: 4.84 ± 0.068	0.788GlyTrp: 0.788 ± 0.031	3.025GlyTyr: 3.025 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.29HisAla: 1.29 ± 0.031	0.363HisCys: 0.363 ± 0.02	0.923HisAsp: 0.923 ± 0.03	0.976HisGlu: 0.976 ± 0.032	0.95HisPhe: 0.95 ± 0.029	1.238HisGly: 1.238 ± 0.032	0.388HisHis: 0.388 ± 0.02	1.305HisIle: 1.305 ± 0.038	0.82HisLys: 0.82 ± 0.029	1.893HisLeu: 1.893 ± 0.041	0.469HisMet: 0.469 ± 0.021	0.64HisAsn: 0.64 ± 0.024	0.996HisPro: 0.996 ± 0.033	0.604HisGln: 0.604 ± 0.024	0.809HisArg: 0.809 ± 0.027	1.206HisSer: 1.206 ± 0.033	1.057HisThr: 1.057 ± 0.028	1.052HisVal: 1.052 ± 0.032	0.214HisTrp: 0.214 ± 0.014	0.682HisTyr: 0.682 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.466IleAla: 6.466 ± 0.086	1.072IleCys: 1.072 ± 0.031	4.004IleAsp: 4.004 ± 0.069	4.498IleGlu: 4.498 ± 0.066	2.913IlePhe: 2.913 ± 0.06	5.493IleGly: 5.493 ± 0.069	1.271IleHis: 1.271 ± 0.035	4.765IleIle: 4.765 ± 0.08	3.415IleLys: 3.415 ± 0.064	7.508IleLeu: 7.508 ± 0.106	1.581IleMet: 1.581 ± 0.046	2.512IleAsn: 2.512 ± 0.053	3.732IlePro: 3.732 ± 0.055	2.197IleGln: 2.197 ± 0.042	3.013IleArg: 3.013 ± 0.047	5.143IleSer: 5.143 ± 0.086	4.017IleThr: 4.017 ± 0.064	4.977IleVal: 4.977 ± 0.082	0.631IleTrp: 0.631 ± 0.028	2.042IleTyr: 2.042 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	5.217LysAla: 5.217 ± 0.069	0.442LysCys: 0.442 ± 0.022	3.516LysAsp: 3.516 ± 0.063	4.949LysGlu: 4.949 ± 0.075	1.678LysPhe: 1.678 ± 0.044	4.507LysGly: 4.507 ± 0.064	0.987LysHis: 0.987 ± 0.027	3.895LysIle: 3.895 ± 0.066	4.889LysLys: 4.889 ± 0.08	4.783LysLeu: 4.783 ± 0.068	1.739LysMet: 1.739 ± 0.039	2.859LysAsn: 2.859 ± 0.05	2.169LysPro: 2.169 ± 0.047	2.517LysGln: 2.517 ± 0.049	2.952LysArg: 2.952 ± 0.053	3.286LysSer: 3.286 ± 0.064	3.91LysThr: 3.91 ± 0.06	3.935LysVal: 3.935 ± 0.062	0.527LysTrp: 0.527 ± 0.025	1.672LysTyr: 1.672 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	8.649LeuAla: 8.649 ± 0.085	1.618LeuCys: 1.618 ± 0.046	5.697LeuAsp: 5.697 ± 0.077	6.158LeuGlu: 6.158 ± 0.085	5.565LeuPhe: 5.565 ± 0.092	7.587LeuGly: 7.587 ± 0.1	1.935LeuHis: 1.935 ± 0.04	6.228LeuIle: 6.228 ± 0.104	5.63LeuLys: 5.63 ± 0.072	11.262LeuLeu: 11.262 ± 0.144	2.664LeuMet: 2.664 ± 0.055	3.473LeuAsn: 3.473 ± 0.059	4.406LeuPro: 4.406 ± 0.06	3.844LeuGln: 3.844 ± 0.071	3.992LeuArg: 3.992 ± 0.064	8.576LeuSer: 8.576 ± 0.107	5.238LeuThr: 5.238 ± 0.078	7.786LeuVal: 7.786 ± 0.08	0.914LeuTrp: 0.914 ± 0.035	3.428LeuTyr: 3.428 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.317MetAla: 2.317 ± 0.048	0.27MetCys: 0.27 ± 0.016	1.484MetAsp: 1.484 ± 0.038	1.832MetGlu: 1.832 ± 0.043	1.106MetPhe: 1.106 ± 0.037	2.125MetGly: 2.125 ± 0.048	0.583MetHis: 0.583 ± 0.024	1.853MetIle: 1.853 ± 0.041	2.067MetLys: 2.067 ± 0.04	2.764MetLeu: 2.764 ± 0.056	0.756MetMet: 0.756 ± 0.027	1.147MetAsn: 1.147 ± 0.038	1.004MetPro: 1.004 ± 0.031	1.136MetGln: 1.136 ± 0.035	1.133MetArg: 1.133 ± 0.032	1.499MetSer: 1.499 ± 0.036	1.439MetThr: 1.439 ± 0.04	2.261MetVal: 2.261 ± 0.046	0.175MetTrp: 0.175 ± 0.014	0.745MetTyr: 0.745 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.963AsnAla: 2.963 ± 0.061	0.518AsnCys: 0.518 ± 0.024	1.961AsnAsp: 1.961 ± 0.046	2.311AsnGlu: 2.311 ± 0.047	1.537AsnPhe: 1.537 ± 0.039	3.105AsnGly: 3.105 ± 0.061	0.761AsnHis: 0.761 ± 0.029	2.71AsnIle: 2.71 ± 0.052	2.067AsnLys: 2.067 ± 0.046	4.509AsnLeu: 4.509 ± 0.058	0.989AsnMet: 0.989 ± 0.031	1.554AsnAsn: 1.554 ± 0.041	2.252AsnPro: 2.252 ± 0.046	1.469AsnGln: 1.469 ± 0.039	1.943AsnArg: 1.943 ± 0.04	2.485AsnSer: 2.485 ± 0.048	2.368AsnThr: 2.368 ± 0.055	2.327AsnVal: 2.327 ± 0.05	0.451AsnTrp: 0.451 ± 0.022	1.446AsnTyr: 1.446 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.575ProAla: 2.575 ± 0.058	0.463ProCys: 0.463 ± 0.024	2.074ProAsp: 2.074 ± 0.047	2.524ProGlu: 2.524 ± 0.058	2.211ProPhe: 2.211 ± 0.041	2.344ProGly: 2.344 ± 0.052	0.689ProHis: 0.689 ± 0.026	2.59ProIle: 2.59 ± 0.065	1.885ProLys: 1.885 ± 0.04	4.267ProLeu: 4.267 ± 0.075	0.99ProMet: 0.99 ± 0.032	1.455ProAsn: 1.455 ± 0.039	1.161ProPro: 1.161 ± 0.031	1.317ProGln: 1.317 ± 0.039	1.232ProArg: 1.232 ± 0.039	3.116ProSer: 3.116 ± 0.064	2.043ProThr: 2.043 ± 0.046	3.327ProVal: 3.327 ± 0.053	0.437ProTrp: 0.437 ± 0.019	1.599ProTyr: 1.599 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.773GlnAla: 2.773 ± 0.054	0.385GlnCys: 0.385 ± 0.019	1.646GlnAsp: 1.646 ± 0.043	2.399GlnGlu: 2.399 ± 0.046	1.408GlnPhe: 1.408 ± 0.037	2.57GlnGly: 2.57 ± 0.052	0.541GlnHis: 0.541 ± 0.021	2.517GlnIle: 2.517 ± 0.049	2.574GlnLys: 2.574 ± 0.051	3.212GlnLeu: 3.212 ± 0.056	1.147GlnMet: 1.147 ± 0.035	1.458GlnAsn: 1.458 ± 0.038	0.942GlnPro: 0.942 ± 0.033	1.52GlnGln: 1.52 ± 0.046	1.591GlnArg: 1.591 ± 0.04	2.031GlnSer: 2.031 ± 0.043	1.714GlnThr: 1.714 ± 0.037	2.56GlnVal: 2.56 ± 0.049	0.409GlnTrp: 0.409 ± 0.019	1.277GlnTyr: 1.277 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.398ArgAla: 2.398 ± 0.051	0.562ArgCys: 0.562 ± 0.023	2.109ArgAsp: 2.109 ± 0.052	2.914ArgGlu: 2.914 ± 0.059	2.231ArgPhe: 2.231 ± 0.045	2.423ArgGly: 2.423 ± 0.046	0.747ArgHis: 0.747 ± 0.028	3.331ArgIle: 3.331 ± 0.052	3.047ArgLys: 3.047 ± 0.053	4.224ArgLeu: 4.224 ± 0.076	1.362ArgMet: 1.362 ± 0.038	1.991ArgAsn: 1.991 ± 0.043	1.317ArgPro: 1.317 ± 0.043	1.631ArgGln: 1.631 ± 0.039	1.874ArgArg: 1.874 ± 0.048	2.643ArgSer: 2.643 ± 0.057	2.266ArgThr: 2.266 ± 0.047	2.507ArgVal: 2.507 ± 0.052	0.472ArgTrp: 0.472 ± 0.021	1.792ArgTyr: 1.792 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.621SerAla: 4.621 ± 0.066	1.036SerCys: 1.036 ± 0.032	3.539SerAsp: 3.539 ± 0.069	4.125SerGlu: 4.125 ± 0.064	4.081SerPhe: 4.081 ± 0.068	5.284SerGly: 5.284 ± 0.069	1.266SerHis: 1.266 ± 0.038	5.344SerIle: 5.344 ± 0.078	3.536SerLys: 3.536 ± 0.05	8.572SerLeu: 8.572 ± 0.117	2.004SerMet: 2.004 ± 0.044	2.507SerAsn: 2.507 ± 0.043	2.496SerPro: 2.496 ± 0.052	2.342SerGln: 2.342 ± 0.046	2.852SerArg: 2.852 ± 0.052	5.007SerSer: 5.007 ± 0.078	3.403SerThr: 3.403 ± 0.064	5.139SerVal: 5.139 ± 0.066	0.82SerTrp: 0.82 ± 0.03	2.77SerTyr: 2.77 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.093ThrAla: 4.093 ± 0.057	0.723ThrCys: 0.723 ± 0.024	2.741ThrAsp: 2.741 ± 0.049	3.133ThrGlu: 3.133 ± 0.053	2.811ThrPhe: 2.811 ± 0.056	4.347ThrGly: 4.347 ± 0.07	0.977ThrHis: 0.977 ± 0.033	4.506ThrIle: 4.506 ± 0.069	2.943ThrLys: 2.943 ± 0.049	6.274ThrLeu: 6.274 ± 0.087	1.508ThrMet: 1.508 ± 0.035	2.003ThrAsn: 2.003 ± 0.043	2.256ThrPro: 2.256 ± 0.046	1.531ThrGln: 1.531 ± 0.041	1.968ThrArg: 1.968 ± 0.04	3.591ThrSer: 3.591 ± 0.06	3.04ThrThr: 3.04 ± 0.064	4.427ThrVal: 4.427 ± 0.072	0.647ThrTrp: 0.647 ± 0.027	2.138ThrTyr: 2.138 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.428ValAla: 5.428 ± 0.08	1.043ValCys: 1.043 ± 0.032	3.443ValAsp: 3.443 ± 0.061	3.839ValGlu: 3.839 ± 0.072	3.733ValPhe: 3.733 ± 0.064	4.607ValGly: 4.607 ± 0.074	1.158ValHis: 1.158 ± 0.034	4.711ValIle: 4.711 ± 0.063	3.743ValLys: 3.743 ± 0.072	7.502ValLeu: 7.502 ± 0.089	1.909ValMet: 1.909 ± 0.04	2.465ValAsn: 2.465 ± 0.047	2.787ValPro: 2.787 ± 0.047	2.228ValGln: 2.228 ± 0.046	2.843ValArg: 2.843 ± 0.052	5.505ValSer: 5.505 ± 0.081	3.93ValThr: 3.93 ± 0.067	5.071ValVal: 5.071 ± 0.081	0.675ValTrp: 0.675 ± 0.027	2.094ValTyr: 2.094 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.703TrpAla: 0.703 ± 0.028	0.124TrpCys: 0.124 ± 0.012	0.617TrpAsp: 0.617 ± 0.026	0.667TrpGlu: 0.667 ± 0.028	0.467TrpPhe: 0.467 ± 0.022	0.754TrpGly: 0.754 ± 0.03	0.217TrpHis: 0.217 ± 0.014	0.672TrpIle: 0.672 ± 0.024	0.739TrpLys: 0.739 ± 0.027	0.828TrpLeu: 0.828 ± 0.028	0.348TrpMet: 0.348 ± 0.019	0.579TrpAsn: 0.579 ± 0.024	0.338TrpPro: 0.338 ± 0.019	0.403TrpGln: 0.403 ± 0.021	0.412TrpArg: 0.412 ± 0.018	0.564TrpSer: 0.564 ± 0.023	0.546TrpThr: 0.546 ± 0.025	0.678TrpVal: 0.678 ± 0.026	0.135TrpTrp: 0.135 ± 0.013	0.415TrpTyr: 0.415 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.814TyrAla: 2.814 ± 0.056	0.586TyrCys: 0.586 ± 0.024	1.969TyrAsp: 1.969 ± 0.046	2.029TyrGlu: 2.029 ± 0.041	1.726TyrPhe: 1.726 ± 0.043	2.565TyrGly: 2.565 ± 0.055	0.748TyrHis: 0.748 ± 0.026	2.151TyrIle: 2.151 ± 0.051	1.686TyrLys: 1.686 ± 0.049	3.889TyrLeu: 3.889 ± 0.059	0.752TyrMet: 0.752 ± 0.026	1.263TyrAsn: 1.263 ± 0.034	1.577TyrPro: 1.577 ± 0.043	1.284TyrGln: 1.284 ± 0.037	1.814TyrArg: 1.814 ± 0.043	2.567TyrSer: 2.567 ± 0.05	2.011TyrThr: 2.011 ± 0.049	1.968TyrVal: 1.968 ± 0.047	0.37TyrTrp: 0.37 ± 0.02	1.309TyrTyr: 1.309 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3150 proteins (1068925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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