Amino acid dipepetide frequency for Sandfly fever Turkey virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.565AlaAla: 4.565 ± 0.874
2.283AlaCys: 2.283 ± 1.448
1.268AlaAsp: 1.268 ± 1.115
4.058AlaGlu: 4.058 ± 0.531
2.029AlaPhe: 2.029 ± 0.986
2.79AlaGly: 2.79 ± 0.606
2.536AlaHis: 2.536 ± 0.956
5.326AlaIle: 5.326 ± 0.324
2.79AlaLys: 2.79 ± 0.741
4.311AlaLeu: 4.311 ± 1.046
2.283AlaMet: 2.283 ± 0.549
1.014AlaAsn: 1.014 ± 0.61
2.029AlaPro: 2.029 ± 0.554
1.014AlaGln: 1.014 ± 0.577
4.819AlaArg: 4.819 ± 0.968
5.58AlaSer: 5.58 ± 1.457
3.551AlaThr: 3.551 ± 0.473
4.058AlaVal: 4.058 ± 2.022
0.761AlaTrp: 0.761 ± 0.458
1.775AlaTyr: 1.775 ± 0.844
0.0AlaXaa: 0.0 ± 0.0
Cys
0.761CysAla: 0.761 ± 0.339
0.507CysCys: 0.507 ± 0.305
1.522CysAsp: 1.522 ± 0.677
2.029CysGlu: 2.029 ± 0.753
0.761CysPhe: 0.761 ± 0.339
0.761CysGly: 0.761 ± 0.385
0.761CysHis: 0.761 ± 0.618
2.029CysIle: 2.029 ± 0.889
2.79CysLys: 2.79 ± 0.684
2.029CysLeu: 2.029 ± 1.235
0.254CysMet: 0.254 ± 0.153
0.761CysAsn: 0.761 ± 0.339
0.507CysPro: 0.507 ± 0.139
0.507CysGln: 0.507 ± 0.446
1.775CysArg: 1.775 ± 0.6
4.058CysSer: 4.058 ± 1.271
1.014CysThr: 1.014 ± 0.277
1.775CysVal: 1.775 ± 0.894
0.254CysTrp: 0.254 ± 0.223
1.522CysTyr: 1.522 ± 0.503
0.0CysXaa: 0.0 ± 0.0
Asp
3.297AspAla: 3.297 ± 1.173
1.268AspCys: 1.268 ± 0.365
3.043AspAsp: 3.043 ± 1.508
4.311AspGlu: 4.311 ± 1.819
2.536AspPhe: 2.536 ± 0.956
3.043AspGly: 3.043 ± 1.205
1.522AspHis: 1.522 ± 0.416
3.297AspIle: 3.297 ± 0.483
3.297AspLys: 3.297 ± 1.078
5.833AspLeu: 5.833 ± 2.074
2.029AspMet: 2.029 ± 0.902
3.297AspAsn: 3.297 ± 0.519
2.029AspPro: 2.029 ± 0.496
1.522AspGln: 1.522 ± 0.773
3.551AspArg: 3.551 ± 0.261
5.58AspSer: 5.58 ± 1.066
2.79AspThr: 2.79 ± 0.423
3.551AspVal: 3.551 ± 0.721
1.268AspTrp: 1.268 ± 0.332
1.014AspTyr: 1.014 ± 0.78
0.0AspXaa: 0.0 ± 0.0
Glu
4.565GluAla: 4.565 ± 0.775
2.029GluCys: 2.029 ± 0.889
5.833GluAsp: 5.833 ± 2.433
6.087GluGlu: 6.087 ± 1.329
3.551GluPhe: 3.551 ± 0.928
5.072GluGly: 5.072 ± 1.038
2.029GluHis: 2.029 ± 0.753
5.58GluIle: 5.58 ± 1.037
3.551GluLys: 3.551 ± 0.564
5.326GluLeu: 5.326 ± 1.273
1.775GluMet: 1.775 ± 0.485
2.79GluAsn: 2.79 ± 1.27
1.268GluPro: 1.268 ± 0.365
1.268GluGln: 1.268 ± 0.332
3.804GluArg: 3.804 ± 0.78
5.326GluSer: 5.326 ± 0.937
2.536GluThr: 2.536 ± 0.693
4.311GluVal: 4.311 ± 0.635
0.254GluTrp: 0.254 ± 0.153
1.268GluTyr: 1.268 ± 0.73
0.0GluXaa: 0.0 ± 0.0
Phe
3.043PheAla: 3.043 ± 0.649
1.268PheCys: 1.268 ± 0.455
3.551PheAsp: 3.551 ± 1.215
3.043PheGlu: 3.043 ± 0.832
2.536PhePhe: 2.536 ± 0.91
2.536PheGly: 2.536 ± 1.295
0.761PheHis: 0.761 ± 0.439
2.283PheIle: 2.283 ± 0.303
2.029PheLys: 2.029 ± 0.626
3.804PheLeu: 3.804 ± 0.996
1.014PheMet: 1.014 ± 0.266
2.029PheAsn: 2.029 ± 0.485
1.014PhePro: 1.014 ± 0.61
0.761PheGln: 0.761 ± 0.4
3.297PheArg: 3.297 ± 1.336
6.087PheSer: 6.087 ± 1.076
2.283PheThr: 2.283 ± 1.053
4.311PheVal: 4.311 ± 1.275
0.254PheTrp: 0.254 ± 0.153
0.254PheTyr: 0.254 ± 0.475
0.0PheXaa: 0.0 ± 0.0
Gly
6.087GlyAla: 6.087 ± 1.012
1.268GlyCys: 1.268 ± 0.293
2.536GlyAsp: 2.536 ± 0.356
2.79GlyGlu: 2.79 ± 0.749
3.297GlyPhe: 3.297 ± 0.177
4.311GlyGly: 4.311 ± 0.635
1.014GlyHis: 1.014 ± 0.61
5.072GlyIle: 5.072 ± 0.352
4.311GlyLys: 4.311 ± 0.801
4.311GlyLeu: 4.311 ± 1.24
2.283GlyMet: 2.283 ± 0.442
2.283GlyAsn: 2.283 ± 0.453
3.043GlyPro: 3.043 ± 1.061
1.268GlyGln: 1.268 ± 0.332
4.058GlyArg: 4.058 ± 1.578
3.043GlySer: 3.043 ± 0.202
1.268GlyThr: 1.268 ± 0.777
4.058GlyVal: 4.058 ± 1.109
0.507GlyTrp: 0.507 ± 0.462
2.79GlyTyr: 2.79 ± 0.323
0.0GlyXaa: 0.0 ± 0.0
His
0.507HisAla: 0.507 ± 0.446
2.029HisCys: 2.029 ± 0.889
1.014HisAsp: 1.014 ± 0.336
2.029HisGlu: 2.029 ± 0.554
1.014HisPhe: 1.014 ± 0.313
2.283HisGly: 2.283 ± 0.563
0.507HisHis: 0.507 ± 0.446
1.775HisIle: 1.775 ± 0.493
0.761HisLys: 0.761 ± 0.762
2.283HisLeu: 2.283 ± 0.563
0.0HisMet: 0.0 ± 0.0
0.761HisAsn: 0.761 ± 0.439
1.014HisPro: 1.014 ± 0.577
1.268HisGln: 1.268 ± 0.455
1.775HisArg: 1.775 ± 0.381
1.522HisSer: 1.522 ± 0.76
1.775HisThr: 1.775 ± 0.381
1.014HisVal: 1.014 ± 0.336
0.0HisTrp: 0.0 ± 0.0
2.283HisTyr: 2.283 ± 0.262
0.0HisXaa: 0.0 ± 0.0
Ile
2.79IleAla: 2.79 ± 0.606
2.029IleCys: 2.029 ± 0.557
4.819IleAsp: 4.819 ± 0.968
4.819IleGlu: 4.819 ± 1.671
2.283IlePhe: 2.283 ± 0.443
3.551IleGly: 3.551 ± 0.573
1.522IleHis: 1.522 ± 0.281
4.819IleIle: 4.819 ± 0.682
3.297IleLys: 3.297 ± 0.82
4.819IleLeu: 4.819 ± 0.806
2.029IleMet: 2.029 ± 0.597
2.79IleAsn: 2.79 ± 1.657
2.283IlePro: 2.283 ± 0.666
4.311IleGln: 4.311 ± 0.862
4.565IleArg: 4.565 ± 0.525
3.297IleSer: 3.297 ± 0.447
2.79IleThr: 2.79 ± 1.098
5.833IleVal: 5.833 ± 1.074
1.014IleTrp: 1.014 ± 0.61
2.029IleTyr: 2.029 ± 0.472
0.0IleXaa: 0.0 ± 0.0
Lys
2.283LysAla: 2.283 ± 0.443
0.761LysCys: 0.761 ± 0.339
4.311LysAsp: 4.311 ± 1.028
3.804LysGlu: 3.804 ± 1.4
3.297LysPhe: 3.297 ± 0.287
2.536LysGly: 2.536 ± 1.554
0.254LysHis: 0.254 ± 0.153
4.565LysIle: 4.565 ± 1.038
6.087LysLys: 6.087 ± 1.246
6.594LysLeu: 6.594 ± 0.741
2.536LysMet: 2.536 ± 0.642
2.283LysAsn: 2.283 ± 0.735
2.79LysPro: 2.79 ± 0.314
1.268LysGln: 1.268 ± 0.467
2.536LysArg: 2.536 ± 0.67
4.819LysSer: 4.819 ± 0.912
4.565LysThr: 4.565 ± 0.935
4.565LysVal: 4.565 ± 1.127
1.268LysTrp: 1.268 ± 0.763
1.268LysTyr: 1.268 ± 0.679
0.0LysXaa: 0.0 ± 0.0
Leu
3.804LeuAla: 3.804 ± 0.8
1.268LeuCys: 1.268 ± 0.455
5.072LeuAsp: 5.072 ± 0.767
4.565LeuGlu: 4.565 ± 0.826
3.804LeuPhe: 3.804 ± 0.389
5.58LeuGly: 5.58 ± 1.26
1.775LeuHis: 1.775 ± 0.493
5.326LeuIle: 5.326 ± 0.369
4.819LeuLys: 4.819 ± 1.291
6.848LeuLeu: 6.848 ± 1.219
2.536LeuMet: 2.536 ± 0.424
1.522LeuAsn: 1.522 ± 0.915
3.551LeuPro: 3.551 ± 0.959
3.804LeuGln: 3.804 ± 1.046
6.848LeuArg: 6.848 ± 0.546
9.637LeuSer: 9.637 ± 1.762
5.326LeuThr: 5.326 ± 1.09
6.34LeuVal: 6.34 ± 2.244
0.254LeuTrp: 0.254 ± 0.475
2.029LeuTyr: 2.029 ± 0.902
0.0LeuXaa: 0.0 ± 0.0
Met
2.029MetAla: 2.029 ± 0.289
0.761MetCys: 0.761 ± 0.385
2.029MetAsp: 2.029 ± 0.706
2.029MetGlu: 2.029 ± 0.554
1.522MetPhe: 1.522 ± 0.581
1.775MetGly: 1.775 ± 0.268
1.014MetHis: 1.014 ± 0.577
1.522MetIle: 1.522 ± 0.574
2.283MetLys: 2.283 ± 0.563
1.522MetLeu: 1.522 ± 0.798
3.043MetMet: 3.043 ± 1.053
2.283MetAsn: 2.283 ± 0.443
0.761MetPro: 0.761 ± 0.669
1.268MetGln: 1.268 ± 0.293
1.014MetArg: 1.014 ± 0.277
3.043MetSer: 3.043 ± 0.202
2.029MetThr: 2.029 ± 0.804
1.775MetVal: 1.775 ± 0.492
0.254MetTrp: 0.254 ± 0.153
0.254MetTyr: 0.254 ± 0.153
0.0MetXaa: 0.0 ± 0.0
Asn
2.536AsnAla: 2.536 ± 0.447
0.761AsnCys: 0.761 ± 0.339
1.775AsnAsp: 1.775 ± 0.268
4.311AsnGlu: 4.311 ± 1.0
3.043AsnPhe: 3.043 ± 0.954
1.775AsnGly: 1.775 ± 0.492
1.014AsnHis: 1.014 ± 0.313
2.283AsnIle: 2.283 ± 0.262
2.79AsnLys: 2.79 ± 0.595
3.551AsnLeu: 3.551 ± 1.585
0.507AsnMet: 0.507 ± 0.504
1.522AsnAsn: 1.522 ± 0.978
1.522AsnPro: 1.522 ± 0.376
0.254AsnGln: 0.254 ± 0.153
0.507AsnArg: 0.507 ± 0.446
5.072AsnSer: 5.072 ± 0.344
2.283AsnThr: 2.283 ± 0.303
2.029AsnVal: 2.029 ± 0.447
0.254AsnTrp: 0.254 ± 0.223
0.507AsnTyr: 0.507 ± 0.446
0.0AsnXaa: 0.0 ± 0.0
Pro
1.775ProAla: 1.775 ± 1.264
0.507ProCys: 0.507 ± 0.139
2.79ProAsp: 2.79 ± 0.323
3.297ProGlu: 3.297 ± 0.783
3.297ProPhe: 3.297 ± 0.423
3.043ProGly: 3.043 ± 0.649
0.254ProHis: 0.254 ± 0.153
1.268ProIle: 1.268 ± 0.638
2.283ProLys: 2.283 ± 0.678
2.283ProLeu: 2.283 ± 0.817
1.014ProMet: 1.014 ± 0.804
1.268ProAsn: 1.268 ± 0.588
0.761ProPro: 0.761 ± 0.669
2.029ProGln: 2.029 ± 0.554
1.775ProArg: 1.775 ± 0.606
3.043ProSer: 3.043 ± 0.74
1.268ProThr: 1.268 ± 0.763
1.775ProVal: 1.775 ± 0.596
0.507ProTrp: 0.507 ± 0.305
0.254ProTyr: 0.254 ± 0.223
0.0ProXaa: 0.0 ± 0.0
Gln
3.043GlnAla: 3.043 ± 1.249
1.014GlnCys: 1.014 ± 0.556
1.268GlnAsp: 1.268 ± 0.399
1.522GlnGlu: 1.522 ± 0.581
1.775GlnPhe: 1.775 ± 0.752
2.029GlnGly: 2.029 ± 0.639
0.761GlnHis: 0.761 ± 0.458
2.283GlnIle: 2.283 ± 0.563
3.297GlnLys: 3.297 ± 0.794
2.283GlnLeu: 2.283 ± 0.453
0.761GlnMet: 0.761 ± 0.5
1.775GlnAsn: 1.775 ± 0.596
1.775GlnPro: 1.775 ± 0.332
1.014GlnGln: 1.014 ± 0.313
2.283GlnArg: 2.283 ± 0.385
1.268GlnSer: 1.268 ± 0.467
1.522GlnThr: 1.522 ± 0.581
1.775GlnVal: 1.775 ± 0.493
0.0GlnTrp: 0.0 ± 0.0
0.507GlnTyr: 0.507 ± 0.504
0.0GlnXaa: 0.0 ± 0.0
Arg
3.804ArgAla: 3.804 ± 0.697
2.029ArgCys: 2.029 ± 0.557
4.058ArgAsp: 4.058 ± 0.531
4.819ArgGlu: 4.819 ± 1.325
1.522ArgPhe: 1.522 ± 0.8
4.058ArgGly: 4.058 ± 0.894
1.268ArgHis: 1.268 ± 0.293
2.283ArgIle: 2.283 ± 0.549
3.297ArgLys: 3.297 ± 0.584
4.058ArgLeu: 4.058 ± 1.537
2.79ArgMet: 2.79 ± 1.097
2.79ArgAsn: 2.79 ± 0.34
2.283ArgPro: 2.283 ± 0.303
1.775ArgGln: 1.775 ± 0.927
4.819ArgArg: 4.819 ± 0.873
3.297ArgSer: 3.297 ± 0.641
2.79ArgThr: 2.79 ± 0.595
4.311ArgVal: 4.311 ± 0.829
1.014ArgTrp: 1.014 ± 0.277
2.536ArgTyr: 2.536 ± 0.585
0.0ArgXaa: 0.0 ± 0.0
Ser
3.804SerAla: 3.804 ± 0.694
2.79SerCys: 2.79 ± 1.776
5.326SerAsp: 5.326 ± 2.775
4.565SerGlu: 4.565 ± 1.099
4.565SerPhe: 4.565 ± 1.339
4.819SerGly: 4.819 ± 0.243
3.551SerHis: 3.551 ± 0.762
5.072SerIle: 5.072 ± 1.13
4.311SerLys: 4.311 ± 0.647
10.145SerLeu: 10.145 ± 2.214
3.043SerMet: 3.043 ± 1.354
1.775SerAsn: 1.775 ± 0.418
3.297SerPro: 3.297 ± 1.101
3.043SerGln: 3.043 ± 0.378
4.819SerArg: 4.819 ± 0.338
8.369SerSer: 8.369 ± 1.664
5.072SerThr: 5.072 ± 0.739
5.326SerVal: 5.326 ± 0.663
2.029SerTrp: 2.029 ± 0.921
2.536SerTyr: 2.536 ± 1.094
0.0SerXaa: 0.0 ± 0.0
Thr
3.804ThrAla: 3.804 ± 0.325
1.522ThrCys: 1.522 ± 0.677
2.283ThrAsp: 2.283 ± 0.563
3.043ThrGlu: 3.043 ± 0.456
2.283ThrPhe: 2.283 ± 0.443
4.565ThrGly: 4.565 ± 1.248
1.268ThrHis: 1.268 ± 0.365
4.058ThrIle: 4.058 ± 1.278
3.297ThrLys: 3.297 ± 0.584
5.833ThrLeu: 5.833 ± 0.986
1.014ThrMet: 1.014 ± 0.361
3.551ThrAsn: 3.551 ± 0.986
1.268ThrPro: 1.268 ± 0.336
1.775ThrGln: 1.775 ± 0.596
2.536ThrArg: 2.536 ± 0.815
5.072ThrSer: 5.072 ± 0.739
3.551ThrThr: 3.551 ± 0.97
1.522ThrVal: 1.522 ± 0.773
0.0ThrTrp: 0.0 ± 0.0
1.014ThrTyr: 1.014 ± 0.673
0.0ThrXaa: 0.0 ± 0.0
Val
4.565ValAla: 4.565 ± 1.149
1.268ValCys: 1.268 ± 0.638
3.804ValAsp: 3.804 ± 0.51
4.565ValGlu: 4.565 ± 1.899
2.283ValPhe: 2.283 ± 0.549
2.283ValGly: 2.283 ± 0.549
2.536ValHis: 2.536 ± 0.934
4.819ValIle: 4.819 ± 0.975
4.565ValLys: 4.565 ± 0.545
6.087ValLeu: 6.087 ± 1.629
1.268ValMet: 1.268 ± 0.455
2.029ValAsn: 2.029 ± 0.554
1.522ValPro: 1.522 ± 0.435
2.79ValGln: 2.79 ± 0.876
2.283ValArg: 2.283 ± 0.666
6.848ValSer: 6.848 ± 0.873
3.804ValThr: 3.804 ± 0.956
6.34ValVal: 6.34 ± 1.241
0.761ValTrp: 0.761 ± 0.188
2.536ValTyr: 2.536 ± 0.356
0.0ValXaa: 0.0 ± 0.0
Trp
1.014TrpAla: 1.014 ± 0.313
0.0TrpCys: 0.0 ± 0.0
0.507TrpAsp: 0.507 ± 0.139
0.761TrpGlu: 0.761 ± 0.5
0.254TrpPhe: 0.254 ± 0.153
1.014TrpGly: 1.014 ± 0.484
0.254TrpHis: 0.254 ± 0.153
0.761TrpIle: 0.761 ± 0.339
0.254TrpLys: 0.254 ± 0.153
0.761TrpLeu: 0.761 ± 0.385
0.254TrpMet: 0.254 ± 0.153
0.507TrpAsn: 0.507 ± 0.139
0.254TrpPro: 0.254 ± 0.475
0.0TrpGln: 0.0 ± 0.0
0.761TrpArg: 0.761 ± 0.188
1.014TrpSer: 1.014 ± 0.313
1.775TrpThr: 1.775 ± 0.492
1.014TrpVal: 1.014 ± 0.61
0.0TrpTrp: 0.0 ± 0.0
0.254TrpTyr: 0.254 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.761TyrAla: 0.761 ± 0.339
1.014TyrCys: 1.014 ± 0.556
1.268TyrAsp: 1.268 ± 0.336
2.029TyrGlu: 2.029 ± 0.332
0.507TyrPhe: 0.507 ± 0.305
1.775TyrGly: 1.775 ± 0.687
1.014TyrHis: 1.014 ± 0.313
1.268TyrIle: 1.268 ± 0.801
2.283TyrLys: 2.283 ± 0.385
2.029TyrLeu: 2.029 ± 0.902
1.522TyrMet: 1.522 ± 0.281
1.268TyrAsn: 1.268 ± 0.588
1.522TyrPro: 1.522 ± 0.574
1.014TyrGln: 1.014 ± 0.854
1.775TyrArg: 1.775 ± 0.492
2.283TyrSer: 2.283 ± 0.442
1.268TyrThr: 1.268 ± 0.336
1.268TyrVal: 1.268 ± 0.588
0.761TyrTrp: 0.761 ± 0.339
1.268TyrTyr: 1.268 ± 0.293
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski