Amino acid dipepetide frequency for Aureibacillus halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.65AlaAla: 6.65 ± 0.084
0.736AlaCys: 0.736 ± 0.026
3.916AlaAsp: 3.916 ± 0.068
5.239AlaGlu: 5.239 ± 0.079
3.885AlaPhe: 3.885 ± 0.068
5.577AlaGly: 5.577 ± 0.073
1.627AlaHis: 1.627 ± 0.042
5.693AlaIle: 5.693 ± 0.067
4.392AlaLys: 4.392 ± 0.069
8.678AlaLeu: 8.678 ± 0.1
2.462AlaMet: 2.462 ± 0.051
2.939AlaAsn: 2.939 ± 0.05
2.804AlaPro: 2.804 ± 0.17
2.816AlaGln: 2.816 ± 0.057
3.103AlaArg: 3.103 ± 0.055
5.237AlaSer: 5.237 ± 0.074
4.412AlaThr: 4.412 ± 0.08
5.934AlaVal: 5.934 ± 0.084
0.85AlaTrp: 0.85 ± 0.029
2.611AlaTyr: 2.611 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.536CysAla: 0.536 ± 0.022
0.104CysCys: 0.104 ± 0.01
0.382CysAsp: 0.382 ± 0.017
0.451CysGlu: 0.451 ± 0.021
0.354CysPhe: 0.354 ± 0.02
0.688CysGly: 0.688 ± 0.028
0.217CysHis: 0.217 ± 0.015
0.515CysIle: 0.515 ± 0.02
0.32CysLys: 0.32 ± 0.016
0.776CysLeu: 0.776 ± 0.027
0.195CysMet: 0.195 ± 0.015
0.25CysAsn: 0.25 ± 0.016
0.352CysPro: 0.352 ± 0.018
0.282CysGln: 0.282 ± 0.017
0.352CysArg: 0.352 ± 0.017
0.523CysSer: 0.523 ± 0.021
0.438CysThr: 0.438 ± 0.018
0.502CysVal: 0.502 ± 0.022
0.097CysTrp: 0.097 ± 0.008
0.201CysTyr: 0.201 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.296AspAla: 4.296 ± 0.066
0.34AspCys: 0.34 ± 0.02
2.866AspAsp: 2.866 ± 0.069
4.619AspGlu: 4.619 ± 0.075
2.129AspPhe: 2.129 ± 0.041
3.838AspGly: 3.838 ± 0.067
1.262AspHis: 1.262 ± 0.03
3.956AspIle: 3.956 ± 0.069
2.424AspLys: 2.424 ± 0.055
4.877AspLeu: 4.877 ± 0.064
1.462AspMet: 1.462 ± 0.038
1.712AspAsn: 1.712 ± 0.04
2.172AspPro: 2.172 ± 0.041
2.331AspGln: 2.331 ± 0.045
2.461AspArg: 2.461 ± 0.045
2.572AspSer: 2.572 ± 0.058
2.736AspThr: 2.736 ± 0.047
4.731AspVal: 4.731 ± 0.077
0.781AspTrp: 0.781 ± 0.027
1.856AspTyr: 1.856 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.601GluAla: 6.601 ± 0.102
0.409GluCys: 0.409 ± 0.02
4.1GluAsp: 4.1 ± 0.068
6.699GluGlu: 6.699 ± 0.085
2.148GluPhe: 2.148 ± 0.042
4.71GluGly: 4.71 ± 0.074
1.738GluHis: 1.738 ± 0.037
3.811GluIle: 3.811 ± 0.057
5.056GluLys: 5.056 ± 0.066
6.764GluLeu: 6.764 ± 0.078
2.129GluMet: 2.129 ± 0.045
3.134GluAsn: 3.134 ± 0.065
2.238GluPro: 2.238 ± 0.054
3.598GluGln: 3.598 ± 0.066
3.914GluArg: 3.914 ± 0.06
3.66GluSer: 3.66 ± 0.108
4.352GluThr: 4.352 ± 0.067
4.685GluVal: 4.685 ± 0.06
0.988GluTrp: 0.988 ± 0.033
1.704GluTyr: 1.704 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.384PheAla: 3.384 ± 0.068
0.404PheCys: 0.404 ± 0.018
2.428PheAsp: 2.428 ± 0.047
2.642PheGlu: 2.642 ± 0.052
2.276PhePhe: 2.276 ± 0.061
3.1PheGly: 3.1 ± 0.055
1.06PheHis: 1.06 ± 0.029
3.204PheIle: 3.204 ± 0.067
1.884PheLys: 1.884 ± 0.046
4.413PheLeu: 4.413 ± 0.083
1.125PheMet: 1.125 ± 0.034
1.531PheAsn: 1.531 ± 0.041
1.707PhePro: 1.707 ± 0.042
1.768PheGln: 1.768 ± 0.038
1.679PheArg: 1.679 ± 0.036
3.35PheSer: 3.35 ± 0.054
2.696PheThr: 2.696 ± 0.057
3.195PheVal: 3.195 ± 0.051
0.578PheTrp: 0.578 ± 0.022
1.585PheTyr: 1.585 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.26GlyAla: 5.26 ± 0.097
0.67GlyCys: 0.67 ± 0.024
3.436GlyAsp: 3.436 ± 0.059
4.649GlyGlu: 4.649 ± 0.078
3.218GlyPhe: 3.218 ± 0.063
4.763GlyGly: 4.763 ± 0.074
1.638GlyHis: 1.638 ± 0.037
5.05GlyIle: 5.05 ± 0.076
3.986GlyLys: 3.986 ± 0.056
6.558GlyLeu: 6.558 ± 0.083
2.143GlyMet: 2.143 ± 0.048
2.392GlyAsn: 2.392 ± 0.048
2.074GlyPro: 2.074 ± 0.125
2.528GlyGln: 2.528 ± 0.045
2.966GlyArg: 2.966 ± 0.061
4.109GlySer: 4.109 ± 0.064
4.182GlyThr: 4.182 ± 0.075
5.231GlyVal: 5.231 ± 0.085
0.907GlyTrp: 0.907 ± 0.033
2.531GlyTyr: 2.531 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.764HisAla: 1.764 ± 0.038
0.244HisCys: 0.244 ± 0.013
1.153HisAsp: 1.153 ± 0.038
1.528HisGlu: 1.528 ± 0.039
1.181HisPhe: 1.181 ± 0.03
1.582HisGly: 1.582 ± 0.039
0.78HisHis: 0.78 ± 0.026
1.463HisIle: 1.463 ± 0.04
0.975HisLys: 0.975 ± 0.029
2.464HisLeu: 2.464 ± 0.054
0.675HisMet: 0.675 ± 0.026
0.726HisAsn: 0.726 ± 0.025
1.263HisPro: 1.263 ± 0.034
1.051HisGln: 1.051 ± 0.029
1.164HisArg: 1.164 ± 0.032
1.409HisSer: 1.409 ± 0.035
1.31HisThr: 1.31 ± 0.035
1.736HisVal: 1.736 ± 0.036
0.367HisTrp: 0.367 ± 0.019
1.031HisTyr: 1.031 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.743IleAla: 5.743 ± 0.07
0.558IleCys: 0.558 ± 0.024
4.023IleAsp: 4.023 ± 0.062
4.933IleGlu: 4.933 ± 0.075
2.483IlePhe: 2.483 ± 0.054
5.241IleGly: 5.241 ± 0.069
1.59IleHis: 1.59 ± 0.037
4.066IleIle: 4.066 ± 0.076
2.92IleLys: 2.92 ± 0.054
5.671IleLeu: 5.671 ± 0.084
1.452IleMet: 1.452 ± 0.036
2.35IleAsn: 2.35 ± 0.046
2.782IlePro: 2.782 ± 0.052
2.899IleGln: 2.899 ± 0.057
3.01IleArg: 3.01 ± 0.049
4.103IleSer: 4.103 ± 0.066
3.54IleThr: 3.54 ± 0.056
5.383IleVal: 5.383 ± 0.059
0.67IleTrp: 0.67 ± 0.027
1.886IleTyr: 1.886 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.684LysAla: 4.684 ± 0.064
0.237LysCys: 0.237 ± 0.014
3.209LysAsp: 3.209 ± 0.053
5.157LysGlu: 5.157 ± 0.064
1.187LysPhe: 1.187 ± 0.035
3.623LysGly: 3.623 ± 0.057
1.323LysHis: 1.323 ± 0.034
2.815LysIle: 2.815 ± 0.05
4.191LysLys: 4.191 ± 0.059
4.5LysLeu: 4.5 ± 0.065
1.657LysMet: 1.657 ± 0.034
2.264LysAsn: 2.264 ± 0.046
1.983LysPro: 1.983 ± 0.038
2.982LysGln: 2.982 ± 0.046
3.229LysArg: 3.229 ± 0.058
2.802LysSer: 2.802 ± 0.048
3.453LysThr: 3.453 ± 0.057
3.488LysVal: 3.488 ± 0.058
0.653LysTrp: 0.653 ± 0.023
1.357LysTyr: 1.357 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
7.965LeuAla: 7.965 ± 0.09
0.803LeuCys: 0.803 ± 0.026
5.003LeuAsp: 5.003 ± 0.072
6.292LeuGlu: 6.292 ± 0.073
4.994LeuPhe: 4.994 ± 0.085
6.363LeuGly: 6.363 ± 0.08
2.47LeuHis: 2.47 ± 0.046
6.203LeuIle: 6.203 ± 0.084
5.208LeuLys: 5.208 ± 0.078
11.022LeuLeu: 11.022 ± 0.14
2.516LeuMet: 2.516 ± 0.051
3.626LeuAsn: 3.626 ± 0.056
4.53LeuPro: 4.53 ± 0.066
4.418LeuGln: 4.418 ± 0.064
4.371LeuArg: 4.371 ± 0.069
7.176LeuSer: 7.176 ± 0.084
5.785LeuThr: 5.785 ± 0.07
6.567LeuVal: 6.567 ± 0.084
1.044LeuTrp: 1.044 ± 0.03
3.337LeuTyr: 3.337 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.316MetAla: 2.316 ± 0.042
0.155MetCys: 0.155 ± 0.013
1.548MetAsp: 1.548 ± 0.032
1.819MetGlu: 1.819 ± 0.064
1.09MetPhe: 1.09 ± 0.035
1.617MetGly: 1.617 ± 0.04
0.583MetHis: 0.583 ± 0.021
1.892MetIle: 1.892 ± 0.039
2.124MetLys: 2.124 ± 0.04
2.801MetLeu: 2.801 ± 0.05
0.866MetMet: 0.866 ± 0.029
1.411MetAsn: 1.411 ± 0.035
1.149MetPro: 1.149 ± 0.031
1.022MetGln: 1.022 ± 0.031
1.219MetArg: 1.219 ± 0.032
1.812MetSer: 1.812 ± 0.037
1.986MetThr: 1.986 ± 0.043
1.774MetVal: 1.774 ± 0.037
0.222MetTrp: 0.222 ± 0.012
0.836MetTyr: 0.836 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.098AsnAla: 3.098 ± 0.055
0.237AsnCys: 0.237 ± 0.015
2.33AsnAsp: 2.33 ± 0.052
3.341AsnGlu: 3.341 ± 0.056
1.237AsnPhe: 1.237 ± 0.031
3.05AsnGly: 3.05 ± 0.065
0.924AsnHis: 0.924 ± 0.032
2.329AsnIle: 2.329 ± 0.041
1.826AsnLys: 1.826 ± 0.037
2.931AsnLeu: 2.931 ± 0.056
0.898AsnMet: 0.898 ± 0.028
1.458AsnAsn: 1.458 ± 0.043
1.661AsnPro: 1.661 ± 0.041
1.708AsnGln: 1.708 ± 0.042
1.757AsnArg: 1.757 ± 0.041
1.866AsnSer: 1.866 ± 0.044
2.11AsnThr: 2.11 ± 0.042
3.054AsnVal: 3.054 ± 0.049
0.467AsnTrp: 0.467 ± 0.021
1.176AsnTyr: 1.176 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
2.793ProAla: 2.793 ± 0.047
0.236ProCys: 0.236 ± 0.015
2.319ProAsp: 2.319 ± 0.05
3.351ProGlu: 3.351 ± 0.062
2.088ProPhe: 2.088 ± 0.046
2.606ProGly: 2.606 ± 0.056
0.958ProHis: 0.958 ± 0.029
2.517ProIle: 2.517 ± 0.046
1.869ProLys: 1.869 ± 0.039
3.894ProLeu: 3.894 ± 0.062
1.0ProMet: 1.0 ± 0.027
1.523ProAsn: 1.523 ± 0.03
1.341ProPro: 1.341 ± 0.033
1.348ProGln: 1.348 ± 0.035
1.211ProArg: 1.211 ± 0.034
2.698ProSer: 2.698 ± 0.052
2.268ProThr: 2.268 ± 0.042
3.431ProVal: 3.431 ± 0.469
0.517ProTrp: 0.517 ± 0.02
1.415ProTyr: 1.415 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.463GlnAla: 3.463 ± 0.061
0.268GlnCys: 0.268 ± 0.015
1.84GlnAsp: 1.84 ± 0.039
2.97GlnGlu: 2.97 ± 0.049
1.682GlnPhe: 1.682 ± 0.037
2.482GlnGly: 2.482 ± 0.053
1.094GlnHis: 1.094 ± 0.033
2.286GlnIle: 2.286 ± 0.047
2.555GlnLys: 2.555 ± 0.047
4.673GlnLeu: 4.673 ± 0.061
1.388GlnMet: 1.388 ± 0.034
1.511GlnAsn: 1.511 ± 0.036
1.605GlnPro: 1.605 ± 0.038
2.462GlnGln: 2.462 ± 0.056
2.167GlnArg: 2.167 ± 0.044
2.631GlnSer: 2.631 ± 0.052
2.558GlnThr: 2.558 ± 0.05
2.517GlnVal: 2.517 ± 0.047
0.674GlnTrp: 0.674 ± 0.025
1.247GlnTyr: 1.247 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.051ArgAla: 3.051 ± 0.052
0.313ArgCys: 0.313 ± 0.016
2.268ArgAsp: 2.268 ± 0.043
3.174ArgGlu: 3.174 ± 0.061
2.181ArgPhe: 2.181 ± 0.04
2.532ArgGly: 2.532 ± 0.048
1.109ArgHis: 1.109 ± 0.034
2.906ArgIle: 2.906 ± 0.056
2.938ArgLys: 2.938 ± 0.051
4.808ArgLeu: 4.808 ± 0.067
1.488ArgMet: 1.488 ± 0.036
1.643ArgAsn: 1.643 ± 0.042
1.62ArgPro: 1.62 ± 0.033
2.046ArgGln: 2.046 ± 0.038
2.267ArgArg: 2.267 ± 0.05
2.776ArgSer: 2.776 ± 0.055
2.479ArgThr: 2.479 ± 0.049
3.008ArgVal: 3.008 ± 0.055
0.64ArgTrp: 0.64 ± 0.021
1.586ArgTyr: 1.586 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.402SerAla: 4.402 ± 0.068
0.437SerCys: 0.437 ± 0.022
3.154SerAsp: 3.154 ± 0.049
3.993SerGlu: 3.993 ± 0.066
3.421SerPhe: 3.421 ± 0.057
4.368SerGly: 4.368 ± 0.077
1.462SerHis: 1.462 ± 0.036
4.531SerIle: 4.531 ± 0.064
3.11SerLys: 3.11 ± 0.05
6.586SerLeu: 6.586 ± 0.082
1.957SerMet: 1.957 ± 0.038
2.217SerAsn: 2.217 ± 0.047
2.561SerPro: 2.561 ± 0.105
2.29SerGln: 2.29 ± 0.043
2.51SerArg: 2.51 ± 0.044
4.383SerSer: 4.383 ± 0.074
3.562SerThr: 3.562 ± 0.053
4.541SerVal: 4.541 ± 0.061
0.807SerTrp: 0.807 ± 0.028
2.249SerTyr: 2.249 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.522ThrAla: 4.522 ± 0.065
0.361ThrCys: 0.361 ± 0.018
2.992ThrAsp: 2.992 ± 0.054
3.625ThrGlu: 3.625 ± 0.066
2.872ThrPhe: 2.872 ± 0.054
4.262ThrGly: 4.262 ± 0.142
1.251ThrHis: 1.251 ± 0.035
4.356ThrIle: 4.356 ± 0.07
3.005ThrLys: 3.005 ± 0.051
6.117ThrLeu: 6.117 ± 0.072
1.62ThrMet: 1.62 ± 0.041
2.246ThrAsn: 2.246 ± 0.042
2.69ThrPro: 2.69 ± 0.082
1.785ThrGln: 1.785 ± 0.042
2.107ThrArg: 2.107 ± 0.04
3.932ThrSer: 3.932 ± 0.055
3.579ThrThr: 3.579 ± 0.06
4.528ThrVal: 4.528 ± 0.062
0.652ThrTrp: 0.652 ± 0.023
2.149ThrTyr: 2.149 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.834ValAla: 5.834 ± 0.179
0.639ValCys: 0.639 ± 0.022
3.986ValAsp: 3.986 ± 0.068
4.734ValGlu: 4.734 ± 0.069
3.431ValPhe: 3.431 ± 0.058
4.723ValGly: 4.723 ± 0.114
1.676ValHis: 1.676 ± 0.041
4.893ValIle: 4.893 ± 0.068
3.696ValLys: 3.696 ± 0.053
7.607ValLeu: 7.607 ± 0.094
1.978ValMet: 1.978 ± 0.066
2.805ValAsn: 2.805 ± 0.051
3.043ValPro: 3.043 ± 0.056
2.812ValGln: 2.812 ± 0.05
3.119ValArg: 3.119 ± 0.053
4.746ValSer: 4.746 ± 0.062
4.677ValThr: 4.677 ± 0.095
5.34ValVal: 5.34 ± 0.078
0.814ValTrp: 0.814 ± 0.033
2.372ValTyr: 2.372 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.798TrpAla: 0.798 ± 0.029
0.111TrpCys: 0.111 ± 0.01
0.58TrpAsp: 0.58 ± 0.024
0.785TrpGlu: 0.785 ± 0.03
0.585TrpPhe: 0.585 ± 0.024
0.78TrpGly: 0.78 ± 0.027
0.299TrpHis: 0.299 ± 0.017
0.815TrpIle: 0.815 ± 0.025
0.688TrpLys: 0.688 ± 0.026
1.487TrpLeu: 1.487 ± 0.037
0.429TrpMet: 0.429 ± 0.02
0.564TrpAsn: 0.564 ± 0.027
0.423TrpPro: 0.423 ± 0.02
0.501TrpGln: 0.501 ± 0.02
0.595TrpArg: 0.595 ± 0.024
0.793TrpSer: 0.793 ± 0.026
0.705TrpThr: 0.705 ± 0.024
0.858TrpVal: 0.858 ± 0.03
0.182TrpTrp: 0.182 ± 0.011
0.348TrpTyr: 0.348 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.401TyrAla: 2.401 ± 0.044
0.272TyrCys: 0.272 ± 0.014
1.89TyrAsp: 1.89 ± 0.041
2.438TyrGlu: 2.438 ± 0.05
1.568TyrPhe: 1.568 ± 0.034
2.387TyrGly: 2.387 ± 0.044
0.808TyrHis: 0.808 ± 0.029
2.0TyrIle: 2.0 ± 0.042
1.627TyrLys: 1.627 ± 0.039
3.066TyrLeu: 3.066 ± 0.058
0.8TyrMet: 0.8 ± 0.027
1.158TyrAsn: 1.158 ± 0.032
1.387TyrPro: 1.387 ± 0.036
1.422TyrGln: 1.422 ± 0.034
1.632TyrArg: 1.632 ± 0.034
1.963TyrSer: 1.963 ± 0.046
1.823TyrThr: 1.823 ± 0.045
2.421TyrVal: 2.421 ± 0.041
0.415TyrTrp: 0.415 ± 0.018
1.177TyrTyr: 1.177 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4165 proteins (1211138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski