Amino acid dipepetide frequency for Cellulophaga algicola (strain DSM 14237 / IC166 / ACAM 630)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.683AlaAla: 4.683 ± 0.078	0.535AlaCys: 0.535 ± 0.019	3.517AlaAsp: 3.517 ± 0.086	3.816AlaGlu: 3.816 ± 0.054	3.229AlaPhe: 3.229 ± 0.06	4.001AlaGly: 4.001 ± 0.072	1.095AlaHis: 1.095 ± 0.03	5.976AlaIle: 5.976 ± 0.079	4.654AlaLys: 4.654 ± 0.081	6.621AlaLeu: 6.621 ± 0.068	1.516AlaMet: 1.516 ± 0.037	3.65AlaAsn: 3.65 ± 0.064	2.127AlaPro: 2.127 ± 0.054	2.359AlaGln: 2.359 ± 0.038	1.782AlaArg: 1.782 ± 0.035	4.469AlaSer: 4.469 ± 0.078	4.421AlaThr: 4.421 ± 0.101	4.129AlaVal: 4.129 ± 0.063	0.604AlaTrp: 0.604 ± 0.022	2.646AlaTyr: 2.646 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.455CysAla: 0.455 ± 0.018	0.106CysCys: 0.106 ± 0.008	0.426CysAsp: 0.426 ± 0.021	0.449CysGlu: 0.449 ± 0.023	0.419CysPhe: 0.419 ± 0.021	0.549CysGly: 0.549 ± 0.022	0.16CysHis: 0.16 ± 0.014	0.594CysIle: 0.594 ± 0.023	0.504CysLys: 0.504 ± 0.024	0.601CysLeu: 0.601 ± 0.021	0.145CysMet: 0.145 ± 0.011	0.439CysAsn: 0.439 ± 0.019	0.29CysPro: 0.29 ± 0.018	0.208CysGln: 0.208 ± 0.017	0.186CysArg: 0.186 ± 0.01	0.59CysSer: 0.59 ± 0.027	0.484CysThr: 0.484 ± 0.028	0.416CysVal: 0.416 ± 0.021	0.061CysTrp: 0.061 ± 0.007	0.28CysTyr: 0.28 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.139AspAla: 4.139 ± 0.073	0.413AspCys: 0.413 ± 0.019	3.127AspAsp: 3.127 ± 0.096	3.571AspGlu: 3.571 ± 0.056	3.663AspPhe: 3.663 ± 0.062	4.34AspGly: 4.34 ± 0.141	0.91AspHis: 0.91 ± 0.024	4.436AspIle: 4.436 ± 0.071	4.156AspLys: 4.156 ± 0.067	5.297AspLeu: 5.297 ± 0.07	1.067AspMet: 1.067 ± 0.026	3.262AspAsn: 3.262 ± 0.083	1.68AspPro: 1.68 ± 0.05	1.584AspGln: 1.584 ± 0.044	1.781AspArg: 1.781 ± 0.045	3.285AspSer: 3.285 ± 0.064	3.353AspThr: 3.353 ± 0.092	3.634AspVal: 3.634 ± 0.064	0.804AspTrp: 0.804 ± 0.025	2.788AspTyr: 2.788 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.42GluAla: 4.42 ± 0.069	0.339GluCys: 0.339 ± 0.015	3.925GluAsp: 3.925 ± 0.059	5.066GluGlu: 5.066 ± 0.097	2.964GluPhe: 2.964 ± 0.051	3.811GluGly: 3.811 ± 0.055	1.176GluHis: 1.176 ± 0.03	5.551GluIle: 5.551 ± 0.079	5.853GluLys: 5.853 ± 0.083	6.219GluLeu: 6.219 ± 0.073	1.543GluMet: 1.543 ± 0.033	4.858GluAsn: 4.858 ± 0.06	1.469GluPro: 1.469 ± 0.036	2.203GluGln: 2.203 ± 0.043	2.326GluArg: 2.326 ± 0.05	3.316GluSer: 3.316 ± 0.05	3.731GluThr: 3.731 ± 0.056	4.381GluVal: 4.381 ± 0.06	0.691GluTrp: 0.691 ± 0.025	2.506GluTyr: 2.506 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.863PheAla: 2.863 ± 0.049	0.426PheCys: 0.426 ± 0.018	3.3PheAsp: 3.3 ± 0.065	3.422PheGlu: 3.422 ± 0.055	2.705PhePhe: 2.705 ± 0.053	3.515PheGly: 3.515 ± 0.054	0.769PheHis: 0.769 ± 0.026	4.071PheIle: 4.071 ± 0.063	3.958PheLys: 3.958 ± 0.057	4.793PheLeu: 4.793 ± 0.065	1.107PheMet: 1.107 ± 0.029	3.203PheAsn: 3.203 ± 0.06	1.651PhePro: 1.651 ± 0.034	1.497PheGln: 1.497 ± 0.034	1.522PheArg: 1.522 ± 0.036	4.171PheSer: 4.171 ± 0.059	3.265PheThr: 3.265 ± 0.074	2.839PheVal: 2.839 ± 0.047	0.555PheTrp: 0.555 ± 0.02	2.211PheTyr: 2.211 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.43GlyAla: 4.43 ± 0.068	0.59GlyCys: 0.59 ± 0.035	3.618GlyAsp: 3.618 ± 0.085	3.653GlyGlu: 3.653 ± 0.052	3.611GlyPhe: 3.611 ± 0.063	4.439GlyGly: 4.439 ± 0.078	1.082GlyHis: 1.082 ± 0.03	5.67GlyIle: 5.67 ± 0.087	4.757GlyLys: 4.757 ± 0.068	5.817GlyLeu: 5.817 ± 0.07	1.484GlyMet: 1.484 ± 0.037	3.481GlyAsn: 3.481 ± 0.068	1.315GlyPro: 1.315 ± 0.034	1.779GlyGln: 1.779 ± 0.038	1.934GlyArg: 1.934 ± 0.044	4.065GlySer: 4.065 ± 0.066	4.393GlyThr: 4.393 ± 0.115	4.511GlyVal: 4.511 ± 0.062	0.727GlyTrp: 0.727 ± 0.021	2.823GlyTyr: 2.823 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	0.914HisAla: 0.914 ± 0.027	0.156HisCys: 0.156 ± 0.011	0.794HisAsp: 0.794 ± 0.026	0.946HisGlu: 0.946 ± 0.033	1.006HisPhe: 1.006 ± 0.028	0.991HisGly: 0.991 ± 0.029	0.447HisHis: 0.447 ± 0.023	1.354HisIle: 1.354 ± 0.034	1.298HisLys: 1.298 ± 0.031	1.694HisLeu: 1.694 ± 0.039	0.342HisMet: 0.342 ± 0.015	0.838HisAsn: 0.838 ± 0.026	0.78HisPro: 0.78 ± 0.027	0.665HisGln: 0.665 ± 0.024	0.573HisArg: 0.573 ± 0.024	1.021HisSer: 1.021 ± 0.031	1.023HisThr: 1.023 ± 0.025	0.907HisVal: 0.907 ± 0.026	0.22HisTrp: 0.22 ± 0.013	0.795HisTyr: 0.795 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.062IleAla: 6.062 ± 0.075	0.598IleCys: 0.598 ± 0.023	4.901IleAsp: 4.901 ± 0.067	5.362IleGlu: 5.362 ± 0.069	3.833IlePhe: 3.833 ± 0.061	5.14IleGly: 5.14 ± 0.074	1.31IleHis: 1.31 ± 0.032	6.125IleIle: 6.125 ± 0.084	5.919IleLys: 5.919 ± 0.085	7.41IleLeu: 7.41 ± 0.092	1.315IleMet: 1.315 ± 0.031	4.705IleAsn: 4.705 ± 0.067	3.248IlePro: 3.248 ± 0.052	2.439IleGln: 2.439 ± 0.045	2.505IleArg: 2.505 ± 0.044	5.914IleSer: 5.914 ± 0.075	5.499IleThr: 5.499 ± 0.117	4.711IleVal: 4.711 ± 0.066	0.698IleTrp: 0.698 ± 0.024	2.834IleTyr: 2.834 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.833LysAla: 4.833 ± 0.08	0.34LysCys: 0.34 ± 0.016	4.509LysAsp: 4.509 ± 0.066	6.667LysGlu: 6.667 ± 0.085	3.066LysPhe: 3.066 ± 0.049	4.493LysGly: 4.493 ± 0.064	1.264LysHis: 1.264 ± 0.031	6.457LysIle: 6.457 ± 0.089	7.218LysLys: 7.218 ± 0.101	6.656LysLeu: 6.656 ± 0.084	1.966LysMet: 1.966 ± 0.04	5.557LysAsn: 5.557 ± 0.077	2.235LysPro: 2.235 ± 0.048	2.41LysGln: 2.41 ± 0.045	2.578LysArg: 2.578 ± 0.045	4.539LysSer: 4.539 ± 0.065	4.726LysThr: 4.726 ± 0.065	4.455LysVal: 4.455 ± 0.07	0.756LysTrp: 0.756 ± 0.025	2.966LysTyr: 2.966 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.124LeuAla: 6.124 ± 0.078	0.664LeuCys: 0.664 ± 0.023	5.252LeuAsp: 5.252 ± 0.087	6.403LeuGlu: 6.403 ± 0.08	4.977LeuPhe: 4.977 ± 0.075	5.87LeuGly: 5.87 ± 0.079	1.491LeuHis: 1.491 ± 0.039	6.978LeuIle: 6.978 ± 0.092	8.08LeuLys: 8.08 ± 0.107	8.978LeuLeu: 8.978 ± 0.12	1.997LeuMet: 1.997 ± 0.039	5.754LeuAsn: 5.754 ± 0.069	3.464LeuPro: 3.464 ± 0.055	3.114LeuGln: 3.114 ± 0.047	2.939LeuArg: 2.939 ± 0.048	6.646LeuSer: 6.646 ± 0.078	5.222LeuThr: 5.222 ± 0.068	5.545LeuVal: 5.545 ± 0.075	0.827LeuTrp: 0.827 ± 0.027	3.26LeuTyr: 3.26 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.516MetAla: 1.516 ± 0.037	0.138MetCys: 0.138 ± 0.01	1.087MetAsp: 1.087 ± 0.027	1.305MetGlu: 1.305 ± 0.035	0.84MetPhe: 0.84 ± 0.029	1.412MetGly: 1.412 ± 0.033	0.405MetHis: 0.405 ± 0.018	1.451MetIle: 1.451 ± 0.034	2.085MetLys: 2.085 ± 0.041	1.874MetLeu: 1.874 ± 0.043	0.516MetMet: 0.516 ± 0.02	1.261MetAsn: 1.261 ± 0.034	0.82MetPro: 0.82 ± 0.023	0.744MetGln: 0.744 ± 0.026	0.755MetArg: 0.755 ± 0.022	1.322MetSer: 1.322 ± 0.036	1.104MetThr: 1.104 ± 0.029	1.315MetVal: 1.315 ± 0.034	0.161MetTrp: 0.161 ± 0.01	0.752MetTyr: 0.752 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.872AsnAla: 3.872 ± 0.074	0.483AsnCys: 0.483 ± 0.023	3.39AsnAsp: 3.39 ± 0.088	3.748AsnGlu: 3.748 ± 0.056	3.252AsnPhe: 3.252 ± 0.047	4.194AsnGly: 4.194 ± 0.084	0.996AsnHis: 0.996 ± 0.031	4.561AsnIle: 4.561 ± 0.062	4.248AsnLys: 4.248 ± 0.06	5.441AsnLeu: 5.441 ± 0.076	1.179AsnMet: 1.179 ± 0.025	3.685AsnAsn: 3.685 ± 0.071	2.617AsnPro: 2.617 ± 0.049	2.068AsnGln: 2.068 ± 0.04	2.005AsnArg: 2.005 ± 0.039	4.058AsnSer: 4.058 ± 0.073	4.039AsnThr: 4.039 ± 0.071	3.403AsnVal: 3.403 ± 0.056	0.727AsnTrp: 0.727 ± 0.025	2.878AsnTyr: 2.878 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.824ProAla: 1.824 ± 0.043	0.194ProCys: 0.194 ± 0.012	1.979ProAsp: 1.979 ± 0.056	2.886ProGlu: 2.886 ± 0.045	1.771ProPhe: 1.771 ± 0.039	1.771ProGly: 1.771 ± 0.044	0.552ProHis: 0.552 ± 0.021	2.842ProIle: 2.842 ± 0.054	2.536ProLys: 2.536 ± 0.049	2.991ProLeu: 2.991 ± 0.047	0.69ProMet: 0.69 ± 0.027	2.243ProAsn: 2.243 ± 0.046	0.775ProPro: 0.775 ± 0.029	0.982ProGln: 0.982 ± 0.028	0.865ProArg: 0.865 ± 0.026	2.162ProSer: 2.162 ± 0.046	2.137ProThr: 2.137 ± 0.061	2.113ProVal: 2.113 ± 0.04	0.335ProTrp: 0.335 ± 0.016	1.313ProTyr: 1.313 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.829GlnAla: 1.829 ± 0.037	0.173GlnCys: 0.173 ± 0.013	1.607GlnAsp: 1.607 ± 0.033	2.495GlnGlu: 2.495 ± 0.044	1.552GlnPhe: 1.552 ± 0.036	1.802GlnGly: 1.802 ± 0.065	0.578GlnHis: 0.578 ± 0.019	2.468GlnIle: 2.468 ± 0.041	2.723GlnLys: 2.723 ± 0.05	3.366GlnLeu: 3.366 ± 0.052	0.706GlnMet: 0.706 ± 0.021	1.973GlnAsn: 1.973 ± 0.044	1.023GlnPro: 1.023 ± 0.027	1.218GlnGln: 1.218 ± 0.031	1.096GlnArg: 1.096 ± 0.031	1.739GlnSer: 1.739 ± 0.036	1.715GlnThr: 1.715 ± 0.037	1.839GlnVal: 1.839 ± 0.037	0.385GlnTrp: 0.385 ± 0.015	1.256GlnTyr: 1.256 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.968ArgAla: 1.968 ± 0.044	0.178ArgCys: 0.178 ± 0.011	1.633ArgAsp: 1.633 ± 0.038	1.988ArgGlu: 1.988 ± 0.044	1.704ArgPhe: 1.704 ± 0.037	1.846ArgGly: 1.846 ± 0.043	0.511ArgHis: 0.511 ± 0.02	2.711ArgIle: 2.711 ± 0.044	2.614ArgLys: 2.614 ± 0.047	2.942ArgLeu: 2.942 ± 0.051	0.81ArgMet: 0.81 ± 0.027	1.898ArgAsn: 1.898 ± 0.038	1.045ArgPro: 1.045 ± 0.032	0.917ArgGln: 0.917 ± 0.027	1.14ArgArg: 1.14 ± 0.034	1.844ArgSer: 1.844 ± 0.048	1.837ArgThr: 1.837 ± 0.038	1.968ArgVal: 1.968 ± 0.038	0.356ArgTrp: 0.356 ± 0.017	1.488ArgTyr: 1.488 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	3.942SerAla: 3.942 ± 0.066	0.705SerCys: 0.705 ± 0.024	3.782SerAsp: 3.782 ± 0.072	4.198SerGlu: 4.198 ± 0.062	3.852SerPhe: 3.852 ± 0.058	4.762SerGly: 4.762 ± 0.085	1.012SerHis: 1.012 ± 0.027	5.533SerIle: 5.533 ± 0.072	5.004SerLys: 5.004 ± 0.061	6.252SerLeu: 6.252 ± 0.082	1.227SerMet: 1.227 ± 0.028	3.843SerAsn: 3.843 ± 0.067	1.936SerPro: 1.936 ± 0.039	1.871SerGln: 1.871 ± 0.037	2.005SerArg: 2.005 ± 0.039	4.657SerSer: 4.657 ± 0.081	3.802SerThr: 3.802 ± 0.064	3.898SerVal: 3.898 ± 0.066	0.71SerTrp: 0.71 ± 0.024	2.954SerTyr: 2.954 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.399ThrAla: 4.399 ± 0.125	0.389ThrCys: 0.389 ± 0.033	3.783ThrAsp: 3.783 ± 0.098	3.695ThrGlu: 3.695 ± 0.055	3.098ThrPhe: 3.098 ± 0.055	4.191ThrGly: 4.191 ± 0.094	0.975ThrHis: 0.975 ± 0.026	5.475ThrIle: 5.475 ± 0.094	4.123ThrLys: 4.123 ± 0.065	5.71ThrLeu: 5.71 ± 0.053	0.976ThrMet: 0.976 ± 0.028	3.59ThrAsn: 3.59 ± 0.079	2.658ThrPro: 2.658 ± 0.066	1.82ThrGln: 1.82 ± 0.036	1.677ThrArg: 1.677 ± 0.04	4.18ThrSer: 4.18 ± 0.073	4.203ThrThr: 4.203 ± 0.107	4.061ThrVal: 4.061 ± 0.102	0.628ThrTrp: 0.628 ± 0.028	2.612ThrTyr: 2.612 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.435ValAla: 4.435 ± 0.062	0.489ValCys: 0.489 ± 0.018	3.494ValAsp: 3.494 ± 0.06	3.58ValGlu: 3.58 ± 0.062	3.333ValPhe: 3.333 ± 0.049	3.737ValGly: 3.737 ± 0.057	1.02ValHis: 1.02 ± 0.028	4.718ValIle: 4.718 ± 0.074	4.083ValLys: 4.083 ± 0.065	6.192ValLeu: 6.192 ± 0.078	1.196ValMet: 1.196 ± 0.034	3.482ValAsn: 3.482 ± 0.054	2.128ValPro: 2.128 ± 0.036	1.75ValGln: 1.75 ± 0.038	1.888ValArg: 1.888 ± 0.044	4.492ValSer: 4.492 ± 0.067	4.031ValThr: 4.031 ± 0.105	4.276ValVal: 4.276 ± 0.069	0.594ValTrp: 0.594 ± 0.025	2.356ValTyr: 2.356 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.573TrpAla: 0.573 ± 0.021	0.086TrpCys: 0.086 ± 0.008	0.671TrpAsp: 0.671 ± 0.022	0.691TrpGlu: 0.691 ± 0.022	0.529TrpPhe: 0.529 ± 0.02	0.674TrpGly: 0.674 ± 0.027	0.227TrpHis: 0.227 ± 0.012	0.751TrpIle: 0.751 ± 0.025	0.785TrpLys: 0.785 ± 0.024	0.944TrpLeu: 0.944 ± 0.029	0.31TrpMet: 0.31 ± 0.014	0.669TrpAsn: 0.669 ± 0.026	0.259TrpPro: 0.259 ± 0.016	0.423TrpGln: 0.423 ± 0.015	0.375TrpArg: 0.375 ± 0.017	0.674TrpSer: 0.674 ± 0.024	0.565TrpThr: 0.565 ± 0.024	0.654TrpVal: 0.654 ± 0.023	0.141TrpTrp: 0.141 ± 0.01	0.448TrpTyr: 0.448 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.551TyrAla: 2.551 ± 0.042	0.36TyrCys: 0.36 ± 0.023	2.497TyrAsp: 2.497 ± 0.046	2.406TyrGlu: 2.406 ± 0.048	2.439TyrPhe: 2.439 ± 0.045	2.64TyrGly: 2.64 ± 0.047	0.783TyrHis: 0.783 ± 0.028	2.806TyrIle: 2.806 ± 0.043	3.093TyrLys: 3.093 ± 0.054	3.785TyrLeu: 3.785 ± 0.056	0.769TyrMet: 0.769 ± 0.024	2.455TyrAsn: 2.455 ± 0.049	1.441TyrPro: 1.441 ± 0.038	1.494TyrGln: 1.494 ± 0.036	1.468TyrArg: 1.468 ± 0.037	2.801TyrSer: 2.801 ± 0.053	2.694TyrThr: 2.694 ± 0.051	2.216TyrVal: 2.216 ± 0.046	0.468TyrTrp: 0.468 ± 0.019	1.89TyrTyr: 1.89 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4114 proteins (1411819 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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