Amino acid dipepetide frequency for Culex nigripalpus nucleopolyhedrovirus (isolate Florida/1997) (CuniNPV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.361AlaAla: 4.361 ± 0.424
1.006AlaCys: 1.006 ± 0.182
3.263AlaAsp: 3.263 ± 0.35
4.818AlaGlu: 4.818 ± 0.562
2.104AlaPhe: 2.104 ± 0.247
3.08AlaGly: 3.08 ± 0.26
1.067AlaHis: 1.067 ± 0.153
2.988AlaIle: 2.988 ± 0.27
4.117AlaLys: 4.117 ± 0.376
6.465AlaLeu: 6.465 ± 0.473
1.555AlaMet: 1.555 ± 0.187
3.507AlaAsn: 3.507 ± 0.311
3.019AlaPro: 3.019 ± 0.282
3.202AlaGln: 3.202 ± 0.329
3.69AlaArg: 3.69 ± 0.378
3.202AlaSer: 3.202 ± 0.319
2.775AlaThr: 2.775 ± 0.279
4.757AlaVal: 4.757 ± 0.367
0.457AlaTrp: 0.457 ± 0.101
1.403AlaTyr: 1.403 ± 0.179
0.0AlaXaa: 0.0 ± 0.0
Cys
1.342CysAla: 1.342 ± 0.207
0.274CysCys: 0.274 ± 0.135
1.189CysAsp: 1.189 ± 0.216
1.555CysGlu: 1.555 ± 0.249
0.64CysPhe: 0.64 ± 0.119
1.494CysGly: 1.494 ± 0.226
0.335CysHis: 0.335 ± 0.085
1.22CysIle: 1.22 ± 0.204
1.342CysLys: 1.342 ± 0.168
1.433CysLeu: 1.433 ± 0.236
0.305CysMet: 0.305 ± 0.091
1.006CysAsn: 1.006 ± 0.138
1.006CysPro: 1.006 ± 0.195
0.549CysGln: 0.549 ± 0.134
1.281CysArg: 1.281 ± 0.211
1.555CysSer: 1.555 ± 0.212
1.708CysThr: 1.708 ± 0.256
1.525CysVal: 1.525 ± 0.227
0.152CysTrp: 0.152 ± 0.064
0.579CysTyr: 0.579 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
2.897AspAla: 2.897 ± 0.346
1.128AspCys: 1.128 ± 0.195
3.019AspAsp: 3.019 ± 0.465
4.452AspGlu: 4.452 ± 0.366
2.074AspPhe: 2.074 ± 0.23
3.934AspGly: 3.934 ± 0.447
1.281AspHis: 1.281 ± 0.192
2.775AspIle: 2.775 ± 0.296
1.891AspLys: 1.891 ± 0.209
5.977AspLeu: 5.977 ± 0.423
1.494AspMet: 1.494 ± 0.19
2.561AspAsn: 2.561 ± 0.28
3.141AspPro: 3.141 ± 0.369
1.86AspGln: 1.86 ± 0.224
3.232AspArg: 3.232 ± 0.291
3.598AspSer: 3.598 ± 0.398
2.897AspThr: 2.897 ± 0.27
3.72AspVal: 3.72 ± 0.403
0.427AspTrp: 0.427 ± 0.135
1.403AspTyr: 1.403 ± 0.214
0.0AspXaa: 0.0 ± 0.0
Glu
3.873GluAla: 3.873 ± 0.409
1.342GluCys: 1.342 ± 0.219
3.69GluAsp: 3.69 ± 0.381
4.391GluGlu: 4.391 ± 0.445
2.653GluPhe: 2.653 ± 0.309
3.171GluGly: 3.171 ± 0.384
1.555GluHis: 1.555 ± 0.263
3.842GluIle: 3.842 ± 0.429
3.049GluLys: 3.049 ± 0.433
8.904GluLeu: 8.904 ± 0.782
1.921GluMet: 1.921 ± 0.233
2.927GluAsn: 2.927 ± 0.298
3.385GluPro: 3.385 ± 0.431
2.714GluGln: 2.714 ± 0.357
6.19GluArg: 6.19 ± 0.51
4.269GluSer: 4.269 ± 0.399
3.568GluThr: 3.568 ± 0.397
4.696GluVal: 4.696 ± 0.344
0.762GluTrp: 0.762 ± 0.176
2.958GluTyr: 2.958 ± 0.389
0.0GluXaa: 0.0 ± 0.0
Phe
2.866PheAla: 2.866 ± 0.288
0.488PheCys: 0.488 ± 0.114
1.891PheAsp: 1.891 ± 0.235
2.866PheGlu: 2.866 ± 0.333
1.769PhePhe: 1.769 ± 0.25
2.714PheGly: 2.714 ± 0.242
0.732PheHis: 0.732 ± 0.185
2.653PheIle: 2.653 ± 0.281
2.317PheLys: 2.317 ± 0.248
2.257PheLeu: 2.257 ± 0.25
1.342PheMet: 1.342 ± 0.167
2.531PheAsn: 2.531 ± 0.307
1.403PhePro: 1.403 ± 0.231
1.159PheGln: 1.159 ± 0.162
2.104PheArg: 2.104 ± 0.263
1.982PheSer: 1.982 ± 0.273
2.439PheThr: 2.439 ± 0.243
3.385PheVal: 3.385 ± 0.399
0.396PheTrp: 0.396 ± 0.108
1.799PheTyr: 1.799 ± 0.219
0.0PheXaa: 0.0 ± 0.0
Gly
3.568GlyAla: 3.568 ± 0.301
1.067GlyCys: 1.067 ± 0.165
2.805GlyAsp: 2.805 ± 0.263
4.269GlyGlu: 4.269 ± 0.342
1.738GlyPhe: 1.738 ± 0.193
4.452GlyGly: 4.452 ± 0.38
1.342GlyHis: 1.342 ± 0.185
2.47GlyIle: 2.47 ± 0.262
2.47GlyLys: 2.47 ± 0.286
4.147GlyLeu: 4.147 ± 0.383
1.037GlyMet: 1.037 ± 0.155
2.958GlyAsn: 2.958 ± 0.289
2.622GlyPro: 2.622 ± 0.244
1.86GlyGln: 1.86 ± 0.246
3.537GlyArg: 3.537 ± 0.371
3.415GlySer: 3.415 ± 0.32
3.202GlyThr: 3.202 ± 0.313
4.056GlyVal: 4.056 ± 0.319
0.366GlyTrp: 0.366 ± 0.09
2.165GlyTyr: 2.165 ± 0.242
0.0GlyXaa: 0.0 ± 0.0
His
0.976HisAla: 0.976 ± 0.169
0.427HisCys: 0.427 ± 0.117
1.494HisAsp: 1.494 ± 0.219
1.281HisGlu: 1.281 ± 0.187
0.945HisPhe: 0.945 ± 0.188
0.884HisGly: 0.884 ± 0.158
0.762HisHis: 0.762 ± 0.15
1.403HisIle: 1.403 ± 0.176
0.884HisLys: 0.884 ± 0.167
2.5HisLeu: 2.5 ± 0.3
0.579HisMet: 0.579 ± 0.134
1.342HisAsn: 1.342 ± 0.222
1.433HisPro: 1.433 ± 0.198
1.006HisGln: 1.006 ± 0.189
1.982HisArg: 1.982 ± 0.26
1.159HisSer: 1.159 ± 0.21
1.159HisThr: 1.159 ± 0.189
1.738HisVal: 1.738 ± 0.267
0.274HisTrp: 0.274 ± 0.086
0.823HisTyr: 0.823 ± 0.15
0.0HisXaa: 0.0 ± 0.0
Ile
3.476IleAla: 3.476 ± 0.37
0.945IleCys: 0.945 ± 0.154
3.263IleAsp: 3.263 ± 0.34
4.422IleGlu: 4.422 ± 0.405
2.135IlePhe: 2.135 ± 0.234
1.921IleGly: 1.921 ± 0.244
1.159IleHis: 1.159 ± 0.183
2.226IleIle: 2.226 ± 0.289
2.561IleLys: 2.561 ± 0.295
3.842IleLeu: 3.842 ± 0.341
1.342IleMet: 1.342 ± 0.22
2.866IleAsn: 2.866 ± 0.288
2.592IlePro: 2.592 ± 0.261
1.586IleGln: 1.586 ± 0.194
3.263IleArg: 3.263 ± 0.354
3.11IleSer: 3.11 ± 0.281
3.385IleThr: 3.385 ± 0.318
4.635IleVal: 4.635 ± 0.438
0.61IleTrp: 0.61 ± 0.173
2.196IleTyr: 2.196 ± 0.247
0.0IleXaa: 0.0 ± 0.0
Lys
2.287LysAla: 2.287 ± 0.33
0.976LysCys: 0.976 ± 0.157
1.86LysAsp: 1.86 ± 0.268
1.677LysGlu: 1.677 ± 0.209
2.653LysPhe: 2.653 ± 0.28
1.708LysGly: 1.708 ± 0.257
1.067LysHis: 1.067 ± 0.214
3.11LysIle: 3.11 ± 0.497
2.47LysLys: 2.47 ± 0.319
5.794LysLeu: 5.794 ± 0.587
1.677LysMet: 1.677 ± 0.219
2.561LysAsn: 2.561 ± 0.261
2.409LysPro: 2.409 ± 0.35
1.403LysGln: 1.403 ± 0.198
4.848LysArg: 4.848 ± 0.372
3.781LysSer: 3.781 ± 0.397
1.799LysThr: 1.799 ± 0.251
3.629LysVal: 3.629 ± 0.374
0.518LysTrp: 0.518 ± 0.117
1.921LysTyr: 1.921 ± 0.242
0.0LysXaa: 0.0 ± 0.0
Leu
6.556LeuAla: 6.556 ± 0.469
1.769LeuCys: 1.769 ± 0.207
5.855LeuAsp: 5.855 ± 0.387
7.318LeuGlu: 7.318 ± 0.663
3.11LeuPhe: 3.11 ± 0.369
4.665LeuGly: 4.665 ± 0.407
1.891LeuHis: 1.891 ± 0.225
4.665LeuIle: 4.665 ± 0.41
5.062LeuLys: 5.062 ± 0.543
7.867LeuLeu: 7.867 ± 0.497
2.196LeuMet: 2.196 ± 0.235
5.092LeuAsn: 5.092 ± 0.467
4.787LeuPro: 4.787 ± 0.492
3.69LeuGln: 3.69 ± 0.425
6.617LeuArg: 6.617 ± 0.484
6.068LeuSer: 6.068 ± 0.39
4.696LeuThr: 4.696 ± 0.375
7.745LeuVal: 7.745 ± 0.52
0.915LeuTrp: 0.915 ± 0.168
4.056LeuTyr: 4.056 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
1.921MetAla: 1.921 ± 0.282
0.549MetCys: 0.549 ± 0.112
1.616MetAsp: 1.616 ± 0.188
2.135MetGlu: 2.135 ± 0.252
1.433MetPhe: 1.433 ± 0.183
1.22MetGly: 1.22 ± 0.222
0.61MetHis: 0.61 ± 0.156
1.342MetIle: 1.342 ± 0.182
1.159MetLys: 1.159 ± 0.165
2.561MetLeu: 2.561 ± 0.268
1.037MetMet: 1.037 ± 0.168
1.494MetAsn: 1.494 ± 0.195
0.976MetPro: 0.976 ± 0.192
0.854MetGln: 0.854 ± 0.173
1.83MetArg: 1.83 ± 0.188
2.013MetSer: 2.013 ± 0.237
1.25MetThr: 1.25 ± 0.191
2.531MetVal: 2.531 ± 0.272
0.274MetTrp: 0.274 ± 0.082
1.098MetTyr: 1.098 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
2.744AsnAla: 2.744 ± 0.295
1.22AsnCys: 1.22 ± 0.206
2.043AsnAsp: 2.043 ± 0.243
3.476AsnGlu: 3.476 ± 0.287
2.47AsnPhe: 2.47 ± 0.231
2.836AsnGly: 2.836 ± 0.327
1.22AsnHis: 1.22 ± 0.242
2.531AsnIle: 2.531 ± 0.29
2.409AsnLys: 2.409 ± 0.264
5.092AsnLeu: 5.092 ± 0.465
1.799AsnMet: 1.799 ± 0.26
2.592AsnAsn: 2.592 ± 0.367
2.47AsnPro: 2.47 ± 0.274
2.196AsnGln: 2.196 ± 0.269
3.72AsnArg: 3.72 ± 0.314
3.812AsnSer: 3.812 ± 0.343
2.378AsnThr: 2.378 ± 0.257
4.544AsnVal: 4.544 ± 0.407
0.61AsnTrp: 0.61 ± 0.119
1.586AsnTyr: 1.586 ± 0.204
0.0AsnXaa: 0.0 ± 0.0
Pro
2.622ProAla: 2.622 ± 0.303
0.671ProCys: 0.671 ± 0.149
3.171ProAsp: 3.171 ± 0.295
4.239ProGlu: 4.239 ± 0.452
1.647ProPhe: 1.647 ± 0.192
2.5ProGly: 2.5 ± 0.244
1.616ProHis: 1.616 ± 0.215
2.622ProIle: 2.622 ± 0.318
2.074ProLys: 2.074 ± 0.262
4.3ProLeu: 4.3 ± 0.379
1.128ProMet: 1.128 ± 0.183
3.507ProAsn: 3.507 ± 0.282
3.263ProPro: 3.263 ± 0.486
2.165ProGln: 2.165 ± 0.359
2.744ProArg: 2.744 ± 0.281
3.324ProSer: 3.324 ± 0.306
3.598ProThr: 3.598 ± 0.366
3.202ProVal: 3.202 ± 0.302
0.427ProTrp: 0.427 ± 0.099
1.098ProTyr: 1.098 ± 0.14
0.0ProXaa: 0.0 ± 0.0
Gln
1.708GlnAla: 1.708 ± 0.224
0.762GlnCys: 0.762 ± 0.144
1.433GlnAsp: 1.433 ± 0.242
1.25GlnGlu: 1.25 ± 0.233
1.464GlnPhe: 1.464 ± 0.182
1.098GlnGly: 1.098 ± 0.193
1.098GlnHis: 1.098 ± 0.188
2.013GlnIle: 2.013 ± 0.265
1.037GlnLys: 1.037 ± 0.19
4.94GlnLeu: 4.94 ± 0.392
1.281GlnMet: 1.281 ± 0.187
1.586GlnAsn: 1.586 ± 0.217
2.378GlnPro: 2.378 ± 0.435
2.135GlnGln: 2.135 ± 0.378
3.446GlnArg: 3.446 ± 0.406
2.226GlnSer: 2.226 ± 0.278
2.317GlnThr: 2.317 ± 0.252
2.378GlnVal: 2.378 ± 0.243
0.396GlnTrp: 0.396 ± 0.103
1.403GlnTyr: 1.403 ± 0.211
0.0GlnXaa: 0.0 ± 0.0
Arg
5.062ArgAla: 5.062 ± 0.399
2.165ArgCys: 2.165 ± 0.28
3.507ArgAsp: 3.507 ± 0.366
5.001ArgGlu: 5.001 ± 0.54
3.019ArgPhe: 3.019 ± 0.238
3.263ArgGly: 3.263 ± 0.33
1.342ArgHis: 1.342 ± 0.202
3.659ArgIle: 3.659 ± 0.311
3.812ArgLys: 3.812 ± 0.449
6.221ArgLeu: 6.221 ± 0.417
2.074ArgMet: 2.074 ± 0.213
3.476ArgAsn: 3.476 ± 0.335
3.08ArgPro: 3.08 ± 0.316
2.592ArgGln: 2.592 ± 0.275
4.757ArgArg: 4.757 ± 0.4
5.184ArgSer: 5.184 ± 0.44
4.269ArgThr: 4.269 ± 0.329
5.306ArgVal: 5.306 ± 0.462
0.732ArgTrp: 0.732 ± 0.145
3.232ArgTyr: 3.232 ± 0.365
0.0ArgXaa: 0.0 ± 0.0
Ser
4.818SerAla: 4.818 ± 0.328
1.555SerCys: 1.555 ± 0.243
3.232SerAsp: 3.232 ± 0.284
4.3SerGlu: 4.3 ± 0.469
2.317SerPhe: 2.317 ± 0.272
4.483SerGly: 4.483 ± 0.309
1.281SerHis: 1.281 ± 0.23
2.775SerIle: 2.775 ± 0.305
3.202SerLys: 3.202 ± 0.318
5.397SerLeu: 5.397 ± 0.357
1.708SerMet: 1.708 ± 0.237
2.927SerAsn: 2.927 ± 0.31
3.903SerPro: 3.903 ± 0.44
1.525SerGln: 1.525 ± 0.267
5.397SerArg: 5.397 ± 0.564
5.977SerSer: 5.977 ± 0.596
4.391SerThr: 4.391 ± 0.443
4.544SerVal: 4.544 ± 0.346
0.579SerTrp: 0.579 ± 0.111
2.683SerTyr: 2.683 ± 0.31
0.0SerXaa: 0.0 ± 0.0
Thr
3.08ThrAla: 3.08 ± 0.261
0.884ThrCys: 0.884 ± 0.18
2.592ThrAsp: 2.592 ± 0.306
3.446ThrGlu: 3.446 ± 0.318
2.714ThrPhe: 2.714 ± 0.367
2.958ThrGly: 2.958 ± 0.406
1.128ThrHis: 1.128 ± 0.155
3.232ThrIle: 3.232 ± 0.289
2.744ThrLys: 2.744 ± 0.271
6.617ThrLeu: 6.617 ± 0.345
2.196ThrMet: 2.196 ± 0.258
2.653ThrAsn: 2.653 ± 0.298
2.592ThrPro: 2.592 ± 0.257
1.159ThrGln: 1.159 ± 0.172
3.324ThrArg: 3.324 ± 0.312
3.69ThrSer: 3.69 ± 0.326
3.537ThrThr: 3.537 ± 0.284
5.489ThrVal: 5.489 ± 0.393
0.396ThrTrp: 0.396 ± 0.099
1.738ThrTyr: 1.738 ± 0.225
0.0ThrXaa: 0.0 ± 0.0
Val
4.452ValAla: 4.452 ± 0.377
1.708ValCys: 1.708 ± 0.215
5.001ValAsp: 5.001 ± 0.407
6.251ValGlu: 6.251 ± 0.455
2.348ValPhe: 2.348 ± 0.276
4.544ValGly: 4.544 ± 0.358
2.378ValHis: 2.378 ± 0.262
3.263ValIle: 3.263 ± 0.332
3.324ValLys: 3.324 ± 0.328
6.8ValLeu: 6.8 ± 0.462
1.952ValMet: 1.952 ± 0.237
3.446ValAsn: 3.446 ± 0.388
3.812ValPro: 3.812 ± 0.288
3.385ValGln: 3.385 ± 0.315
6.404ValArg: 6.404 ± 0.481
4.97ValSer: 4.97 ± 0.492
3.507ValThr: 3.507 ± 0.295
6.983ValVal: 6.983 ± 0.422
0.884ValTrp: 0.884 ± 0.197
2.744ValTyr: 2.744 ± 0.299
0.0ValXaa: 0.0 ± 0.0
Trp
0.488TrpAla: 0.488 ± 0.137
0.488TrpCys: 0.488 ± 0.137
0.671TrpAsp: 0.671 ± 0.153
0.488TrpGlu: 0.488 ± 0.115
0.366TrpPhe: 0.366 ± 0.117
0.488TrpGly: 0.488 ± 0.133
0.244TrpHis: 0.244 ± 0.085
0.396TrpIle: 0.396 ± 0.134
0.274TrpLys: 0.274 ± 0.081
0.854TrpLeu: 0.854 ± 0.155
0.305TrpMet: 0.305 ± 0.095
0.549TrpAsn: 0.549 ± 0.107
0.427TrpPro: 0.427 ± 0.116
0.183TrpGln: 0.183 ± 0.073
0.793TrpArg: 0.793 ± 0.15
0.701TrpSer: 0.701 ± 0.169
0.732TrpThr: 0.732 ± 0.139
0.701TrpVal: 0.701 ± 0.134
0.122TrpTrp: 0.122 ± 0.057
0.427TrpTyr: 0.427 ± 0.11
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.738TyrAla: 1.738 ± 0.213
1.067TyrCys: 1.067 ± 0.224
2.165TyrAsp: 2.165 ± 0.289
2.226TyrGlu: 2.226 ± 0.215
1.494TyrPhe: 1.494 ± 0.225
2.135TyrGly: 2.135 ± 0.254
0.945TyrHis: 0.945 ± 0.173
2.348TyrIle: 2.348 ± 0.316
1.952TyrLys: 1.952 ± 0.225
2.653TyrLeu: 2.653 ± 0.315
0.945TyrMet: 0.945 ± 0.16
2.165TyrAsn: 2.165 ± 0.296
1.22TyrPro: 1.22 ± 0.183
1.128TyrGln: 1.128 ± 0.174
2.592TyrArg: 2.592 ± 0.3
2.958TyrSer: 2.958 ± 0.298
2.561TyrThr: 2.561 ± 0.31
2.622TyrVal: 2.622 ± 0.302
0.396TyrTrp: 0.396 ± 0.106
1.067TyrTyr: 1.067 ± 0.207
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 109 proteins (32795 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski