Amino acid dipepetide frequency for Fusobacterium naviforme

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.347AlaAla: 11.347 ± 0.198
1.224AlaCys: 1.224 ± 0.045
4.876AlaAsp: 4.876 ± 0.082
8.982AlaGlu: 8.982 ± 0.151
3.275AlaPhe: 3.275 ± 0.08
7.645AlaGly: 7.645 ± 0.11
1.358AlaHis: 1.358 ± 0.045
4.731AlaIle: 4.731 ± 0.092
4.282AlaLys: 4.282 ± 0.089
9.771AlaLeu: 9.771 ± 0.145
2.602AlaMet: 2.602 ± 0.06
2.309AlaAsn: 2.309 ± 0.063
2.732AlaPro: 2.732 ± 0.079
2.701AlaGln: 2.701 ± 0.062
4.32AlaArg: 4.32 ± 0.09
4.418AlaSer: 4.418 ± 0.078
3.302AlaThr: 3.302 ± 0.076
7.46AlaVal: 7.46 ± 0.117
0.697AlaTrp: 0.697 ± 0.031
2.653AlaTyr: 2.653 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.33CysAla: 1.33 ± 0.052
0.302CysCys: 0.302 ± 0.021
0.749CysAsp: 0.749 ± 0.037
0.907CysGlu: 0.907 ± 0.038
0.703CysPhe: 0.703 ± 0.034
1.658CysGly: 1.658 ± 0.055
0.27CysHis: 0.27 ± 0.019
0.919CysIle: 0.919 ± 0.037
0.498CysLys: 0.498 ± 0.029
1.179CysLeu: 1.179 ± 0.039
0.402CysMet: 0.402 ± 0.024
0.442CysAsn: 0.442 ± 0.028
0.648CysPro: 0.648 ± 0.032
0.309CysGln: 0.309 ± 0.024
0.928CysArg: 0.928 ± 0.039
0.919CysSer: 0.919 ± 0.036
0.774CysThr: 0.774 ± 0.031
1.005CysVal: 1.005 ± 0.036
0.133CysTrp: 0.133 ± 0.013
0.543CysTyr: 0.543 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.883AspAla: 4.883 ± 0.085
0.892AspCys: 0.892 ± 0.038
2.322AspAsp: 2.322 ± 0.073
4.075AspGlu: 4.075 ± 0.085
2.39AspPhe: 2.39 ± 0.064
4.456AspGly: 4.456 ± 0.116
0.966AspHis: 0.966 ± 0.051
3.726AspIle: 3.726 ± 0.081
2.294AspLys: 2.294 ± 0.074
4.182AspLeu: 4.182 ± 0.082
1.6AspMet: 1.6 ± 0.048
1.614AspAsn: 1.614 ± 0.048
2.117AspPro: 2.117 ± 0.06
1.383AspGln: 1.383 ± 0.044
3.135AspArg: 3.135 ± 0.065
3.023AspSer: 3.023 ± 0.073
2.679AspThr: 2.679 ± 0.066
3.081AspVal: 3.081 ± 0.073
0.588AspTrp: 0.588 ± 0.033
2.329AspTyr: 2.329 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
7.305GluAla: 7.305 ± 0.118
0.721GluCys: 0.721 ± 0.033
3.95GluAsp: 3.95 ± 0.092
7.453GluGlu: 7.453 ± 0.136
2.231GluPhe: 2.231 ± 0.057
5.042GluGly: 5.042 ± 0.08
1.563GluHis: 1.563 ± 0.06
5.126GluIle: 5.126 ± 0.084
5.576GluLys: 5.576 ± 0.115
8.963GluLeu: 8.963 ± 0.16
2.126GluMet: 2.126 ± 0.056
3.338GluAsn: 3.338 ± 0.07
2.151GluPro: 2.151 ± 0.059
3.37GluGln: 3.37 ± 0.087
5.44GluArg: 5.44 ± 0.106
4.016GluSer: 4.016 ± 0.08
3.897GluThr: 3.897 ± 0.073
4.132GluVal: 4.132 ± 0.081
0.613GluTrp: 0.613 ± 0.029
2.63GluTyr: 2.63 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.18PheAla: 3.18 ± 0.078
0.709PheCys: 0.709 ± 0.032
2.285PheAsp: 2.285 ± 0.057
2.326PheGlu: 2.326 ± 0.056
1.735PhePhe: 1.735 ± 0.062
2.999PheGly: 2.999 ± 0.062
0.787PheHis: 0.787 ± 0.033
2.275PheIle: 2.275 ± 0.061
1.434PheLys: 1.434 ± 0.051
3.93PheLeu: 3.93 ± 0.106
1.116PheMet: 1.116 ± 0.041
1.25PheAsn: 1.25 ± 0.046
1.476PhePro: 1.476 ± 0.047
1.292PheGln: 1.292 ± 0.038
2.406PheArg: 2.406 ± 0.057
2.793PheSer: 2.793 ± 0.064
2.182PheThr: 2.182 ± 0.06
2.532PheVal: 2.532 ± 0.064
0.403PheTrp: 0.403 ± 0.026
1.514PheTyr: 1.514 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
6.5GlyAla: 6.5 ± 0.115
1.185GlyCys: 1.185 ± 0.047
3.666GlyAsp: 3.666 ± 0.08
5.604GlyGlu: 5.604 ± 0.104
3.183GlyPhe: 3.183 ± 0.073
5.772GlyGly: 5.772 ± 0.113
1.341GlyHis: 1.341 ± 0.042
5.877GlyIle: 5.877 ± 0.101
4.622GlyLys: 4.622 ± 0.091
6.445GlyLeu: 6.445 ± 0.126
2.501GlyMet: 2.501 ± 0.065
2.813GlyAsn: 2.813 ± 0.065
1.682GlyPro: 1.682 ± 0.051
2.189GlyGln: 2.189 ± 0.055
4.507GlyArg: 4.507 ± 0.082
5.01GlySer: 5.01 ± 0.103
4.257GlyThr: 4.257 ± 0.091
5.107GlyVal: 5.107 ± 0.085
0.763GlyTrp: 0.763 ± 0.04
2.935GlyTyr: 2.935 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.498HisAla: 1.498 ± 0.042
0.343HisCys: 0.343 ± 0.02
0.816HisAsp: 0.816 ± 0.035
1.214HisGlu: 1.214 ± 0.056
0.965HisPhe: 0.965 ± 0.038
1.367HisGly: 1.367 ± 0.047
0.413HisHis: 0.413 ± 0.051
1.386HisIle: 1.386 ± 0.041
0.661HisLys: 0.661 ± 0.026
1.435HisLeu: 1.435 ± 0.044
0.566HisMet: 0.566 ± 0.028
0.549HisAsn: 0.549 ± 0.027
1.007HisPro: 1.007 ± 0.035
0.505HisGln: 0.505 ± 0.027
1.102HisArg: 1.102 ± 0.043
1.239HisSer: 1.239 ± 0.042
0.928HisThr: 0.928 ± 0.032
1.029HisVal: 1.029 ± 0.043
0.204HisTrp: 0.204 ± 0.017
0.853HisTyr: 0.853 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.78IleAla: 5.78 ± 0.098
1.122IleCys: 1.122 ± 0.045
3.389IleAsp: 3.389 ± 0.076
4.122IleGlu: 4.122 ± 0.077
2.376IlePhe: 2.376 ± 0.071
4.752IleGly: 4.752 ± 0.103
1.204IleHis: 1.204 ± 0.04
3.922IleIle: 3.922 ± 0.084
2.485IleLys: 2.485 ± 0.073
6.218IleLeu: 6.218 ± 0.111
1.683IleMet: 1.683 ± 0.048
2.119IleAsn: 2.119 ± 0.06
3.16IlePro: 3.16 ± 0.075
2.089IleGln: 2.089 ± 0.057
4.189IleArg: 4.189 ± 0.086
4.488IleSer: 4.488 ± 0.092
3.489IleThr: 3.489 ± 0.076
4.142IleVal: 4.142 ± 0.088
0.525IleTrp: 0.525 ± 0.026
2.226IleTyr: 2.226 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.503LysAla: 4.503 ± 0.088
0.507LysCys: 0.507 ± 0.032
2.8LysAsp: 2.8 ± 0.075
4.699LysGlu: 4.699 ± 0.098
1.41LysPhe: 1.41 ± 0.046
3.342LysGly: 3.342 ± 0.073
0.871LysHis: 0.871 ± 0.035
3.44LysIle: 3.44 ± 0.083
4.317LysLys: 4.317 ± 0.093
5.118LysLeu: 5.118 ± 0.1
1.518LysMet: 1.518 ± 0.055
2.59LysAsn: 2.59 ± 0.068
1.781LysPro: 1.781 ± 0.052
1.995LysGln: 1.995 ± 0.053
3.184LysArg: 3.184 ± 0.077
2.865LysSer: 2.865 ± 0.062
3.03LysThr: 3.03 ± 0.071
2.974LysVal: 2.974 ± 0.076
0.447LysTrp: 0.447 ± 0.024
2.037LysTyr: 2.037 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
7.649LeuAla: 7.649 ± 0.117
1.83LeuCys: 1.83 ± 0.059
4.766LeuAsp: 4.766 ± 0.085
5.972LeuGlu: 5.972 ± 0.098
3.978LeuPhe: 3.978 ± 0.086
6.556LeuGly: 6.556 ± 0.111
1.871LeuHis: 1.871 ± 0.06
5.915LeuIle: 5.915 ± 0.108
5.987LeuLys: 5.987 ± 0.085
10.748LeuLeu: 10.748 ± 0.235
2.994LeuMet: 2.994 ± 0.077
3.678LeuAsn: 3.678 ± 0.073
4.416LeuPro: 4.416 ± 0.09
2.953LeuGln: 2.953 ± 0.062
6.456LeuArg: 6.456 ± 0.125
7.803LeuSer: 7.803 ± 0.136
5.163LeuThr: 5.163 ± 0.09
5.444LeuVal: 5.444 ± 0.092
0.877LeuTrp: 0.877 ± 0.043
3.181LeuTyr: 3.181 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.508MetAla: 2.508 ± 0.059
0.318MetCys: 0.318 ± 0.022
1.511MetAsp: 1.511 ± 0.05
2.247MetGlu: 2.247 ± 0.064
0.847MetPhe: 0.847 ± 0.037
2.018MetGly: 2.018 ± 0.059
0.48MetHis: 0.48 ± 0.026
1.86MetIle: 1.86 ± 0.053
2.159MetLys: 2.159 ± 0.057
2.827MetLeu: 2.827 ± 0.078
0.833MetMet: 0.833 ± 0.039
1.446MetAsn: 1.446 ± 0.046
1.14MetPro: 1.14 ± 0.042
1.126MetGln: 1.126 ± 0.039
1.756MetArg: 1.756 ± 0.045
1.813MetSer: 1.813 ± 0.054
1.514MetThr: 1.514 ± 0.046
1.721MetVal: 1.721 ± 0.051
0.188MetTrp: 0.188 ± 0.017
0.697MetTyr: 0.697 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.3AsnAla: 3.3 ± 0.081
0.468AsnCys: 0.468 ± 0.029
1.603AsnAsp: 1.603 ± 0.052
2.275AsnGlu: 2.275 ± 0.057
1.392AsnPhe: 1.392 ± 0.047
2.884AsnGly: 2.884 ± 0.076
0.77AsnHis: 0.77 ± 0.037
2.554AsnIle: 2.554 ± 0.066
1.563AsnLys: 1.563 ± 0.051
3.158AsnLeu: 3.158 ± 0.082
1.099AsnMet: 1.099 ± 0.044
1.224AsnAsn: 1.224 ± 0.045
1.882AsnPro: 1.882 ± 0.048
1.235AsnGln: 1.235 ± 0.037
2.166AsnArg: 2.166 ± 0.056
2.028AsnSer: 2.028 ± 0.051
1.923AsnThr: 1.923 ± 0.052
2.305AsnVal: 2.305 ± 0.063
0.343AsnTrp: 0.343 ± 0.023
1.463AsnTyr: 1.463 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
3.285ProAla: 3.285 ± 0.075
0.454ProCys: 0.454 ± 0.03
2.319ProAsp: 2.319 ± 0.057
4.461ProGlu: 4.461 ± 0.081
1.396ProPhe: 1.396 ± 0.045
3.099ProGly: 3.099 ± 0.068
0.609ProHis: 0.609 ± 0.032
1.839ProIle: 1.839 ± 0.055
1.711ProLys: 1.711 ± 0.053
3.393ProLeu: 3.393 ± 0.079
0.927ProMet: 0.927 ± 0.033
1.151ProAsn: 1.151 ± 0.048
0.951ProPro: 0.951 ± 0.041
1.047ProGln: 1.047 ± 0.035
1.476ProArg: 1.476 ± 0.047
1.921ProSer: 1.921 ± 0.053
1.488ProThr: 1.488 ± 0.045
3.104ProVal: 3.104 ± 0.073
0.361ProTrp: 0.361 ± 0.025
1.351ProTyr: 1.351 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
2.585GlnAla: 2.585 ± 0.072
0.356GlnCys: 0.356 ± 0.021
1.502GlnAsp: 1.502 ± 0.053
2.676GlnGlu: 2.676 ± 0.062
1.01GlnPhe: 1.01 ± 0.036
2.051GlnGly: 2.051 ± 0.063
0.543GlnHis: 0.543 ± 0.025
2.133GlnIle: 2.133 ± 0.055
2.222GlnLys: 2.222 ± 0.053
3.478GlnLeu: 3.478 ± 0.076
1.0GlnMet: 1.0 ± 0.038
1.393GlnAsn: 1.393 ± 0.052
1.047GlnPro: 1.047 ± 0.039
1.242GlnGln: 1.242 ± 0.049
2.072GlnArg: 2.072 ± 0.062
1.939GlnSer: 1.939 ± 0.051
1.589GlnThr: 1.589 ± 0.049
1.788GlnVal: 1.788 ± 0.052
0.311GlnTrp: 0.311 ± 0.02
1.245GlnTyr: 1.245 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
5.018ArgAla: 5.018 ± 0.108
0.9ArgCys: 0.9 ± 0.038
3.061ArgAsp: 3.061 ± 0.063
5.891ArgGlu: 5.891 ± 0.129
2.459ArgPhe: 2.459 ± 0.07
4.04ArgGly: 4.04 ± 0.086
1.095ArgHis: 1.095 ± 0.04
4.052ArgIle: 4.052 ± 0.083
3.452ArgLys: 3.452 ± 0.075
5.5ArgLeu: 5.5 ± 0.103
1.911ArgMet: 1.911 ± 0.049
2.056ArgAsn: 2.056 ± 0.053
1.902ArgPro: 1.902 ± 0.059
1.976ArgGln: 1.976 ± 0.056
4.414ArgArg: 4.414 ± 0.101
3.438ArgSer: 3.438 ± 0.078
2.754ArgThr: 2.754 ± 0.06
3.571ArgVal: 3.571 ± 0.066
0.581ArgTrp: 0.581 ± 0.031
2.343ArgTyr: 2.343 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
6.017SerAla: 6.017 ± 0.112
1.042SerCys: 1.042 ± 0.041
3.072SerAsp: 3.072 ± 0.061
4.544SerGlu: 4.544 ± 0.095
3.135SerPhe: 3.135 ± 0.068
6.129SerGly: 6.129 ± 0.11
1.0SerHis: 1.0 ± 0.037
3.568SerIle: 3.568 ± 0.078
2.42SerLys: 2.42 ± 0.056
5.402SerLeu: 5.402 ± 0.102
1.686SerMet: 1.686 ± 0.055
1.739SerAsn: 1.739 ± 0.063
1.91SerPro: 1.91 ± 0.053
1.539SerGln: 1.539 ± 0.047
3.488SerArg: 3.488 ± 0.074
3.867SerSer: 3.867 ± 0.104
2.698SerThr: 2.698 ± 0.067
4.519SerVal: 4.519 ± 0.087
0.66SerTrp: 0.66 ± 0.031
2.63SerTyr: 2.63 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
5.542ThrAla: 5.542 ± 0.094
0.463ThrCys: 0.463 ± 0.026
2.94ThrAsp: 2.94 ± 0.081
4.68ThrGlu: 4.68 ± 0.09
1.56ThrPhe: 1.56 ± 0.055
4.411ThrGly: 4.411 ± 0.084
0.854ThrHis: 0.854 ± 0.035
3.079ThrIle: 3.079 ± 0.069
2.24ThrLys: 2.24 ± 0.068
5.051ThrLeu: 5.051 ± 0.082
1.264ThrMet: 1.264 ± 0.043
1.57ThrAsn: 1.57 ± 0.048
2.183ThrPro: 2.183 ± 0.07
1.361ThrGln: 1.361 ± 0.055
2.28ThrArg: 2.28 ± 0.057
2.252ThrSer: 2.252 ± 0.053
2.481ThrThr: 2.481 ± 0.064
4.429ThrVal: 4.429 ± 0.088
0.361ThrTrp: 0.361 ± 0.023
1.333ThrTyr: 1.333 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.911ValAla: 4.911 ± 0.096
1.063ValCys: 1.063 ± 0.036
3.404ValAsp: 3.404 ± 0.074
4.217ValGlu: 4.217 ± 0.092
2.665ValPhe: 2.665 ± 0.061
4.163ValGly: 4.163 ± 0.094
1.07ValHis: 1.07 ± 0.039
4.279ValIle: 4.279 ± 0.085
3.418ValLys: 3.418 ± 0.071
7.012ValLeu: 7.012 ± 0.121
1.949ValMet: 1.949 ± 0.052
2.614ValAsn: 2.614 ± 0.072
2.582ValPro: 2.582 ± 0.068
2.252ValGln: 2.252 ± 0.057
4.077ValArg: 4.077 ± 0.085
4.617ValSer: 4.617 ± 0.078
3.838ValThr: 3.838 ± 0.079
4.227ValVal: 4.227 ± 0.088
0.595ValTrp: 0.595 ± 0.029
2.268ValTyr: 2.268 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.636TrpAla: 0.636 ± 0.034
0.137TrpCys: 0.137 ± 0.014
0.468TrpAsp: 0.468 ± 0.03
0.62TrpGlu: 0.62 ± 0.034
0.391TrpPhe: 0.391 ± 0.024
0.626TrpGly: 0.626 ± 0.038
0.189TrpHis: 0.189 ± 0.014
0.618TrpIle: 0.618 ± 0.032
0.651TrpLys: 0.651 ± 0.039
0.92TrpLeu: 0.92 ± 0.035
0.35TrpMet: 0.35 ± 0.025
0.433TrpAsn: 0.433 ± 0.026
0.241TrpPro: 0.241 ± 0.019
0.337TrpGln: 0.337 ± 0.023
0.528TrpArg: 0.528 ± 0.028
0.472TrpSer: 0.472 ± 0.023
0.455TrpThr: 0.455 ± 0.021
0.475TrpVal: 0.475 ± 0.029
0.091TrpTrp: 0.091 ± 0.01
0.413TrpTyr: 0.413 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.908TyrAla: 2.908 ± 0.065
0.587TyrCys: 0.587 ± 0.03
2.235TyrAsp: 2.235 ± 0.059
2.676TyrGlu: 2.676 ± 0.069
1.525TyrPhe: 1.525 ± 0.048
2.949TyrGly: 2.949 ± 0.063
0.826TyrHis: 0.826 ± 0.037
2.184TyrIle: 2.184 ± 0.058
1.438TyrLys: 1.438 ± 0.054
3.508TyrLeu: 3.508 ± 0.071
0.881TyrMet: 0.881 ± 0.037
1.305TyrAsn: 1.305 ± 0.041
1.336TyrPro: 1.336 ± 0.044
1.28TyrGln: 1.28 ± 0.05
2.487TyrArg: 2.487 ± 0.066
2.142TyrSer: 2.142 ± 0.063
1.893TyrThr: 1.893 ± 0.054
2.177TyrVal: 2.177 ± 0.054
0.308TyrTrp: 0.308 ± 0.023
1.612TyrTyr: 1.612 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2187 proteins (714170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski