Amino acid dipepetide frequency for Burkholderiales bacterium YL45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.735AlaAla: 8.735 ± 0.163	1.3AlaCys: 1.3 ± 0.049	4.204AlaAsp: 4.204 ± 0.068	5.491AlaGlu: 5.491 ± 0.096	3.718AlaPhe: 3.718 ± 0.076	6.197AlaGly: 6.197 ± 0.102	1.367AlaHis: 1.367 ± 0.039	5.289AlaIle: 5.289 ± 0.098	5.631AlaLys: 5.631 ± 0.106	8.796AlaLeu: 8.796 ± 0.127	2.12AlaMet: 2.12 ± 0.054	3.009AlaAsn: 3.009 ± 0.073	3.168AlaPro: 3.168 ± 0.074	3.25AlaGln: 3.25 ± 0.064	3.616AlaArg: 3.616 ± 0.068	5.362AlaSer: 5.362 ± 0.087	3.591AlaThr: 3.591 ± 0.077	6.521AlaVal: 6.521 ± 0.101	0.96AlaTrp: 0.96 ± 0.035	2.156AlaTyr: 2.156 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.099CysAla: 1.099 ± 0.041	0.237CysCys: 0.237 ± 0.017	0.593CysAsp: 0.593 ± 0.026	0.679CysGlu: 0.679 ± 0.029	0.657CysPhe: 0.657 ± 0.031	1.233CysGly: 1.233 ± 0.043	0.374CysHis: 0.374 ± 0.035	0.809CysIle: 0.809 ± 0.034	0.685CysLys: 0.685 ± 0.034	1.398CysLeu: 1.398 ± 0.042	0.285CysMet: 0.285 ± 0.019	0.399CysAsn: 0.399 ± 0.024	0.729CysPro: 0.729 ± 0.036	0.426CysGln: 0.426 ± 0.025	0.634CysArg: 0.634 ± 0.028	1.032CysSer: 1.032 ± 0.043	0.675CysThr: 0.675 ± 0.031	0.932CysVal: 0.932 ± 0.04	0.162CysTrp: 0.162 ± 0.013	0.348CysTyr: 0.348 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.678AspAla: 3.678 ± 0.079	0.687AspCys: 0.687 ± 0.033	2.119AspAsp: 2.119 ± 0.053	3.395AspGlu: 3.395 ± 0.073	2.657AspPhe: 2.657 ± 0.068	3.456AspGly: 3.456 ± 0.071	0.826AspHis: 0.826 ± 0.033	3.263AspIle: 3.263 ± 0.072	3.573AspLys: 3.573 ± 0.083	5.064AspLeu: 5.064 ± 0.074	1.18AspMet: 1.18 ± 0.04	1.918AspAsn: 1.918 ± 0.049	2.712AspPro: 2.712 ± 0.058	1.449AspGln: 1.449 ± 0.044	2.225AspArg: 2.225 ± 0.054	3.136AspSer: 3.136 ± 0.065	2.181AspThr: 2.181 ± 0.053	3.345AspVal: 3.345 ± 0.074	0.725AspTrp: 0.725 ± 0.038	1.601AspTyr: 1.601 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.739GluAla: 5.739 ± 0.098	0.638GluCys: 0.638 ± 0.031	3.283GluAsp: 3.283 ± 0.066	5.354GluGlu: 5.354 ± 0.103	2.521GluPhe: 2.521 ± 0.063	4.24GluGly: 4.24 ± 0.083	1.099GluHis: 1.099 ± 0.036	4.684GluIle: 4.684 ± 0.093	5.996GluLys: 5.996 ± 0.087	6.479GluLeu: 6.479 ± 0.107	1.588GluMet: 1.588 ± 0.042	3.197GluAsn: 3.197 ± 0.072	2.317GluPro: 2.317 ± 0.061	2.511GluGln: 2.511 ± 0.059	3.335GluArg: 3.335 ± 0.074	3.249GluSer: 3.249 ± 0.061	3.253GluThr: 3.253 ± 0.073	4.543GluVal: 4.543 ± 0.073	0.657GluTrp: 0.657 ± 0.028	1.681GluTyr: 1.681 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.653PheAla: 3.653 ± 0.079	0.75PheCys: 0.75 ± 0.036	2.483PheAsp: 2.483 ± 0.066	2.668PheGlu: 2.668 ± 0.06	2.344PhePhe: 2.344 ± 0.063	3.607PheGly: 3.607 ± 0.068	0.671PheHis: 0.671 ± 0.031	2.794PheIle: 2.794 ± 0.061	2.574PheLys: 2.574 ± 0.058	4.721PheLeu: 4.721 ± 0.092	1.001PheMet: 1.001 ± 0.035	2.009PheAsn: 2.009 ± 0.053	1.701PhePro: 1.701 ± 0.048	1.346PheGln: 1.346 ± 0.041	1.691PheArg: 1.691 ± 0.045	3.664PheSer: 3.664 ± 0.089	2.094PheThr: 2.094 ± 0.052	3.176PheVal: 3.176 ± 0.067	0.572PheTrp: 0.572 ± 0.029	1.417PheTyr: 1.417 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.779GlyAla: 5.779 ± 0.1	1.087GlyCys: 1.087 ± 0.038	3.095GlyAsp: 3.095 ± 0.065	4.009GlyGlu: 4.009 ± 0.075	3.442GlyPhe: 3.442 ± 0.066	5.248GlyGly: 5.248 ± 0.141	1.325GlyHis: 1.325 ± 0.041	5.111GlyIle: 5.111 ± 0.09	5.419GlyLys: 5.419 ± 0.089	7.307GlyLeu: 7.307 ± 0.104	1.952GlyMet: 1.952 ± 0.052	2.653GlyAsn: 2.653 ± 0.066	2.078GlyPro: 2.078 ± 0.052	2.274GlyGln: 2.274 ± 0.054	3.315GlyArg: 3.315 ± 0.075	4.57GlySer: 4.57 ± 0.092	4.19GlyThr: 4.19 ± 0.073	5.318GlyVal: 5.318 ± 0.096	1.079GlyTrp: 1.079 ± 0.035	2.445GlyTyr: 2.445 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.292HisAla: 1.292 ± 0.04	0.307HisCys: 0.307 ± 0.018	0.824HisAsp: 0.824 ± 0.029	0.9HisGlu: 0.9 ± 0.036	0.789HisPhe: 0.789 ± 0.031	1.365HisGly: 1.365 ± 0.042	0.494HisHis: 0.494 ± 0.028	1.029HisIle: 1.029 ± 0.037	0.973HisLys: 0.973 ± 0.039	1.791HisLeu: 1.791 ± 0.053	0.431HisMet: 0.431 ± 0.025	0.734HisAsn: 0.734 ± 0.035	1.064HisPro: 1.064 ± 0.036	0.667HisGln: 0.667 ± 0.028	0.816HisArg: 0.816 ± 0.032	1.172HisSer: 1.172 ± 0.032	0.855HisThr: 0.855 ± 0.036	1.021HisVal: 1.021 ± 0.037	0.234HisTrp: 0.234 ± 0.016	0.627HisTyr: 0.627 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.686IleAla: 5.686 ± 0.1	0.995IleCys: 0.995 ± 0.041	3.416IleAsp: 3.416 ± 0.073	4.484IleGlu: 4.484 ± 0.081	2.891IlePhe: 2.891 ± 0.066	4.933IleGly: 4.933 ± 0.085	1.129IleHis: 1.129 ± 0.037	3.495IleIle: 3.495 ± 0.073	4.057IleLys: 4.057 ± 0.065	5.892IleLeu: 5.892 ± 0.091	1.17IleMet: 1.17 ± 0.046	2.809IleAsn: 2.809 ± 0.068	3.113IlePro: 3.113 ± 0.066	2.15IleGln: 2.15 ± 0.057	3.007IleArg: 3.007 ± 0.067	4.634IleSer: 4.634 ± 0.078	3.131IleThr: 3.131 ± 0.06	4.387IleVal: 4.387 ± 0.085	0.628IleTrp: 0.628 ± 0.028	1.776IleTyr: 1.776 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	6.036LysAla: 6.036 ± 0.096	0.606LysCys: 0.606 ± 0.032	4.178LysAsp: 4.178 ± 0.085	6.051LysGlu: 6.051 ± 0.107	2.449LysPhe: 2.449 ± 0.056	4.559LysGly: 4.559 ± 0.082	1.026LysHis: 1.026 ± 0.036	4.473LysIle: 4.473 ± 0.071	5.501LysLys: 5.501 ± 0.092	6.167LysLeu: 6.167 ± 0.09	1.836LysMet: 1.836 ± 0.052	3.554LysAsn: 3.554 ± 0.075	2.808LysPro: 2.808 ± 0.056	2.338LysGln: 2.338 ± 0.056	3.21LysArg: 3.21 ± 0.076	3.67LysSer: 3.67 ± 0.07	3.998LysThr: 3.998 ± 0.084	4.824LysVal: 4.824 ± 0.081	0.679LysTrp: 0.679 ± 0.032	1.828LysTyr: 1.828 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	8.537LeuAla: 8.537 ± 0.111	1.345LeuCys: 1.345 ± 0.048	4.904LeuAsp: 4.904 ± 0.08	6.304LeuGlu: 6.304 ± 0.099	4.289LeuPhe: 4.289 ± 0.097	7.282LeuGly: 7.282 ± 0.113	1.597LeuHis: 1.597 ± 0.043	6.306LeuIle: 6.306 ± 0.104	7.166LeuLys: 7.166 ± 0.102	9.559LeuLeu: 9.559 ± 0.151	2.298LeuMet: 2.298 ± 0.054	4.417LeuAsn: 4.417 ± 0.08	4.745LeuPro: 4.745 ± 0.083	3.27LeuGln: 3.27 ± 0.073	4.767LeuArg: 4.767 ± 0.09	7.57LeuSer: 7.57 ± 0.115	5.666LeuThr: 5.666 ± 0.083	6.416LeuVal: 6.416 ± 0.092	1.078LeuTrp: 1.078 ± 0.037	2.597LeuTyr: 2.597 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.257MetAla: 2.257 ± 0.06	0.259MetCys: 0.259 ± 0.02	1.169MetAsp: 1.169 ± 0.037	1.386MetGlu: 1.386 ± 0.049	0.89MetPhe: 0.89 ± 0.036	1.659MetGly: 1.659 ± 0.053	0.432MetHis: 0.432 ± 0.024	1.407MetIle: 1.407 ± 0.041	1.847MetLys: 1.847 ± 0.044	2.333MetLeu: 2.333 ± 0.054	0.632MetMet: 0.632 ± 0.028	1.204MetAsn: 1.204 ± 0.041	1.206MetPro: 1.206 ± 0.04	0.845MetGln: 0.845 ± 0.031	1.2MetArg: 1.2 ± 0.039	1.686MetSer: 1.686 ± 0.048	1.527MetThr: 1.527 ± 0.047	1.514MetVal: 1.514 ± 0.045	0.209MetTrp: 0.209 ± 0.017	0.489MetTyr: 0.489 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.257AsnAla: 3.257 ± 0.076	0.577AsnCys: 0.577 ± 0.035	1.778AsnAsp: 1.778 ± 0.058	2.47AsnGlu: 2.47 ± 0.057	2.036AsnPhe: 2.036 ± 0.055	3.072AsnGly: 3.072 ± 0.057	0.8AsnHis: 0.8 ± 0.034	2.511AsnIle: 2.511 ± 0.054	2.859AsnLys: 2.859 ± 0.063	4.432AsnLeu: 4.432 ± 0.081	0.925AsnMet: 0.925 ± 0.034	1.766AsnAsn: 1.766 ± 0.046	2.608AsnPro: 2.608 ± 0.058	1.487AsnGln: 1.487 ± 0.045	1.968AsnArg: 1.968 ± 0.05	2.842AsnSer: 2.842 ± 0.065	2.034AsnThr: 2.034 ± 0.052	2.652AsnVal: 2.652 ± 0.061	0.609AsnTrp: 0.609 ± 0.029	1.355AsnTyr: 1.355 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.639ProAla: 3.639 ± 0.085	0.46ProCys: 0.46 ± 0.024	2.331ProAsp: 2.331 ± 0.05	3.783ProGlu: 3.783 ± 0.074	1.948ProPhe: 1.948 ± 0.053	2.86ProGly: 2.86 ± 0.072	0.826ProHis: 0.826 ± 0.031	2.622ProIle: 2.622 ± 0.061	2.78ProLys: 2.78 ± 0.065	4.205ProLeu: 4.205 ± 0.079	1.043ProMet: 1.043 ± 0.036	1.861ProAsn: 1.861 ± 0.049	1.281ProPro: 1.281 ± 0.044	1.606ProGln: 1.606 ± 0.049	1.674ProArg: 1.674 ± 0.05	2.802ProSer: 2.802 ± 0.066	2.349ProThr: 2.349 ± 0.054	3.39ProVal: 3.39 ± 0.065	0.575ProTrp: 0.575 ± 0.03	1.331ProTyr: 1.331 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.1GlnAla: 3.1 ± 0.062	0.365GlnCys: 0.365 ± 0.024	1.512GlnAsp: 1.512 ± 0.044	2.508GlnGlu: 2.508 ± 0.066	1.434GlnPhe: 1.434 ± 0.049	2.107GlnGly: 2.107 ± 0.049	0.551GlnHis: 0.551 ± 0.026	2.439GlnIle: 2.439 ± 0.06	2.901GlnLys: 2.901 ± 0.066	3.295GlnLeu: 3.295 ± 0.061	0.937GlnMet: 0.937 ± 0.033	1.583GlnAsn: 1.583 ± 0.048	1.345GlnPro: 1.345 ± 0.048	1.391GlnGln: 1.391 ± 0.051	1.73GlnArg: 1.73 ± 0.054	1.914GlnSer: 1.914 ± 0.057	1.947GlnThr: 1.947 ± 0.054	2.283GlnVal: 2.283 ± 0.053	0.447GlnTrp: 0.447 ± 0.023	1.0GlnTyr: 1.0 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.45ArgAla: 3.45 ± 0.077	0.56ArgCys: 0.56 ± 0.027	2.166ArgAsp: 2.166 ± 0.06	3.214ArgGlu: 3.214 ± 0.073	2.115ArgPhe: 2.115 ± 0.051	2.864ArgGly: 2.864 ± 0.069	0.9ArgHis: 0.9 ± 0.035	3.133ArgIle: 3.133 ± 0.076	3.461ArgLys: 3.461 ± 0.065	4.808ArgLeu: 4.808 ± 0.086	1.206ArgMet: 1.206 ± 0.038	2.101ArgAsn: 2.101 ± 0.051	1.889ArgPro: 1.889 ± 0.055	1.796ArgGln: 1.796 ± 0.051	2.595ArgArg: 2.595 ± 0.056	2.749ArgSer: 2.749 ± 0.065	2.518ArgThr: 2.518 ± 0.055	2.857ArgVal: 2.857 ± 0.058	0.525ArgTrp: 0.525 ± 0.026	1.479ArgTyr: 1.479 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.266SerAla: 5.266 ± 0.096	0.875SerCys: 0.875 ± 0.038	3.114SerAsp: 3.114 ± 0.064	4.036SerGlu: 4.036 ± 0.081	3.218SerPhe: 3.218 ± 0.065	4.932SerGly: 4.932 ± 0.084	1.24SerHis: 1.24 ± 0.035	4.088SerIle: 4.088 ± 0.083	4.214SerLys: 4.214 ± 0.087	7.059SerLeu: 7.059 ± 0.102	1.611SerMet: 1.611 ± 0.052	2.463SerAsn: 2.463 ± 0.057	2.852SerPro: 2.852 ± 0.068	2.504SerGln: 2.504 ± 0.054	3.005SerArg: 3.005 ± 0.066	5.069SerSer: 5.069 ± 0.12	3.267SerThr: 3.267 ± 0.064	4.543SerVal: 4.543 ± 0.081	0.828SerTrp: 0.828 ± 0.035	1.982SerTyr: 1.982 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.598ThrAla: 4.598 ± 0.084	0.616ThrCys: 0.616 ± 0.034	2.584ThrAsp: 2.584 ± 0.054	3.056ThrGlu: 3.056 ± 0.066	2.333ThrPhe: 2.333 ± 0.056	4.201ThrGly: 4.201 ± 0.078	0.936ThrHis: 0.936 ± 0.031	3.279ThrIle: 3.279 ± 0.063	3.123ThrLys: 3.123 ± 0.071	5.086ThrLeu: 5.086 ± 0.087	1.138ThrMet: 1.138 ± 0.036	1.859ThrAsn: 1.859 ± 0.046	2.698ThrPro: 2.698 ± 0.066	1.712ThrGln: 1.712 ± 0.044	2.134ThrArg: 2.134 ± 0.058	3.326ThrSer: 3.326 ± 0.075	2.623ThrThr: 2.623 ± 0.065	4.222ThrVal: 4.222 ± 0.068	0.592ThrTrp: 0.592 ± 0.028	1.458ThrTyr: 1.458 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.625ValAla: 5.625 ± 0.088	1.093ValCys: 1.093 ± 0.033	3.501ValAsp: 3.501 ± 0.073	4.25ValGlu: 4.25 ± 0.063	3.191ValPhe: 3.191 ± 0.067	4.887ValGly: 4.887 ± 0.089	1.113ValHis: 1.113 ± 0.035	4.672ValIle: 4.672 ± 0.075	4.558ValLys: 4.558 ± 0.075	7.175ValLeu: 7.175 ± 0.107	1.78ValMet: 1.78 ± 0.05	2.878ValAsn: 2.878 ± 0.069	3.288ValPro: 3.288 ± 0.071	2.26ValGln: 2.26 ± 0.051	3.304ValArg: 3.304 ± 0.067	4.834ValSer: 4.834 ± 0.071	3.668ValThr: 3.668 ± 0.069	5.226ValVal: 5.226 ± 0.087	0.758ValTrp: 0.758 ± 0.036	1.842ValTyr: 1.842 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.823TrpAla: 0.823 ± 0.034	0.169TrpCys: 0.169 ± 0.015	0.537TrpAsp: 0.537 ± 0.025	0.638TrpGlu: 0.638 ± 0.026	0.513TrpPhe: 0.513 ± 0.028	0.749TrpGly: 0.749 ± 0.034	0.236TrpHis: 0.236 ± 0.017	0.892TrpIle: 0.892 ± 0.036	0.841TrpLys: 0.841 ± 0.035	1.491TrpLeu: 1.491 ± 0.047	0.391TrpMet: 0.391 ± 0.025	0.582TrpAsn: 0.582 ± 0.031	0.378TrpPro: 0.378 ± 0.024	0.45TrpGln: 0.45 ± 0.024	0.593TrpArg: 0.593 ± 0.029	0.725TrpSer: 0.725 ± 0.029	0.662TrpThr: 0.662 ± 0.03	0.773TrpVal: 0.773 ± 0.033	0.147TrpTrp: 0.147 ± 0.015	0.338TrpTyr: 0.338 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.232TyrAla: 2.232 ± 0.052	0.464TyrCys: 0.464 ± 0.029	1.401TyrAsp: 1.401 ± 0.042	1.689TyrGlu: 1.689 ± 0.044	1.501TyrPhe: 1.501 ± 0.044	2.247TyrGly: 2.247 ± 0.061	0.444TyrHis: 0.444 ± 0.021	1.486TyrIle: 1.486 ± 0.039	1.631TyrLys: 1.631 ± 0.049	3.053TyrLeu: 3.053 ± 0.069	0.626TyrMet: 0.626 ± 0.026	1.043TyrAsn: 1.043 ± 0.036	1.386TyrPro: 1.386 ± 0.043	1.056TyrGln: 1.056 ± 0.037	1.567TyrArg: 1.567 ± 0.05	2.156TyrSer: 2.156 ± 0.055	1.348TyrThr: 1.348 ± 0.041	1.958TyrVal: 1.958 ± 0.053	0.464TyrTrp: 0.464 ± 0.026	0.828TyrTyr: 0.828 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2449 proteins (802378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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