Amino acid dipepetide frequency for Pseudooceanicola nitratireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.05AlaAla: 16.05 ± 0.158	1.041AlaCys: 1.041 ± 0.031	7.27AlaAsp: 7.27 ± 0.083	7.949AlaGlu: 7.949 ± 0.107	4.219AlaPhe: 4.219 ± 0.067	10.539AlaGly: 10.539 ± 0.106	2.24AlaHis: 2.24 ± 0.048	5.839AlaIle: 5.839 ± 0.067	3.858AlaLys: 3.858 ± 0.062	13.986AlaLeu: 13.986 ± 0.145	3.794AlaMet: 3.794 ± 0.057	2.642AlaAsn: 2.642 ± 0.051	6.018AlaPro: 6.018 ± 0.087	4.805AlaGln: 4.805 ± 0.068	8.977AlaArg: 8.977 ± 0.113	5.631AlaSer: 5.631 ± 0.073	6.025AlaThr: 6.025 ± 0.076	8.342AlaVal: 8.342 ± 0.086	1.425AlaTrp: 1.425 ± 0.04	2.522AlaTyr: 2.522 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.032	0.102CysCys: 0.102 ± 0.008	0.625CysAsp: 0.625 ± 0.024	0.368CysGlu: 0.368 ± 0.017	0.305CysPhe: 0.305 ± 0.015	0.905CysGly: 0.905 ± 0.031	0.257CysHis: 0.257 ± 0.015	0.389CysIle: 0.389 ± 0.018	0.203CysLys: 0.203 ± 0.014	0.859CysLeu: 0.859 ± 0.026	0.166CysMet: 0.166 ± 0.012	0.202CysAsn: 0.202 ± 0.012	0.527CysPro: 0.527 ± 0.022	0.245CysGln: 0.245 ± 0.013	0.512CysArg: 0.512 ± 0.021	0.435CysSer: 0.435 ± 0.019	0.436CysThr: 0.436 ± 0.021	0.622CysVal: 0.622 ± 0.023	0.1CysTrp: 0.1 ± 0.01	0.207CysTyr: 0.207 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.476AspAla: 7.476 ± 0.088	0.528AspCys: 0.528 ± 0.022	3.569AspAsp: 3.569 ± 0.088	3.55AspGlu: 3.55 ± 0.069	2.445AspPhe: 2.445 ± 0.049	5.549AspGly: 5.549 ± 0.082	1.684AspHis: 1.684 ± 0.044	3.094AspIle: 3.094 ± 0.045	1.753AspLys: 1.753 ± 0.047	7.016AspLeu: 7.016 ± 0.088	1.791AspMet: 1.791 ± 0.04	1.282AspAsn: 1.282 ± 0.037	3.962AspPro: 3.962 ± 0.065	2.391AspGln: 2.391 ± 0.044	4.944AspArg: 4.944 ± 0.07	2.286AspSer: 2.286 ± 0.057	3.2AspThr: 3.2 ± 0.075	4.162AspVal: 4.162 ± 0.067	1.221AspTrp: 1.221 ± 0.035	1.593AspTyr: 1.593 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.831GluAla: 7.831 ± 0.103	0.353GluCys: 0.353 ± 0.017	3.807GluAsp: 3.807 ± 0.067	3.642GluGlu: 3.642 ± 0.072	1.716GluPhe: 1.716 ± 0.043	4.989GluGly: 4.989 ± 0.073	1.057GluHis: 1.057 ± 0.032	3.533GluIle: 3.533 ± 0.053	2.282GluLys: 2.282 ± 0.05	4.749GluLeu: 4.749 ± 0.075	1.863GluMet: 1.863 ± 0.041	1.698GluAsn: 1.698 ± 0.036	2.316GluPro: 2.316 ± 0.046	1.851GluGln: 1.851 ± 0.046	3.559GluArg: 3.559 ± 0.062	1.977GluSer: 1.977 ± 0.042	3.753GluThr: 3.753 ± 0.056	4.352GluVal: 4.352 ± 0.058	0.635GluTrp: 0.635 ± 0.021	1.045GluTyr: 1.045 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.46PheAla: 4.46 ± 0.07	0.393PheCys: 0.393 ± 0.016	2.928PheAsp: 2.928 ± 0.055	2.018PheGlu: 2.018 ± 0.043	1.402PhePhe: 1.402 ± 0.037	3.722PheGly: 3.722 ± 0.056	0.741PheHis: 0.741 ± 0.026	1.505PheIle: 1.505 ± 0.034	0.946PheLys: 0.946 ± 0.024	3.39PheLeu: 3.39 ± 0.06	0.794PheMet: 0.794 ± 0.028	1.033PheAsn: 1.033 ± 0.034	1.557PhePro: 1.557 ± 0.038	1.045PheGln: 1.045 ± 0.029	2.155PheArg: 2.155 ± 0.044	2.05PheSer: 2.05 ± 0.045	2.028PheThr: 2.028 ± 0.041	2.652PheVal: 2.652 ± 0.048	0.497PheTrp: 0.497 ± 0.023	0.904PheTyr: 0.904 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.06GlyAla: 10.06 ± 0.106	0.82GlyCys: 0.82 ± 0.026	5.154GlyAsp: 5.154 ± 0.083	4.676GlyGlu: 4.676 ± 0.067	3.664GlyPhe: 3.664 ± 0.061	7.649GlyGly: 7.649 ± 0.098	1.944GlyHis: 1.944 ± 0.044	4.436GlyIle: 4.436 ± 0.067	3.147GlyLys: 3.147 ± 0.055	9.36GlyLeu: 9.36 ± 0.113	2.733GlyMet: 2.733 ± 0.05	2.1GlyAsn: 2.1 ± 0.05	3.834GlyPro: 3.834 ± 0.064	3.395GlyGln: 3.395 ± 0.053	5.754GlyArg: 5.754 ± 0.081	4.403GlySer: 4.403 ± 0.065	4.847GlyThr: 4.847 ± 0.064	6.446GlyVal: 6.446 ± 0.075	1.459GlyTrp: 1.459 ± 0.037	2.354GlyTyr: 2.354 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.314HisAla: 2.314 ± 0.045	0.228HisCys: 0.228 ± 0.017	1.323HisAsp: 1.323 ± 0.039	0.979HisGlu: 0.979 ± 0.032	0.805HisPhe: 0.805 ± 0.026	1.956HisGly: 1.956 ± 0.042	0.572HisHis: 0.572 ± 0.028	0.949HisIle: 0.949 ± 0.028	0.506HisLys: 0.506 ± 0.02	2.125HisLeu: 2.125 ± 0.045	0.56HisMet: 0.56 ± 0.021	0.431HisAsn: 0.431 ± 0.019	1.419HisPro: 1.419 ± 0.037	0.628HisGln: 0.628 ± 0.024	1.303HisArg: 1.303 ± 0.036	0.924HisSer: 0.924 ± 0.03	0.766HisThr: 0.766 ± 0.026	1.572HisVal: 1.572 ± 0.037	0.358HisTrp: 0.358 ± 0.02	0.483HisTyr: 0.483 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.897IleAla: 6.897 ± 0.089	0.618IleCys: 0.618 ± 0.019	3.577IleAsp: 3.577 ± 0.057	3.436IleGlu: 3.436 ± 0.061	1.831IlePhe: 1.831 ± 0.048	4.982IleGly: 4.982 ± 0.068	0.865IleHis: 0.865 ± 0.031	2.091IleIle: 2.091 ± 0.049	1.417IleLys: 1.417 ± 0.039	4.948IleLeu: 4.948 ± 0.065	1.011IleMet: 1.011 ± 0.03	1.263IleAsn: 1.263 ± 0.035	2.333IlePro: 2.333 ± 0.042	1.311IleGln: 1.311 ± 0.038	3.34IleArg: 3.34 ± 0.057	2.855IleSer: 2.855 ± 0.048	2.99IleThr: 2.99 ± 0.053	3.701IleVal: 3.701 ± 0.064	0.714IleTrp: 0.714 ± 0.025	1.192IleTyr: 1.192 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.938LysAla: 3.938 ± 0.057	0.161LysCys: 0.161 ± 0.012	1.95LysAsp: 1.95 ± 0.048	1.643LysGlu: 1.643 ± 0.043	0.934LysPhe: 0.934 ± 0.03	2.799LysGly: 2.799 ± 0.062	0.618LysHis: 0.618 ± 0.022	1.691LysIle: 1.691 ± 0.041	1.231LysLys: 1.231 ± 0.039	2.886LysLeu: 2.886 ± 0.053	0.904LysMet: 0.904 ± 0.03	0.78LysAsn: 0.78 ± 0.028	1.756LysPro: 1.756 ± 0.044	0.884LysGln: 0.884 ± 0.03	2.167LysArg: 2.167 ± 0.05	1.856LysSer: 1.856 ± 0.046	1.972LysThr: 1.972 ± 0.045	2.465LysVal: 2.465 ± 0.049	0.375LysTrp: 0.375 ± 0.017	0.656LysTyr: 0.656 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.96LeuAla: 12.96 ± 0.122	0.899LeuCys: 0.899 ± 0.025	6.268LeuAsp: 6.268 ± 0.076	4.937LeuGlu: 4.937 ± 0.076	3.389LeuPhe: 3.389 ± 0.064	8.485LeuGly: 8.485 ± 0.099	1.802LeuHis: 1.802 ± 0.041	5.376LeuIle: 5.376 ± 0.085	3.29LeuLys: 3.29 ± 0.057	8.69LeuLeu: 8.69 ± 0.116	2.786LeuMet: 2.786 ± 0.054	2.709LeuAsn: 2.709 ± 0.044	5.733LeuPro: 5.733 ± 0.073	2.596LeuGln: 2.596 ± 0.047	7.207LeuArg: 7.207 ± 0.086	6.777LeuSer: 6.777 ± 0.093	6.581LeuThr: 6.581 ± 0.085	6.912LeuVal: 6.912 ± 0.081	1.275LeuTrp: 1.275 ± 0.036	1.953LeuTyr: 1.953 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.483MetAla: 3.483 ± 0.048	0.193MetCys: 0.193 ± 0.014	1.512MetAsp: 1.512 ± 0.039	1.427MetGlu: 1.427 ± 0.033	0.796MetPhe: 0.796 ± 0.026	2.33MetGly: 2.33 ± 0.043	0.446MetHis: 0.446 ± 0.018	1.623MetIle: 1.623 ± 0.036	1.128MetLys: 1.128 ± 0.029	2.625MetLeu: 2.625 ± 0.049	0.764MetMet: 0.764 ± 0.028	0.83MetAsn: 0.83 ± 0.026	1.524MetPro: 1.524 ± 0.039	1.037MetGln: 1.037 ± 0.03	1.863MetArg: 1.863 ± 0.041	1.822MetSer: 1.822 ± 0.036	2.271MetThr: 2.271 ± 0.044	1.911MetVal: 1.911 ± 0.042	0.229MetTrp: 0.229 ± 0.011	0.327MetTyr: 0.327 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.109AsnAla: 3.109 ± 0.045	0.268AsnCys: 0.268 ± 0.016	1.436AsnAsp: 1.436 ± 0.048	1.077AsnGlu: 1.077 ± 0.032	0.913AsnPhe: 0.913 ± 0.029	2.275AsnGly: 2.275 ± 0.046	0.467AsnHis: 0.467 ± 0.019	1.327AsnIle: 1.327 ± 0.036	0.645AsnLys: 0.645 ± 0.023	2.523AsnLeu: 2.523 ± 0.039	0.704AsnMet: 0.704 ± 0.024	0.647AsnAsn: 0.647 ± 0.025	1.83AsnPro: 1.83 ± 0.044	0.735AsnGln: 0.735 ± 0.025	1.801AsnArg: 1.801 ± 0.044	1.155AsnSer: 1.155 ± 0.034	1.303AsnThr: 1.303 ± 0.037	1.796AsnVal: 1.796 ± 0.043	0.375AsnTrp: 0.375 ± 0.017	0.635AsnTyr: 0.635 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.996ProAla: 5.996 ± 0.103	0.366ProCys: 0.366 ± 0.018	4.004ProAsp: 4.004 ± 0.061	4.254ProGlu: 4.254 ± 0.074	1.864ProPhe: 1.864 ± 0.039	4.755ProGly: 4.755 ± 0.066	1.039ProHis: 1.039 ± 0.03	2.241ProIle: 2.241 ± 0.049	1.716ProLys: 1.716 ± 0.041	4.826ProLeu: 4.826 ± 0.076	1.367ProMet: 1.367 ± 0.036	1.257ProAsn: 1.257 ± 0.039	2.254ProPro: 2.254 ± 0.048	1.88ProGln: 1.88 ± 0.041	2.974ProArg: 2.974 ± 0.058	2.501ProSer: 2.501 ± 0.05	2.394ProThr: 2.394 ± 0.047	4.335ProVal: 4.335 ± 0.072	0.642ProTrp: 0.642 ± 0.024	1.17ProTyr: 1.17 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.576GlnAla: 4.576 ± 0.068	0.203GlnCys: 0.203 ± 0.013	1.962GlnAsp: 1.962 ± 0.036	1.65GlnGlu: 1.65 ± 0.035	1.066GlnPhe: 1.066 ± 0.032	2.885GlnGly: 2.885 ± 0.047	0.594GlnHis: 0.594 ± 0.024	2.139GlnIle: 2.139 ± 0.046	1.098GlnLys: 1.098 ± 0.034	2.921GlnLeu: 2.921 ± 0.045	1.128GlnMet: 1.128 ± 0.032	0.846GlnAsn: 0.846 ± 0.027	1.652GlnPro: 1.652 ± 0.041	1.109GlnGln: 1.109 ± 0.036	2.024GlnArg: 2.024 ± 0.04	1.776GlnSer: 1.776 ± 0.037	1.842GlnThr: 1.842 ± 0.037	2.66GlnVal: 2.66 ± 0.043	0.36GlnTrp: 0.36 ± 0.017	0.555GlnTyr: 0.555 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.375ArgAla: 8.375 ± 0.106	0.456ArgCys: 0.456 ± 0.02	4.73ArgAsp: 4.73 ± 0.063	3.515ArgGlu: 3.515 ± 0.057	2.557ArgPhe: 2.557 ± 0.048	4.764ArgGly: 4.764 ± 0.071	1.527ArgHis: 1.527 ± 0.039	3.994ArgIle: 3.994 ± 0.062	2.289ArgLys: 2.289 ± 0.042	7.131ArgLeu: 7.131 ± 0.105	1.995ArgMet: 1.995 ± 0.038	1.784ArgAsn: 1.784 ± 0.041	3.388ArgPro: 3.388 ± 0.06	2.343ArgGln: 2.343 ± 0.045	5.012ArgArg: 5.012 ± 0.073	3.192ArgSer: 3.192 ± 0.057	2.995ArgThr: 2.995 ± 0.054	4.74ArgVal: 4.74 ± 0.064	0.819ArgTrp: 0.819 ± 0.027	1.512ArgTyr: 1.512 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.737SerAla: 5.737 ± 0.079	0.43SerCys: 0.43 ± 0.02	3.457SerAsp: 3.457 ± 0.059	2.702SerGlu: 2.702 ± 0.045	2.145SerPhe: 2.145 ± 0.044	5.422SerGly: 5.422 ± 0.071	1.069SerHis: 1.069 ± 0.029	2.407SerIle: 2.407 ± 0.054	1.477SerLys: 1.477 ± 0.037	5.014SerLeu: 5.014 ± 0.069	1.429SerMet: 1.429 ± 0.036	1.308SerAsn: 1.308 ± 0.033	2.541SerPro: 2.541 ± 0.042	1.574SerGln: 1.574 ± 0.039	3.187SerArg: 3.187 ± 0.055	2.569SerSer: 2.569 ± 0.05	2.49SerThr: 2.49 ± 0.05	3.786SerVal: 3.786 ± 0.057	0.67SerTrp: 0.67 ± 0.024	1.339SerTyr: 1.339 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.34ThrAla: 6.34 ± 0.091	0.476ThrCys: 0.476 ± 0.023	3.368ThrAsp: 3.368 ± 0.056	2.967ThrGlu: 2.967 ± 0.048	2.01ThrPhe: 2.01 ± 0.043	5.725ThrGly: 5.725 ± 0.082	1.099ThrHis: 1.099 ± 0.028	2.742ThrIle: 2.742 ± 0.052	1.493ThrLys: 1.493 ± 0.038	6.215ThrLeu: 6.215 ± 0.078	1.292ThrMet: 1.292 ± 0.032	1.258ThrAsn: 1.258 ± 0.032	3.735ThrPro: 3.735 ± 0.062	1.756ThrGln: 1.756 ± 0.043	3.764ThrArg: 3.764 ± 0.057	2.603ThrSer: 2.603 ± 0.046	2.956ThrThr: 2.956 ± 0.057	3.916ThrVal: 3.916 ± 0.075	0.739ThrTrp: 0.739 ± 0.025	1.314ThrTyr: 1.314 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.679ValAla: 8.679 ± 0.102	0.611ValCys: 0.611 ± 0.024	4.076ValAsp: 4.076 ± 0.057	4.382ValGlu: 4.382 ± 0.064	2.753ValPhe: 2.753 ± 0.054	5.316ValGly: 5.316 ± 0.082	1.318ValHis: 1.318 ± 0.033	4.327ValIle: 4.327 ± 0.072	2.167ValLys: 2.167 ± 0.052	7.63ValLeu: 7.63 ± 0.096	2.123ValMet: 2.123 ± 0.041	1.98ValAsn: 1.98 ± 0.041	3.729ValPro: 3.729 ± 0.061	2.234ValGln: 2.234 ± 0.046	4.051ValArg: 4.051 ± 0.054	4.058ValSer: 4.058 ± 0.068	5.001ValThr: 5.001 ± 0.076	5.607ValVal: 5.607 ± 0.091	0.879ValTrp: 0.879 ± 0.032	1.46ValTyr: 1.46 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.249TrpAla: 1.249 ± 0.035	0.125TrpCys: 0.125 ± 0.01	0.812TrpAsp: 0.812 ± 0.032	0.588TrpGlu: 0.588 ± 0.024	0.511TrpPhe: 0.511 ± 0.019	1.023TrpGly: 1.023 ± 0.028	0.34TrpHis: 0.34 ± 0.015	0.747TrpIle: 0.747 ± 0.026	0.453TrpLys: 0.453 ± 0.02	1.512TrpLeu: 1.512 ± 0.037	0.432TrpMet: 0.432 ± 0.018	0.403TrpAsn: 0.403 ± 0.02	0.668TrpPro: 0.668 ± 0.03	0.556TrpGln: 0.556 ± 0.021	0.969TrpArg: 0.969 ± 0.033	0.797TrpSer: 0.797 ± 0.028	0.789TrpThr: 0.789 ± 0.029	0.884TrpVal: 0.884 ± 0.029	0.197TrpTrp: 0.197 ± 0.015	0.275TrpTyr: 0.275 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.584TyrAla: 2.584 ± 0.048	0.247TyrCys: 0.247 ± 0.013	1.668TyrAsp: 1.668 ± 0.044	1.248TyrGlu: 1.248 ± 0.036	0.895TyrPhe: 0.895 ± 0.034	2.165TyrGly: 2.165 ± 0.041	0.524TyrHis: 0.524 ± 0.023	0.923TyrIle: 0.923 ± 0.032	0.565TyrLys: 0.565 ± 0.023	2.224TyrLeu: 2.224 ± 0.04	0.507TyrMet: 0.507 ± 0.021	0.565TyrAsn: 0.565 ± 0.022	1.059TyrPro: 1.059 ± 0.029	0.673TyrGln: 0.673 ± 0.025	1.554TyrArg: 1.554 ± 0.036	1.084TyrSer: 1.084 ± 0.033	1.129TyrThr: 1.129 ± 0.031	1.521TyrVal: 1.521 ± 0.036	0.361TyrTrp: 0.361 ± 0.015	0.604TyrTyr: 0.604 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3828 proteins (1200732 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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