Amino acid dipepetide frequency for Anolis carolinensis (Green anole) (American chameleon)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.757AlaAla: 5.757 ± 0.036	1.289AlaCys: 1.289 ± 0.014	2.777AlaAsp: 2.777 ± 0.018	4.535AlaGlu: 4.535 ± 0.037	2.615AlaPhe: 2.615 ± 0.021	3.893AlaGly: 3.893 ± 0.03	1.47AlaHis: 1.47 ± 0.012	2.991AlaIle: 2.991 ± 0.021	3.676AlaLys: 3.676 ± 0.025	6.493AlaLeu: 6.493 ± 0.035	1.464AlaMet: 1.464 ± 0.014	2.231AlaAsn: 2.231 ± 0.016	3.146AlaPro: 3.146 ± 0.029	2.794AlaGln: 2.794 ± 0.024	3.096AlaArg: 3.096 ± 0.021	5.32AlaSer: 5.32 ± 0.028	3.412AlaThr: 3.412 ± 0.024	4.364AlaVal: 4.364 ± 0.025	0.735AlaTrp: 0.735 ± 0.01	1.583AlaTyr: 1.583 ± 0.015	0.0AlaXaa: 0.0 ± 0.0
Cys	1.184CysAla: 1.184 ± 0.015	0.633CysCys: 0.633 ± 0.01	1.015CysAsp: 1.015 ± 0.014	1.294CysGlu: 1.294 ± 0.017	1.051CysPhe: 1.051 ± 0.016	2.388CysGly: 2.388 ± 0.042	0.669CysHis: 0.669 ± 0.009	1.141CysIle: 1.141 ± 0.013	1.282CysLys: 1.282 ± 0.014	2.687CysLeu: 2.687 ± 0.031	0.55CysMet: 0.55 ± 0.013	0.922CysAsn: 0.922 ± 0.011	1.326CysPro: 1.326 ± 0.02	1.188CysGln: 1.188 ± 0.019	1.213CysArg: 1.213 ± 0.013	2.028CysSer: 2.028 ± 0.019	1.144CysThr: 1.144 ± 0.014	1.244CysVal: 1.244 ± 0.015	0.311CysTrp: 0.311 ± 0.006	0.639CysTyr: 0.639 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	2.767AspAla: 2.767 ± 0.021	1.11AspCys: 1.11 ± 0.014	2.64AspAsp: 2.64 ± 0.024	3.449AspGlu: 3.449 ± 0.024	2.163AspPhe: 2.163 ± 0.019	3.215AspGly: 3.215 ± 0.027	1.134AspHis: 1.134 ± 0.012	2.822AspIle: 2.822 ± 0.02	2.643AspLys: 2.643 ± 0.022	4.885AspLeu: 4.885 ± 0.031	1.135AspMet: 1.135 ± 0.012	1.914AspAsn: 1.914 ± 0.019	2.66AspPro: 2.66 ± 0.021	1.771AspGln: 1.771 ± 0.014	2.283AspArg: 2.283 ± 0.018	3.908AspSer: 3.908 ± 0.028	2.339AspThr: 2.339 ± 0.018	3.001AspVal: 3.001 ± 0.031	0.627AspTrp: 0.627 ± 0.01	1.576AspTyr: 1.576 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	4.83GluAla: 4.83 ± 0.035	2.158GluCys: 2.158 ± 0.044	4.269GluAsp: 4.269 ± 0.024	8.147GluGlu: 8.147 ± 0.066	2.107GluPhe: 2.107 ± 0.016	4.061GluGly: 4.061 ± 0.027	1.477GluHis: 1.477 ± 0.011	3.551GluIle: 3.551 ± 0.023	6.45GluLys: 6.45 ± 0.055	6.036GluLeu: 6.036 ± 0.042	1.84GluMet: 1.84 ± 0.015	3.315GluAsn: 3.315 ± 0.022	2.685GluPro: 2.685 ± 0.018	3.032GluGln: 3.032 ± 0.023	4.037GluArg: 4.037 ± 0.029	4.426GluSer: 4.426 ± 0.033	3.498GluThr: 3.498 ± 0.023	3.986GluVal: 3.986 ± 0.027	0.757GluTrp: 0.757 ± 0.01	1.699GluTyr: 1.699 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	2.318PheAla: 2.318 ± 0.021	0.999PheCys: 0.999 ± 0.012	1.722PheAsp: 1.722 ± 0.015	2.049PheGlu: 2.049 ± 0.016	1.73PhePhe: 1.73 ± 0.019	2.283PheGly: 2.283 ± 0.018	1.125PheHis: 1.125 ± 0.013	2.027PheIle: 2.027 ± 0.018	2.031PheLys: 2.031 ± 0.02	4.271PheLeu: 4.271 ± 0.027	0.799PheMet: 0.799 ± 0.009	1.499PheAsn: 1.499 ± 0.015	2.055PhePro: 2.055 ± 0.02	1.87PheGln: 1.87 ± 0.014	1.973PheArg: 1.973 ± 0.016	3.647PheSer: 3.647 ± 0.027	2.342PheThr: 2.342 ± 0.024	2.261PheVal: 2.261 ± 0.019	0.53PheTrp: 0.53 ± 0.008	1.27PheTyr: 1.27 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	3.669GlyAla: 3.669 ± 0.028	1.23GlyCys: 1.23 ± 0.016	2.938GlyAsp: 2.938 ± 0.026	4.726GlyGlu: 4.726 ± 0.05	2.502GlyPhe: 2.502 ± 0.022	4.656GlyGly: 4.656 ± 0.045	1.613GlyHis: 1.613 ± 0.017	3.051GlyIle: 3.051 ± 0.021	4.478GlyLys: 4.478 ± 0.035	5.462GlyLeu: 5.462 ± 0.036	1.354GlyMet: 1.354 ± 0.018	2.607GlyAsn: 2.607 ± 0.02	3.168GlyPro: 3.168 ± 0.066	2.791GlyGln: 2.791 ± 0.026	3.339GlyArg: 3.339 ± 0.02	5.209GlySer: 5.209 ± 0.04	3.336GlyThr: 3.336 ± 0.024	3.242GlyVal: 3.242 ± 0.022	0.756GlyTrp: 0.756 ± 0.011	1.809GlyTyr: 1.809 ± 0.017	0.001GlyXaa: 0.001 ± 0.0
His	1.296HisAla: 1.296 ± 0.01	0.717HisCys: 0.717 ± 0.009	0.924HisAsp: 0.924 ± 0.009	1.399HisGlu: 1.399 ± 0.014	1.132HisPhe: 1.132 ± 0.012	1.481HisGly: 1.481 ± 0.014	0.926HisHis: 0.926 ± 0.015	1.332HisIle: 1.332 ± 0.012	1.547HisLys: 1.547 ± 0.02	2.971HisLeu: 2.971 ± 0.023	0.578HisMet: 0.578 ± 0.008	1.029HisAsn: 1.029 ± 0.011	1.524HisPro: 1.524 ± 0.015	1.914HisGln: 1.914 ± 0.033	1.533HisArg: 1.533 ± 0.016	2.335HisSer: 2.335 ± 0.02	2.16HisThr: 2.16 ± 0.042	1.381HisVal: 1.381 ± 0.014	0.358HisTrp: 0.358 ± 0.006	0.844HisTyr: 0.844 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.866IleAla: 2.866 ± 0.018	1.264IleCys: 1.264 ± 0.014	2.251IleAsp: 2.251 ± 0.017	2.889IleGlu: 2.889 ± 0.022	2.056IlePhe: 2.056 ± 0.018	2.469IleGly: 2.469 ± 0.02	1.589IleHis: 1.589 ± 0.017	2.741IleIle: 2.741 ± 0.023	2.992IleLys: 2.992 ± 0.021	4.94IleLeu: 4.94 ± 0.028	1.079IleMet: 1.079 ± 0.013	2.094IleAsn: 2.094 ± 0.019	2.772IlePro: 2.772 ± 0.021	2.472IleGln: 2.472 ± 0.018	2.486IleArg: 2.486 ± 0.017	4.051IleSer: 4.051 ± 0.023	2.785IleThr: 2.785 ± 0.02	2.792IleVal: 2.792 ± 0.019	0.622IleTrp: 0.622 ± 0.009	1.591IleTyr: 1.591 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.106LysAla: 4.106 ± 0.023	1.801LysCys: 1.801 ± 0.035	3.344LysAsp: 3.344 ± 0.025	5.677LysGlu: 5.677 ± 0.042	1.773LysPhe: 1.773 ± 0.016	3.655LysGly: 3.655 ± 0.042	1.626LysHis: 1.626 ± 0.016	3.201LysIle: 3.201 ± 0.023	5.219LysLys: 5.219 ± 0.037	5.449LysLeu: 5.449 ± 0.033	1.6LysMet: 1.6 ± 0.016	2.713LysAsn: 2.713 ± 0.021	3.809LysPro: 3.809 ± 0.045	2.825LysGln: 2.825 ± 0.023	3.693LysArg: 3.693 ± 0.027	4.361LysSer: 4.361 ± 0.029	3.335LysThr: 3.335 ± 0.018	3.585LysVal: 3.585 ± 0.024	0.701LysTrp: 0.701 ± 0.011	1.771LysTyr: 1.771 ± 0.017	0.001LysXaa: 0.001 ± 0.0
Leu	6.195LeuAla: 6.195 ± 0.039	2.158LeuCys: 2.158 ± 0.018	4.709LeuAsp: 4.709 ± 0.028	7.256LeuGlu: 7.256 ± 0.047	3.539LeuPhe: 3.539 ± 0.025	5.182LeuGly: 5.182 ± 0.028	2.923LeuHis: 2.923 ± 0.022	4.121LeuIle: 4.121 ± 0.023	6.242LeuLys: 6.242 ± 0.035	10.185LeuLeu: 10.185 ± 0.058	2.002LeuMet: 2.002 ± 0.016	3.792LeuAsn: 3.792 ± 0.022	5.521LeuPro: 5.521 ± 0.032	5.461LeuGln: 5.461 ± 0.034	5.622LeuArg: 5.622 ± 0.036	7.784LeuSer: 7.784 ± 0.035	4.793LeuThr: 4.793 ± 0.021	5.31LeuVal: 5.31 ± 0.031	1.097LeuTrp: 1.097 ± 0.013	2.702LeuTyr: 2.702 ± 0.019	0.001LeuXaa: 0.001 ± 0.0
Met	1.812MetAla: 1.812 ± 0.015	0.421MetCys: 0.421 ± 0.007	1.298MetAsp: 1.298 ± 0.011	2.082MetGlu: 2.082 ± 0.018	0.79MetPhe: 0.79 ± 0.01	1.312MetGly: 1.312 ± 0.014	0.509MetHis: 0.509 ± 0.007	0.94MetIle: 0.94 ± 0.01	1.579MetLys: 1.579 ± 0.014	1.973MetLeu: 1.973 ± 0.018	0.593MetMet: 0.593 ± 0.008	0.973MetAsn: 0.973 ± 0.011	1.106MetPro: 1.106 ± 0.02	0.984MetGln: 0.984 ± 0.01	1.052MetArg: 1.052 ± 0.01	1.57MetSer: 1.57 ± 0.011	1.113MetThr: 1.113 ± 0.011	1.391MetVal: 1.391 ± 0.013	0.255MetTrp: 0.255 ± 0.005	0.619MetTyr: 0.619 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.333AsnAla: 2.333 ± 0.02	1.063AsnCys: 1.063 ± 0.015	1.688AsnAsp: 1.688 ± 0.017	2.466AsnGlu: 2.466 ± 0.018	1.599AsnPhe: 1.599 ± 0.014	2.766AsnGly: 2.766 ± 0.029	1.03AsnHis: 1.03 ± 0.011	2.49AsnIle: 2.49 ± 0.02	2.549AsnLys: 2.549 ± 0.019	4.032AsnLeu: 4.032 ± 0.023	1.011AsnMet: 1.011 ± 0.011	1.906AsnAsn: 1.906 ± 0.02	2.234AsnPro: 2.234 ± 0.016	1.744AsnGln: 1.744 ± 0.016	1.963AsnArg: 1.963 ± 0.014	3.316AsnSer: 3.316 ± 0.022	2.131AsnThr: 2.131 ± 0.017	2.383AsnVal: 2.383 ± 0.018	0.537AsnTrp: 0.537 ± 0.007	1.275AsnTyr: 1.275 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	3.643ProAla: 3.643 ± 0.028	1.082ProCys: 1.082 ± 0.018	2.552ProAsp: 2.552 ± 0.025	3.96ProGlu: 3.96 ± 0.026	2.126ProPhe: 2.126 ± 0.022	3.99ProGly: 3.99 ± 0.08	1.37ProHis: 1.37 ± 0.016	2.046ProIle: 2.046 ± 0.017	2.881ProLys: 2.881 ± 0.038	4.755ProLeu: 4.755 ± 0.026	0.999ProMet: 0.999 ± 0.011	1.973ProAsn: 1.973 ± 0.015	4.985ProPro: 4.985 ± 0.055	2.355ProGln: 2.355 ± 0.021	2.66ProArg: 2.66 ± 0.021	5.057ProSer: 5.057 ± 0.034	2.706ProThr: 2.706 ± 0.023	3.463ProVal: 3.463 ± 0.025	0.599ProTrp: 0.599 ± 0.009	2.044ProTyr: 2.044 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.076GlnAla: 3.076 ± 0.026	1.125GlnCys: 1.125 ± 0.02	2.158GlnAsp: 2.158 ± 0.017	3.783GlnGlu: 3.783 ± 0.032	1.418GlnPhe: 1.418 ± 0.012	2.54GlnGly: 2.54 ± 0.023	1.258GlnHis: 1.258 ± 0.011	2.161GlnIle: 2.161 ± 0.016	3.219GlnLys: 3.219 ± 0.025	4.436GlnLeu: 4.436 ± 0.027	1.115GlnMet: 1.115 ± 0.012	2.065GlnAsn: 2.065 ± 0.015	2.328GlnPro: 2.328 ± 0.023	2.966GlnGln: 2.966 ± 0.04	3.28GlnArg: 3.28 ± 0.035	3.424GlnSer: 3.424 ± 0.028	2.295GlnThr: 2.295 ± 0.018	2.602GlnVal: 2.602 ± 0.018	0.54GlnTrp: 0.54 ± 0.009	1.224GlnTyr: 1.224 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	3.089ArgAla: 3.089 ± 0.019	1.159ArgCys: 1.159 ± 0.015	2.51ArgAsp: 2.51 ± 0.018	3.731ArgGlu: 3.731 ± 0.026	1.967ArgPhe: 1.967 ± 0.016	3.12ArgGly: 3.12 ± 0.031	1.623ArgHis: 1.623 ± 0.017	2.73ArgIle: 2.73 ± 0.017	3.892ArgLys: 3.892 ± 0.029	4.985ArgLeu: 4.985 ± 0.031	1.207ArgMet: 1.207 ± 0.01	2.273ArgAsn: 2.273 ± 0.017	2.614ArgPro: 2.614 ± 0.021	2.452ArgGln: 2.452 ± 0.019	3.968ArgArg: 3.968 ± 0.029	4.318ArgSer: 4.318 ± 0.041	3.102ArgThr: 3.102 ± 0.028	2.775ArgVal: 2.775 ± 0.016	0.691ArgTrp: 0.691 ± 0.009	1.483ArgTyr: 1.483 ± 0.013	0.001ArgXaa: 0.001 ± 0.0
Ser	4.973SerAla: 4.973 ± 0.029	1.836SerCys: 1.836 ± 0.019	3.843SerAsp: 3.843 ± 0.027	4.97SerGlu: 4.97 ± 0.033	3.774SerPhe: 3.774 ± 0.035	5.35SerGly: 5.35 ± 0.03	2.516SerHis: 2.516 ± 0.027	3.569SerIle: 3.569 ± 0.022	4.309SerLys: 4.309 ± 0.027	8.019SerLeu: 8.019 ± 0.038	1.596SerMet: 1.596 ± 0.014	3.038SerAsn: 3.038 ± 0.019	5.277SerPro: 5.277 ± 0.042	3.715SerGln: 3.715 ± 0.023	4.128SerArg: 4.128 ± 0.028	9.292SerSer: 9.292 ± 0.063	4.34SerThr: 4.34 ± 0.036	4.677SerVal: 4.677 ± 0.026	1.009SerTrp: 1.009 ± 0.011	2.177SerTyr: 2.177 ± 0.017	0.001SerXaa: 0.001 ± 0.0
Thr	3.518ThrAla: 3.518 ± 0.023	1.434ThrCys: 1.434 ± 0.02	2.507ThrAsp: 2.507 ± 0.022	3.626ThrGlu: 3.626 ± 0.02	2.193ThrPhe: 2.193 ± 0.017	4.072ThrGly: 4.072 ± 0.042	1.876ThrHis: 1.876 ± 0.036	2.608ThrIle: 2.608 ± 0.021	2.841ThrLys: 2.841 ± 0.02	5.085ThrLeu: 5.085 ± 0.025	1.125ThrMet: 1.125 ± 0.011	1.881ThrAsn: 1.881 ± 0.014	3.022ThrPro: 3.022 ± 0.023	2.187ThrGln: 2.187 ± 0.016	2.303ThrArg: 2.303 ± 0.016	4.455ThrSer: 4.455 ± 0.037	3.024ThrThr: 3.024 ± 0.048	3.712ThrVal: 3.712 ± 0.024	0.694ThrTrp: 0.694 ± 0.009	1.486ThrTyr: 1.486 ± 0.014	0.001ThrXaa: 0.001 ± 0.0
Val	4.006ValAla: 4.006 ± 0.024	1.445ValCys: 1.445 ± 0.014	2.846ValAsp: 2.846 ± 0.024	3.759ValGlu: 3.759 ± 0.027	2.466ValPhe: 2.466 ± 0.019	3.137ValGly: 3.137 ± 0.02	1.544ValHis: 1.544 ± 0.016	3.031ValIle: 3.031 ± 0.022	3.535ValLys: 3.535 ± 0.024	5.858ValLeu: 5.858 ± 0.032	1.332ValMet: 1.332 ± 0.013	2.338ValAsn: 2.338 ± 0.02	3.267ValPro: 3.267 ± 0.024	2.623ValGln: 2.623 ± 0.018	2.758ValArg: 2.758 ± 0.018	4.668ValSer: 4.668 ± 0.026	3.471ValThr: 3.471 ± 0.022	3.872ValVal: 3.872 ± 0.027	0.699ValTrp: 0.699 ± 0.009	1.679ValTyr: 1.679 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.712TrpAla: 0.712 ± 0.009	0.241TrpCys: 0.241 ± 0.005	0.676TrpAsp: 0.676 ± 0.01	0.823TrpGlu: 0.823 ± 0.01	0.445TrpPhe: 0.445 ± 0.007	0.648TrpGly: 0.648 ± 0.011	0.31TrpHis: 0.31 ± 0.006	0.659TrpIle: 0.659 ± 0.009	0.926TrpLys: 0.926 ± 0.01	1.245TrpLeu: 1.245 ± 0.012	0.34TrpMet: 0.34 ± 0.006	0.582TrpAsn: 0.582 ± 0.008	0.457TrpPro: 0.457 ± 0.008	0.523TrpGln: 0.523 ± 0.007	0.719TrpArg: 0.719 ± 0.009	0.894TrpSer: 0.894 ± 0.012	0.66TrpThr: 0.66 ± 0.009	0.678TrpVal: 0.678 ± 0.009	0.202TrpTrp: 0.202 ± 0.005	0.364TrpTyr: 0.364 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.492TyrAla: 1.492 ± 0.014	0.744TyrCys: 0.744 ± 0.01	1.374TyrAsp: 1.374 ± 0.014	1.741TyrGlu: 1.741 ± 0.016	1.354TyrPhe: 1.354 ± 0.014	1.715TyrGly: 1.715 ± 0.017	0.793TyrHis: 0.793 ± 0.009	1.59TyrIle: 1.59 ± 0.015	1.955TyrLys: 1.955 ± 0.025	2.827TyrLeu: 2.827 ± 0.02	0.652TyrMet: 0.652 ± 0.008	1.369TyrAsn: 1.369 ± 0.016	1.289TyrPro: 1.289 ± 0.013	1.344TyrGln: 1.344 ± 0.017	1.583TyrArg: 1.583 ± 0.015	2.345TyrSer: 2.345 ± 0.019	1.663TyrThr: 1.663 ± 0.015	1.618TyrVal: 1.618 ± 0.014	0.387TyrTrp: 0.387 ± 0.007	1.077TyrTyr: 1.077 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.039XaaXaa: 0.039 ± 0.011

Statistics based on 19108 proteins (10131167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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