Amino acid dipepetide frequency for Acidovorax sp. MR-S7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.24AlaAla: 20.24 ± 0.211
1.582AlaCys: 1.582 ± 0.03
6.399AlaAsp: 6.399 ± 0.063
6.678AlaGlu: 6.678 ± 0.075
4.13AlaPhe: 4.13 ± 0.049
11.916AlaGly: 11.916 ± 0.122
3.108AlaHis: 3.108 ± 0.046
4.968AlaIle: 4.968 ± 0.061
3.523AlaLys: 3.523 ± 0.071
16.614AlaLeu: 16.614 ± 0.156
3.592AlaMet: 3.592 ± 0.053
2.526AlaAsn: 2.526 ± 0.045
7.555AlaPro: 7.555 ± 0.096
7.414AlaGln: 7.414 ± 0.093
10.437AlaArg: 10.437 ± 0.109
6.637AlaSer: 6.637 ± 0.081
6.377AlaThr: 6.377 ± 0.08
9.681AlaVal: 9.681 ± 0.096
2.261AlaTrp: 2.261 ± 0.049
2.46AlaTyr: 2.46 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.38CysAla: 1.38 ± 0.032
0.13CysCys: 0.13 ± 0.01
0.534CysAsp: 0.534 ± 0.021
0.526CysGlu: 0.526 ± 0.018
0.31CysPhe: 0.31 ± 0.014
1.03CysGly: 1.03 ± 0.03
0.277CysHis: 0.277 ± 0.014
0.435CysIle: 0.435 ± 0.017
0.217CysLys: 0.217 ± 0.011
0.879CysLeu: 0.879 ± 0.025
0.26CysMet: 0.26 ± 0.014
0.229CysAsn: 0.229 ± 0.012
0.504CysPro: 0.504 ± 0.019
0.293CysGln: 0.293 ± 0.012
0.563CysArg: 0.563 ± 0.02
0.502CysSer: 0.502 ± 0.021
0.575CysThr: 0.575 ± 0.023
0.804CysVal: 0.804 ± 0.024
0.123CysTrp: 0.123 ± 0.009
0.207CysTyr: 0.207 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.512AspAla: 7.512 ± 0.077
0.455AspCys: 0.455 ± 0.017
2.449AspAsp: 2.449 ± 0.039
2.818AspGlu: 2.818 ± 0.043
1.963AspPhe: 1.963 ± 0.035
4.689AspGly: 4.689 ± 0.059
1.1AspHis: 1.1 ± 0.033
2.168AspIle: 2.168 ± 0.041
1.578AspLys: 1.578 ± 0.033
5.077AspLeu: 5.077 ± 0.057
1.32AspMet: 1.32 ± 0.03
1.123AspAsn: 1.123 ± 0.028
2.732AspPro: 2.732 ± 0.042
1.464AspGln: 1.464 ± 0.032
3.02AspArg: 3.02 ± 0.049
1.965AspSer: 1.965 ± 0.032
2.54AspThr: 2.54 ± 0.041
3.974AspVal: 3.974 ± 0.057
0.973AspTrp: 0.973 ± 0.024
1.345AspTyr: 1.345 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
6.909GluAla: 6.909 ± 0.07
0.444GluCys: 0.444 ± 0.019
2.253GluAsp: 2.253 ± 0.042
2.456GluGlu: 2.456 ± 0.054
1.585GluPhe: 1.585 ± 0.037
3.978GluGly: 3.978 ± 0.063
1.363GluHis: 1.363 ± 0.032
2.387GluIle: 2.387 ± 0.043
1.661GluLys: 1.661 ± 0.038
5.508GluLeu: 5.508 ± 0.069
1.22GluMet: 1.22 ± 0.028
1.159GluAsn: 1.159 ± 0.027
2.451GluPro: 2.451 ± 0.041
2.525GluGln: 2.525 ± 0.042
4.925GluArg: 4.925 ± 0.07
2.299GluSer: 2.299 ± 0.039
2.239GluThr: 2.239 ± 0.04
3.94GluVal: 3.94 ± 0.047
0.714GluTrp: 0.714 ± 0.022
0.984GluTyr: 0.984 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.289PheAla: 4.289 ± 0.055
0.375PheCys: 0.375 ± 0.016
2.32PheAsp: 2.32 ± 0.04
1.83PheGlu: 1.83 ± 0.034
1.186PhePhe: 1.186 ± 0.029
3.18PheGly: 3.18 ± 0.052
0.726PheHis: 0.726 ± 0.025
1.38PheIle: 1.38 ± 0.032
1.07PheLys: 1.07 ± 0.031
2.714PheLeu: 2.714 ± 0.049
0.751PheMet: 0.751 ± 0.026
0.963PheAsn: 0.963 ± 0.028
1.462PhePro: 1.462 ± 0.034
1.068PheGln: 1.068 ± 0.029
1.74PheArg: 1.74 ± 0.033
1.902PheSer: 1.902 ± 0.036
1.991PheThr: 1.991 ± 0.039
2.516PheVal: 2.516 ± 0.041
0.489PheTrp: 0.489 ± 0.021
0.811PheTyr: 0.811 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.567GlyAla: 10.567 ± 0.115
0.971GlyCys: 0.971 ± 0.03
3.99GlyAsp: 3.99 ± 0.054
4.42GlyGlu: 4.42 ± 0.054
3.15GlyPhe: 3.15 ± 0.048
7.736GlyGly: 7.736 ± 0.099
2.0GlyHis: 2.0 ± 0.034
3.745GlyIle: 3.745 ± 0.052
2.933GlyLys: 2.933 ± 0.053
9.199GlyLeu: 9.199 ± 0.098
2.544GlyMet: 2.544 ± 0.041
2.107GlyAsn: 2.107 ± 0.041
3.309GlyPro: 3.309 ± 0.056
3.802GlyGln: 3.802 ± 0.054
5.846GlyArg: 5.846 ± 0.06
4.581GlySer: 4.581 ± 0.051
4.874GlyThr: 4.874 ± 0.071
6.808GlyVal: 6.808 ± 0.073
1.567GlyTrp: 1.567 ± 0.039
2.411GlyTyr: 2.411 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
3.454HisAla: 3.454 ± 0.055
0.312HisCys: 0.312 ± 0.012
1.184HisAsp: 1.184 ± 0.03
1.163HisGlu: 1.163 ± 0.029
0.869HisPhe: 0.869 ± 0.028
2.3HisGly: 2.3 ± 0.043
0.648HisHis: 0.648 ± 0.022
0.986HisIle: 0.986 ± 0.022
0.571HisLys: 0.571 ± 0.021
2.43HisLeu: 2.43 ± 0.041
0.55HisMet: 0.55 ± 0.017
0.473HisAsn: 0.473 ± 0.017
1.571HisPro: 1.571 ± 0.035
0.792HisGln: 0.792 ± 0.022
1.539HisArg: 1.539 ± 0.034
1.002HisSer: 1.002 ± 0.027
1.203HisThr: 1.203 ± 0.03
1.698HisVal: 1.698 ± 0.035
0.489HisTrp: 0.489 ± 0.022
0.626HisTyr: 0.626 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.092IleAla: 6.092 ± 0.072
0.354IleCys: 0.354 ± 0.018
2.746IleAsp: 2.746 ± 0.044
2.68IleGlu: 2.68 ± 0.047
1.066IlePhe: 1.066 ± 0.03
3.785IleGly: 3.785 ± 0.059
0.845IleHis: 0.845 ± 0.027
1.216IleIle: 1.216 ± 0.033
1.275IleLys: 1.275 ± 0.034
3.039IleLeu: 3.039 ± 0.056
0.651IleMet: 0.651 ± 0.023
1.176IleAsn: 1.176 ± 0.028
1.878IlePro: 1.878 ± 0.032
1.271IleGln: 1.271 ± 0.026
2.349IleArg: 2.349 ± 0.04
2.008IleSer: 2.008 ± 0.037
2.349IleThr: 2.349 ± 0.043
3.338IleVal: 3.338 ± 0.054
0.402IleTrp: 0.402 ± 0.016
0.822IleTyr: 0.822 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
3.685LysAla: 3.685 ± 0.072
0.147LysCys: 0.147 ± 0.01
1.595LysAsp: 1.595 ± 0.04
1.445LysGlu: 1.445 ± 0.037
0.789LysPhe: 0.789 ± 0.027
2.279LysGly: 2.279 ± 0.046
0.586LysHis: 0.586 ± 0.021
1.253LysIle: 1.253 ± 0.033
1.231LysLys: 1.231 ± 0.038
3.008LysLeu: 3.008 ± 0.052
0.725LysMet: 0.725 ± 0.02
0.852LysAsn: 0.852 ± 0.026
1.808LysPro: 1.808 ± 0.036
1.093LysGln: 1.093 ± 0.028
1.942LysArg: 1.942 ± 0.033
1.51LysSer: 1.51 ± 0.034
1.74LysThr: 1.74 ± 0.04
2.184LysVal: 2.184 ± 0.047
0.332LysTrp: 0.332 ± 0.015
0.577LysTyr: 0.577 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
16.522LeuAla: 16.522 ± 0.152
1.114LeuCys: 1.114 ± 0.027
5.605LeuAsp: 5.605 ± 0.072
5.097LeuGlu: 5.097 ± 0.065
3.176LeuPhe: 3.176 ± 0.046
9.067LeuGly: 9.067 ± 0.095
2.745LeuHis: 2.745 ± 0.051
3.709LeuIle: 3.709 ± 0.056
3.056LeuLys: 3.056 ± 0.047
11.667LeuLeu: 11.667 ± 0.132
2.377LeuMet: 2.377 ± 0.043
2.368LeuAsn: 2.368 ± 0.041
6.669LeuPro: 6.669 ± 0.074
4.767LeuGln: 4.767 ± 0.065
8.434LeuArg: 8.434 ± 0.079
5.523LeuSer: 5.523 ± 0.063
4.946LeuThr: 4.946 ± 0.063
7.779LeuVal: 7.779 ± 0.082
1.466LeuTrp: 1.466 ± 0.038
2.068LeuTyr: 2.068 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.312MetAla: 3.312 ± 0.057
0.169MetCys: 0.169 ± 0.01
1.164MetAsp: 1.164 ± 0.031
1.161MetGlu: 1.161 ± 0.029
0.694MetPhe: 0.694 ± 0.024
2.034MetGly: 2.034 ± 0.038
0.616MetHis: 0.616 ± 0.02
0.794MetIle: 0.794 ± 0.024
0.878MetLys: 0.878 ± 0.022
2.616MetLeu: 2.616 ± 0.044
0.487MetMet: 0.487 ± 0.019
0.714MetAsn: 0.714 ± 0.02
1.519MetPro: 1.519 ± 0.031
1.178MetGln: 1.178 ± 0.025
1.835MetArg: 1.835 ± 0.036
1.37MetSer: 1.37 ± 0.034
1.459MetThr: 1.459 ± 0.031
1.766MetVal: 1.766 ± 0.032
0.202MetTrp: 0.202 ± 0.012
0.37MetTyr: 0.37 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.12AsnAla: 3.12 ± 0.054
0.235AsnCys: 0.235 ± 0.013
1.16AsnAsp: 1.16 ± 0.027
1.009AsnGlu: 1.009 ± 0.026
0.795AsnPhe: 0.795 ± 0.022
2.023AsnGly: 2.023 ± 0.044
0.488AsnHis: 0.488 ± 0.018
0.986AsnIle: 0.986 ± 0.027
0.742AsnLys: 0.742 ± 0.025
2.355AsnLeu: 2.355 ± 0.042
0.519AsnMet: 0.519 ± 0.017
0.626AsnAsn: 0.626 ± 0.022
1.689AsnPro: 1.689 ± 0.035
0.847AsnGln: 0.847 ± 0.028
1.522AsnArg: 1.522 ± 0.033
0.973AsnSer: 0.973 ± 0.025
1.284AsnThr: 1.284 ± 0.036
1.841AsnVal: 1.841 ± 0.037
0.374AsnTrp: 0.374 ± 0.016
0.606AsnTyr: 0.606 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.11ProAla: 8.11 ± 0.096
0.409ProCys: 0.409 ± 0.018
3.069ProAsp: 3.069 ± 0.039
3.239ProGlu: 3.239 ± 0.05
1.757ProPhe: 1.757 ± 0.035
5.253ProGly: 5.253 ± 0.066
1.314ProHis: 1.314 ± 0.03
1.841ProIle: 1.841 ± 0.035
1.303ProLys: 1.303 ± 0.037
5.8ProLeu: 5.8 ± 0.074
1.309ProMet: 1.309 ± 0.028
1.089ProAsn: 1.089 ± 0.032
3.208ProPro: 3.208 ± 0.06
2.588ProGln: 2.588 ± 0.045
3.411ProArg: 3.411 ± 0.047
2.622ProSer: 2.622 ± 0.042
2.485ProThr: 2.485 ± 0.04
4.449ProVal: 4.449 ± 0.06
0.909ProTrp: 0.909 ± 0.024
1.27ProTyr: 1.27 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
6.935GlnAla: 6.935 ± 0.093
0.359GlnCys: 0.359 ± 0.014
1.937GlnAsp: 1.937 ± 0.041
2.018GlnGlu: 2.018 ± 0.042
1.219GlnPhe: 1.219 ± 0.029
3.681GlnGly: 3.681 ± 0.058
1.061GlnHis: 1.061 ± 0.029
1.708GlnIle: 1.708 ± 0.031
1.04GlnLys: 1.04 ± 0.031
4.267GlnLeu: 4.267 ± 0.062
0.991GlnMet: 0.991 ± 0.024
0.822GlnAsn: 0.822 ± 0.028
2.653GlnPro: 2.653 ± 0.045
2.111GlnGln: 2.111 ± 0.043
3.767GlnArg: 3.767 ± 0.056
2.038GlnSer: 2.038 ± 0.042
1.863GlnThr: 1.863 ± 0.037
3.201GlnVal: 3.201 ± 0.049
0.796GlnTrp: 0.796 ± 0.022
0.795GlnTyr: 0.795 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.028ArgAla: 9.028 ± 0.09
0.627ArgCys: 0.627 ± 0.023
3.339ArgAsp: 3.339 ± 0.054
4.193ArgGlu: 4.193 ± 0.058
2.682ArgPhe: 2.682 ± 0.042
5.032ArgGly: 5.032 ± 0.057
2.004ArgHis: 2.004 ± 0.04
3.441ArgIle: 3.441 ± 0.045
2.007ArgLys: 2.007 ± 0.036
8.453ArgLeu: 8.453 ± 0.089
2.093ArgMet: 2.093 ± 0.039
1.681ArgAsn: 1.681 ± 0.037
3.543ArgPro: 3.543 ± 0.048
3.238ArgGln: 3.238 ± 0.043
5.439ArgArg: 5.439 ± 0.071
3.392ArgSer: 3.392 ± 0.051
3.512ArgThr: 3.512 ± 0.054
5.14ArgVal: 5.14 ± 0.06
1.332ArgTrp: 1.332 ± 0.03
1.824ArgTyr: 1.824 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.333SerAla: 6.333 ± 0.073
0.426SerCys: 0.426 ± 0.017
2.339SerAsp: 2.339 ± 0.037
2.247SerGlu: 2.247 ± 0.039
1.792SerPhe: 1.792 ± 0.035
4.975SerGly: 4.975 ± 0.058
1.155SerHis: 1.155 ± 0.028
2.104SerIle: 2.104 ± 0.038
1.323SerLys: 1.323 ± 0.031
5.161SerLeu: 5.161 ± 0.066
1.228SerMet: 1.228 ± 0.027
1.195SerAsn: 1.195 ± 0.035
2.846SerPro: 2.846 ± 0.052
1.773SerGln: 1.773 ± 0.037
3.195SerArg: 3.195 ± 0.048
2.781SerSer: 2.781 ± 0.049
2.681SerThr: 2.681 ± 0.046
3.748SerVal: 3.748 ± 0.049
0.659SerTrp: 0.659 ± 0.022
1.183SerTyr: 1.183 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.239ThrAla: 6.239 ± 0.085
0.444ThrCys: 0.444 ± 0.018
2.434ThrAsp: 2.434 ± 0.046
2.15ThrGlu: 2.15 ± 0.031
1.659ThrPhe: 1.659 ± 0.035
4.818ThrGly: 4.818 ± 0.068
1.233ThrHis: 1.233 ± 0.029
1.873ThrIle: 1.873 ± 0.038
1.076ThrLys: 1.076 ± 0.028
6.308ThrLeu: 6.308 ± 0.06
1.074ThrMet: 1.074 ± 0.031
1.119ThrAsn: 1.119 ± 0.033
3.719ThrPro: 3.719 ± 0.054
2.06ThrGln: 2.06 ± 0.042
3.309ThrArg: 3.309 ± 0.056
2.474ThrSer: 2.474 ± 0.042
2.646ThrThr: 2.646 ± 0.053
4.298ThrVal: 4.298 ± 0.065
0.686ThrTrp: 0.686 ± 0.02
1.111ThrTyr: 1.111 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.961ValAla: 9.961 ± 0.094
0.78ValCys: 0.78 ± 0.023
3.855ValAsp: 3.855 ± 0.054
4.135ValGlu: 4.135 ± 0.053
2.569ValPhe: 2.569 ± 0.056
5.68ValGly: 5.68 ± 0.068
1.719ValHis: 1.719 ± 0.035
3.01ValIle: 3.01 ± 0.056
2.179ValLys: 2.179 ± 0.043
8.605ValLeu: 8.605 ± 0.076
1.772ValMet: 1.772 ± 0.034
2.009ValAsn: 2.009 ± 0.035
4.402ValPro: 4.402 ± 0.054
3.306ValGln: 3.306 ± 0.051
5.695ValArg: 5.695 ± 0.065
3.656ValSer: 3.656 ± 0.048
3.951ValThr: 3.951 ± 0.063
6.329ValVal: 6.329 ± 0.075
0.983ValTrp: 0.983 ± 0.026
1.485ValTyr: 1.485 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.635TrpAla: 1.635 ± 0.035
0.19TrpCys: 0.19 ± 0.01
0.683TrpAsp: 0.683 ± 0.026
0.581TrpGlu: 0.581 ± 0.017
0.547TrpPhe: 0.547 ± 0.021
1.091TrpGly: 1.091 ± 0.027
0.418TrpHis: 0.418 ± 0.02
0.62TrpIle: 0.62 ± 0.021
0.429TrpLys: 0.429 ± 0.016
2.148TrpLeu: 2.148 ± 0.048
0.455TrpMet: 0.455 ± 0.017
0.447TrpAsn: 0.447 ± 0.018
0.805TrpPro: 0.805 ± 0.028
0.833TrpGln: 0.833 ± 0.027
1.356TrpArg: 1.356 ± 0.032
0.826TrpSer: 0.826 ± 0.027
0.722TrpThr: 0.722 ± 0.024
1.034TrpVal: 1.034 ± 0.028
0.303TrpTrp: 0.303 ± 0.016
0.286TrpTyr: 0.286 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.777TyrAla: 2.777 ± 0.044
0.253TyrCys: 0.253 ± 0.012
1.21TyrAsp: 1.21 ± 0.025
1.152TyrGlu: 1.152 ± 0.03
0.825TyrPhe: 0.825 ± 0.023
2.013TyrGly: 2.013 ± 0.036
0.454TyrHis: 0.454 ± 0.017
0.719TyrIle: 0.719 ± 0.024
0.691TyrLys: 0.691 ± 0.024
2.312TyrLeu: 2.312 ± 0.039
0.42TyrMet: 0.42 ± 0.017
0.515TyrAsn: 0.515 ± 0.019
1.11TyrPro: 1.11 ± 0.031
0.842TyrGln: 0.842 ± 0.025
1.675TyrArg: 1.675 ± 0.034
1.082TyrSer: 1.082 ± 0.027
1.292TyrThr: 1.292 ± 0.032
1.554TyrVal: 1.554 ± 0.033
0.348TyrTrp: 0.348 ± 0.015
0.56TyrTyr: 0.56 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4762 proteins (1533141 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski