Amino acid dipepetide frequency for Lactobacillus versmoldensis DSM 14857 = KCTC 3814

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.312AlaAla: 5.312 ± 0.108	0.35AlaCys: 0.35 ± 0.023	4.542AlaAsp: 4.542 ± 0.09	3.883AlaGlu: 3.883 ± 0.088	2.993AlaPhe: 2.993 ± 0.073	5.156AlaGly: 5.156 ± 0.105	1.205AlaHis: 1.205 ± 0.05	5.81AlaIle: 5.81 ± 0.108	5.14AlaLys: 5.14 ± 0.089	6.446AlaLeu: 6.446 ± 0.161	1.965AlaMet: 1.965 ± 0.058	3.635AlaAsn: 3.635 ± 0.072	2.116AlaPro: 2.116 ± 0.055	2.846AlaGln: 2.846 ± 0.07	2.149AlaArg: 2.149 ± 0.058	4.243AlaSer: 4.243 ± 0.099	4.327AlaThr: 4.327 ± 0.092	5.042AlaVal: 5.042 ± 0.101	0.588AlaTrp: 0.588 ± 0.032	2.207AlaTyr: 2.207 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.301CysAla: 0.301 ± 0.021	0.044CysCys: 0.044 ± 0.009	0.266CysAsp: 0.266 ± 0.019	0.202CysGlu: 0.202 ± 0.016	0.24CysPhe: 0.24 ± 0.018	0.502CysGly: 0.502 ± 0.03	0.128CysHis: 0.128 ± 0.015	0.324CysIle: 0.324 ± 0.021	0.199CysLys: 0.199 ± 0.018	0.484CysLeu: 0.484 ± 0.03	0.118CysMet: 0.118 ± 0.015	0.208CysAsn: 0.208 ± 0.02	0.231CysPro: 0.231 ± 0.02	0.192CysGln: 0.192 ± 0.019	0.163CysArg: 0.163 ± 0.015	0.315CysSer: 0.315 ± 0.021	0.237CysThr: 0.237 ± 0.017	0.308CysVal: 0.308 ± 0.019	0.046CysTrp: 0.046 ± 0.009	0.167CysTyr: 0.167 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.925AspAla: 3.925 ± 0.079	0.286AspCys: 0.286 ± 0.021	4.523AspAsp: 4.523 ± 0.121	4.395AspGlu: 4.395 ± 0.093	3.167AspPhe: 3.167 ± 0.075	3.886AspGly: 3.886 ± 0.087	1.343AspHis: 1.343 ± 0.041	4.472AspIle: 4.472 ± 0.08	4.78AspLys: 4.78 ± 0.083	6.174AspLeu: 6.174 ± 0.103	1.464AspMet: 1.464 ± 0.046	3.401AspAsn: 3.401 ± 0.078	2.53AspPro: 2.53 ± 0.063	3.315AspGln: 3.315 ± 0.085	2.18AspArg: 2.18 ± 0.062	4.022AspSer: 4.022 ± 0.095	3.229AspThr: 3.229 ± 0.068	4.221AspVal: 4.221 ± 0.082	0.694AspTrp: 0.694 ± 0.031	2.749AspTyr: 2.749 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	3.529GluAla: 3.529 ± 0.074	0.189GluCys: 0.189 ± 0.018	3.315GluAsp: 3.315 ± 0.079	3.164GluGlu: 3.164 ± 0.08	2.303GluPhe: 2.303 ± 0.057	2.551GluGly: 2.551 ± 0.073	1.117GluHis: 1.117 ± 0.042	4.455GluIle: 4.455 ± 0.083	4.83GluLys: 4.83 ± 0.087	5.319GluLeu: 5.319 ± 0.103	1.774GluMet: 1.774 ± 0.052	3.475GluAsn: 3.475 ± 0.089	1.683GluPro: 1.683 ± 0.062	2.654GluGln: 2.654 ± 0.072	1.969GluArg: 1.969 ± 0.065	3.049GluSer: 3.049 ± 0.06	3.263GluThr: 3.263 ± 0.071	3.489GluVal: 3.489 ± 0.075	0.479GluTrp: 0.479 ± 0.027	1.944GluTyr: 1.944 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.125PheAla: 3.125 ± 0.069	0.277PheCys: 0.277 ± 0.022	3.102PheAsp: 3.102 ± 0.06	2.376PheGlu: 2.376 ± 0.063	2.071PhePhe: 2.071 ± 0.074	3.225PheGly: 3.225 ± 0.075	0.809PheHis: 0.809 ± 0.034	3.349PheIle: 3.349 ± 0.084	2.728PheLys: 2.728 ± 0.065	4.057PheLeu: 4.057 ± 0.098	1.106PheMet: 1.106 ± 0.043	2.464PheAsn: 2.464 ± 0.063	1.432PhePro: 1.432 ± 0.046	1.506PheGln: 1.506 ± 0.053	1.275PheArg: 1.275 ± 0.049	3.266PheSer: 3.266 ± 0.078	2.532PheThr: 2.532 ± 0.058	3.123PheVal: 3.123 ± 0.078	0.502PheTrp: 0.502 ± 0.028	1.647PheTyr: 1.647 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.475GlyAla: 4.475 ± 0.104	0.391GlyCys: 0.391 ± 0.025	3.627GlyAsp: 3.627 ± 0.08	3.115GlyGlu: 3.115 ± 0.062	3.193GlyPhe: 3.193 ± 0.075	4.179GlyGly: 4.179 ± 0.1	1.419GlyHis: 1.419 ± 0.05	5.743GlyIle: 5.743 ± 0.111	4.696GlyLys: 4.696 ± 0.082	6.286GlyLeu: 6.286 ± 0.199	1.908GlyMet: 1.908 ± 0.045	3.154GlyAsn: 3.154 ± 0.075	1.621GlyPro: 1.621 ± 0.044	2.71GlyGln: 2.71 ± 0.066	2.148GlyArg: 2.148 ± 0.054	4.499GlySer: 4.499 ± 0.094	4.183GlyThr: 4.183 ± 0.079	4.772GlyVal: 4.772 ± 0.084	0.694GlyTrp: 0.694 ± 0.034	2.58GlyTyr: 2.58 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.194HisAla: 1.194 ± 0.035	0.091HisCys: 0.091 ± 0.012	1.205HisAsp: 1.205 ± 0.039	1.066HisGlu: 1.066 ± 0.044	0.918HisPhe: 0.918 ± 0.037	1.426HisGly: 1.426 ± 0.049	0.558HisHis: 0.558 ± 0.029	1.271HisIle: 1.271 ± 0.038	1.099HisLys: 1.099 ± 0.045	1.86HisLeu: 1.86 ± 0.05	0.437HisMet: 0.437 ± 0.024	0.934HisAsn: 0.934 ± 0.041	0.963HisPro: 0.963 ± 0.039	1.011HisGln: 1.011 ± 0.042	0.736HisArg: 0.736 ± 0.03	1.199HisSer: 1.199 ± 0.042	0.906HisThr: 0.906 ± 0.036	1.249HisVal: 1.249 ± 0.045	0.195HisTrp: 0.195 ± 0.017	0.791HisTyr: 0.791 ± 0.042	0.0HisXaa: 0.0 ± 0.0
Ile	6.067IleAla: 6.067 ± 0.122	0.484IleCys: 0.484 ± 0.027	5.152IleAsp: 5.152 ± 0.087	4.057IleGlu: 4.057 ± 0.084	3.678IlePhe: 3.678 ± 0.09	5.588IleGly: 5.588 ± 0.113	1.374IleHis: 1.374 ± 0.046	6.019IleIle: 6.019 ± 0.124	5.294IleLys: 5.294 ± 0.085	7.189IleLeu: 7.189 ± 0.136	1.925IleMet: 1.925 ± 0.052	4.136IleAsn: 4.136 ± 0.081	3.09IlePro: 3.09 ± 0.085	2.538IleGln: 2.538 ± 0.06	2.393IleArg: 2.393 ± 0.06	5.455IleSer: 5.455 ± 0.091	4.455IleThr: 4.455 ± 0.078	5.698IleVal: 5.698 ± 0.092	0.642IleTrp: 0.642 ± 0.035	2.514IleTyr: 2.514 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	4.693LysAla: 4.693 ± 0.09	0.189LysCys: 0.189 ± 0.018	4.709LysAsp: 4.709 ± 0.083	4.394LysGlu: 4.394 ± 0.091	2.665LysPhe: 2.665 ± 0.059	3.45LysGly: 3.45 ± 0.079	1.348LysHis: 1.348 ± 0.039	5.714LysIle: 5.714 ± 0.11	6.431LysLys: 6.431 ± 0.129	6.531LysLeu: 6.531 ± 0.098	2.386LysMet: 2.386 ± 0.062	4.586LysAsn: 4.586 ± 0.1	2.358LysPro: 2.358 ± 0.064	3.148LysGln: 3.148 ± 0.071	2.691LysArg: 2.691 ± 0.071	4.329LysSer: 4.329 ± 0.098	4.515LysThr: 4.515 ± 0.082	4.782LysVal: 4.782 ± 0.085	0.61LysTrp: 0.61 ± 0.03	3.02LysTyr: 3.02 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	7.211LeuAla: 7.211 ± 0.167	0.449LeuCys: 0.449 ± 0.023	5.704LeuAsp: 5.704 ± 0.098	4.48LeuGlu: 4.48 ± 0.082	3.937LeuPhe: 3.937 ± 0.111	6.412LeuGly: 6.412 ± 0.148	1.557LeuHis: 1.557 ± 0.043	7.361LeuIle: 7.361 ± 0.153	6.844LeuLys: 6.844 ± 0.105	9.074LeuLeu: 9.074 ± 0.456	2.418LeuMet: 2.418 ± 0.056	5.254LeuAsn: 5.254 ± 0.103	3.913LeuPro: 3.913 ± 0.161	3.43LeuGln: 3.43 ± 0.083	3.122LeuArg: 3.122 ± 0.069	6.591LeuSer: 6.591 ± 0.098	6.007LeuThr: 6.007 ± 0.115	6.592LeuVal: 6.592 ± 0.13	0.781LeuTrp: 0.781 ± 0.035	2.654LeuTyr: 2.654 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.026MetAla: 2.026 ± 0.058	0.105MetCys: 0.105 ± 0.013	1.6MetAsp: 1.6 ± 0.054	1.226MetGlu: 1.226 ± 0.04	1.072MetPhe: 1.072 ± 0.047	1.706MetGly: 1.706 ± 0.051	0.46MetHis: 0.46 ± 0.03	2.258MetIle: 2.258 ± 0.061	2.107MetLys: 2.107 ± 0.061	2.207MetLeu: 2.207 ± 0.066	0.829MetMet: 0.829 ± 0.04	1.555MetAsn: 1.555 ± 0.054	1.133MetPro: 1.133 ± 0.041	0.993MetGln: 0.993 ± 0.038	0.969MetArg: 0.969 ± 0.035	1.843MetSer: 1.843 ± 0.057	1.894MetThr: 1.894 ± 0.044	1.764MetVal: 1.764 ± 0.049	0.186MetTrp: 0.186 ± 0.016	0.727MetTyr: 0.727 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.356AsnAla: 3.356 ± 0.074	0.296AsnCys: 0.296 ± 0.025	3.78AsnAsp: 3.78 ± 0.083	2.9AsnGlu: 2.9 ± 0.066	2.312AsnPhe: 2.312 ± 0.055	3.854AsnGly: 3.854 ± 0.101	1.131AsnHis: 1.131 ± 0.052	3.941AsnIle: 3.941 ± 0.079	3.881AsnLys: 3.881 ± 0.086	4.956AsnLeu: 4.956 ± 0.098	1.423AsnMet: 1.423 ± 0.043	3.591AsnAsn: 3.591 ± 0.111	2.161AsnPro: 2.161 ± 0.057	2.832AsnGln: 2.832 ± 0.097	1.911AsnArg: 1.911 ± 0.057	3.746AsnSer: 3.746 ± 0.09	2.817AsnThr: 2.817 ± 0.077	3.597AsnVal: 3.597 ± 0.08	0.606AsnTrp: 0.606 ± 0.03	2.191AsnTyr: 2.191 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.373ProAla: 2.373 ± 0.06	0.129ProCys: 0.129 ± 0.012	2.606ProAsp: 2.606 ± 0.068	2.821ProGlu: 2.821 ± 0.075	1.586ProPhe: 1.586 ± 0.053	2.158ProGly: 2.158 ± 0.061	0.623ProHis: 0.623 ± 0.027	2.784ProIle: 2.784 ± 0.09	2.432ProLys: 2.432 ± 0.062	3.174ProLeu: 3.174 ± 0.175	0.852ProMet: 0.852 ± 0.038	1.907ProAsn: 1.907 ± 0.057	0.523ProPro: 0.523 ± 0.029	1.403ProGln: 1.403 ± 0.05	1.009ProArg: 1.009 ± 0.037	2.071ProSer: 2.071 ± 0.058	2.19ProThr: 2.19 ± 0.06	2.804ProVal: 2.804 ± 0.075	0.347ProTrp: 0.347 ± 0.027	1.371ProTyr: 1.371 ± 0.048	0.001ProXaa: 0.001 ± 0.001
Gln	3.526GlnAla: 3.526 ± 0.1	0.126GlnCys: 0.126 ± 0.015	2.171GlnAsp: 2.171 ± 0.061	2.31GlnGlu: 2.31 ± 0.062	1.638GlnPhe: 1.638 ± 0.052	2.123GlnGly: 2.123 ± 0.06	0.768GlnHis: 0.768 ± 0.034	3.267GlnIle: 3.267 ± 0.078	3.488GlnLys: 3.488 ± 0.08	4.205GlnLeu: 4.205 ± 0.098	1.227GlnMet: 1.227 ± 0.045	2.329GlnAsn: 2.329 ± 0.073	1.394GlnPro: 1.394 ± 0.046	2.349GlnGln: 2.349 ± 0.08	1.699GlnArg: 1.699 ± 0.056	2.516GlnSer: 2.516 ± 0.065	2.743GlnThr: 2.743 ± 0.077	2.962GlnVal: 2.962 ± 0.078	0.394GlnTrp: 0.394 ± 0.026	1.349GlnTyr: 1.349 ± 0.041	0.001GlnXaa: 0.001 ± 0.001
Arg	2.103ArgAla: 2.103 ± 0.06	0.144ArgCys: 0.144 ± 0.014	2.113ArgAsp: 2.113 ± 0.057	1.876ArgGlu: 1.876 ± 0.064	1.48ArgPhe: 1.48 ± 0.043	2.027ArgGly: 2.027 ± 0.057	0.732ArgHis: 0.732 ± 0.033	2.621ArgIle: 2.621 ± 0.062	2.58ArgLys: 2.58 ± 0.069	3.176ArgLeu: 3.176 ± 0.07	0.963ArgMet: 0.963 ± 0.038	1.965ArgAsn: 1.965 ± 0.069	1.199ArgPro: 1.199 ± 0.041	1.67ArgGln: 1.67 ± 0.059	1.626ArgArg: 1.626 ± 0.053	2.132ArgSer: 2.132 ± 0.066	1.873ArgThr: 1.873 ± 0.048	2.245ArgVal: 2.245 ± 0.063	0.283ArgTrp: 0.283 ± 0.022	1.333ArgTyr: 1.333 ± 0.046	0.001ArgXaa: 0.001 ± 0.002
Ser	4.443SerAla: 4.443 ± 0.102	0.247SerCys: 0.247 ± 0.019	4.519SerAsp: 4.519 ± 0.093	3.614SerGlu: 3.614 ± 0.081	3.045SerPhe: 3.045 ± 0.075	4.898SerGly: 4.898 ± 0.116	1.194SerHis: 1.194 ± 0.04	4.91SerIle: 4.91 ± 0.089	4.542SerLys: 4.542 ± 0.095	6.073SerLeu: 6.073 ± 0.104	1.727SerMet: 1.727 ± 0.051	3.543SerAsn: 3.543 ± 0.086	1.939SerPro: 1.939 ± 0.065	2.922SerGln: 2.922 ± 0.08	2.261SerArg: 2.261 ± 0.057	4.618SerSer: 4.618 ± 0.129	3.97SerThr: 3.97 ± 0.111	4.223SerVal: 4.223 ± 0.079	0.642SerTrp: 0.642 ± 0.034	2.302SerTyr: 2.302 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.407ThrAla: 4.407 ± 0.103	0.24ThrCys: 0.24 ± 0.021	4.14ThrAsp: 4.14 ± 0.091	3.02ThrGlu: 3.02 ± 0.075	2.463ThrPhe: 2.463 ± 0.069	4.475ThrGly: 4.475 ± 0.084	1.102ThrHis: 1.102 ± 0.037	4.808ThrIle: 4.808 ± 0.09	4.181ThrLys: 4.181 ± 0.094	5.243ThrLeu: 5.243 ± 0.113	1.366ThrMet: 1.366 ± 0.047	3.213ThrAsn: 3.213 ± 0.085	2.53ThrPro: 2.53 ± 0.057	2.021ThrGln: 2.021 ± 0.052	1.773ThrArg: 1.773 ± 0.052	4.028ThrSer: 4.028 ± 0.105	3.838ThrThr: 3.838 ± 0.106	4.397ThrVal: 4.397 ± 0.092	0.568ThrTrp: 0.568 ± 0.031	2.034ThrTyr: 2.034 ± 0.062	0.001ThrXaa: 0.001 ± 0.001
Val	5.159ValAla: 5.159 ± 0.101	0.409ValCys: 0.409 ± 0.022	4.796ValAsp: 4.796 ± 0.087	3.668ValGlu: 3.668 ± 0.079	2.791ValPhe: 2.791 ± 0.073	4.911ValGly: 4.911 ± 0.088	1.181ValHis: 1.181 ± 0.041	5.62ValIle: 5.62 ± 0.113	4.777ValLys: 4.777 ± 0.08	6.312ValLeu: 6.312 ± 0.124	1.667ValMet: 1.667 ± 0.047	3.63ValAsn: 3.63 ± 0.073	2.672ValPro: 2.672 ± 0.069	2.347ValGln: 2.347 ± 0.063	2.104ValArg: 2.104 ± 0.066	4.757ValSer: 4.757 ± 0.082	4.452ValThr: 4.452 ± 0.084	5.156ValVal: 5.156 ± 0.109	0.6ValTrp: 0.6 ± 0.03	2.136ValTyr: 2.136 ± 0.056	0.001ValXaa: 0.001 ± 0.001
Trp	0.571TrpAla: 0.571 ± 0.03	0.049TrpCys: 0.049 ± 0.008	0.549TrpAsp: 0.549 ± 0.029	0.378TrpGlu: 0.378 ± 0.022	0.473TrpPhe: 0.473 ± 0.03	0.552TrpGly: 0.552 ± 0.029	0.221TrpHis: 0.221 ± 0.019	0.813TrpIle: 0.813 ± 0.035	0.55TrpLys: 0.55 ± 0.028	1.07TrpLeu: 1.07 ± 0.049	0.301TrpMet: 0.301 ± 0.024	0.53TrpAsn: 0.53 ± 0.032	0.266TrpPro: 0.266 ± 0.02	0.441TrpGln: 0.441 ± 0.026	0.367TrpArg: 0.367 ± 0.022	0.62TrpSer: 0.62 ± 0.033	0.529TrpThr: 0.529 ± 0.028	0.582TrpVal: 0.582 ± 0.028	0.142TrpTrp: 0.142 ± 0.014	0.404TrpTyr: 0.404 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.161TyrAla: 2.161 ± 0.059	0.177TyrCys: 0.177 ± 0.016	2.338TyrAsp: 2.338 ± 0.063	1.607TyrGlu: 1.607 ± 0.052	1.95TyrPhe: 1.95 ± 0.058	2.313TyrGly: 2.313 ± 0.055	0.841TyrHis: 0.841 ± 0.038	2.21TyrIle: 2.21 ± 0.064	1.965TyrLys: 1.965 ± 0.07	3.953TyrLeu: 3.953 ± 0.089	0.802TyrMet: 0.802 ± 0.035	1.772TyrAsn: 1.772 ± 0.045	1.413TyrPro: 1.413 ± 0.049	2.259TyrGln: 2.259 ± 0.058	1.597TyrArg: 1.597 ± 0.052	2.328TyrSer: 2.328 ± 0.056	1.889TyrThr: 1.889 ± 0.053	2.137TyrVal: 2.137 ± 0.053	0.409TyrTrp: 0.409 ± 0.023	1.515TyrTyr: 1.515 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2261 proteins (688665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---