Amino acid dipepetide frequency for Lactococcus phage 98102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.923AlaAla: 2.923 ± 0.702
0.682AlaCys: 0.682 ± 0.265
3.897AlaAsp: 3.897 ± 0.612
4.579AlaGlu: 4.579 ± 0.801
2.923AlaPhe: 2.923 ± 0.527
3.117AlaGly: 3.117 ± 0.679
0.682AlaHis: 0.682 ± 0.241
5.65AlaIle: 5.65 ± 0.819
4.871AlaLys: 4.871 ± 0.698
5.943AlaLeu: 5.943 ± 0.635
1.461AlaMet: 1.461 ± 0.271
4.774AlaAsn: 4.774 ± 0.624
1.754AlaPro: 1.754 ± 0.424
2.923AlaGln: 2.923 ± 0.603
2.435AlaArg: 2.435 ± 0.492
3.215AlaSer: 3.215 ± 0.546
3.702AlaThr: 3.702 ± 0.708
3.897AlaVal: 3.897 ± 0.636
1.754AlaTrp: 1.754 ± 0.481
2.143AlaTyr: 2.143 ± 0.388
0.0AlaXaa: 0.0 ± 0.0
Cys
0.195CysAla: 0.195 ± 0.126
0.0CysCys: 0.0 ± 0.0
0.877CysAsp: 0.877 ± 0.334
0.585CysGlu: 0.585 ± 0.272
0.39CysPhe: 0.39 ± 0.207
0.292CysGly: 0.292 ± 0.2
0.195CysHis: 0.195 ± 0.145
0.097CysIle: 0.097 ± 0.1
0.779CysLys: 0.779 ± 0.273
0.39CysLeu: 0.39 ± 0.215
0.292CysMet: 0.292 ± 0.201
0.292CysAsn: 0.292 ± 0.187
0.292CysPro: 0.292 ± 0.172
0.0CysGln: 0.0 ± 0.0
0.292CysArg: 0.292 ± 0.173
0.877CysSer: 0.877 ± 0.338
0.39CysThr: 0.39 ± 0.163
0.487CysVal: 0.487 ± 0.23
0.097CysTrp: 0.097 ± 0.108
0.195CysTyr: 0.195 ± 0.136
0.0CysXaa: 0.0 ± 0.0
Asp
2.923AspAla: 2.923 ± 0.603
0.195AspCys: 0.195 ± 0.138
4.189AspAsp: 4.189 ± 0.787
5.943AspGlu: 5.943 ± 0.974
3.312AspPhe: 3.312 ± 0.583
5.455AspGly: 5.455 ± 0.792
0.487AspHis: 0.487 ± 0.223
4.676AspIle: 4.676 ± 0.689
5.748AspLys: 5.748 ± 0.737
3.799AspLeu: 3.799 ± 0.51
1.364AspMet: 1.364 ± 0.323
3.117AspAsn: 3.117 ± 0.528
0.974AspPro: 0.974 ± 0.371
1.364AspGln: 1.364 ± 0.322
2.435AspArg: 2.435 ± 0.409
4.384AspSer: 4.384 ± 0.606
4.286AspThr: 4.286 ± 0.626
3.604AspVal: 3.604 ± 0.683
1.072AspTrp: 1.072 ± 0.285
1.948AspTyr: 1.948 ± 0.393
0.0AspXaa: 0.0 ± 0.0
Glu
3.41GluAla: 3.41 ± 0.674
0.195GluCys: 0.195 ± 0.136
2.63GluAsp: 2.63 ± 0.524
6.624GluGlu: 6.624 ± 1.134
4.481GluPhe: 4.481 ± 0.682
3.117GluGly: 3.117 ± 0.606
0.877GluHis: 0.877 ± 0.312
5.358GluIle: 5.358 ± 0.724
7.793GluLys: 7.793 ± 1.398
8.086GluLeu: 8.086 ± 1.016
1.948GluMet: 1.948 ± 0.465
4.579GluAsn: 4.579 ± 0.738
2.435GluPro: 2.435 ± 0.544
3.312GluGln: 3.312 ± 0.502
3.41GluArg: 3.41 ± 0.601
3.41GluSer: 3.41 ± 0.603
4.774GluThr: 4.774 ± 0.683
6.04GluVal: 6.04 ± 0.954
1.169GluTrp: 1.169 ± 0.332
4.189GluTyr: 4.189 ± 0.752
0.0GluXaa: 0.0 ± 0.0
Phe
2.533PheAla: 2.533 ± 0.582
0.585PheCys: 0.585 ± 0.211
3.312PheAsp: 3.312 ± 0.485
3.312PheGlu: 3.312 ± 0.708
1.559PhePhe: 1.559 ± 0.465
3.117PheGly: 3.117 ± 0.609
0.585PheHis: 0.585 ± 0.232
2.923PheIle: 2.923 ± 0.558
4.676PheLys: 4.676 ± 0.662
2.241PheLeu: 2.241 ± 0.524
1.559PheMet: 1.559 ± 0.437
3.41PheAsn: 3.41 ± 0.624
0.779PhePro: 0.779 ± 0.322
1.656PheGln: 1.656 ± 0.49
0.974PheArg: 0.974 ± 0.378
3.507PheSer: 3.507 ± 0.55
3.215PheThr: 3.215 ± 0.583
2.728PheVal: 2.728 ± 0.548
0.39PheTrp: 0.39 ± 0.196
1.461PheTyr: 1.461 ± 0.36
0.0PheXaa: 0.0 ± 0.0
Gly
3.41GlyAla: 3.41 ± 0.768
0.487GlyCys: 0.487 ± 0.239
3.215GlyAsp: 3.215 ± 0.56
3.604GlyGlu: 3.604 ± 0.755
2.533GlyPhe: 2.533 ± 0.493
4.579GlyGly: 4.579 ± 0.885
0.779GlyHis: 0.779 ± 0.258
5.066GlyIle: 5.066 ± 0.699
5.65GlyLys: 5.65 ± 0.686
5.65GlyLeu: 5.65 ± 1.14
1.948GlyMet: 1.948 ± 0.513
3.215GlyAsn: 3.215 ± 0.855
0.779GlyPro: 0.779 ± 0.332
2.923GlyGln: 2.923 ± 0.709
2.533GlyArg: 2.533 ± 0.691
4.092GlySer: 4.092 ± 0.846
4.384GlyThr: 4.384 ± 0.811
3.994GlyVal: 3.994 ± 0.714
1.072GlyTrp: 1.072 ± 0.371
3.312GlyTyr: 3.312 ± 0.605
0.0GlyXaa: 0.0 ± 0.0
His
1.266HisAla: 1.266 ± 0.362
0.097HisCys: 0.097 ± 0.107
0.779HisAsp: 0.779 ± 0.232
1.656HisGlu: 1.656 ± 0.437
0.877HisPhe: 0.877 ± 0.328
0.974HisGly: 0.974 ± 0.295
0.195HisHis: 0.195 ± 0.12
0.585HisIle: 0.585 ± 0.261
0.682HisLys: 0.682 ± 0.241
0.877HisLeu: 0.877 ± 0.306
0.195HisMet: 0.195 ± 0.15
0.779HisAsn: 0.779 ± 0.263
0.39HisPro: 0.39 ± 0.186
0.585HisGln: 0.585 ± 0.246
0.487HisArg: 0.487 ± 0.183
0.779HisSer: 0.779 ± 0.259
0.292HisThr: 0.292 ± 0.149
0.585HisVal: 0.585 ± 0.189
0.292HisTrp: 0.292 ± 0.172
0.682HisTyr: 0.682 ± 0.253
0.0HisXaa: 0.0 ± 0.0
Ile
4.871IleAla: 4.871 ± 0.919
0.39IleCys: 0.39 ± 0.188
4.092IleAsp: 4.092 ± 0.604
5.943IleGlu: 5.943 ± 0.984
2.63IlePhe: 2.63 ± 0.613
3.41IleGly: 3.41 ± 0.579
0.682IleHis: 0.682 ± 0.306
3.799IleIle: 3.799 ± 0.714
7.209IleLys: 7.209 ± 0.682
4.092IleLeu: 4.092 ± 0.679
1.364IleMet: 1.364 ± 0.282
5.261IleAsn: 5.261 ± 1.043
1.559IlePro: 1.559 ± 0.386
2.825IleGln: 2.825 ± 0.542
2.143IleArg: 2.143 ± 0.389
4.481IleSer: 4.481 ± 0.672
4.774IleThr: 4.774 ± 0.549
3.604IleVal: 3.604 ± 0.844
0.779IleTrp: 0.779 ± 0.319
2.338IleTyr: 2.338 ± 0.516
0.0IleXaa: 0.0 ± 0.0
Lys
7.209LysAla: 7.209 ± 1.146
0.097LysCys: 0.097 ± 0.115
5.65LysAsp: 5.65 ± 0.657
7.209LysGlu: 7.209 ± 1.147
2.825LysPhe: 2.825 ± 0.465
5.748LysGly: 5.748 ± 0.873
2.143LysHis: 2.143 ± 0.512
6.235LysIle: 6.235 ± 0.762
8.183LysLys: 8.183 ± 1.21
7.696LysLeu: 7.696 ± 1.001
2.241LysMet: 2.241 ± 0.413
6.624LysAsn: 6.624 ± 0.949
2.338LysPro: 2.338 ± 0.388
5.066LysGln: 5.066 ± 0.821
3.702LysArg: 3.702 ± 0.682
5.553LysSer: 5.553 ± 0.733
4.384LysThr: 4.384 ± 0.792
3.41LysVal: 3.41 ± 0.625
0.779LysTrp: 0.779 ± 0.309
3.41LysTyr: 3.41 ± 0.638
0.0LysXaa: 0.0 ± 0.0
Leu
4.481LeuAla: 4.481 ± 0.709
0.974LeuCys: 0.974 ± 0.284
5.553LeuAsp: 5.553 ± 0.797
5.455LeuGlu: 5.455 ± 0.946
3.215LeuPhe: 3.215 ± 0.548
4.676LeuGly: 4.676 ± 0.534
0.974LeuHis: 0.974 ± 0.31
4.968LeuIle: 4.968 ± 0.682
7.501LeuLys: 7.501 ± 1.013
6.722LeuLeu: 6.722 ± 0.986
2.241LeuMet: 2.241 ± 0.445
5.553LeuAsn: 5.553 ± 0.625
2.923LeuPro: 2.923 ± 0.632
3.994LeuGln: 3.994 ± 0.708
2.241LeuArg: 2.241 ± 0.477
6.722LeuSer: 6.722 ± 0.737
5.455LeuThr: 5.455 ± 0.824
3.604LeuVal: 3.604 ± 0.67
1.461LeuTrp: 1.461 ± 0.614
2.143LeuTyr: 2.143 ± 0.416
0.0LeuXaa: 0.0 ± 0.0
Met
2.825MetAla: 2.825 ± 0.58
0.195MetCys: 0.195 ± 0.147
1.461MetAsp: 1.461 ± 0.403
1.851MetGlu: 1.851 ± 0.579
0.585MetPhe: 0.585 ± 0.199
1.169MetGly: 1.169 ± 0.345
0.195MetHis: 0.195 ± 0.131
1.461MetIle: 1.461 ± 0.467
2.338MetLys: 2.338 ± 0.545
2.046MetLeu: 2.046 ± 0.476
0.585MetMet: 0.585 ± 0.247
1.948MetAsn: 1.948 ± 0.349
0.487MetPro: 0.487 ± 0.28
1.266MetGln: 1.266 ± 0.296
0.877MetArg: 0.877 ± 0.364
1.754MetSer: 1.754 ± 0.462
2.923MetThr: 2.923 ± 0.539
0.682MetVal: 0.682 ± 0.294
0.195MetTrp: 0.195 ± 0.118
0.682MetTyr: 0.682 ± 0.301
0.0MetXaa: 0.0 ± 0.0
Asn
4.676AsnAla: 4.676 ± 0.763
0.682AsnCys: 0.682 ± 0.285
3.41AsnAsp: 3.41 ± 0.504
4.286AsnGlu: 4.286 ± 0.727
2.63AsnPhe: 2.63 ± 0.498
6.137AsnGly: 6.137 ± 1.106
0.779AsnHis: 0.779 ± 0.342
3.312AsnIle: 3.312 ± 0.559
5.066AsnLys: 5.066 ± 0.598
6.235AsnLeu: 6.235 ± 0.785
1.461AsnMet: 1.461 ± 0.438
4.384AsnAsn: 4.384 ± 0.721
1.948AsnPro: 1.948 ± 0.451
3.02AsnGln: 3.02 ± 0.45
2.046AsnArg: 2.046 ± 0.407
4.481AsnSer: 4.481 ± 0.623
3.02AsnThr: 3.02 ± 0.643
3.799AsnVal: 3.799 ± 0.548
0.974AsnTrp: 0.974 ± 0.314
2.241AsnTyr: 2.241 ± 0.436
0.0AsnXaa: 0.0 ± 0.0
Pro
1.169ProAla: 1.169 ± 0.299
0.097ProCys: 0.097 ± 0.088
1.754ProAsp: 1.754 ± 0.54
2.533ProGlu: 2.533 ± 0.469
1.169ProPhe: 1.169 ± 0.3
0.877ProGly: 0.877 ± 0.254
0.682ProHis: 0.682 ± 0.253
1.461ProIle: 1.461 ± 0.476
2.435ProLys: 2.435 ± 0.56
2.143ProLeu: 2.143 ± 0.471
0.585ProMet: 0.585 ± 0.207
1.754ProAsn: 1.754 ± 0.389
0.487ProPro: 0.487 ± 0.183
0.974ProGln: 0.974 ± 0.323
0.585ProArg: 0.585 ± 0.305
0.877ProSer: 0.877 ± 0.352
1.948ProThr: 1.948 ± 0.452
2.241ProVal: 2.241 ± 0.469
0.195ProTrp: 0.195 ± 0.144
1.169ProTyr: 1.169 ± 0.306
0.0ProXaa: 0.0 ± 0.0
Gln
4.092GlnAla: 4.092 ± 0.587
0.39GlnCys: 0.39 ± 0.195
0.877GlnAsp: 0.877 ± 0.389
4.092GlnGlu: 4.092 ± 0.558
1.461GlnPhe: 1.461 ± 0.408
2.533GlnGly: 2.533 ± 0.659
0.195GlnHis: 0.195 ± 0.136
2.923GlnIle: 2.923 ± 0.658
3.02GlnLys: 3.02 ± 0.615
3.215GlnLeu: 3.215 ± 0.513
1.364GlnMet: 1.364 ± 0.374
2.728GlnAsn: 2.728 ± 0.447
1.461GlnPro: 1.461 ± 0.425
2.143GlnGln: 2.143 ± 0.486
1.656GlnArg: 1.656 ± 0.428
1.948GlnSer: 1.948 ± 0.53
2.825GlnThr: 2.825 ± 0.544
3.117GlnVal: 3.117 ± 0.639
0.779GlnTrp: 0.779 ± 0.342
1.754GlnTyr: 1.754 ± 0.303
0.0GlnXaa: 0.0 ± 0.0
Arg
2.63ArgAla: 2.63 ± 0.468
0.39ArgCys: 0.39 ± 0.272
2.338ArgAsp: 2.338 ± 0.519
2.728ArgGlu: 2.728 ± 0.624
1.656ArgPhe: 1.656 ± 0.353
1.851ArgGly: 1.851 ± 0.432
0.195ArgHis: 0.195 ± 0.111
2.533ArgIle: 2.533 ± 0.459
4.384ArgLys: 4.384 ± 0.696
4.286ArgLeu: 4.286 ± 0.946
1.364ArgMet: 1.364 ± 0.354
1.851ArgAsn: 1.851 ± 0.396
0.779ArgPro: 0.779 ± 0.401
0.974ArgGln: 0.974 ± 0.291
1.169ArgArg: 1.169 ± 0.4
2.241ArgSer: 2.241 ± 0.399
1.656ArgThr: 1.656 ± 0.33
2.435ArgVal: 2.435 ± 0.456
0.292ArgTrp: 0.292 ± 0.172
1.072ArgTyr: 1.072 ± 0.367
0.0ArgXaa: 0.0 ± 0.0
Ser
4.189SerAla: 4.189 ± 0.96
0.585SerCys: 0.585 ± 0.26
5.65SerAsp: 5.65 ± 0.6
4.481SerGlu: 4.481 ± 0.712
3.41SerPhe: 3.41 ± 0.613
4.676SerGly: 4.676 ± 0.798
1.072SerHis: 1.072 ± 0.244
3.41SerIle: 3.41 ± 0.459
4.286SerLys: 4.286 ± 0.73
4.092SerLeu: 4.092 ± 0.505
1.559SerMet: 1.559 ± 0.394
4.092SerAsn: 4.092 ± 0.757
1.169SerPro: 1.169 ± 0.317
2.63SerGln: 2.63 ± 0.593
2.143SerArg: 2.143 ± 0.377
4.481SerSer: 4.481 ± 0.844
3.994SerThr: 3.994 ± 0.548
4.384SerVal: 4.384 ± 0.577
0.877SerTrp: 0.877 ± 0.234
2.338SerTyr: 2.338 ± 0.391
0.0SerXaa: 0.0 ± 0.0
Thr
4.871ThrAla: 4.871 ± 0.618
0.292ThrCys: 0.292 ± 0.191
3.994ThrAsp: 3.994 ± 0.578
4.676ThrGlu: 4.676 ± 0.836
3.215ThrPhe: 3.215 ± 0.52
5.066ThrGly: 5.066 ± 0.682
0.585ThrHis: 0.585 ± 0.229
4.384ThrIle: 4.384 ± 0.798
5.65ThrLys: 5.65 ± 0.666
5.066ThrLeu: 5.066 ± 0.76
1.169ThrMet: 1.169 ± 0.383
3.02ThrAsn: 3.02 ± 0.588
1.461ThrPro: 1.461 ± 0.346
1.656ThrGln: 1.656 ± 0.413
2.923ThrArg: 2.923 ± 0.52
3.02ThrSer: 3.02 ± 0.507
4.189ThrThr: 4.189 ± 0.563
4.871ThrVal: 4.871 ± 0.772
0.682ThrTrp: 0.682 ± 0.26
1.851ThrTyr: 1.851 ± 0.455
0.0ThrXaa: 0.0 ± 0.0
Val
3.02ValAla: 3.02 ± 0.602
0.292ValCys: 0.292 ± 0.171
4.579ValAsp: 4.579 ± 0.828
4.968ValGlu: 4.968 ± 0.793
2.825ValPhe: 2.825 ± 0.519
3.41ValGly: 3.41 ± 0.744
0.974ValHis: 0.974 ± 0.338
3.604ValIle: 3.604 ± 0.507
6.04ValLys: 6.04 ± 0.833
4.286ValLeu: 4.286 ± 0.578
1.364ValMet: 1.364 ± 0.415
3.897ValAsn: 3.897 ± 0.699
1.461ValPro: 1.461 ± 0.396
2.338ValGln: 2.338 ± 0.534
1.948ValArg: 1.948 ± 0.437
4.676ValSer: 4.676 ± 0.561
4.092ValThr: 4.092 ± 0.871
4.579ValVal: 4.579 ± 0.566
0.877ValTrp: 0.877 ± 0.23
1.559ValTyr: 1.559 ± 0.407
0.0ValXaa: 0.0 ± 0.0
Trp
1.266TrpAla: 1.266 ± 0.273
0.097TrpCys: 0.097 ± 0.085
0.779TrpAsp: 0.779 ± 0.404
1.072TrpGlu: 1.072 ± 0.319
0.682TrpPhe: 0.682 ± 0.228
0.585TrpGly: 0.585 ± 0.25
0.292TrpHis: 0.292 ± 0.156
1.559TrpIle: 1.559 ± 0.338
1.266TrpLys: 1.266 ± 0.355
0.877TrpLeu: 0.877 ± 0.331
0.195TrpMet: 0.195 ± 0.142
1.169TrpAsn: 1.169 ± 0.457
0.097TrpPro: 0.097 ± 0.094
0.877TrpGln: 0.877 ± 0.389
0.974TrpArg: 0.974 ± 0.297
0.682TrpSer: 0.682 ± 0.213
0.682TrpThr: 0.682 ± 0.299
0.682TrpVal: 0.682 ± 0.287
0.39TrpTrp: 0.39 ± 0.214
0.39TrpTyr: 0.39 ± 0.238
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.364TyrAla: 1.364 ± 0.3
0.292TyrCys: 0.292 ± 0.155
2.241TyrAsp: 2.241 ± 0.429
2.241TyrGlu: 2.241 ± 0.533
2.143TyrPhe: 2.143 ± 0.49
2.435TyrGly: 2.435 ± 0.634
0.487TyrHis: 0.487 ± 0.204
2.241TyrIle: 2.241 ± 0.47
2.923TyrLys: 2.923 ± 0.599
3.215TyrLeu: 3.215 ± 0.717
1.169TyrMet: 1.169 ± 0.32
2.143TyrAsn: 2.143 ± 0.521
1.559TyrPro: 1.559 ± 0.375
2.046TyrGln: 2.046 ± 0.402
1.851TyrArg: 1.851 ± 0.518
2.338TyrSer: 2.338 ± 0.433
1.656TyrThr: 1.656 ± 0.43
2.046TyrVal: 2.046 ± 0.362
0.487TyrTrp: 0.487 ± 0.226
1.072TyrTyr: 1.072 ± 0.371
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (10266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski