Amino acid dipepetide frequency for SR1 bacterium human oral taxon HOT-345

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.116AlaAla: 3.116 ± 0.142
0.615AlaCys: 0.615 ± 0.046
2.993AlaAsp: 2.993 ± 0.108
4.645AlaGlu: 4.645 ± 0.134
3.276AlaPhe: 3.276 ± 0.134
4.344AlaGly: 4.344 ± 0.142
0.96AlaHis: 0.96 ± 0.054
4.304AlaIle: 4.304 ± 0.121
5.291AlaLys: 5.291 ± 0.153
6.236AlaLeu: 6.236 ± 0.174
1.664AlaMet: 1.664 ± 0.083
2.907AlaAsn: 2.907 ± 0.128
2.221AlaPro: 2.221 ± 0.115
2.772AlaGln: 2.772 ± 0.101
2.323AlaArg: 2.323 ± 0.093
4.199AlaSer: 4.199 ± 0.131
3.458AlaThr: 3.458 ± 0.119
3.513AlaVal: 3.513 ± 0.131
0.48AlaTrp: 0.48 ± 0.04
2.261AlaTyr: 2.261 ± 0.097
0.0AlaXaa: 0.0 ± 0.0
Cys
0.434CysAla: 0.434 ± 0.035
0.178CysCys: 0.178 ± 0.021
0.566CysAsp: 0.566 ± 0.057
0.652CysGlu: 0.652 ± 0.041
0.631CysPhe: 0.631 ± 0.054
0.886CysGly: 0.886 ± 0.059
0.209CysHis: 0.209 ± 0.027
0.591CysIle: 0.591 ± 0.053
0.809CysLys: 0.809 ± 0.067
0.772CysLeu: 0.772 ± 0.05
0.145CysMet: 0.145 ± 0.02
0.452CysAsn: 0.452 ± 0.041
0.492CysPro: 0.492 ± 0.047
0.308CysGln: 0.308 ± 0.031
0.4CysArg: 0.4 ± 0.04
0.729CysSer: 0.729 ± 0.055
0.369CysThr: 0.369 ± 0.038
0.474CysVal: 0.474 ± 0.043
0.071CysTrp: 0.071 ± 0.014
0.4CysTyr: 0.4 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.243AspAla: 3.243 ± 0.108
0.501AspCys: 0.501 ± 0.047
2.132AspAsp: 2.132 ± 0.096
3.806AspGlu: 3.806 ± 0.113
3.593AspPhe: 3.593 ± 0.107
3.452AspGly: 3.452 ± 0.138
0.871AspHis: 0.871 ± 0.049
3.624AspIle: 3.624 ± 0.136
3.596AspLys: 3.596 ± 0.127
5.144AspLeu: 5.144 ± 0.139
1.129AspMet: 1.129 ± 0.063
1.984AspAsn: 1.984 ± 0.08
2.126AspPro: 2.126 ± 0.097
2.452AspGln: 2.452 ± 0.093
1.855AspArg: 1.855 ± 0.069
2.646AspSer: 2.646 ± 0.087
2.716AspThr: 2.716 ± 0.094
2.415AspVal: 2.415 ± 0.098
0.437AspTrp: 0.437 ± 0.038
2.289AspTyr: 2.289 ± 0.106
0.0AspXaa: 0.0 ± 0.0
Glu
4.375GluAla: 4.375 ± 0.134
0.575GluCys: 0.575 ± 0.054
3.119GluAsp: 3.119 ± 0.108
6.187GluGlu: 6.187 ± 0.219
2.68GluPhe: 2.68 ± 0.103
4.393GluGly: 4.393 ± 0.108
1.271GluHis: 1.271 ± 0.089
5.713GluIle: 5.713 ± 0.149
8.362GluLys: 8.362 ± 0.23
7.067GluLeu: 7.067 ± 0.161
1.87GluMet: 1.87 ± 0.081
3.981GluAsn: 3.981 ± 0.105
1.511GluPro: 1.511 ± 0.081
3.498GluGln: 3.498 ± 0.131
3.276GluArg: 3.276 ± 0.137
3.846GluSer: 3.846 ± 0.133
3.566GluThr: 3.566 ± 0.137
4.236GluVal: 4.236 ± 0.121
0.471GluTrp: 0.471 ± 0.036
2.55GluTyr: 2.55 ± 0.097
0.0GluXaa: 0.0 ± 0.0
Phe
3.159PheAla: 3.159 ± 0.107
0.714PheCys: 0.714 ± 0.046
2.935PheAsp: 2.935 ± 0.103
2.972PheGlu: 2.972 ± 0.109
3.538PhePhe: 3.538 ± 0.138
3.892PheGly: 3.892 ± 0.13
0.828PheHis: 0.828 ± 0.054
3.246PheIle: 3.246 ± 0.11
3.024PheLys: 3.024 ± 0.092
6.217PheLeu: 6.217 ± 0.209
1.043PheMet: 1.043 ± 0.058
2.098PheAsn: 2.098 ± 0.108
2.178PhePro: 2.178 ± 0.083
1.803PheGln: 1.803 ± 0.082
1.954PheArg: 1.954 ± 0.086
4.744PheSer: 4.744 ± 0.154
2.587PheThr: 2.587 ± 0.099
3.123PheVal: 3.123 ± 0.112
0.563PheTrp: 0.563 ± 0.044
1.926PheTyr: 1.926 ± 0.085
0.0PheXaa: 0.0 ± 0.0
Gly
4.362GlyAla: 4.362 ± 0.161
0.744GlyCys: 0.744 ± 0.061
3.409GlyAsp: 3.409 ± 0.11
5.168GlyGlu: 5.168 ± 0.149
3.633GlyPhe: 3.633 ± 0.1
5.058GlyGly: 5.058 ± 0.198
1.034GlyHis: 1.034 ± 0.06
5.654GlyIle: 5.654 ± 0.153
6.713GlyLys: 6.713 ± 0.147
6.251GlyLeu: 6.251 ± 0.171
1.763GlyMet: 1.763 ± 0.079
3.593GlyAsn: 3.593 ± 0.15
1.24GlyPro: 1.24 ± 0.061
2.193GlyGln: 2.193 ± 0.083
2.4GlyArg: 2.4 ± 0.086
4.005GlySer: 4.005 ± 0.13
4.076GlyThr: 4.076 ± 0.126
4.384GlyVal: 4.384 ± 0.129
0.492GlyTrp: 0.492 ± 0.041
2.741GlyTyr: 2.741 ± 0.102
0.0GlyXaa: 0.0 ± 0.0
His
0.858HisAla: 0.858 ± 0.051
0.286HisCys: 0.286 ± 0.032
0.704HisAsp: 0.704 ± 0.048
1.055HisGlu: 1.055 ± 0.077
1.095HisPhe: 1.095 ± 0.063
0.929HisGly: 0.929 ± 0.046
0.505HisHis: 0.505 ± 0.055
1.108HisIle: 1.108 ± 0.058
1.037HisLys: 1.037 ± 0.062
1.92HisLeu: 1.92 ± 0.083
0.326HisMet: 0.326 ± 0.031
0.692HisAsn: 0.692 ± 0.046
0.809HisPro: 0.809 ± 0.05
0.892HisGln: 0.892 ± 0.054
0.646HisArg: 0.646 ± 0.046
0.963HisSer: 0.963 ± 0.053
0.877HisThr: 0.877 ± 0.05
0.686HisVal: 0.686 ± 0.054
0.154HisTrp: 0.154 ± 0.021
0.911HisTyr: 0.911 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
4.879IleAla: 4.879 ± 0.131
0.655IleCys: 0.655 ± 0.053
3.95IleAsp: 3.95 ± 0.104
4.584IleGlu: 4.584 ± 0.152
3.698IlePhe: 3.698 ± 0.136
5.618IleGly: 5.618 ± 0.255
1.163IleHis: 1.163 ± 0.057
5.175IleIle: 5.175 ± 0.178
5.867IleLys: 5.867 ± 0.139
7.356IleLeu: 7.356 ± 0.172
1.221IleMet: 1.221 ± 0.059
3.203IleAsn: 3.203 ± 0.115
3.218IlePro: 3.218 ± 0.122
3.255IleGln: 3.255 ± 0.099
2.892IleArg: 2.892 ± 0.097
5.165IleSer: 5.165 ± 0.125
3.922IleThr: 3.922 ± 0.124
4.135IleVal: 4.135 ± 0.113
0.529IleTrp: 0.529 ± 0.044
2.32IleTyr: 2.32 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
5.353LysAla: 5.353 ± 0.127
0.489LysCys: 0.489 ± 0.042
4.381LysAsp: 4.381 ± 0.134
6.47LysGlu: 6.47 ± 0.175
3.101LysPhe: 3.101 ± 0.098
5.215LysGly: 5.215 ± 0.152
1.292LysHis: 1.292 ± 0.069
6.977LysIle: 6.977 ± 0.182
8.931LysLys: 8.931 ± 0.225
7.836LysLeu: 7.836 ± 0.173
2.083LysMet: 2.083 ± 0.085
5.159LysAsn: 5.159 ± 0.137
2.467LysPro: 2.467 ± 0.098
3.206LysGln: 3.206 ± 0.123
3.338LysArg: 3.338 ± 0.117
4.956LysSer: 4.956 ± 0.115
4.781LysThr: 4.781 ± 0.139
5.021LysVal: 5.021 ± 0.153
0.649LysTrp: 0.649 ± 0.042
3.212LysTyr: 3.212 ± 0.114
0.0LysXaa: 0.0 ± 0.0
Leu
6.848LeuAla: 6.848 ± 0.165
0.944LeuCys: 0.944 ± 0.053
5.138LeuAsp: 5.138 ± 0.151
7.137LeuGlu: 7.137 ± 0.192
5.313LeuPhe: 5.313 ± 0.176
6.974LeuGly: 6.974 ± 0.204
1.658LeuHis: 1.658 ± 0.078
7.242LeuIle: 7.242 ± 0.178
8.122LeuLys: 8.122 ± 0.186
10.952LeuLeu: 10.952 ± 0.331
2.313LeuMet: 2.313 ± 0.095
4.581LeuAsn: 4.581 ± 0.126
4.199LeuPro: 4.199 ± 0.116
4.676LeuGln: 4.676 ± 0.133
3.95LeuArg: 3.95 ± 0.119
7.669LeuSer: 7.669 ± 0.185
5.491LeuThr: 5.491 ± 0.155
5.319LeuVal: 5.319 ± 0.158
0.821LeuTrp: 0.821 ± 0.054
3.227LeuTyr: 3.227 ± 0.112
0.0LeuXaa: 0.0 ± 0.0
Met
1.283MetAla: 1.283 ± 0.075
0.102MetCys: 0.102 ± 0.018
0.994MetAsp: 0.994 ± 0.064
1.412MetGlu: 1.412 ± 0.066
0.84MetPhe: 0.84 ± 0.069
1.474MetGly: 1.474 ± 0.073
0.32MetHis: 0.32 ± 0.032
1.772MetIle: 1.772 ± 0.085
2.36MetLys: 2.36 ± 0.092
2.31MetLeu: 2.31 ± 0.108
0.634MetMet: 0.634 ± 0.052
1.148MetAsn: 1.148 ± 0.055
0.806MetPro: 0.806 ± 0.051
1.246MetGln: 1.246 ± 0.061
1.077MetArg: 1.077 ± 0.048
1.068MetSer: 1.068 ± 0.06
1.203MetThr: 1.203 ± 0.074
1.098MetVal: 1.098 ± 0.069
0.142MetTrp: 0.142 ± 0.017
0.597MetTyr: 0.597 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
3.092AsnAla: 3.092 ± 0.112
0.458AsnCys: 0.458 ± 0.042
2.086AsnAsp: 2.086 ± 0.088
2.833AsnGlu: 2.833 ± 0.11
2.501AsnPhe: 2.501 ± 0.093
3.43AsnGly: 3.43 ± 0.16
0.741AsnHis: 0.741 ± 0.052
3.461AsnIle: 3.461 ± 0.115
3.535AsnLys: 3.535 ± 0.126
5.082AsnLeu: 5.082 ± 0.125
0.96AsnMet: 0.96 ± 0.053
2.304AsnAsn: 2.304 ± 0.118
2.523AsnPro: 2.523 ± 0.089
2.67AsnGln: 2.67 ± 0.091
1.658AsnArg: 1.658 ± 0.065
2.596AsnSer: 2.596 ± 0.099
2.916AsnThr: 2.916 ± 0.114
2.381AsnVal: 2.381 ± 0.114
0.378AsnTrp: 0.378 ± 0.047
2.046AsnTyr: 2.046 ± 0.085
0.0AsnXaa: 0.0 ± 0.0
Pro
2.181ProAla: 2.181 ± 0.083
0.295ProCys: 0.295 ± 0.035
1.932ProAsp: 1.932 ± 0.075
3.646ProGlu: 3.646 ± 0.125
1.815ProPhe: 1.815 ± 0.08
1.984ProGly: 1.984 ± 0.093
0.711ProHis: 0.711 ± 0.049
2.486ProIle: 2.486 ± 0.087
2.738ProLys: 2.738 ± 0.103
3.689ProLeu: 3.689 ± 0.134
0.643ProMet: 0.643 ± 0.047
1.667ProAsn: 1.667 ± 0.102
0.895ProPro: 0.895 ± 0.059
1.544ProGln: 1.544 ± 0.083
1.381ProArg: 1.381 ± 0.07
2.427ProSer: 2.427 ± 0.103
2.187ProThr: 2.187 ± 0.121
1.877ProVal: 1.877 ± 0.086
0.212ProTrp: 0.212 ± 0.025
1.495ProTyr: 1.495 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
2.729GlnAla: 2.729 ± 0.104
0.274GlnCys: 0.274 ± 0.032
2.015GlnAsp: 2.015 ± 0.084
3.919GlnGlu: 3.919 ± 0.162
1.701GlnPhe: 1.701 ± 0.08
2.578GlnGly: 2.578 ± 0.093
0.735GlnHis: 0.735 ± 0.042
3.384GlnIle: 3.384 ± 0.103
4.347GlnLys: 4.347 ± 0.139
4.568GlnLeu: 4.568 ± 0.125
0.849GlnMet: 0.849 ± 0.045
2.32GlnAsn: 2.32 ± 0.101
1.307GlnPro: 1.307 ± 0.065
2.175GlnGln: 2.175 ± 0.102
1.76GlnArg: 1.76 ± 0.075
2.283GlnSer: 2.283 ± 0.08
2.489GlnThr: 2.489 ± 0.099
2.51GlnVal: 2.51 ± 0.099
0.298GlnTrp: 0.298 ± 0.03
1.427GlnTyr: 1.427 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
2.332ArgAla: 2.332 ± 0.091
0.403ArgCys: 0.403 ± 0.042
2.009ArgAsp: 2.009 ± 0.072
3.276ArgGlu: 3.276 ± 0.122
2.147ArgPhe: 2.147 ± 0.088
2.686ArgGly: 2.686 ± 0.092
0.554ArgHis: 0.554 ± 0.04
3.119ArgIle: 3.119 ± 0.095
3.609ArgLys: 3.609 ± 0.108
3.547ArgLeu: 3.547 ± 0.122
0.957ArgMet: 0.957 ± 0.055
2.064ArgAsn: 2.064 ± 0.087
1.212ArgPro: 1.212 ± 0.075
1.292ArgGln: 1.292 ± 0.065
1.683ArgArg: 1.683 ± 0.081
2.32ArgSer: 2.32 ± 0.083
1.729ArgThr: 1.729 ± 0.082
2.178ArgVal: 2.178 ± 0.094
0.394ArgTrp: 0.394 ± 0.039
1.877ArgTyr: 1.877 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
3.716SerAla: 3.716 ± 0.115
0.714SerCys: 0.714 ± 0.065
3.824SerAsp: 3.824 ± 0.114
4.584SerGlu: 4.584 ± 0.114
4.172SerPhe: 4.172 ± 0.143
4.935SerGly: 4.935 ± 0.143
1.058SerHis: 1.058 ± 0.053
3.978SerIle: 3.978 ± 0.122
4.562SerLys: 4.562 ± 0.135
7.156SerLeu: 7.156 ± 0.161
1.12SerMet: 1.12 ± 0.066
2.495SerAsn: 2.495 ± 0.118
2.409SerPro: 2.409 ± 0.096
2.821SerGln: 2.821 ± 0.111
2.381SerArg: 2.381 ± 0.089
4.947SerSer: 4.947 ± 0.173
3.076SerThr: 3.076 ± 0.122
3.495SerVal: 3.495 ± 0.126
0.505SerTrp: 0.505 ± 0.043
2.695SerTyr: 2.695 ± 0.089
0.0SerXaa: 0.0 ± 0.0
Thr
3.089ThrAla: 3.089 ± 0.113
0.56ThrCys: 0.56 ± 0.048
2.393ThrAsp: 2.393 ± 0.087
3.273ThrGlu: 3.273 ± 0.095
2.864ThrPhe: 2.864 ± 0.09
3.766ThrGly: 3.766 ± 0.131
0.824ThrHis: 0.824 ± 0.049
4.15ThrIle: 4.15 ± 0.134
4.165ThrLys: 4.165 ± 0.11
5.633ThrLeu: 5.633 ± 0.155
1.104ThrMet: 1.104 ± 0.057
2.467ThrAsn: 2.467 ± 0.093
2.787ThrPro: 2.787 ± 0.139
2.28ThrGln: 2.28 ± 0.1
1.957ThrArg: 1.957 ± 0.081
3.55ThrSer: 3.55 ± 0.135
3.421ThrThr: 3.421 ± 0.132
3.095ThrVal: 3.095 ± 0.136
0.372ThrTrp: 0.372 ± 0.04
1.79ThrTyr: 1.79 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
3.852ValAla: 3.852 ± 0.155
0.56ValCys: 0.56 ± 0.049
2.978ValAsp: 2.978 ± 0.107
3.864ValGlu: 3.864 ± 0.113
3.279ValPhe: 3.279 ± 0.11
4.015ValGly: 4.015 ± 0.122
0.812ValHis: 0.812 ± 0.05
4.147ValIle: 4.147 ± 0.122
4.602ValLys: 4.602 ± 0.151
5.654ValLeu: 5.654 ± 0.163
1.301ValMet: 1.301 ± 0.066
2.443ValAsn: 2.443 ± 0.097
1.861ValPro: 1.861 ± 0.079
2.101ValGln: 2.101 ± 0.08
2.153ValArg: 2.153 ± 0.08
3.682ValSer: 3.682 ± 0.104
2.2ValThr: 2.2 ± 0.136
3.981ValVal: 3.981 ± 0.147
0.492ValTrp: 0.492 ± 0.039
1.987ValTyr: 1.987 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.351TrpAla: 0.351 ± 0.037
0.062TrpCys: 0.062 ± 0.014
0.4TrpAsp: 0.4 ± 0.05
0.505TrpGlu: 0.505 ± 0.044
0.345TrpPhe: 0.345 ± 0.04
0.508TrpGly: 0.508 ± 0.032
0.126TrpHis: 0.126 ± 0.02
0.711TrpIle: 0.711 ± 0.048
0.855TrpLys: 0.855 ± 0.056
0.772TrpLeu: 0.772 ± 0.054
0.16TrpMet: 0.16 ± 0.022
0.523TrpAsn: 0.523 ± 0.049
0.058TrpPro: 0.058 ± 0.015
0.261TrpGln: 0.261 ± 0.031
0.437TrpArg: 0.437 ± 0.041
0.461TrpSer: 0.461 ± 0.04
0.465TrpThr: 0.465 ± 0.037
0.354TrpVal: 0.354 ± 0.032
0.095TrpTrp: 0.095 ± 0.018
0.348TrpTyr: 0.348 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.329TyrAla: 2.329 ± 0.09
0.437TyrCys: 0.437 ± 0.038
2.052TyrAsp: 2.052 ± 0.085
2.556TyrGlu: 2.556 ± 0.093
2.32TyrPhe: 2.32 ± 0.094
2.781TyrGly: 2.781 ± 0.099
0.781TyrHis: 0.781 ± 0.052
1.963TyrIle: 1.963 ± 0.096
2.39TyrLys: 2.39 ± 0.094
4.418TyrLeu: 4.418 ± 0.141
0.594TyrMet: 0.594 ± 0.045
1.572TyrAsn: 1.572 ± 0.08
1.486TyrPro: 1.486 ± 0.074
2.224TyrGln: 2.224 ± 0.093
1.867TyrArg: 1.867 ± 0.084
2.384TyrSer: 2.384 ± 0.099
2.012TyrThr: 2.012 ± 0.081
1.692TyrVal: 1.692 ± 0.072
0.24TyrTrp: 0.24 ± 0.028
1.649TyrTyr: 1.649 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1055 proteins (325055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski