Amino acid dipepetide frequency for Rariglobus hedericola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.55AlaAla: 14.55 ± 0.16	1.035AlaCys: 1.035 ± 0.033	6.324AlaAsp: 6.324 ± 0.076	6.291AlaGlu: 6.291 ± 0.088	4.15AlaPhe: 4.15 ± 0.059	9.842AlaGly: 9.842 ± 0.142	2.216AlaHis: 2.216 ± 0.047	5.245AlaIle: 5.245 ± 0.07	4.425AlaLys: 4.425 ± 0.081	11.989AlaLeu: 11.989 ± 0.122	2.245AlaMet: 2.245 ± 0.043	3.371AlaAsn: 3.371 ± 0.069	5.442AlaPro: 5.442 ± 0.087	3.741AlaGln: 3.741 ± 0.06	7.26AlaArg: 7.26 ± 0.105	6.8AlaSer: 6.8 ± 0.091	6.884AlaThr: 6.884 ± 0.12	7.914AlaVal: 7.914 ± 0.08	1.725AlaTrp: 1.725 ± 0.044	2.639AlaTyr: 2.639 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.985CysAla: 0.985 ± 0.033	0.109CysCys: 0.109 ± 0.01	0.492CysAsp: 0.492 ± 0.025	0.489CysGlu: 0.489 ± 0.02	0.371CysPhe: 0.371 ± 0.018	0.829CysGly: 0.829 ± 0.028	0.245CysHis: 0.245 ± 0.017	0.416CysIle: 0.416 ± 0.02	0.238CysLys: 0.238 ± 0.014	0.847CysLeu: 0.847 ± 0.03	0.152CysMet: 0.152 ± 0.01	0.229CysAsn: 0.229 ± 0.013	0.458CysPro: 0.458 ± 0.018	0.202CysGln: 0.202 ± 0.011	0.558CysArg: 0.558 ± 0.022	0.493CysSer: 0.493 ± 0.022	0.4CysThr: 0.4 ± 0.018	0.695CysVal: 0.695 ± 0.027	0.133CysTrp: 0.133 ± 0.01	0.231CysTyr: 0.231 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.93AspAla: 5.93 ± 0.08	0.435AspCys: 0.435 ± 0.022	2.617AspAsp: 2.617 ± 0.045	3.076AspGlu: 3.076 ± 0.062	2.42AspPhe: 2.42 ± 0.05	4.475AspGly: 4.475 ± 0.087	1.147AspHis: 1.147 ± 0.03	2.491AspIle: 2.491 ± 0.054	1.775AspLys: 1.775 ± 0.04	5.39AspLeu: 5.39 ± 0.08	0.769AspMet: 0.769 ± 0.024	1.515AspAsn: 1.515 ± 0.041	2.869AspPro: 2.869 ± 0.053	1.61AspGln: 1.61 ± 0.034	3.218AspArg: 3.218 ± 0.056	2.736AspSer: 2.736 ± 0.055	2.898AspThr: 2.898 ± 0.058	3.577AspVal: 3.577 ± 0.057	0.948AspTrp: 0.948 ± 0.03	1.758AspTyr: 1.758 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.959GluAla: 5.959 ± 0.093	0.389GluCys: 0.389 ± 0.016	2.156GluAsp: 2.156 ± 0.046	2.597GluGlu: 2.597 ± 0.062	2.122GluPhe: 2.122 ± 0.043	3.475GluGly: 3.475 ± 0.061	1.077GluHis: 1.077 ± 0.037	3.313GluIle: 3.313 ± 0.06	2.88GluLys: 2.88 ± 0.053	5.797GluLeu: 5.797 ± 0.083	1.031GluMet: 1.031 ± 0.027	1.758GluAsn: 1.758 ± 0.037	2.392GluPro: 2.392 ± 0.049	1.935GluGln: 1.935 ± 0.054	3.714GluArg: 3.714 ± 0.072	2.962GluSer: 2.962 ± 0.049	3.367GluThr: 3.367 ± 0.057	3.654GluVal: 3.654 ± 0.064	0.796GluTrp: 0.796 ± 0.028	0.985GluTyr: 0.985 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.463PheAla: 4.463 ± 0.062	0.412PheCys: 0.412 ± 0.019	2.366PheAsp: 2.366 ± 0.043	2.025PheGlu: 2.025 ± 0.042	1.808PhePhe: 1.808 ± 0.044	3.232PheGly: 3.232 ± 0.059	0.824PheHis: 0.824 ± 0.03	2.091PheIle: 2.091 ± 0.041	1.498PheLys: 1.498 ± 0.035	3.646PheLeu: 3.646 ± 0.059	0.734PheMet: 0.734 ± 0.028	1.619PheAsn: 1.619 ± 0.044	1.821PhePro: 1.821 ± 0.04	1.175PheGln: 1.175 ± 0.03	2.196PheArg: 2.196 ± 0.037	2.938PheSer: 2.938 ± 0.061	3.046PheThr: 3.046 ± 0.062	2.81PheVal: 2.81 ± 0.053	0.611PheTrp: 0.611 ± 0.025	1.126PheTyr: 1.126 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.881GlyAla: 7.881 ± 0.128	0.79GlyCys: 0.79 ± 0.028	3.975GlyAsp: 3.975 ± 0.065	4.04GlyGlu: 4.04 ± 0.067	3.503GlyPhe: 3.503 ± 0.058	6.996GlyGly: 6.996 ± 0.162	1.719GlyHis: 1.719 ± 0.036	4.21GlyIle: 4.21 ± 0.076	3.399GlyLys: 3.399 ± 0.057	8.126GlyLeu: 8.126 ± 0.101	1.649GlyMet: 1.649 ± 0.042	2.698GlyAsn: 2.698 ± 0.083	2.888GlyPro: 2.888 ± 0.054	2.497GlyGln: 2.497 ± 0.054	4.934GlyArg: 4.934 ± 0.067	5.09GlySer: 5.09 ± 0.145	5.34GlyThr: 5.34 ± 0.167	6.169GlyVal: 6.169 ± 0.084	1.467GlyTrp: 1.467 ± 0.041	2.452GlyTyr: 2.452 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.483HisAla: 2.483 ± 0.044	0.236HisCys: 0.236 ± 0.015	1.111HisAsp: 1.111 ± 0.035	1.135HisGlu: 1.135 ± 0.027	0.956HisPhe: 0.956 ± 0.027	1.882HisGly: 1.882 ± 0.039	0.62HisHis: 0.62 ± 0.022	0.96HisIle: 0.96 ± 0.03	0.535HisLys: 0.535 ± 0.021	2.188HisLeu: 2.188 ± 0.052	0.342HisMet: 0.342 ± 0.016	0.571HisAsn: 0.571 ± 0.021	1.398HisPro: 1.398 ± 0.036	0.663HisGln: 0.663 ± 0.026	1.391HisArg: 1.391 ± 0.036	1.056HisSer: 1.056 ± 0.028	1.206HisThr: 1.206 ± 0.034	1.413HisVal: 1.413 ± 0.039	0.369HisTrp: 0.369 ± 0.016	0.652HisTyr: 0.652 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.036IleAla: 6.036 ± 0.077	0.466IleCys: 0.466 ± 0.02	3.308IleAsp: 3.308 ± 0.063	3.286IleGlu: 3.286 ± 0.056	1.886IlePhe: 1.886 ± 0.048	4.381IleGly: 4.381 ± 0.078	1.046IleHis: 1.046 ± 0.032	2.603IleIle: 2.603 ± 0.06	1.977IleLys: 1.977 ± 0.044	4.4IleLeu: 4.4 ± 0.075	0.792IleMet: 0.792 ± 0.028	1.968IleAsn: 1.968 ± 0.053	2.57IlePro: 2.57 ± 0.051	1.445IleGln: 1.445 ± 0.035	2.904IleArg: 2.904 ± 0.054	3.185IleSer: 3.185 ± 0.068	3.804IleThr: 3.804 ± 0.084	3.655IleVal: 3.655 ± 0.061	0.592IleTrp: 0.592 ± 0.024	1.255IleTyr: 1.255 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.18LysAla: 4.18 ± 0.074	0.198LysCys: 0.198 ± 0.013	1.946LysAsp: 1.946 ± 0.053	1.894LysGlu: 1.894 ± 0.046	1.414LysPhe: 1.414 ± 0.034	2.579LysGly: 2.579 ± 0.057	0.824LysHis: 0.824 ± 0.026	2.401LysIle: 2.401 ± 0.047	2.303LysLys: 2.303 ± 0.056	4.129LysLeu: 4.129 ± 0.064	0.867LysMet: 0.867 ± 0.024	1.504LysAsn: 1.504 ± 0.042	2.494LysPro: 2.494 ± 0.053	1.331LysGln: 1.331 ± 0.042	2.412LysArg: 2.412 ± 0.053	2.431LysSer: 2.431 ± 0.048	2.764LysThr: 2.764 ± 0.047	2.563LysVal: 2.563 ± 0.054	0.499LysTrp: 0.499 ± 0.022	0.806LysTyr: 0.806 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.669LeuAla: 12.669 ± 0.14	1.004LeuCys: 1.004 ± 0.03	5.228LeuAsp: 5.228 ± 0.073	4.924LeuGlu: 4.924 ± 0.077	3.804LeuPhe: 3.804 ± 0.064	7.947LeuGly: 7.947 ± 0.104	2.167LeuHis: 2.167 ± 0.045	5.245LeuIle: 5.245 ± 0.083	4.344LeuLys: 4.344 ± 0.062	10.353LeuLeu: 10.353 ± 0.142	1.828LeuMet: 1.828 ± 0.048	3.401LeuAsn: 3.401 ± 0.065	5.881LeuPro: 5.881 ± 0.085	3.131LeuGln: 3.131 ± 0.056	7.195LeuArg: 7.195 ± 0.086	6.551LeuSer: 6.551 ± 0.078	6.774LeuThr: 6.774 ± 0.116	7.536LeuVal: 7.536 ± 0.091	1.301LeuTrp: 1.301 ± 0.037	2.141LeuTyr: 2.141 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.894MetAla: 1.894 ± 0.042	0.137MetCys: 0.137 ± 0.009	0.874MetAsp: 0.874 ± 0.027	0.914MetGlu: 0.914 ± 0.032	0.603MetPhe: 0.603 ± 0.027	1.242MetGly: 1.242 ± 0.036	0.408MetHis: 0.408 ± 0.02	1.068MetIle: 1.068 ± 0.03	1.087MetLys: 1.087 ± 0.032	1.812MetLeu: 1.812 ± 0.045	0.417MetMet: 0.417 ± 0.022	0.825MetAsn: 0.825 ± 0.023	1.197MetPro: 1.197 ± 0.029	0.625MetGln: 0.625 ± 0.021	1.224MetArg: 1.224 ± 0.035	1.461MetSer: 1.461 ± 0.035	1.184MetThr: 1.184 ± 0.033	1.147MetVal: 1.147 ± 0.032	0.191MetTrp: 0.191 ± 0.013	0.21MetTyr: 0.21 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.53AsnAla: 3.53 ± 0.062	0.259AsnCys: 0.259 ± 0.016	1.586AsnAsp: 1.586 ± 0.035	1.543AsnGlu: 1.543 ± 0.033	1.304AsnPhe: 1.304 ± 0.043	2.858AsnGly: 2.858 ± 0.102	0.698AsnHis: 0.698 ± 0.026	1.577AsnIle: 1.577 ± 0.055	0.973AsnLys: 0.973 ± 0.03	3.425AsnLeu: 3.425 ± 0.06	0.465AsnMet: 0.465 ± 0.018	1.247AsnAsn: 1.247 ± 0.047	2.192AsnPro: 2.192 ± 0.047	1.098AsnGln: 1.098 ± 0.033	1.986AsnArg: 1.986 ± 0.045	1.99AsnSer: 1.99 ± 0.054	2.218AsnThr: 2.218 ± 0.062	2.174AsnVal: 2.174 ± 0.056	0.541AsnTrp: 0.541 ± 0.027	1.015AsnTyr: 1.015 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	7.269ProAla: 7.269 ± 0.112	0.323ProCys: 0.323 ± 0.014	3.174ProAsp: 3.174 ± 0.052	3.363ProGlu: 3.363 ± 0.052	2.041ProPhe: 2.041 ± 0.046	4.031ProGly: 4.031 ± 0.063	1.139ProHis: 1.139 ± 0.032	2.04ProIle: 2.04 ± 0.045	1.959ProLys: 1.959 ± 0.05	4.953ProLeu: 4.953 ± 0.074	0.961ProMet: 0.961 ± 0.032	1.389ProAsn: 1.389 ± 0.036	2.529ProPro: 2.529 ± 0.064	1.444ProGln: 1.444 ± 0.034	2.792ProArg: 2.792 ± 0.058	3.391ProSer: 3.391 ± 0.069	2.796ProThr: 2.796 ± 0.074	4.61ProVal: 4.61 ± 0.071	0.805ProTrp: 0.805 ± 0.03	1.137ProTyr: 1.137 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.542GlnAla: 3.542 ± 0.06	0.208GlnCys: 0.208 ± 0.012	1.223GlnAsp: 1.223 ± 0.032	1.361GlnGlu: 1.361 ± 0.037	1.201GlnPhe: 1.201 ± 0.031	2.14GlnGly: 2.14 ± 0.04	0.674GlnHis: 0.674 ± 0.025	1.863GlnIle: 1.863 ± 0.037	1.425GlnLys: 1.425 ± 0.034	3.626GlnLeu: 3.626 ± 0.062	0.646GlnMet: 0.646 ± 0.022	0.983GlnAsn: 0.983 ± 0.029	1.926GlnPro: 1.926 ± 0.048	1.278GlnGln: 1.278 ± 0.053	2.272GlnArg: 2.272 ± 0.056	2.044GlnSer: 2.044 ± 0.042	1.977GlnThr: 1.977 ± 0.044	2.331GlnVal: 2.331 ± 0.046	0.458GlnTrp: 0.458 ± 0.019	0.553GlnTyr: 0.553 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	6.634ArgAla: 6.634 ± 0.094	0.519ArgCys: 0.519 ± 0.021	3.389ArgAsp: 3.389 ± 0.065	3.94ArgGlu: 3.94 ± 0.075	2.737ArgPhe: 2.737 ± 0.049	4.007ArgGly: 4.007 ± 0.064	1.495ArgHis: 1.495 ± 0.037	3.7ArgIle: 3.7 ± 0.053	2.3ArgLys: 2.3 ± 0.055	7.092ArgLeu: 7.092 ± 0.084	1.429ArgMet: 1.429 ± 0.037	1.836ArgAsn: 1.836 ± 0.04	3.017ArgPro: 3.017 ± 0.058	2.139ArgGln: 2.139 ± 0.044	4.499ArgArg: 4.499 ± 0.072	3.496ArgSer: 3.496 ± 0.067	3.572ArgThr: 3.572 ± 0.067	4.686ArgVal: 4.686 ± 0.061	1.118ArgTrp: 1.118 ± 0.033	1.74ArgTyr: 1.74 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.301SerAla: 7.301 ± 0.108	0.458SerCys: 0.458 ± 0.024	3.042SerAsp: 3.042 ± 0.052	2.923SerGlu: 2.923 ± 0.053	2.565SerPhe: 2.565 ± 0.062	5.891SerGly: 5.891 ± 0.128	1.229SerHis: 1.229 ± 0.037	3.073SerIle: 3.073 ± 0.069	2.016SerLys: 2.016 ± 0.047	6.731SerLeu: 6.731 ± 0.085	1.147SerMet: 1.147 ± 0.032	1.894SerAsn: 1.894 ± 0.054	3.39SerPro: 3.39 ± 0.061	1.806SerGln: 1.806 ± 0.044	3.59SerArg: 3.59 ± 0.05	4.285SerSer: 4.285 ± 0.083	3.919SerThr: 3.919 ± 0.077	4.448SerVal: 4.448 ± 0.077	0.963SerTrp: 0.963 ± 0.028	1.573SerTyr: 1.573 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.174ThrAla: 7.174 ± 0.117	0.431ThrCys: 0.431 ± 0.02	3.102ThrAsp: 3.102 ± 0.061	2.793ThrGlu: 2.793 ± 0.054	2.549ThrPhe: 2.549 ± 0.059	6.183ThrGly: 6.183 ± 0.158	1.342ThrHis: 1.342 ± 0.036	3.087ThrIle: 3.087 ± 0.081	2.059ThrLys: 2.059 ± 0.042	7.163ThrLeu: 7.163 ± 0.125	0.861ThrMet: 0.861 ± 0.027	1.96ThrAsn: 1.96 ± 0.063	4.187ThrPro: 4.187 ± 0.083	1.967ThrGln: 1.967 ± 0.043	3.546ThrArg: 3.546 ± 0.061	3.832ThrSer: 3.832 ± 0.081	4.286ThrThr: 4.286 ± 0.119	4.834ThrVal: 4.834 ± 0.093	1.009ThrTrp: 1.009 ± 0.042	1.743ThrTyr: 1.743 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	7.738ValAla: 7.738 ± 0.071	0.741ValCys: 0.741 ± 0.024	3.498ValAsp: 3.498 ± 0.052	3.866ValGlu: 3.866 ± 0.067	3.203ValPhe: 3.203 ± 0.055	4.879ValGly: 4.879 ± 0.079	1.371ValHis: 1.371 ± 0.033	4.331ValIle: 4.331 ± 0.077	2.856ValLys: 2.856 ± 0.063	7.35ValLeu: 7.35 ± 0.093	1.46ValMet: 1.46 ± 0.04	2.437ValAsn: 2.437 ± 0.059	3.571ValPro: 3.571 ± 0.058	2.098ValGln: 2.098 ± 0.039	4.638ValArg: 4.638 ± 0.074	4.996ValSer: 4.996 ± 0.079	5.059ValThr: 5.059 ± 0.098	5.646ValVal: 5.646 ± 0.068	1.05ValTrp: 1.05 ± 0.035	1.692ValTyr: 1.692 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.239TrpAla: 1.239 ± 0.037	0.186TrpCys: 0.186 ± 0.012	0.76TrpAsp: 0.76 ± 0.029	0.674TrpGlu: 0.674 ± 0.028	0.646TrpPhe: 0.646 ± 0.024	0.956TrpGly: 0.956 ± 0.034	0.369TrpHis: 0.369 ± 0.018	0.836TrpIle: 0.836 ± 0.03	0.694TrpLys: 0.694 ± 0.028	1.92TrpLeu: 1.92 ± 0.052	0.389TrpMet: 0.389 ± 0.021	0.638TrpAsn: 0.638 ± 0.022	0.673TrpPro: 0.673 ± 0.026	0.62TrpGln: 0.62 ± 0.023	1.135TrpArg: 1.135 ± 0.038	0.996TrpSer: 0.996 ± 0.033	1.016TrpThr: 1.016 ± 0.032	0.997TrpVal: 0.997 ± 0.029	0.313TrpTrp: 0.313 ± 0.019	0.276TrpTyr: 0.276 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.631TyrAla: 2.631 ± 0.052	0.235TyrCys: 0.235 ± 0.015	1.485TyrAsp: 1.485 ± 0.043	1.225TyrGlu: 1.225 ± 0.03	1.158TyrPhe: 1.158 ± 0.037	1.999TyrGly: 1.999 ± 0.04	0.559TyrHis: 0.559 ± 0.02	1.01TyrIle: 1.01 ± 0.031	0.795TyrLys: 0.795 ± 0.03	2.482TyrLeu: 2.482 ± 0.046	0.337TyrMet: 0.337 ± 0.017	0.834TyrAsn: 0.834 ± 0.03	1.251TyrPro: 1.251 ± 0.034	0.927TyrGln: 0.927 ± 0.03	1.882TyrArg: 1.882 ± 0.043	1.511TyrSer: 1.511 ± 0.042	1.599TyrThr: 1.599 ± 0.041	1.62TyrVal: 1.62 ± 0.037	0.444TyrTrp: 0.444 ± 0.02	0.799TyrTyr: 0.799 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3424 proteins (1258522 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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