Amino acid dipepetide frequency for Burkholderiales bacterium GJ-E10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.554AlaAla: 20.554 ± 0.305	1.38AlaCys: 1.38 ± 0.046	7.017AlaAsp: 7.017 ± 0.088	7.087AlaGlu: 7.087 ± 0.112	3.863AlaPhe: 3.863 ± 0.074	11.317AlaGly: 11.317 ± 0.16	2.81AlaHis: 2.81 ± 0.065	6.391AlaIle: 6.391 ± 0.095	3.173AlaLys: 3.173 ± 0.072	14.323AlaLeu: 14.323 ± 0.172	3.494AlaMet: 3.494 ± 0.054	2.958AlaAsn: 2.958 ± 0.072	6.46AlaPro: 6.46 ± 0.119	5.659AlaGln: 5.659 ± 0.096	11.023AlaArg: 11.023 ± 0.135	6.44AlaSer: 6.44 ± 0.183	6.209AlaThr: 6.209 ± 0.151	9.871AlaVal: 9.871 ± 0.127	1.809AlaTrp: 1.809 ± 0.046	2.617AlaTyr: 2.617 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.345CysAla: 1.345 ± 0.042	0.164CysCys: 0.164 ± 0.012	0.577CysAsp: 0.577 ± 0.027	0.528CysGlu: 0.528 ± 0.023	0.323CysPhe: 0.323 ± 0.02	1.094CysGly: 1.094 ± 0.04	0.245CysHis: 0.245 ± 0.019	0.381CysIle: 0.381 ± 0.019	0.2CysLys: 0.2 ± 0.016	0.76CysLeu: 0.76 ± 0.032	0.179CysMet: 0.179 ± 0.015	0.295CysAsn: 0.295 ± 0.02	0.596CysPro: 0.596 ± 0.028	0.207CysGln: 0.207 ± 0.015	0.766CysArg: 0.766 ± 0.03	0.485CysSer: 0.485 ± 0.027	0.496CysThr: 0.496 ± 0.022	0.699CysVal: 0.699 ± 0.029	0.103CysTrp: 0.103 ± 0.009	0.214CysTyr: 0.214 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.09AspAla: 8.09 ± 0.097	0.553AspCys: 0.553 ± 0.025	2.941AspAsp: 2.941 ± 0.061	3.232AspGlu: 3.232 ± 0.066	2.156AspPhe: 2.156 ± 0.049	4.845AspGly: 4.845 ± 0.082	1.155AspHis: 1.155 ± 0.035	2.38AspIle: 2.38 ± 0.055	1.223AspLys: 1.223 ± 0.04	6.156AspLeu: 6.156 ± 0.083	0.975AspMet: 0.975 ± 0.033	1.063AspAsn: 1.063 ± 0.035	3.833AspPro: 3.833 ± 0.066	1.478AspGln: 1.478 ± 0.046	4.755AspArg: 4.755 ± 0.078	2.3AspSer: 2.3 ± 0.047	2.398AspThr: 2.398 ± 0.052	4.006AspVal: 4.006 ± 0.077	0.928AspTrp: 0.928 ± 0.03	1.22AspTyr: 1.22 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.809GluAla: 6.809 ± 0.086	0.465GluCys: 0.465 ± 0.025	2.467GluAsp: 2.467 ± 0.056	3.004GluGlu: 3.004 ± 0.072	1.966GluPhe: 1.966 ± 0.058	3.622GluGly: 3.622 ± 0.064	1.413GluHis: 1.413 ± 0.044	3.338GluIle: 3.338 ± 0.066	1.53GluLys: 1.53 ± 0.056	5.142GluLeu: 5.142 ± 0.097	1.255GluMet: 1.255 ± 0.039	1.215GluAsn: 1.215 ± 0.039	2.684GluPro: 2.684 ± 0.062	2.237GluGln: 2.237 ± 0.06	5.541GluArg: 5.541 ± 0.098	3.0GluSer: 3.0 ± 0.063	2.946GluThr: 2.946 ± 0.064	3.656GluVal: 3.656 ± 0.065	0.685GluTrp: 0.685 ± 0.031	1.134GluTyr: 1.134 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.461PheAla: 4.461 ± 0.076	0.36PheCys: 0.36 ± 0.021	2.603PheAsp: 2.603 ± 0.055	1.897PheGlu: 1.897 ± 0.056	1.316PhePhe: 1.316 ± 0.043	3.305PheGly: 3.305 ± 0.059	0.826PheHis: 0.826 ± 0.028	1.171PheIle: 1.171 ± 0.034	0.692PheLys: 0.692 ± 0.029	3.501PheLeu: 3.501 ± 0.08	0.522PheMet: 0.522 ± 0.022	0.816PheAsn: 0.816 ± 0.031	1.709PhePro: 1.709 ± 0.045	0.997PheGln: 0.997 ± 0.033	2.482PheArg: 2.482 ± 0.056	2.037PheSer: 2.037 ± 0.05	1.671PheThr: 1.671 ± 0.043	2.836PheVal: 2.836 ± 0.061	0.465PheTrp: 0.465 ± 0.023	0.801PheTyr: 0.801 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.322GlyAla: 10.322 ± 0.184	0.948GlyCys: 0.948 ± 0.034	4.359GlyAsp: 4.359 ± 0.069	4.284GlyGlu: 4.284 ± 0.087	3.186GlyPhe: 3.186 ± 0.064	7.294GlyGly: 7.294 ± 0.156	1.825GlyHis: 1.825 ± 0.048	4.428GlyIle: 4.428 ± 0.075	2.899GlyLys: 2.899 ± 0.066	7.868GlyLeu: 7.868 ± 0.093	2.334GlyMet: 2.334 ± 0.05	2.353GlyAsn: 2.353 ± 0.079	3.347GlyPro: 3.347 ± 0.065	2.54GlyGln: 2.54 ± 0.063	6.295GlyArg: 6.295 ± 0.096	5.0GlySer: 5.0 ± 0.158	4.899GlyThr: 4.899 ± 0.112	6.49GlyVal: 6.49 ± 0.118	1.262GlyTrp: 1.262 ± 0.042	2.187GlyTyr: 2.187 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	3.101HisAla: 3.101 ± 0.06	0.314HisCys: 0.314 ± 0.019	1.289HisAsp: 1.289 ± 0.042	1.13HisGlu: 1.13 ± 0.04	0.886HisPhe: 0.886 ± 0.029	2.194HisGly: 2.194 ± 0.046	0.647HisHis: 0.647 ± 0.035	0.903HisIle: 0.903 ± 0.032	0.435HisLys: 0.435 ± 0.021	2.26HisLeu: 2.26 ± 0.05	0.449HisMet: 0.449 ± 0.022	0.472HisAsn: 0.472 ± 0.021	1.646HisPro: 1.646 ± 0.042	0.614HisGln: 0.614 ± 0.025	1.931HisArg: 1.931 ± 0.048	0.967HisSer: 0.967 ± 0.037	0.978HisThr: 0.978 ± 0.032	1.598HisVal: 1.598 ± 0.044	0.399HisTrp: 0.399 ± 0.022	0.607HisTyr: 0.607 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.15IleAla: 7.15 ± 0.091	0.375IleCys: 0.375 ± 0.02	3.527IleAsp: 3.527 ± 0.063	3.502IleGlu: 3.502 ± 0.072	1.329IlePhe: 1.329 ± 0.039	4.496IleGly: 4.496 ± 0.073	1.083IleHis: 1.083 ± 0.036	1.425IleIle: 1.425 ± 0.042	1.125IleLys: 1.125 ± 0.038	4.085IleLeu: 4.085 ± 0.067	0.667IleMet: 0.667 ± 0.027	1.168IleAsn: 1.168 ± 0.042	2.643IlePro: 2.643 ± 0.05	1.246IleGln: 1.246 ± 0.035	3.474IleArg: 3.474 ± 0.073	2.286IleSer: 2.286 ± 0.06	2.23IleThr: 2.23 ± 0.06	3.852IleVal: 3.852 ± 0.072	0.515IleTrp: 0.515 ± 0.026	0.934IleTyr: 0.934 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.048LysAla: 3.048 ± 0.076	0.158LysCys: 0.158 ± 0.015	1.207LysAsp: 1.207 ± 0.036	1.245LysGlu: 1.245 ± 0.041	0.75LysPhe: 0.75 ± 0.034	1.824LysGly: 1.824 ± 0.046	0.475LysHis: 0.475 ± 0.021	1.386LysIle: 1.386 ± 0.041	1.019LysLys: 1.019 ± 0.048	2.466LysLeu: 2.466 ± 0.056	0.62LysMet: 0.62 ± 0.029	0.704LysAsn: 0.704 ± 0.031	1.606LysPro: 1.606 ± 0.039	0.864LysGln: 0.864 ± 0.03	2.077LysArg: 2.077 ± 0.052	1.409LysSer: 1.409 ± 0.04	1.576LysThr: 1.576 ± 0.043	1.795LysVal: 1.795 ± 0.051	0.316LysTrp: 0.316 ± 0.019	0.515LysTyr: 0.515 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.626LeuAla: 14.626 ± 0.167	0.938LeuCys: 0.938 ± 0.033	6.04LeuAsp: 6.04 ± 0.093	4.975LeuGlu: 4.975 ± 0.093	3.357LeuPhe: 3.357 ± 0.067	8.131LeuGly: 8.131 ± 0.103	2.568LeuHis: 2.568 ± 0.054	4.027LeuIle: 4.027 ± 0.071	2.239LeuLys: 2.239 ± 0.057	10.433LeuLeu: 10.433 ± 0.147	1.821LeuMet: 1.821 ± 0.045	2.117LeuAsn: 2.117 ± 0.05	5.815LeuPro: 5.815 ± 0.087	3.747LeuGln: 3.747 ± 0.061	9.623LeuArg: 9.623 ± 0.132	5.338LeuSer: 5.338 ± 0.091	4.786LeuThr: 4.786 ± 0.076	7.26LeuVal: 7.26 ± 0.096	1.169LeuTrp: 1.169 ± 0.039	1.944LeuTyr: 1.944 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.694MetAla: 2.694 ± 0.064	0.129MetCys: 0.129 ± 0.012	0.972MetAsp: 0.972 ± 0.031	1.05MetGlu: 1.05 ± 0.034	0.61MetPhe: 0.61 ± 0.025	1.557MetGly: 1.557 ± 0.043	0.564MetHis: 0.564 ± 0.025	1.05MetIle: 1.05 ± 0.033	0.769MetLys: 0.769 ± 0.028	2.419MetLeu: 2.419 ± 0.052	0.504MetMet: 0.504 ± 0.024	0.769MetAsn: 0.769 ± 0.029	1.405MetPro: 1.405 ± 0.04	0.956MetGln: 0.956 ± 0.031	1.966MetArg: 1.966 ± 0.05	1.319MetSer: 1.319 ± 0.038	1.497MetThr: 1.497 ± 0.041	1.5MetVal: 1.5 ± 0.037	0.166MetTrp: 0.166 ± 0.011	0.375MetTyr: 0.375 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.981AsnAla: 2.981 ± 0.064	0.265AsnCys: 0.265 ± 0.019	1.228AsnAsp: 1.228 ± 0.048	1.132AsnGlu: 1.132 ± 0.035	0.866AsnPhe: 0.866 ± 0.03	2.212AsnGly: 2.212 ± 0.074	0.503AsnHis: 0.503 ± 0.022	1.137AsnIle: 1.137 ± 0.041	0.543AsnLys: 0.543 ± 0.03	2.608AsnLeu: 2.608 ± 0.056	0.475AsnMet: 0.475 ± 0.025	0.606AsnAsn: 0.606 ± 0.028	1.93AsnPro: 1.93 ± 0.046	0.789AsnGln: 0.789 ± 0.033	2.003AsnArg: 2.003 ± 0.046	1.122AsnSer: 1.122 ± 0.048	1.168AsnThr: 1.168 ± 0.044	1.768AsnVal: 1.768 ± 0.057	0.369AsnTrp: 0.369 ± 0.02	0.531AsnTyr: 0.531 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.427ProAla: 7.427 ± 0.124	0.395ProCys: 0.395 ± 0.02	3.714ProAsp: 3.714 ± 0.067	3.503ProGlu: 3.503 ± 0.065	1.763ProPhe: 1.763 ± 0.042	5.005ProGly: 5.005 ± 0.075	1.113ProHis: 1.113 ± 0.031	2.325ProIle: 2.325 ± 0.047	1.278ProLys: 1.278 ± 0.033	4.732ProLeu: 4.732 ± 0.08	1.289ProMet: 1.289 ± 0.038	1.246ProAsn: 1.246 ± 0.036	3.296ProPro: 3.296 ± 0.072	2.009ProGln: 2.009 ± 0.049	3.556ProArg: 3.556 ± 0.066	2.749ProSer: 2.749 ± 0.052	2.615ProThr: 2.615 ± 0.056	4.476ProVal: 4.476 ± 0.073	0.813ProTrp: 0.813 ± 0.03	1.27ProTyr: 1.27 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.896GlnAla: 4.896 ± 0.093	0.29GlnCys: 0.29 ± 0.018	1.692GlnAsp: 1.692 ± 0.036	1.879GlnGlu: 1.879 ± 0.051	1.207GlnPhe: 1.207 ± 0.038	2.609GlnGly: 2.609 ± 0.057	0.799GlnHis: 0.799 ± 0.03	1.888GlnIle: 1.888 ± 0.048	0.816GlnLys: 0.816 ± 0.029	3.084GlnLeu: 3.084 ± 0.058	0.874GlnMet: 0.874 ± 0.032	0.829GlnAsn: 0.829 ± 0.034	1.785GlnPro: 1.785 ± 0.047	1.418GlnGln: 1.418 ± 0.043	3.262GlnArg: 3.262 ± 0.066	1.832GlnSer: 1.832 ± 0.054	1.9GlnThr: 1.9 ± 0.054	2.598GlnVal: 2.598 ± 0.058	0.55GlnTrp: 0.55 ± 0.025	0.757GlnTyr: 0.757 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.963ArgAla: 9.963 ± 0.143	0.725ArgCys: 0.725 ± 0.029	4.621ArgAsp: 4.621 ± 0.072	4.873ArgGlu: 4.873 ± 0.093	3.432ArgPhe: 3.432 ± 0.065	5.713ArgGly: 5.713 ± 0.088	2.115ArgHis: 2.115 ± 0.054	4.898ArgIle: 4.898 ± 0.09	2.36ArgLys: 2.36 ± 0.053	8.508ArgLeu: 8.508 ± 0.122	2.271ArgMet: 2.271 ± 0.053	2.326ArgAsn: 2.326 ± 0.054	3.653ArgPro: 3.653 ± 0.07	2.954ArgGln: 2.954 ± 0.065	7.037ArgArg: 7.037 ± 0.114	4.121ArgSer: 4.121 ± 0.075	3.846ArgThr: 3.846 ± 0.066	5.676ArgVal: 5.676 ± 0.088	1.349ArgTrp: 1.349 ± 0.041	2.186ArgTyr: 2.186 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.636SerAla: 6.636 ± 0.144	0.54SerCys: 0.54 ± 0.028	2.539SerAsp: 2.539 ± 0.053	2.418SerGlu: 2.418 ± 0.053	1.822SerPhe: 1.822 ± 0.047	5.513SerGly: 5.513 ± 0.175	1.086SerHis: 1.086 ± 0.034	2.46SerIle: 2.46 ± 0.057	1.154SerLys: 1.154 ± 0.038	5.105SerLeu: 5.105 ± 0.07	1.261SerMet: 1.261 ± 0.04	1.25SerAsn: 1.25 ± 0.052	2.882SerPro: 2.882 ± 0.063	1.584SerGln: 1.584 ± 0.052	3.746SerArg: 3.746 ± 0.077	2.874SerSer: 2.874 ± 0.127	2.63SerThr: 2.63 ± 0.088	3.962SerVal: 3.962 ± 0.112	0.808SerTrp: 0.808 ± 0.03	1.168SerTyr: 1.168 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.259ThrAla: 6.259 ± 0.136	0.395ThrCys: 0.395 ± 0.023	2.46ThrAsp: 2.46 ± 0.047	2.443ThrGlu: 2.443 ± 0.051	1.557ThrPhe: 1.557 ± 0.041	4.815ThrGly: 4.815 ± 0.106	1.06ThrHis: 1.06 ± 0.036	2.583ThrIle: 2.583 ± 0.065	1.06ThrLys: 1.06 ± 0.034	5.554ThrLeu: 5.554 ± 0.079	1.081ThrMet: 1.081 ± 0.034	1.249ThrAsn: 1.249 ± 0.047	3.392ThrPro: 3.392 ± 0.067	1.736ThrGln: 1.736 ± 0.057	3.379ThrArg: 3.379 ± 0.066	2.335ThrSer: 2.335 ± 0.098	2.777ThrThr: 2.777 ± 0.092	4.474ThrVal: 4.474 ± 0.109	0.591ThrTrp: 0.591 ± 0.027	1.034ThrTyr: 1.034 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	10.187ValAla: 10.187 ± 0.17	0.809ValCys: 0.809 ± 0.026	4.512ValAsp: 4.512 ± 0.069	4.209ValGlu: 4.209 ± 0.065	2.652ValPhe: 2.652 ± 0.052	5.623ValGly: 5.623 ± 0.134	1.699ValHis: 1.699 ± 0.039	3.336ValIle: 3.336 ± 0.061	1.665ValLys: 1.665 ± 0.05	7.974ValLeu: 7.974 ± 0.1	1.47ValMet: 1.47 ± 0.04	1.875ValAsn: 1.875 ± 0.059	4.177ValPro: 4.177 ± 0.069	2.578ValGln: 2.578 ± 0.065	6.32ValArg: 6.32 ± 0.101	3.956ValSer: 3.956 ± 0.089	3.846ValThr: 3.846 ± 0.102	6.288ValVal: 6.288 ± 0.107	0.847ValTrp: 0.847 ± 0.03	1.528ValTyr: 1.528 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.252TrpAla: 1.252 ± 0.036	0.171TrpCys: 0.171 ± 0.012	0.693TrpAsp: 0.693 ± 0.027	0.669TrpGlu: 0.669 ± 0.03	0.573TrpPhe: 0.573 ± 0.024	0.896TrpGly: 0.896 ± 0.036	0.368TrpHis: 0.368 ± 0.02	0.853TrpIle: 0.853 ± 0.031	0.399TrpLys: 0.399 ± 0.02	1.629TrpLeu: 1.629 ± 0.043	0.394TrpMet: 0.394 ± 0.022	0.427TrpAsn: 0.427 ± 0.024	0.595TrpPro: 0.595 ± 0.029	0.592TrpGln: 0.592 ± 0.024	1.317TrpArg: 1.317 ± 0.038	0.702TrpSer: 0.702 ± 0.025	0.707TrpThr: 0.707 ± 0.026	1.002TrpVal: 1.002 ± 0.04	0.213TrpTrp: 0.213 ± 0.016	0.282TrpTyr: 0.282 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.653TyrAla: 2.653 ± 0.058	0.284TyrCys: 0.284 ± 0.019	1.229TyrAsp: 1.229 ± 0.039	1.052TyrGlu: 1.052 ± 0.033	0.853TyrPhe: 0.853 ± 0.034	2.057TyrGly: 2.057 ± 0.052	0.464TyrHis: 0.464 ± 0.021	0.753TyrIle: 0.753 ± 0.033	0.484TyrLys: 0.484 ± 0.024	2.348TyrLeu: 2.348 ± 0.053	0.334TyrMet: 0.334 ± 0.019	0.495TyrAsn: 0.495 ± 0.023	1.118TyrPro: 1.118 ± 0.035	0.76TyrGln: 0.76 ± 0.027	2.073TyrArg: 2.073 ± 0.047	1.167TyrSer: 1.167 ± 0.042	1.057TyrThr: 1.057 ± 0.038	1.743TyrVal: 1.743 ± 0.043	0.379TyrTrp: 0.379 ± 0.02	0.614TyrTyr: 0.614 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2955 proteins (952706 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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