Amino acid dipepetide frequency for Caloramator australicus RC3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.496AlaAla: 4.496 ± 0.116
0.552AlaCys: 0.552 ± 0.03
2.572AlaAsp: 2.572 ± 0.056
3.767AlaGlu: 3.767 ± 0.074
2.86AlaPhe: 2.86 ± 0.068
3.713AlaGly: 3.713 ± 0.081
0.856AlaHis: 0.856 ± 0.034
6.095AlaIle: 6.095 ± 0.113
5.18AlaLys: 5.18 ± 0.091
6.342AlaLeu: 6.342 ± 0.106
1.67AlaMet: 1.67 ± 0.045
2.626AlaAsn: 2.626 ± 0.059
1.464AlaPro: 1.464 ± 0.047
1.455AlaGln: 1.455 ± 0.044
2.381AlaArg: 2.381 ± 0.057
3.131AlaSer: 3.131 ± 0.075
2.559AlaThr: 2.559 ± 0.062
4.235AlaVal: 4.235 ± 0.095
0.374AlaTrp: 0.374 ± 0.025
2.226AlaTyr: 2.226 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.545CysAla: 0.545 ± 0.03
0.16CysCys: 0.16 ± 0.016
0.599CysAsp: 0.599 ± 0.03
0.578CysGlu: 0.578 ± 0.033
0.44CysPhe: 0.44 ± 0.023
0.946CysGly: 0.946 ± 0.037
0.207CysHis: 0.207 ± 0.018
0.878CysIle: 0.878 ± 0.034
0.827CysLys: 0.827 ± 0.039
0.748CysLeu: 0.748 ± 0.033
0.222CysMet: 0.222 ± 0.018
0.513CysAsn: 0.513 ± 0.027
0.54CysPro: 0.54 ± 0.032
0.215CysGln: 0.215 ± 0.017
0.36CysArg: 0.36 ± 0.022
0.611CysSer: 0.611 ± 0.029
0.342CysThr: 0.342 ± 0.02
0.525CysVal: 0.525 ± 0.026
0.055CysTrp: 0.055 ± 0.008
0.39CysTyr: 0.39 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.041AspAla: 3.041 ± 0.07
0.556AspCys: 0.556 ± 0.031
2.925AspAsp: 2.925 ± 0.07
5.109AspGlu: 5.109 ± 0.101
3.142AspPhe: 3.142 ± 0.072
3.484AspGly: 3.484 ± 0.082
0.532AspHis: 0.532 ± 0.025
6.37AspIle: 6.37 ± 0.098
5.203AspLys: 5.203 ± 0.089
5.012AspLeu: 5.012 ± 0.095
1.349AspMet: 1.349 ± 0.043
2.692AspAsn: 2.692 ± 0.069
1.557AspPro: 1.557 ± 0.051
0.723AspGln: 0.723 ± 0.032
1.966AspArg: 1.966 ± 0.048
2.431AspSer: 2.431 ± 0.058
2.101AspThr: 2.101 ± 0.061
4.264AspVal: 4.264 ± 0.08
0.374AspTrp: 0.374 ± 0.022
2.775AspTyr: 2.775 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.483GluAla: 4.483 ± 0.084
0.592GluCys: 0.592 ± 0.027
4.499GluAsp: 4.499 ± 0.087
6.881GluGlu: 6.881 ± 0.145
3.42GluPhe: 3.42 ± 0.079
4.901GluGly: 4.901 ± 0.08
0.949GluHis: 0.949 ± 0.041
8.26GluIle: 8.26 ± 0.118
7.942GluLys: 7.942 ± 0.124
6.687GluLeu: 6.687 ± 0.093
2.082GluMet: 2.082 ± 0.054
4.858GluAsn: 4.858 ± 0.09
1.448GluPro: 1.448 ± 0.047
1.333GluGln: 1.333 ± 0.041
3.625GluArg: 3.625 ± 0.068
2.654GluSer: 2.654 ± 0.062
2.757GluThr: 2.757 ± 0.057
5.184GluVal: 5.184 ± 0.091
0.514GluTrp: 0.514 ± 0.026
3.237GluTyr: 3.237 ± 0.075
0.001GluXaa: 0.001 ± 0.001
Phe
2.632PheAla: 2.632 ± 0.066
0.497PheCys: 0.497 ± 0.028
2.847PheAsp: 2.847 ± 0.06
3.482PheGlu: 3.482 ± 0.072
2.146PhePhe: 2.146 ± 0.068
3.037PheGly: 3.037 ± 0.07
0.51PheHis: 0.51 ± 0.024
5.119PheIle: 5.119 ± 0.09
4.248PheLys: 4.248 ± 0.082
4.653PheLeu: 4.653 ± 0.1
1.083PheMet: 1.083 ± 0.04
2.938PheAsn: 2.938 ± 0.063
1.298PhePro: 1.298 ± 0.04
0.892PheGln: 0.892 ± 0.034
1.489PheArg: 1.489 ± 0.044
3.006PheSer: 3.006 ± 0.069
2.256PheThr: 2.256 ± 0.062
2.91PheVal: 2.91 ± 0.063
0.329PheTrp: 0.329 ± 0.02
2.161PheTyr: 2.161 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
3.929GlyAla: 3.929 ± 0.092
0.851GlyCys: 0.851 ± 0.042
3.161GlyAsp: 3.161 ± 0.074
4.229GlyGlu: 4.229 ± 0.072
3.211GlyPhe: 3.211 ± 0.068
4.174GlyGly: 4.174 ± 0.1
1.028GlyHis: 1.028 ± 0.037
6.924GlyIle: 6.924 ± 0.093
5.693GlyLys: 5.693 ± 0.093
5.732GlyLeu: 5.732 ± 0.102
1.575GlyMet: 1.575 ± 0.045
2.847GlyAsn: 2.847 ± 0.06
1.452GlyPro: 1.452 ± 0.048
1.594GlyGln: 1.594 ± 0.046
2.757GlyArg: 2.757 ± 0.068
3.207GlySer: 3.207 ± 0.076
3.077GlyThr: 3.077 ± 0.078
4.385GlyVal: 4.385 ± 0.1
0.483GlyTrp: 0.483 ± 0.026
3.171GlyTyr: 3.171 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
0.758HisAla: 0.758 ± 0.028
0.147HisCys: 0.147 ± 0.014
0.802HisAsp: 0.802 ± 0.034
0.896HisGlu: 0.896 ± 0.035
0.611HisPhe: 0.611 ± 0.029
0.989HisGly: 0.989 ± 0.042
0.277HisHis: 0.277 ± 0.021
1.236HisIle: 1.236 ± 0.035
0.959HisLys: 0.959 ± 0.035
1.203HisLeu: 1.203 ± 0.04
0.249HisMet: 0.249 ± 0.016
0.689HisAsn: 0.689 ± 0.032
0.738HisPro: 0.738 ± 0.032
0.333HisGln: 0.333 ± 0.02
0.574HisArg: 0.574 ± 0.029
0.723HisSer: 0.723 ± 0.031
0.573HisThr: 0.573 ± 0.029
0.899HisVal: 0.899 ± 0.037
0.103HisTrp: 0.103 ± 0.012
0.611HisTyr: 0.611 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.375IleAla: 6.375 ± 0.108
0.956IleCys: 0.956 ± 0.036
6.319IleAsp: 6.319 ± 0.107
7.967IleGlu: 7.967 ± 0.123
4.779IlePhe: 4.779 ± 0.092
5.929IleGly: 5.929 ± 0.104
1.166IleHis: 1.166 ± 0.04
10.091IleIle: 10.091 ± 0.151
10.253IleLys: 10.253 ± 0.128
9.838IleLeu: 9.838 ± 0.15
2.226IleMet: 2.226 ± 0.053
6.111IleAsn: 6.111 ± 0.104
3.435IlePro: 3.435 ± 0.074
2.095IleGln: 2.095 ± 0.062
3.549IleArg: 3.549 ± 0.072
6.152IleSer: 6.152 ± 0.107
4.578IleThr: 4.578 ± 0.081
6.183IleVal: 6.183 ± 0.105
0.553IleTrp: 0.553 ± 0.023
3.981IleTyr: 3.981 ± 0.078
0.001IleXaa: 0.001 ± 0.001
Lys
4.944LysAla: 4.944 ± 0.083
0.701LysCys: 0.701 ± 0.036
6.106LysAsp: 6.106 ± 0.108
9.264LysGlu: 9.264 ± 0.13
3.579LysPhe: 3.579 ± 0.073
5.646LysGly: 5.646 ± 0.09
1.119LysHis: 1.119 ± 0.038
9.223LysIle: 9.223 ± 0.12
8.1LysLys: 8.1 ± 0.119
8.146LysLeu: 8.146 ± 0.115
2.208LysMet: 2.208 ± 0.053
6.248LysAsn: 6.248 ± 0.1
2.236LysPro: 2.236 ± 0.063
2.013LysGln: 2.013 ± 0.051
4.246LysArg: 4.246 ± 0.087
4.422LysSer: 4.422 ± 0.086
4.016LysThr: 4.016 ± 0.076
6.054LysVal: 6.054 ± 0.096
0.595LysTrp: 0.595 ± 0.031
4.0LysTyr: 4.0 ± 0.075
0.001LysXaa: 0.001 ± 0.001
Leu
5.4LeuAla: 5.4 ± 0.094
0.869LeuCys: 0.869 ± 0.041
5.188LeuAsp: 5.188 ± 0.081
6.76LeuGlu: 6.76 ± 0.093
4.029LeuPhe: 4.029 ± 0.095
6.165LeuGly: 6.165 ± 0.093
1.121LeuHis: 1.121 ± 0.039
9.08LeuIle: 9.08 ± 0.156
9.809LeuLys: 9.809 ± 0.153
8.797LeuLeu: 8.797 ± 0.159
2.149LeuMet: 2.149 ± 0.06
6.255LeuAsn: 6.255 ± 0.103
3.006LeuPro: 3.006 ± 0.072
2.184LeuGln: 2.184 ± 0.051
3.682LeuArg: 3.682 ± 0.073
6.426LeuSer: 6.426 ± 0.101
4.525LeuThr: 4.525 ± 0.081
5.309LeuVal: 5.309 ± 0.107
0.632LeuTrp: 0.632 ± 0.03
3.421LeuTyr: 3.421 ± 0.082
0.001LeuXaa: 0.001 ± 0.001
Met
1.755MetAla: 1.755 ± 0.058
0.184MetCys: 0.184 ± 0.014
1.442MetAsp: 1.442 ± 0.041
1.774MetGlu: 1.774 ± 0.055
1.123MetPhe: 1.123 ± 0.041
1.652MetGly: 1.652 ± 0.048
0.367MetHis: 0.367 ± 0.023
2.08MetIle: 2.08 ± 0.056
2.185MetLys: 2.185 ± 0.049
2.414MetLeu: 2.414 ± 0.058
0.638MetMet: 0.638 ± 0.031
1.328MetAsn: 1.328 ± 0.042
0.954MetPro: 0.954 ± 0.038
0.724MetGln: 0.724 ± 0.032
0.864MetArg: 0.864 ± 0.034
1.186MetSer: 1.186 ± 0.037
1.028MetThr: 1.028 ± 0.037
1.448MetVal: 1.448 ± 0.044
0.141MetTrp: 0.141 ± 0.013
0.688MetTyr: 0.688 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.919AsnAla: 2.919 ± 0.06
0.53AsnCys: 0.53 ± 0.029
2.696AsnAsp: 2.696 ± 0.06
3.862AsnGlu: 3.862 ± 0.076
2.857AsnPhe: 2.857 ± 0.062
3.374AsnGly: 3.374 ± 0.081
0.663AsnHis: 0.663 ± 0.034
6.826AsnIle: 6.826 ± 0.102
5.347AsnLys: 5.347 ± 0.103
5.886AsnLeu: 5.886 ± 0.105
1.391AsnMet: 1.391 ± 0.038
3.356AsnAsn: 3.356 ± 0.085
2.409AsnPro: 2.409 ± 0.058
1.276AsnGln: 1.276 ± 0.042
1.969AsnArg: 1.969 ± 0.046
3.071AsnSer: 3.071 ± 0.068
2.309AsnThr: 2.309 ± 0.06
3.43AsnVal: 3.43 ± 0.073
0.463AsnTrp: 0.463 ± 0.028
2.454AsnTyr: 2.454 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.503ProAla: 1.503 ± 0.048
0.286ProCys: 0.286 ± 0.019
1.704ProAsp: 1.704 ± 0.057
2.379ProGlu: 2.379 ± 0.064
1.649ProPhe: 1.649 ± 0.041
1.793ProGly: 1.793 ± 0.051
0.57ProHis: 0.57 ± 0.026
2.944ProIle: 2.944 ± 0.058
2.671ProLys: 2.671 ± 0.067
2.733ProLeu: 2.733 ± 0.061
0.697ProMet: 0.697 ± 0.031
1.688ProAsn: 1.688 ± 0.05
0.862ProPro: 0.862 ± 0.036
0.883ProGln: 0.883 ± 0.035
0.959ProArg: 0.959 ± 0.032
1.84ProSer: 1.84 ± 0.057
1.533ProThr: 1.533 ± 0.049
2.131ProVal: 2.131 ± 0.049
0.241ProTrp: 0.241 ± 0.016
1.527ProTyr: 1.527 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.337GlnAla: 1.337 ± 0.044
0.168GlnCys: 0.168 ± 0.015
1.138GlnAsp: 1.138 ± 0.041
1.661GlnGlu: 1.661 ± 0.046
0.887GlnPhe: 0.887 ± 0.033
1.393GlnGly: 1.393 ± 0.045
0.351GlnHis: 0.351 ± 0.02
2.187GlnIle: 2.187 ± 0.054
2.169GlnLys: 2.169 ± 0.051
1.811GlnLeu: 1.811 ± 0.052
0.592GlnMet: 0.592 ± 0.028
1.619GlnAsn: 1.619 ± 0.046
0.62GlnPro: 0.62 ± 0.028
0.648GlnGln: 0.648 ± 0.035
1.345GlnArg: 1.345 ± 0.048
1.088GlnSer: 1.088 ± 0.039
0.984GlnThr: 0.984 ± 0.039
1.367GlnVal: 1.367 ± 0.04
0.15GlnTrp: 0.15 ± 0.016
0.962GlnTyr: 0.962 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.343ArgAla: 2.343 ± 0.057
0.419ArgCys: 0.419 ± 0.025
2.159ArgAsp: 2.159 ± 0.057
3.352ArgGlu: 3.352 ± 0.074
1.863ArgPhe: 1.863 ± 0.061
2.3ArgGly: 2.3 ± 0.058
0.561ArgHis: 0.561 ± 0.027
4.214ArgIle: 4.214 ± 0.075
3.164ArgLys: 3.164 ± 0.064
3.745ArgLeu: 3.745 ± 0.077
1.13ArgMet: 1.13 ± 0.04
2.034ArgAsn: 2.034 ± 0.059
1.189ArgPro: 1.189 ± 0.043
1.196ArgGln: 1.196 ± 0.04
1.892ArgArg: 1.892 ± 0.061
1.498ArgSer: 1.498 ± 0.05
1.707ArgThr: 1.707 ± 0.046
2.623ArgVal: 2.623 ± 0.059
0.36ArgTrp: 0.36 ± 0.022
1.651ArgTyr: 1.651 ± 0.055
0.001ArgXaa: 0.001 ± 0.001
Ser
2.766SerAla: 2.766 ± 0.069
0.573SerCys: 0.573 ± 0.028
2.521SerAsp: 2.521 ± 0.057
3.21SerGlu: 3.21 ± 0.066
3.124SerPhe: 3.124 ± 0.068
3.522SerGly: 3.522 ± 0.075
0.749SerHis: 0.749 ± 0.034
5.694SerIle: 5.694 ± 0.086
5.172SerLys: 5.172 ± 0.079
5.71SerLeu: 5.71 ± 0.112
1.311SerMet: 1.311 ± 0.041
2.87SerAsn: 2.87 ± 0.077
1.812SerPro: 1.812 ± 0.051
1.382SerGln: 1.382 ± 0.037
2.081SerArg: 2.081 ± 0.054
3.485SerSer: 3.485 ± 0.088
2.346SerThr: 2.346 ± 0.06
2.932SerVal: 2.932 ± 0.06
0.381SerTrp: 0.381 ± 0.026
2.312SerTyr: 2.312 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
2.817ThrAla: 2.817 ± 0.066
0.423ThrCys: 0.423 ± 0.023
2.072ThrAsp: 2.072 ± 0.056
2.534ThrGlu: 2.534 ± 0.066
2.105ThrPhe: 2.105 ± 0.059
3.275ThrGly: 3.275 ± 0.071
0.714ThrHis: 0.714 ± 0.032
4.469ThrIle: 4.469 ± 0.072
3.49ThrLys: 3.49 ± 0.077
4.555ThrLeu: 4.555 ± 0.082
0.895ThrMet: 0.895 ± 0.037
2.269ThrAsn: 2.269 ± 0.058
1.764ThrPro: 1.764 ± 0.048
1.057ThrGln: 1.057 ± 0.036
1.583ThrArg: 1.583 ± 0.046
2.621ThrSer: 2.621 ± 0.061
2.269ThrThr: 2.269 ± 0.064
3.07ThrVal: 3.07 ± 0.069
0.299ThrTrp: 0.299 ± 0.021
1.764ThrTyr: 1.764 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.047ValAla: 4.047 ± 0.101
0.68ValCys: 0.68 ± 0.027
3.818ValAsp: 3.818 ± 0.07
5.089ValGlu: 5.089 ± 0.092
2.98ValPhe: 2.98 ± 0.071
4.097ValGly: 4.097 ± 0.077
0.894ValHis: 0.894 ± 0.033
6.04ValIle: 6.04 ± 0.077
6.006ValLys: 6.006 ± 0.086
6.23ValLeu: 6.23 ± 0.099
1.418ValMet: 1.418 ± 0.047
3.31ValAsn: 3.31 ± 0.078
2.208ValPro: 2.208 ± 0.051
1.29ValGln: 1.29 ± 0.038
2.222ValArg: 2.222 ± 0.058
3.576ValSer: 3.576 ± 0.067
2.966ValThr: 2.966 ± 0.059
4.612ValVal: 4.612 ± 0.09
0.39ValTrp: 0.39 ± 0.023
2.671ValTyr: 2.671 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.404TrpAla: 0.404 ± 0.026
0.067TrpCys: 0.067 ± 0.01
0.449TrpAsp: 0.449 ± 0.026
0.474TrpGlu: 0.474 ± 0.027
0.348TrpPhe: 0.348 ± 0.02
0.493TrpGly: 0.493 ± 0.028
0.125TrpHis: 0.125 ± 0.015
0.658TrpIle: 0.658 ± 0.032
0.454TrpLys: 0.454 ± 0.027
0.575TrpLeu: 0.575 ± 0.03
0.2TrpMet: 0.2 ± 0.017
0.374TrpAsn: 0.374 ± 0.025
0.193TrpPro: 0.193 ± 0.017
0.23TrpGln: 0.23 ± 0.016
0.265TrpArg: 0.265 ± 0.02
0.363TrpSer: 0.363 ± 0.027
0.378TrpThr: 0.378 ± 0.023
0.418TrpVal: 0.418 ± 0.026
0.097TrpTrp: 0.097 ± 0.014
0.267TrpTyr: 0.267 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.059TyrAla: 2.059 ± 0.047
0.491TyrCys: 0.491 ± 0.027
2.59TyrAsp: 2.59 ± 0.068
3.04TyrGlu: 3.04 ± 0.069
2.38TyrPhe: 2.38 ± 0.062
2.595TyrGly: 2.595 ± 0.059
0.611TyrHis: 0.611 ± 0.03
4.152TyrIle: 4.152 ± 0.08
3.993TyrLys: 3.993 ± 0.086
3.993TyrLeu: 3.993 ± 0.093
0.889TyrMet: 0.889 ± 0.035
2.461TyrAsn: 2.461 ± 0.068
1.407TyrPro: 1.407 ± 0.044
0.952TyrGln: 0.952 ± 0.04
1.593TyrArg: 1.593 ± 0.05
2.459TyrSer: 2.459 ± 0.062
1.741TyrThr: 1.741 ± 0.05
2.565TyrVal: 2.565 ± 0.062
0.297TyrTrp: 0.297 ± 0.02
2.058TyrTyr: 2.058 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.001
0.003XaaLys: 0.003 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2679 proteins (766429 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski