Amino acid dipepetide frequency for Clostridium taeniosporum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.157AlaAla: 3.157 ± 0.073	0.698AlaCys: 0.698 ± 0.033	2.439AlaAsp: 2.439 ± 0.057	3.159AlaGlu: 3.159 ± 0.063	2.176AlaPhe: 2.176 ± 0.051	3.295AlaGly: 3.295 ± 0.073	0.754AlaHis: 0.754 ± 0.026	5.561AlaIle: 5.561 ± 0.099	4.611AlaLys: 4.611 ± 0.071	5.311AlaLeu: 5.311 ± 0.076	1.484AlaMet: 1.484 ± 0.045	2.639AlaAsn: 2.639 ± 0.057	1.271AlaPro: 1.271 ± 0.043	1.272AlaGln: 1.272 ± 0.037	1.613AlaArg: 1.613 ± 0.047	3.053AlaSer: 3.053 ± 0.062	2.766AlaThr: 2.766 ± 0.068	3.393AlaVal: 3.393 ± 0.084	0.318AlaTrp: 0.318 ± 0.017	1.873AlaTyr: 1.873 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.611CysAla: 0.611 ± 0.028	0.208CysCys: 0.208 ± 0.023	0.768CysAsp: 0.768 ± 0.029	0.871CysGlu: 0.871 ± 0.034	0.483CysPhe: 0.483 ± 0.025	1.105CysGly: 1.105 ± 0.037	0.2CysHis: 0.2 ± 0.013	1.25CysIle: 1.25 ± 0.035	1.079CysLys: 1.079 ± 0.039	0.914CysLeu: 0.914 ± 0.033	0.286CysMet: 0.286 ± 0.021	0.893CysAsn: 0.893 ± 0.032	0.488CysPro: 0.488 ± 0.026	0.184CysGln: 0.184 ± 0.013	0.384CysArg: 0.384 ± 0.025	0.799CysSer: 0.799 ± 0.028	0.624CysThr: 0.624 ± 0.029	0.643CysVal: 0.643 ± 0.026	0.058CysTrp: 0.058 ± 0.009	0.487CysTyr: 0.487 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.527AspAla: 2.527 ± 0.051	0.621AspCys: 0.621 ± 0.024	3.115AspAsp: 3.115 ± 0.064	4.889AspGlu: 4.889 ± 0.081	2.824AspPhe: 2.824 ± 0.057	3.569AspGly: 3.569 ± 0.073	0.576AspHis: 0.576 ± 0.028	6.581AspIle: 6.581 ± 0.095	5.868AspLys: 5.868 ± 0.087	5.155AspLeu: 5.155 ± 0.078	1.488AspMet: 1.488 ± 0.039	3.842AspAsn: 3.842 ± 0.08	1.277AspPro: 1.277 ± 0.056	0.784AspGln: 0.784 ± 0.03	1.661AspArg: 1.661 ± 0.041	3.274AspSer: 3.274 ± 0.059	2.463AspThr: 2.463 ± 0.055	3.455AspVal: 3.455 ± 0.068	0.338AspTrp: 0.338 ± 0.021	2.678AspTyr: 2.678 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	3.828GluAla: 3.828 ± 0.081	0.804GluCys: 0.804 ± 0.027	4.309GluAsp: 4.309 ± 0.079	7.058GluGlu: 7.058 ± 0.114	3.427GluPhe: 3.427 ± 0.076	3.828GluGly: 3.828 ± 0.073	0.873GluHis: 0.873 ± 0.035	7.654GluIle: 7.654 ± 0.113	7.985GluLys: 7.985 ± 0.124	6.808GluLeu: 6.808 ± 0.09	1.888GluMet: 1.888 ± 0.05	5.901GluAsn: 5.901 ± 0.097	1.314GluPro: 1.314 ± 0.043	1.741GluGln: 1.741 ± 0.05	2.383GluArg: 2.383 ± 0.057	3.706GluSer: 3.706 ± 0.071	2.896GluThr: 2.896 ± 0.058	4.85GluVal: 4.85 ± 0.074	0.457GluTrp: 0.457 ± 0.023	3.238GluTyr: 3.238 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	2.028PheAla: 2.028 ± 0.053	0.522PheCys: 0.522 ± 0.024	2.562PheAsp: 2.562 ± 0.051	2.777PheGlu: 2.777 ± 0.06	1.933PhePhe: 1.933 ± 0.055	2.735PheGly: 2.735 ± 0.064	0.501PheHis: 0.501 ± 0.021	4.936PheIle: 4.936 ± 0.087	4.288PheLys: 4.288 ± 0.062	3.939PheLeu: 3.939 ± 0.08	1.128PheMet: 1.128 ± 0.041	3.4PheAsn: 3.4 ± 0.063	1.019PhePro: 1.019 ± 0.033	0.921PheGln: 0.921 ± 0.035	1.255PheArg: 1.255 ± 0.036	3.017PheSer: 3.017 ± 0.062	2.237PheThr: 2.237 ± 0.048	2.448PheVal: 2.448 ± 0.058	0.292PheTrp: 0.292 ± 0.016	1.721PheTyr: 1.721 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	3.782GlyAla: 3.782 ± 0.079	0.927GlyCys: 0.927 ± 0.037	3.195GlyAsp: 3.195 ± 0.072	4.224GlyGlu: 4.224 ± 0.077	2.922GlyPhe: 2.922 ± 0.06	3.942GlyGly: 3.942 ± 0.083	0.887GlyHis: 0.887 ± 0.036	6.8GlyIle: 6.8 ± 0.098	5.611GlyLys: 5.611 ± 0.089	5.166GlyLeu: 5.166 ± 0.084	1.578GlyMet: 1.578 ± 0.048	3.548GlyAsn: 3.548 ± 0.069	1.161GlyPro: 1.161 ± 0.044	1.317GlyGln: 1.317 ± 0.037	2.01GlyArg: 2.01 ± 0.047	3.441GlySer: 3.441 ± 0.066	3.392GlyThr: 3.392 ± 0.075	4.266GlyVal: 4.266 ± 0.087	0.588GlyTrp: 0.588 ± 0.04	2.88GlyTyr: 2.88 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.571HisAla: 0.571 ± 0.024	0.205HisCys: 0.205 ± 0.015	0.636HisAsp: 0.636 ± 0.028	0.829HisGlu: 0.829 ± 0.033	0.547HisPhe: 0.547 ± 0.022	0.917HisGly: 0.917 ± 0.03	0.254HisHis: 0.254 ± 0.019	1.295HisIle: 1.295 ± 0.041	1.085HisLys: 1.085 ± 0.034	1.05HisLeu: 1.05 ± 0.038	0.321HisMet: 0.321 ± 0.02	0.829HisAsn: 0.829 ± 0.032	0.499HisPro: 0.499 ± 0.025	0.255HisGln: 0.255 ± 0.015	0.431HisArg: 0.431 ± 0.023	0.799HisSer: 0.799 ± 0.031	0.635HisThr: 0.635 ± 0.025	0.693HisVal: 0.693 ± 0.03	0.093HisTrp: 0.093 ± 0.01	0.554HisTyr: 0.554 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.346IleAla: 5.346 ± 0.087	1.325IleCys: 1.325 ± 0.038	6.398IleAsp: 6.398 ± 0.104	7.443IleGlu: 7.443 ± 0.12	4.457IlePhe: 4.457 ± 0.085	6.296IleGly: 6.296 ± 0.101	1.131IleHis: 1.131 ± 0.039	10.216IleIle: 10.216 ± 0.167	10.062IleLys: 10.062 ± 0.122	9.699IleLeu: 9.699 ± 0.151	2.396IleMet: 2.396 ± 0.057	7.687IleAsn: 7.687 ± 0.113	3.313IlePro: 3.313 ± 0.059	2.284IleGln: 2.284 ± 0.049	3.037IleArg: 3.037 ± 0.057	7.414IleSer: 7.414 ± 0.119	5.035IleThr: 5.035 ± 0.074	6.044IleVal: 6.044 ± 0.088	0.528IleTrp: 0.528 ± 0.025	3.724IleTyr: 3.724 ± 0.08	0.0IleXaa: 0.0 ± 0.0
Lys	4.654LysAla: 4.654 ± 0.074	1.075LysCys: 1.075 ± 0.052	6.457LysAsp: 6.457 ± 0.106	9.508LysGlu: 9.508 ± 0.133	3.628LysPhe: 3.628 ± 0.061	5.226LysGly: 5.226 ± 0.081	1.112LysHis: 1.112 ± 0.035	9.352LysIle: 9.352 ± 0.115	9.155LysLys: 9.155 ± 0.103	8.244LysLeu: 8.244 ± 0.107	2.299LysMet: 2.299 ± 0.046	7.514LysAsn: 7.514 ± 0.104	2.062LysPro: 2.062 ± 0.056	2.268LysGln: 2.268 ± 0.051	3.023LysArg: 3.023 ± 0.063	5.732LysSer: 5.732 ± 0.086	4.165LysThr: 4.165 ± 0.065	6.2LysVal: 6.2 ± 0.09	0.686LysTrp: 0.686 ± 0.03	4.544LysTyr: 4.544 ± 0.078	0.0LysXaa: 0.0 ± 0.0
Leu	4.577LeuAla: 4.577 ± 0.083	1.093LeuCys: 1.093 ± 0.039	5.343LeuAsp: 5.343 ± 0.094	6.587LeuGlu: 6.587 ± 0.094	3.643LeuPhe: 3.643 ± 0.078	5.734LeuGly: 5.734 ± 0.092	1.052LeuHis: 1.052 ± 0.033	8.68LeuIle: 8.68 ± 0.128	9.183LeuLys: 9.183 ± 0.124	7.583LeuLeu: 7.583 ± 0.12	2.128LeuMet: 2.128 ± 0.054	6.834LeuAsn: 6.834 ± 0.094	2.64LeuPro: 2.64 ± 0.051	2.055LeuGln: 2.055 ± 0.045	2.886LeuArg: 2.886 ± 0.065	6.526LeuSer: 6.526 ± 0.09	4.399LeuThr: 4.399 ± 0.063	5.212LeuVal: 5.212 ± 0.079	0.518LeuTrp: 0.518 ± 0.023	3.305LeuTyr: 3.305 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.489MetAla: 1.489 ± 0.046	0.282MetCys: 0.282 ± 0.018	1.398MetAsp: 1.398 ± 0.043	1.678MetGlu: 1.678 ± 0.045	1.062MetPhe: 1.062 ± 0.035	1.592MetGly: 1.592 ± 0.051	0.32MetHis: 0.32 ± 0.018	2.301MetIle: 2.301 ± 0.054	2.488MetLys: 2.488 ± 0.059	2.088MetLeu: 2.088 ± 0.05	0.567MetMet: 0.567 ± 0.028	1.809MetAsn: 1.809 ± 0.049	0.801MetPro: 0.801 ± 0.029	0.67MetGln: 0.67 ± 0.03	0.828MetArg: 0.828 ± 0.035	1.62MetSer: 1.62 ± 0.047	1.106MetThr: 1.106 ± 0.036	1.417MetVal: 1.417 ± 0.04	0.151MetTrp: 0.151 ± 0.013	0.919MetTyr: 0.919 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.899AsnAla: 2.899 ± 0.061	0.764AsnCys: 0.764 ± 0.026	3.763AsnAsp: 3.763 ± 0.073	5.218AsnGlu: 5.218 ± 0.092	2.969AsnPhe: 2.969 ± 0.064	4.076AsnGly: 4.076 ± 0.075	0.83AsnHis: 0.83 ± 0.029	8.284AsnIle: 8.284 ± 0.108	7.618AsnLys: 7.618 ± 0.109	6.373AsnLeu: 6.373 ± 0.083	1.751AsnMet: 1.751 ± 0.042	6.065AsnAsn: 6.065 ± 0.102	2.122AsnPro: 2.122 ± 0.067	1.4AsnGln: 1.4 ± 0.04	2.024AsnArg: 2.024 ± 0.053	4.573AsnSer: 4.573 ± 0.082	3.237AsnThr: 3.237 ± 0.068	3.881AsnVal: 3.881 ± 0.078	0.498AsnTrp: 0.498 ± 0.029	2.984AsnTyr: 2.984 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	1.227ProAla: 1.227 ± 0.044	0.342ProCys: 0.342 ± 0.02	1.31ProAsp: 1.31 ± 0.038	1.964ProGlu: 1.964 ± 0.046	1.267ProPhe: 1.267 ± 0.04	1.578ProGly: 1.578 ± 0.056	0.4ProHis: 0.4 ± 0.019	2.752ProIle: 2.752 ± 0.065	2.304ProLys: 2.304 ± 0.052	2.316ProLeu: 2.316 ± 0.054	0.63ProMet: 0.63 ± 0.027	1.714ProAsn: 1.714 ± 0.053	0.561ProPro: 0.561 ± 0.032	0.64ProGln: 0.64 ± 0.033	0.733ProArg: 0.733 ± 0.028	1.632ProSer: 1.632 ± 0.045	1.451ProThr: 1.451 ± 0.053	1.819ProVal: 1.819 ± 0.053	0.235ProTrp: 0.235 ± 0.016	1.17ProTyr: 1.17 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	1.233GlnAla: 1.233 ± 0.039	0.3GlnCys: 0.3 ± 0.02	1.141GlnAsp: 1.141 ± 0.033	1.668GlnGlu: 1.668 ± 0.045	0.86GlnPhe: 0.86 ± 0.038	1.458GlnGly: 1.458 ± 0.036	0.256GlnHis: 0.256 ± 0.017	2.153GlnIle: 2.153 ± 0.051	1.972GlnLys: 1.972 ± 0.046	1.938GlnLeu: 1.938 ± 0.048	0.555GlnMet: 0.555 ± 0.026	1.484GlnAsn: 1.484 ± 0.05	0.514GlnPro: 0.514 ± 0.024	0.561GlnGln: 0.561 ± 0.03	0.787GlnArg: 0.787 ± 0.034	1.275GlnSer: 1.275 ± 0.042	1.059GlnThr: 1.059 ± 0.038	1.458GlnVal: 1.458 ± 0.036	0.208GlnTrp: 0.208 ± 0.015	0.994GlnTyr: 0.994 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.646ArgAla: 1.646 ± 0.047	0.394ArgCys: 0.394 ± 0.022	1.73ArgAsp: 1.73 ± 0.042	2.622ArgGlu: 2.622 ± 0.058	1.311ArgPhe: 1.311 ± 0.037	1.867ArgGly: 1.867 ± 0.049	0.424ArgHis: 0.424 ± 0.023	3.114ArgIle: 3.114 ± 0.064	2.936ArgLys: 2.936 ± 0.061	2.614ArgLeu: 2.614 ± 0.055	0.882ArgMet: 0.882 ± 0.032	2.111ArgAsn: 2.111 ± 0.047	0.726ArgPro: 0.726 ± 0.031	0.75ArgGln: 0.75 ± 0.027	1.284ArgArg: 1.284 ± 0.047	1.483ArgSer: 1.483 ± 0.045	1.496ArgThr: 1.496 ± 0.045	2.027ArgVal: 2.027 ± 0.044	0.23ArgTrp: 0.23 ± 0.016	1.38ArgTyr: 1.38 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	2.925SerAla: 2.925 ± 0.059	0.712SerCys: 0.712 ± 0.029	3.247SerAsp: 3.247 ± 0.06	4.024SerGlu: 4.024 ± 0.07	2.936SerPhe: 2.936 ± 0.067	4.103SerGly: 4.103 ± 0.07	0.859SerHis: 0.859 ± 0.033	6.991SerIle: 6.991 ± 0.104	6.293SerLys: 6.293 ± 0.091	5.956SerLeu: 5.956 ± 0.081	1.552SerMet: 1.552 ± 0.042	4.499SerAsn: 4.499 ± 0.08	1.538SerPro: 1.538 ± 0.044	1.495SerGln: 1.495 ± 0.043	1.926SerArg: 1.926 ± 0.042	4.356SerSer: 4.356 ± 0.093	3.201SerThr: 3.201 ± 0.062	3.613SerVal: 3.613 ± 0.072	0.451SerTrp: 0.451 ± 0.026	2.572SerTyr: 2.572 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.62ThrAla: 2.62 ± 0.067	0.558ThrCys: 0.558 ± 0.024	2.435ThrAsp: 2.435 ± 0.062	2.94ThrGlu: 2.94 ± 0.056	2.221ThrPhe: 2.221 ± 0.056	3.596ThrGly: 3.596 ± 0.084	0.664ThrHis: 0.664 ± 0.03	4.937ThrIle: 4.937 ± 0.091	3.881ThrLys: 3.881 ± 0.068	4.854ThrLeu: 4.854 ± 0.076	1.071ThrMet: 1.071 ± 0.035	2.99ThrAsn: 2.99 ± 0.063	1.714ThrPro: 1.714 ± 0.052	1.062ThrGln: 1.062 ± 0.036	1.36ThrArg: 1.36 ± 0.04	3.148ThrSer: 3.148 ± 0.06	2.683ThrThr: 2.683 ± 0.068	3.21ThrVal: 3.21 ± 0.092	0.36ThrTrp: 0.36 ± 0.022	1.964ThrTyr: 1.964 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	3.504ValAla: 3.504 ± 0.074	0.825ValCys: 0.825 ± 0.028	3.746ValAsp: 3.746 ± 0.074	4.166ValGlu: 4.166 ± 0.076	2.686ValPhe: 2.686 ± 0.057	3.88ValGly: 3.88 ± 0.081	0.776ValHis: 0.776 ± 0.03	6.156ValIle: 6.156 ± 0.086	5.746ValLys: 5.746 ± 0.072	5.602ValLeu: 5.602 ± 0.08	1.458ValMet: 1.458 ± 0.039	3.979ValAsn: 3.979 ± 0.084	1.756ValPro: 1.756 ± 0.049	1.303ValGln: 1.303 ± 0.039	1.81ValArg: 1.81 ± 0.051	4.101ValSer: 4.101 ± 0.069	3.118ValThr: 3.118 ± 0.077	4.091ValVal: 4.091 ± 0.078	0.347ValTrp: 0.347 ± 0.021	2.357ValTyr: 2.357 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.37TrpAla: 0.37 ± 0.022	0.105TrpCys: 0.105 ± 0.011	0.402TrpAsp: 0.402 ± 0.024	0.423TrpGlu: 0.423 ± 0.024	0.303TrpPhe: 0.303 ± 0.02	0.428TrpGly: 0.428 ± 0.027	0.104TrpHis: 0.104 ± 0.011	0.715TrpIle: 0.715 ± 0.034	0.517TrpLys: 0.517 ± 0.022	0.543TrpLeu: 0.543 ± 0.024	0.188TrpMet: 0.188 ± 0.014	0.496TrpAsn: 0.496 ± 0.026	0.146TrpPro: 0.146 ± 0.014	0.187TrpGln: 0.187 ± 0.014	0.237TrpArg: 0.237 ± 0.014	0.396TrpSer: 0.396 ± 0.023	0.307TrpThr: 0.307 ± 0.02	0.384TrpVal: 0.384 ± 0.02	0.077TrpTrp: 0.077 ± 0.01	0.395TrpTyr: 0.395 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.849TyrAla: 1.849 ± 0.051	0.576TyrCys: 0.576 ± 0.026	2.591TyrAsp: 2.591 ± 0.064	2.899TyrGlu: 2.899 ± 0.06	2.003TyrPhe: 2.003 ± 0.046	2.415TyrGly: 2.415 ± 0.039	0.523TyrHis: 0.523 ± 0.024	4.107TyrIle: 4.107 ± 0.075	4.224TyrLys: 4.224 ± 0.076	3.821TyrLeu: 3.821 ± 0.072	0.936TyrMet: 0.936 ± 0.035	3.095TyrAsn: 3.095 ± 0.066	1.125TyrPro: 1.125 ± 0.04	0.726TyrGln: 0.726 ± 0.027	1.358TyrArg: 1.358 ± 0.038	2.902TyrSer: 2.902 ± 0.054	1.998TyrThr: 1.998 ± 0.059	2.301TyrVal: 2.301 ± 0.042	0.289TyrTrp: 0.289 ± 0.019	2.135TyrTyr: 2.135 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2948 proteins (916512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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