Amino acid dipepetide frequency for Arthrobacter woluwensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.995AlaAla: 18.995 ± 0.211	0.773AlaCys: 0.773 ± 0.03	6.776AlaAsp: 6.776 ± 0.093	8.053AlaGlu: 8.053 ± 0.111	3.98AlaPhe: 3.98 ± 0.06	12.304AlaGly: 12.304 ± 0.121	2.298AlaHis: 2.298 ± 0.049	4.72AlaIle: 4.72 ± 0.08	3.407AlaLys: 3.407 ± 0.075	13.785AlaLeu: 13.785 ± 0.153	2.579AlaMet: 2.579 ± 0.044	2.321AlaAsn: 2.321 ± 0.057	6.657AlaPro: 6.657 ± 0.113	4.406AlaGln: 4.406 ± 0.071	8.232AlaArg: 8.232 ± 0.107	7.109AlaSer: 7.109 ± 0.091	6.653AlaThr: 6.653 ± 0.095	11.418AlaVal: 11.418 ± 0.137	1.83AlaTrp: 1.83 ± 0.047	2.268AlaTyr: 2.268 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.693CysAla: 0.693 ± 0.028	0.058CysCys: 0.058 ± 0.008	0.349CysAsp: 0.349 ± 0.018	0.298CysGlu: 0.298 ± 0.015	0.204CysPhe: 0.204 ± 0.014	0.68CysGly: 0.68 ± 0.023	0.144CysHis: 0.144 ± 0.013	0.206CysIle: 0.206 ± 0.012	0.113CysLys: 0.113 ± 0.011	0.564CysLeu: 0.564 ± 0.025	0.086CysMet: 0.086 ± 0.009	0.127CysAsn: 0.127 ± 0.011	0.35CysPro: 0.35 ± 0.02	0.162CysGln: 0.162 ± 0.012	0.403CysArg: 0.403 ± 0.021	0.401CysSer: 0.401 ± 0.02	0.409CysThr: 0.409 ± 0.022	0.426CysVal: 0.426 ± 0.019	0.113CysTrp: 0.113 ± 0.01	0.144CysTyr: 0.144 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.454AspAla: 7.454 ± 0.103	0.293AspCys: 0.293 ± 0.016	3.245AspAsp: 3.245 ± 0.068	3.465AspGlu: 3.465 ± 0.066	1.848AspPhe: 1.848 ± 0.039	6.255AspGly: 6.255 ± 0.104	1.258AspHis: 1.258 ± 0.037	2.073AspIle: 2.073 ± 0.05	1.295AspLys: 1.295 ± 0.052	5.535AspLeu: 5.535 ± 0.076	0.856AspMet: 0.856 ± 0.024	0.928AspAsn: 0.928 ± 0.032	3.96AspPro: 3.96 ± 0.068	1.636AspGln: 1.636 ± 0.037	3.756AspArg: 3.756 ± 0.07	2.917AspSer: 2.917 ± 0.052	2.579AspThr: 2.579 ± 0.043	4.745AspVal: 4.745 ± 0.074	0.827AspTrp: 0.827 ± 0.027	1.266AspTyr: 1.266 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.383GluAla: 7.383 ± 0.108	0.285GluCys: 0.285 ± 0.015	3.332GluAsp: 3.332 ± 0.064	3.832GluGlu: 3.832 ± 0.076	1.849GluPhe: 1.849 ± 0.045	4.299GluGly: 4.299 ± 0.075	1.518GluHis: 1.518 ± 0.044	2.421GluIle: 2.421 ± 0.054	1.725GluLys: 1.725 ± 0.051	6.753GluLeu: 6.753 ± 0.096	0.919GluMet: 0.919 ± 0.033	1.436GluAsn: 1.436 ± 0.035	2.975GluPro: 2.975 ± 0.062	2.331GluGln: 2.331 ± 0.057	4.622GluArg: 4.622 ± 0.08	3.012GluSer: 3.012 ± 0.057	2.917GluThr: 2.917 ± 0.05	4.319GluVal: 4.319 ± 0.083	0.844GluTrp: 0.844 ± 0.03	1.103GluTyr: 1.103 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.034PheAla: 4.034 ± 0.066	0.24PheCys: 0.24 ± 0.017	2.005PheAsp: 2.005 ± 0.037	1.609PheGlu: 1.609 ± 0.04	1.241PhePhe: 1.241 ± 0.04	3.403PheGly: 3.403 ± 0.064	0.663PheHis: 0.663 ± 0.026	1.219PheIle: 1.219 ± 0.036	0.698PheLys: 0.698 ± 0.028	3.261PheLeu: 3.261 ± 0.064	0.547PheMet: 0.547 ± 0.022	0.833PheAsn: 0.833 ± 0.026	1.513PhePro: 1.513 ± 0.046	0.902PheGln: 0.902 ± 0.029	1.964PheArg: 1.964 ± 0.042	2.02PheSer: 2.02 ± 0.045	2.36PheThr: 2.36 ± 0.047	2.593PheVal: 2.593 ± 0.05	0.509PheTrp: 0.509 ± 0.021	0.71PheTyr: 0.71 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.663GlyAla: 10.663 ± 0.112	0.57GlyCys: 0.57 ± 0.02	4.433GlyAsp: 4.433 ± 0.089	4.837GlyGlu: 4.837 ± 0.075	3.366GlyPhe: 3.366 ± 0.062	7.877GlyGly: 7.877 ± 0.112	2.042GlyHis: 2.042 ± 0.048	4.369GlyIle: 4.369 ± 0.072	3.076GlyLys: 3.076 ± 0.068	9.67GlyLeu: 9.67 ± 0.111	1.987GlyMet: 1.987 ± 0.041	2.152GlyAsn: 2.152 ± 0.072	4.396GlyPro: 4.396 ± 0.063	3.086GlyGln: 3.086 ± 0.061	6.233GlyArg: 6.233 ± 0.085	5.941GlySer: 5.941 ± 0.09	6.067GlyThr: 6.067 ± 0.119	7.836GlyVal: 7.836 ± 0.083	1.603GlyTrp: 1.603 ± 0.041	2.241GlyTyr: 2.241 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.278HisAla: 2.278 ± 0.049	0.155HisCys: 0.155 ± 0.012	1.29HisAsp: 1.29 ± 0.038	1.24HisGlu: 1.24 ± 0.037	0.66HisPhe: 0.66 ± 0.024	2.174HisGly: 2.174 ± 0.053	0.644HisHis: 0.644 ± 0.027	0.629HisIle: 0.629 ± 0.027	0.346HisLys: 0.346 ± 0.017	2.2HisLeu: 2.2 ± 0.048	0.343HisMet: 0.343 ± 0.017	0.365HisAsn: 0.365 ± 0.02	1.514HisPro: 1.514 ± 0.037	0.695HisGln: 0.695 ± 0.023	1.688HisArg: 1.688 ± 0.041	1.129HisSer: 1.129 ± 0.029	1.014HisThr: 1.014 ± 0.029	1.639HisVal: 1.639 ± 0.044	0.363HisTrp: 0.363 ± 0.016	0.437HisTyr: 0.437 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.343IleAla: 5.343 ± 0.072	0.283IleCys: 0.283 ± 0.017	2.403IleAsp: 2.403 ± 0.056	2.209IleGlu: 2.209 ± 0.048	1.168IlePhe: 1.168 ± 0.038	3.883IleGly: 3.883 ± 0.071	0.794IleHis: 0.794 ± 0.027	1.65IleIle: 1.65 ± 0.051	1.099IleLys: 1.099 ± 0.038	3.843IleLeu: 3.843 ± 0.073	0.727IleMet: 0.727 ± 0.025	1.102IleAsn: 1.102 ± 0.037	2.422IlePro: 2.422 ± 0.06	1.156IleGln: 1.156 ± 0.031	2.591IleArg: 2.591 ± 0.054	2.422IleSer: 2.422 ± 0.057	2.604IleThr: 2.604 ± 0.055	3.349IleVal: 3.349 ± 0.068	0.471IleTrp: 0.471 ± 0.023	0.717IleTyr: 0.717 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.577LysAla: 3.577 ± 0.082	0.106LysCys: 0.106 ± 0.009	1.853LysAsp: 1.853 ± 0.063	1.419LysGlu: 1.419 ± 0.04	0.706LysPhe: 0.706 ± 0.027	2.211LysGly: 2.211 ± 0.062	0.554LysHis: 0.554 ± 0.021	1.226LysIle: 1.226 ± 0.04	1.066LysLys: 1.066 ± 0.043	2.356LysLeu: 2.356 ± 0.055	0.512LysMet: 0.512 ± 0.02	0.81LysAsn: 0.81 ± 0.037	1.591LysPro: 1.591 ± 0.045	0.783LysGln: 0.783 ± 0.033	1.566LysArg: 1.566 ± 0.047	1.526LysSer: 1.526 ± 0.044	1.658LysThr: 1.658 ± 0.046	2.344LysVal: 2.344 ± 0.06	0.257LysTrp: 0.257 ± 0.015	0.618LysTyr: 0.618 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.166LeuAla: 14.166 ± 0.156	0.665LeuCys: 0.665 ± 0.026	6.551LeuAsp: 6.551 ± 0.082	5.775LeuGlu: 5.775 ± 0.089	3.048LeuPhe: 3.048 ± 0.062	9.849LeuGly: 9.849 ± 0.11	1.987LeuHis: 1.987 ± 0.047	4.02LeuIle: 4.02 ± 0.076	2.708LeuLys: 2.708 ± 0.066	10.833LeuLeu: 10.833 ± 0.164	1.793LeuMet: 1.793 ± 0.046	2.482LeuAsn: 2.482 ± 0.053	5.853LeuPro: 5.853 ± 0.09	2.682LeuGln: 2.682 ± 0.052	7.188LeuArg: 7.188 ± 0.101	6.663LeuSer: 6.663 ± 0.08	5.969LeuThr: 5.969 ± 0.079	8.81LeuVal: 8.81 ± 0.102	1.374LeuTrp: 1.374 ± 0.041	1.704LeuTyr: 1.704 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.371MetAla: 2.371 ± 0.056	0.121MetCys: 0.121 ± 0.012	0.88MetAsp: 0.88 ± 0.026	0.821MetGlu: 0.821 ± 0.031	0.493MetPhe: 0.493 ± 0.022	1.458MetGly: 1.458 ± 0.038	0.305MetHis: 0.305 ± 0.017	0.85MetIle: 0.85 ± 0.028	0.572MetLys: 0.572 ± 0.023	1.707MetLeu: 1.707 ± 0.038	0.296MetMet: 0.296 ± 0.019	0.552MetAsn: 0.552 ± 0.024	1.022MetPro: 1.022 ± 0.031	0.512MetGln: 0.512 ± 0.022	1.112MetArg: 1.112 ± 0.031	1.619MetSer: 1.619 ± 0.038	1.565MetThr: 1.565 ± 0.035	1.456MetVal: 1.456 ± 0.043	0.151MetTrp: 0.151 ± 0.011	0.288MetTyr: 0.288 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.763AsnAla: 2.763 ± 0.057	0.152AsnCys: 0.152 ± 0.013	1.174AsnAsp: 1.174 ± 0.047	0.983AsnGlu: 0.983 ± 0.033	0.732AsnPhe: 0.732 ± 0.026	2.334AsnGly: 2.334 ± 0.074	0.485AsnHis: 0.485 ± 0.02	0.973AsnIle: 0.973 ± 0.032	0.649AsnLys: 0.649 ± 0.03	2.097AsnLeu: 2.097 ± 0.049	0.363AsnMet: 0.363 ± 0.019	0.688AsnAsn: 0.688 ± 0.035	1.84AsnPro: 1.84 ± 0.051	0.713AsnGln: 0.713 ± 0.032	1.388AsnArg: 1.388 ± 0.043	1.248AsnSer: 1.248 ± 0.042	1.388AsnThr: 1.388 ± 0.045	1.761AsnVal: 1.761 ± 0.048	0.353AsnTrp: 0.353 ± 0.018	0.56AsnTyr: 0.56 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.781ProAla: 7.781 ± 0.113	0.243ProCys: 0.243 ± 0.015	3.632ProAsp: 3.632 ± 0.063	4.474ProGlu: 4.474 ± 0.066	1.748ProPhe: 1.748 ± 0.038	6.18ProGly: 6.18 ± 0.153	1.093ProHis: 1.093 ± 0.033	1.51ProIle: 1.51 ± 0.043	1.225ProLys: 1.225 ± 0.04	5.085ProLeu: 5.085 ± 0.082	0.829ProMet: 0.829 ± 0.028	1.071ProAsn: 1.071 ± 0.037	2.025ProPro: 2.025 ± 0.062	1.952ProGln: 1.952 ± 0.052	3.335ProArg: 3.335 ± 0.068	3.617ProSer: 3.617 ± 0.069	2.896ProThr: 2.896 ± 0.068	5.003ProVal: 5.003 ± 0.066	0.896ProTrp: 0.896 ± 0.032	1.044ProTyr: 1.044 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.264GlnAla: 4.264 ± 0.071	0.167GlnCys: 0.167 ± 0.011	1.852GlnAsp: 1.852 ± 0.045	1.959GlnGlu: 1.959 ± 0.042	0.835GlnPhe: 0.835 ± 0.029	2.789GlnGly: 2.789 ± 0.049	0.731GlnHis: 0.731 ± 0.032	1.342GlnIle: 1.342 ± 0.034	0.86GlnLys: 0.86 ± 0.03	3.391GlnLeu: 3.391 ± 0.062	0.51GlnMet: 0.51 ± 0.022	0.807GlnAsn: 0.807 ± 0.028	1.765GlnPro: 1.765 ± 0.046	1.455GlnGln: 1.455 ± 0.053	2.473GlnArg: 2.473 ± 0.05	1.6GlnSer: 1.6 ± 0.04	1.519GlnThr: 1.519 ± 0.046	2.522GlnVal: 2.522 ± 0.049	0.532GlnTrp: 0.532 ± 0.022	0.7GlnTyr: 0.7 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.521ArgAla: 7.521 ± 0.091	0.377ArgCys: 0.377 ± 0.019	3.676ArgAsp: 3.676 ± 0.064	4.379ArgGlu: 4.379 ± 0.081	2.282ArgPhe: 2.282 ± 0.046	5.041ArgGly: 5.041 ± 0.076	1.659ArgHis: 1.659 ± 0.034	3.221ArgIle: 3.221 ± 0.051	1.966ArgLys: 1.966 ± 0.043	7.234ArgLeu: 7.234 ± 0.096	1.472ArgMet: 1.472 ± 0.036	1.591ArgAsn: 1.591 ± 0.042	3.612ArgPro: 3.612 ± 0.065	2.412ArgGln: 2.412 ± 0.056	5.937ArgArg: 5.937 ± 0.101	3.864ArgSer: 3.864 ± 0.073	3.921ArgThr: 3.921 ± 0.064	5.125ArgVal: 5.125 ± 0.071	1.151ArgTrp: 1.151 ± 0.037	1.43ArgTyr: 1.43 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.399SerAla: 7.399 ± 0.099	0.368SerCys: 0.368 ± 0.022	2.821SerAsp: 2.821 ± 0.053	2.992SerGlu: 2.992 ± 0.054	2.004SerPhe: 2.004 ± 0.043	6.444SerGly: 6.444 ± 0.089	1.151SerHis: 1.151 ± 0.032	2.237SerIle: 2.237 ± 0.047	1.438SerLys: 1.438 ± 0.039	5.994SerLeu: 5.994 ± 0.075	1.247SerMet: 1.247 ± 0.035	1.233SerAsn: 1.233 ± 0.042	3.482SerPro: 3.482 ± 0.063	1.832SerGln: 1.832 ± 0.044	3.985SerArg: 3.985 ± 0.061	4.044SerSer: 4.044 ± 0.075	3.751SerThr: 3.751 ± 0.068	4.819SerVal: 4.819 ± 0.068	1.012SerTrp: 1.012 ± 0.032	1.455SerTyr: 1.455 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.876ThrAla: 7.876 ± 0.087	0.288ThrCys: 0.288 ± 0.02	2.908ThrAsp: 2.908 ± 0.059	3.008ThrGlu: 3.008 ± 0.062	1.912ThrPhe: 1.912 ± 0.044	5.825ThrGly: 5.825 ± 0.086	1.102ThrHis: 1.102 ± 0.029	2.379ThrIle: 2.379 ± 0.053	1.338ThrLys: 1.338 ± 0.045	6.051ThrLeu: 6.051 ± 0.076	0.943ThrMet: 0.943 ± 0.023	1.125ThrAsn: 1.125 ± 0.039	4.08ThrPro: 4.08 ± 0.079	1.64ThrGln: 1.64 ± 0.035	3.346ThrArg: 3.346 ± 0.058	3.458ThrSer: 3.458 ± 0.067	3.787ThrThr: 3.787 ± 0.077	5.984ThrVal: 5.984 ± 0.095	0.802ThrTrp: 0.802 ± 0.027	0.984ThrTyr: 0.984 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.22ValAla: 10.22 ± 0.105	0.519ValCys: 0.519 ± 0.023	5.011ValAsp: 5.011 ± 0.072	4.724ValGlu: 4.724 ± 0.08	2.869ValPhe: 2.869 ± 0.06	6.44ValGly: 6.44 ± 0.091	1.716ValHis: 1.716 ± 0.041	3.857ValIle: 3.857 ± 0.071	2.228ValLys: 2.228 ± 0.063	9.727ValLeu: 9.727 ± 0.125	1.52ValMet: 1.52 ± 0.045	2.061ValAsn: 2.061 ± 0.053	4.837ValPro: 4.837 ± 0.074	2.429ValGln: 2.429 ± 0.05	5.434ValArg: 5.434 ± 0.075	5.003ValSer: 5.003 ± 0.062	5.704ValThr: 5.704 ± 0.09	8.316ValVal: 8.316 ± 0.101	1.029ValTrp: 1.029 ± 0.037	1.461ValTyr: 1.461 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.557TrpAla: 1.557 ± 0.044	0.128TrpCys: 0.128 ± 0.011	0.823TrpAsp: 0.823 ± 0.029	0.739TrpGlu: 0.739 ± 0.028	0.572TrpPhe: 0.572 ± 0.023	1.139TrpGly: 1.139 ± 0.035	0.323TrpHis: 0.323 ± 0.016	0.707TrpIle: 0.707 ± 0.025	0.45TrpLys: 0.45 ± 0.022	1.756TrpLeu: 1.756 ± 0.045	0.324TrpMet: 0.324 ± 0.016	0.462TrpAsn: 0.462 ± 0.021	0.69TrpPro: 0.69 ± 0.025	0.563TrpGln: 0.563 ± 0.023	1.06TrpArg: 1.06 ± 0.037	0.866TrpSer: 0.866 ± 0.027	0.903TrpThr: 0.903 ± 0.03	1.114TrpVal: 1.114 ± 0.033	0.338TrpTrp: 0.338 ± 0.021	0.296TrpTyr: 0.296 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.224TyrAla: 2.224 ± 0.047	0.139TyrCys: 0.139 ± 0.011	1.175TyrAsp: 1.175 ± 0.038	1.056TyrGlu: 1.056 ± 0.034	0.804TyrPhe: 0.804 ± 0.027	1.858TyrGly: 1.858 ± 0.047	0.333TyrHis: 0.333 ± 0.019	0.629TyrIle: 0.629 ± 0.026	0.481TyrLys: 0.481 ± 0.025	2.28TyrLeu: 2.28 ± 0.049	0.3TyrMet: 0.3 ± 0.017	0.501TyrAsn: 0.501 ± 0.021	1.055TyrPro: 1.055 ± 0.031	0.726TyrGln: 0.726 ± 0.026	1.556TyrArg: 1.556 ± 0.044	1.248TyrSer: 1.248 ± 0.033	1.176TyrThr: 1.176 ± 0.034	1.526TyrVal: 1.526 ± 0.036	0.358TyrTrp: 0.358 ± 0.02	0.503TyrTyr: 0.503 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3355 proteins (1100570 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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