Amino acid dipepetide frequency for Candidatus Tokpelaia sp. JSC085

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.134AlaAla: 8.134 ± 0.209
1.242AlaCys: 1.242 ± 0.065
4.617AlaAsp: 4.617 ± 0.136
5.05AlaGlu: 5.05 ± 0.137
3.851AlaPhe: 3.851 ± 0.152
6.567AlaGly: 6.567 ± 0.179
2.179AlaHis: 2.179 ± 0.079
6.921AlaIle: 6.921 ± 0.166
3.674AlaLys: 3.674 ± 0.114
9.055AlaLeu: 9.055 ± 0.156
2.622AlaMet: 2.622 ± 0.082
2.851AlaAsn: 2.851 ± 0.081
2.517AlaPro: 2.517 ± 0.094
2.917AlaGln: 2.917 ± 0.101
5.833AlaArg: 5.833 ± 0.129
4.595AlaSer: 4.595 ± 0.108
4.231AlaThr: 4.231 ± 0.107
6.633AlaVal: 6.633 ± 0.168
0.803AlaTrp: 0.803 ± 0.06
2.34AlaTyr: 2.34 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.058
0.2CysCys: 0.2 ± 0.026
0.662CysAsp: 0.662 ± 0.054
0.541CysGlu: 0.541 ± 0.04
0.665CysPhe: 0.665 ± 0.046
1.104CysGly: 1.104 ± 0.061
0.393CysHis: 0.393 ± 0.046
0.901CysIle: 0.901 ± 0.057
0.587CysLys: 0.587 ± 0.042
1.196CysLeu: 1.196 ± 0.063
0.265CysMet: 0.265 ± 0.029
0.501CysAsn: 0.501 ± 0.04
0.505CysPro: 0.505 ± 0.042
0.439CysGln: 0.439 ± 0.038
0.773CysArg: 0.773 ± 0.05
1.045CysSer: 1.045 ± 0.062
0.619CysThr: 0.619 ± 0.047
0.77CysVal: 0.77 ± 0.048
0.134CysTrp: 0.134 ± 0.022
0.397CysTyr: 0.397 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
4.526AspAla: 4.526 ± 0.11
0.698AspCys: 0.698 ± 0.057
2.605AspAsp: 2.605 ± 0.117
3.084AspGlu: 3.084 ± 0.125
2.281AspPhe: 2.281 ± 0.094
3.703AspGly: 3.703 ± 0.125
1.37AspHis: 1.37 ± 0.064
4.729AspIle: 4.729 ± 0.115
2.36AspLys: 2.36 ± 0.091
4.958AspLeu: 4.958 ± 0.14
1.753AspMet: 1.753 ± 0.071
1.888AspAsn: 1.888 ± 0.073
2.176AspPro: 2.176 ± 0.089
1.658AspGln: 1.658 ± 0.079
3.146AspArg: 3.146 ± 0.111
2.805AspSer: 2.805 ± 0.097
2.72AspThr: 2.72 ± 0.09
3.729AspVal: 3.729 ± 0.116
0.619AspTrp: 0.619 ± 0.042
1.596AspTyr: 1.596 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.844GluAla: 4.844 ± 0.114
0.554GluCys: 0.554 ± 0.043
2.527GluAsp: 2.527 ± 0.091
3.559GluGlu: 3.559 ± 0.137
1.704GluPhe: 1.704 ± 0.076
3.369GluGly: 3.369 ± 0.113
1.37GluHis: 1.37 ± 0.07
4.778GluIle: 4.778 ± 0.122
4.781GluLys: 4.781 ± 0.153
4.46GluLeu: 4.46 ± 0.134
1.596GluMet: 1.596 ± 0.064
2.661GluAsn: 2.661 ± 0.101
1.72GluPro: 1.72 ± 0.076
2.323GluGln: 2.323 ± 0.097
4.123GluArg: 4.123 ± 0.114
2.89GluSer: 2.89 ± 0.104
3.235GluThr: 3.235 ± 0.105
3.444GluVal: 3.444 ± 0.106
0.528GluTrp: 0.528 ± 0.041
1.386GluTyr: 1.386 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
3.123PheAla: 3.123 ± 0.12
0.662PheCys: 0.662 ± 0.047
2.494PheAsp: 2.494 ± 0.105
2.209PheGlu: 2.209 ± 0.086
2.674PhePhe: 2.674 ± 0.127
3.356PheGly: 3.356 ± 0.116
1.091PheHis: 1.091 ± 0.058
3.248PheIle: 3.248 ± 0.113
1.498PheLys: 1.498 ± 0.075
4.286PheLeu: 4.286 ± 0.153
1.091PheMet: 1.091 ± 0.068
1.576PheAsn: 1.576 ± 0.07
1.698PhePro: 1.698 ± 0.074
1.229PheGln: 1.229 ± 0.072
2.183PheArg: 2.183 ± 0.085
3.883PheSer: 3.883 ± 0.118
2.346PheThr: 2.346 ± 0.082
2.632PheVal: 2.632 ± 0.104
0.501PheTrp: 0.501 ± 0.046
1.412PheTyr: 1.412 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
5.719GlyAla: 5.719 ± 0.143
0.944GlyCys: 0.944 ± 0.05
3.408GlyAsp: 3.408 ± 0.129
3.556GlyGlu: 3.556 ± 0.119
3.562GlyPhe: 3.562 ± 0.122
5.201GlyGly: 5.201 ± 0.168
2.088GlyHis: 2.088 ± 0.085
6.364GlyIle: 6.364 ± 0.159
4.169GlyLys: 4.169 ± 0.126
6.997GlyLeu: 6.997 ± 0.17
2.199GlyMet: 2.199 ± 0.079
2.451GlyAsn: 2.451 ± 0.104
2.432GlyPro: 2.432 ± 0.082
2.717GlyGln: 2.717 ± 0.089
4.634GlyArg: 4.634 ± 0.13
4.175GlySer: 4.175 ± 0.128
3.733GlyThr: 3.733 ± 0.11
4.939GlyVal: 4.939 ± 0.128
0.901GlyTrp: 0.901 ± 0.057
2.16GlyTyr: 2.16 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
2.376HisAla: 2.376 ± 0.091
0.36HisCys: 0.36 ± 0.03
1.337HisAsp: 1.337 ± 0.069
1.317HisGlu: 1.317 ± 0.065
1.285HisPhe: 1.285 ± 0.063
2.156HisGly: 2.156 ± 0.088
0.724HisHis: 0.724 ± 0.052
2.006HisIle: 2.006 ± 0.087
1.055HisLys: 1.055 ± 0.063
2.353HisLeu: 2.353 ± 0.102
0.652HisMet: 0.652 ± 0.041
0.852HisAsn: 0.852 ± 0.052
1.393HisPro: 1.393 ± 0.068
0.793HisGln: 0.793 ± 0.051
1.455HisArg: 1.455 ± 0.065
1.419HisSer: 1.419 ± 0.07
1.206HisThr: 1.206 ± 0.065
1.753HisVal: 1.753 ± 0.074
0.259HisTrp: 0.259 ± 0.028
0.816HisTyr: 0.816 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
8.062IleAla: 8.062 ± 0.181
1.052IleCys: 1.052 ± 0.066
4.588IleAsp: 4.588 ± 0.129
4.555IleGlu: 4.555 ± 0.13
3.225IlePhe: 3.225 ± 0.127
6.289IleGly: 6.289 ± 0.179
1.914IleHis: 1.914 ± 0.083
5.879IleIle: 5.879 ± 0.151
3.221IleLys: 3.221 ± 0.112
7.367IleLeu: 7.367 ± 0.18
2.081IleMet: 2.081 ± 0.075
2.933IleAsn: 2.933 ± 0.085
3.438IlePro: 3.438 ± 0.112
2.33IleGln: 2.33 ± 0.083
5.014IleArg: 5.014 ± 0.117
5.142IleSer: 5.142 ± 0.138
4.244IleThr: 4.244 ± 0.125
5.345IleVal: 5.345 ± 0.126
0.826IleTrp: 0.826 ± 0.053
1.95IleTyr: 1.95 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
4.054LysAla: 4.054 ± 0.128
0.426LysCys: 0.426 ± 0.039
2.379LysAsp: 2.379 ± 0.089
2.867LysGlu: 2.867 ± 0.101
1.272LysPhe: 1.272 ± 0.071
3.31LysGly: 3.31 ± 0.103
0.963LysHis: 0.963 ± 0.065
4.359LysIle: 4.359 ± 0.129
4.093LysLys: 4.093 ± 0.115
4.218LysLeu: 4.218 ± 0.133
1.403LysMet: 1.403 ± 0.063
2.871LysAsn: 2.871 ± 0.101
1.983LysPro: 1.983 ± 0.093
1.58LysGln: 1.58 ± 0.069
3.641LysArg: 3.641 ± 0.107
2.845LysSer: 2.845 ± 0.092
3.294LysThr: 3.294 ± 0.102
2.985LysVal: 2.985 ± 0.104
0.492LysTrp: 0.492 ± 0.04
1.134LysTyr: 1.134 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
9.153LeuAla: 9.153 ± 0.203
1.242LeuCys: 1.242 ± 0.07
5.388LeuAsp: 5.388 ± 0.151
5.607LeuGlu: 5.607 ± 0.14
4.267LeuPhe: 4.267 ± 0.165
6.551LeuGly: 6.551 ± 0.197
2.392LeuHis: 2.392 ± 0.099
7.065LeuIle: 7.065 ± 0.149
4.932LeuLys: 4.932 ± 0.127
8.911LeuLeu: 8.911 ± 0.21
2.382LeuMet: 2.382 ± 0.097
3.366LeuAsn: 3.366 ± 0.111
4.283LeuPro: 4.283 ± 0.124
3.572LeuGln: 3.572 ± 0.11
5.692LeuArg: 5.692 ± 0.158
7.334LeuSer: 7.334 ± 0.155
5.247LeuThr: 5.247 ± 0.126
6.328LeuVal: 6.328 ± 0.139
0.934LeuTrp: 0.934 ± 0.07
2.691LeuTyr: 2.691 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
2.474MetAla: 2.474 ± 0.089
0.288MetCys: 0.288 ± 0.03
1.235MetAsp: 1.235 ± 0.069
1.35MetGlu: 1.35 ± 0.074
0.865MetPhe: 0.865 ± 0.048
1.776MetGly: 1.776 ± 0.077
0.724MetHis: 0.724 ± 0.045
2.458MetIle: 2.458 ± 0.089
1.429MetLys: 1.429 ± 0.072
3.077MetLeu: 3.077 ± 0.114
0.954MetMet: 0.954 ± 0.055
1.147MetAsn: 1.147 ± 0.059
1.396MetPro: 1.396 ± 0.064
1.258MetGln: 1.258 ± 0.071
1.858MetArg: 1.858 ± 0.081
1.652MetSer: 1.652 ± 0.076
1.816MetThr: 1.816 ± 0.076
1.757MetVal: 1.757 ± 0.064
0.206MetTrp: 0.206 ± 0.027
0.439MetTyr: 0.439 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.562AsnAla: 3.562 ± 0.11
0.452AsnCys: 0.452 ± 0.039
1.914AsnAsp: 1.914 ± 0.069
1.717AsnGlu: 1.717 ± 0.073
1.485AsnPhe: 1.485 ± 0.062
2.815AsnGly: 2.815 ± 0.095
1.065AsnHis: 1.065 ± 0.059
3.136AsnIle: 3.136 ± 0.102
1.678AsnLys: 1.678 ± 0.079
3.457AsnLeu: 3.457 ± 0.1
1.052AsnMet: 1.052 ± 0.062
1.498AsnAsn: 1.498 ± 0.087
2.169AsnPro: 2.169 ± 0.079
1.226AsnGln: 1.226 ± 0.076
2.52AsnArg: 2.52 ± 0.094
1.973AsnSer: 1.973 ± 0.088
1.999AsnThr: 1.999 ± 0.084
2.523AsnVal: 2.523 ± 0.089
0.492AsnTrp: 0.492 ± 0.04
1.016AsnTyr: 1.016 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.867ProAla: 2.867 ± 0.108
0.541ProCys: 0.541 ± 0.04
2.615ProAsp: 2.615 ± 0.104
2.7ProGlu: 2.7 ± 0.093
1.996ProPhe: 1.996 ± 0.077
3.103ProGly: 3.103 ± 0.102
1.134ProHis: 1.134 ± 0.057
2.789ProIle: 2.789 ± 0.107
1.527ProLys: 1.527 ± 0.068
3.874ProLeu: 3.874 ± 0.114
0.97ProMet: 0.97 ± 0.06
1.334ProAsn: 1.334 ± 0.067
1.396ProPro: 1.396 ± 0.073
1.419ProGln: 1.419 ± 0.074
1.868ProArg: 1.868 ± 0.083
2.35ProSer: 2.35 ± 0.088
1.884ProThr: 1.884 ± 0.084
3.716ProVal: 3.716 ± 0.111
0.475ProTrp: 0.475 ± 0.035
1.229ProTyr: 1.229 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
3.221GlnAla: 3.221 ± 0.115
0.377GlnCys: 0.377 ± 0.034
1.632GlnAsp: 1.632 ± 0.07
1.986GlnGlu: 1.986 ± 0.089
1.285GlnPhe: 1.285 ± 0.071
2.081GlnGly: 2.081 ± 0.079
1.052GlnHis: 1.052 ± 0.068
2.694GlnIle: 2.694 ± 0.101
2.124GlnLys: 2.124 ± 0.083
3.107GlnLeu: 3.107 ± 0.104
1.036GlnMet: 1.036 ± 0.048
1.403GlnAsn: 1.403 ± 0.069
1.327GlnPro: 1.327 ± 0.066
1.373GlnGln: 1.373 ± 0.065
2.33GlnArg: 2.33 ± 0.098
2.065GlnSer: 2.065 ± 0.081
1.75GlnThr: 1.75 ± 0.082
2.196GlnVal: 2.196 ± 0.084
0.416GlnTrp: 0.416 ± 0.037
0.911GlnTyr: 0.911 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
4.716ArgAla: 4.716 ± 0.122
0.695ArgCys: 0.695 ± 0.049
3.117ArgAsp: 3.117 ± 0.113
3.703ArgGlu: 3.703 ± 0.126
2.923ArgPhe: 2.923 ± 0.111
3.772ArgGly: 3.772 ± 0.121
1.658ArgHis: 1.658 ± 0.071
5.296ArgIle: 5.296 ± 0.143
3.507ArgLys: 3.507 ± 0.12
6.869ArgLeu: 6.869 ± 0.193
1.793ArgMet: 1.793 ± 0.076
2.432ArgAsn: 2.432 ± 0.112
2.228ArgPro: 2.228 ± 0.09
2.582ArgGln: 2.582 ± 0.096
4.123ArgArg: 4.123 ± 0.156
3.533ArgSer: 3.533 ± 0.112
3.162ArgThr: 3.162 ± 0.102
4.047ArgVal: 4.047 ± 0.116
0.665ArgTrp: 0.665 ± 0.05
2.038ArgTyr: 2.038 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
5.034SerAla: 5.034 ± 0.138
0.888SerCys: 0.888 ± 0.056
3.185SerAsp: 3.185 ± 0.091
3.343SerGlu: 3.343 ± 0.108
2.985SerPhe: 2.985 ± 0.113
5.486SerGly: 5.486 ± 0.14
1.412SerHis: 1.412 ± 0.07
4.696SerIle: 4.696 ± 0.128
2.491SerLys: 2.491 ± 0.095
6.269SerLeu: 6.269 ± 0.133
1.809SerMet: 1.809 ± 0.071
2.186SerAsn: 2.186 ± 0.09
2.222SerPro: 2.222 ± 0.086
1.789SerGln: 1.789 ± 0.071
3.762SerArg: 3.762 ± 0.104
4.326SerSer: 4.326 ± 0.141
2.904SerThr: 2.904 ± 0.102
4.503SerVal: 4.503 ± 0.131
0.731SerTrp: 0.731 ± 0.051
1.907SerTyr: 1.907 ± 0.085
0.0SerXaa: 0.0 ± 0.0
Thr
4.896ThrAla: 4.896 ± 0.12
0.714ThrCys: 0.714 ± 0.051
2.809ThrAsp: 2.809 ± 0.094
2.677ThrGlu: 2.677 ± 0.101
2.222ThrPhe: 2.222 ± 0.08
4.798ThrGly: 4.798 ± 0.139
1.17ThrHis: 1.17 ± 0.065
3.982ThrIle: 3.982 ± 0.124
1.917ThrLys: 1.917 ± 0.081
5.63ThrLeu: 5.63 ± 0.152
1.478ThrMet: 1.478 ± 0.079
1.622ThrAsn: 1.622 ± 0.067
2.425ThrPro: 2.425 ± 0.086
1.491ThrGln: 1.491 ± 0.066
3.189ThrArg: 3.189 ± 0.093
3.005ThrSer: 3.005 ± 0.099
2.782ThrThr: 2.782 ± 0.104
4.244ThrVal: 4.244 ± 0.108
0.465ThrTrp: 0.465 ± 0.04
1.288ThrTyr: 1.288 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
5.866ValAla: 5.866 ± 0.138
0.823ValCys: 0.823 ± 0.053
3.772ValAsp: 3.772 ± 0.147
4.119ValGlu: 4.119 ± 0.125
3.041ValPhe: 3.041 ± 0.098
4.283ValGly: 4.283 ± 0.117
1.668ValHis: 1.668 ± 0.079
5.47ValIle: 5.47 ± 0.128
3.192ValLys: 3.192 ± 0.12
7.144ValLeu: 7.144 ± 0.159
1.891ValMet: 1.891 ± 0.068
2.455ValAsn: 2.455 ± 0.078
2.838ValPro: 2.838 ± 0.115
2.215ValGln: 2.215 ± 0.093
4.113ValArg: 4.113 ± 0.121
4.683ValSer: 4.683 ± 0.134
3.67ValThr: 3.67 ± 0.109
4.991ValVal: 4.991 ± 0.116
0.655ValTrp: 0.655 ± 0.047
1.678ValTyr: 1.678 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.682TrpAla: 0.682 ± 0.044
0.144TrpCys: 0.144 ± 0.023
0.406TrpAsp: 0.406 ± 0.04
0.387TrpGlu: 0.387 ± 0.034
0.485TrpPhe: 0.485 ± 0.044
0.564TrpGly: 0.564 ± 0.046
0.351TrpHis: 0.351 ± 0.033
0.875TrpIle: 0.875 ± 0.056
0.665TrpLys: 0.665 ± 0.05
1.321TrpLeu: 1.321 ± 0.07
0.423TrpMet: 0.423 ± 0.041
0.534TrpAsn: 0.534 ± 0.042
0.449TrpPro: 0.449 ± 0.041
0.57TrpGln: 0.57 ± 0.042
0.714TrpArg: 0.714 ± 0.044
0.58TrpSer: 0.58 ± 0.044
0.475TrpThr: 0.475 ± 0.043
0.472TrpVal: 0.472 ± 0.039
0.2TrpTrp: 0.2 ± 0.027
0.305TrpTyr: 0.305 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.36TyrAla: 2.36 ± 0.086
0.36TyrCys: 0.36 ± 0.037
1.714TyrAsp: 1.714 ± 0.079
1.524TyrGlu: 1.524 ± 0.069
1.121TyrPhe: 1.121 ± 0.062
2.061TyrGly: 2.061 ± 0.083
0.849TyrHis: 0.849 ± 0.054
1.809TyrIle: 1.809 ± 0.078
1.268TyrLys: 1.268 ± 0.066
2.789TyrLeu: 2.789 ± 0.092
0.708TyrMet: 0.708 ± 0.04
1.19TyrAsn: 1.19 ± 0.062
1.193TyrPro: 1.193 ± 0.057
0.882TyrGln: 0.882 ± 0.058
1.888TyrArg: 1.888 ± 0.091
1.632TyrSer: 1.632 ± 0.076
1.488TyrThr: 1.488 ± 0.069
1.56TyrVal: 1.56 ± 0.075
0.298TyrTrp: 0.298 ± 0.032
0.872TyrTyr: 0.872 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 963 proteins (305146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski