Amino acid dipepetide frequency for Vibrio phage vB_VpaP_MGD2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.486AlaAla: 8.486 ± 1.394
0.664AlaCys: 0.664 ± 0.205
6.199AlaAsp: 6.199 ± 0.545
6.715AlaGlu: 6.715 ± 0.8
2.583AlaPhe: 2.583 ± 0.416
5.535AlaGly: 5.535 ± 0.466
1.476AlaHis: 1.476 ± 0.381
4.649AlaIle: 4.649 ± 0.758
5.608AlaLys: 5.608 ± 0.641
5.608AlaLeu: 5.608 ± 0.607
2.435AlaMet: 2.435 ± 0.423
3.69AlaAsn: 3.69 ± 0.564
2.878AlaPro: 2.878 ± 0.516
3.468AlaGln: 3.468 ± 0.561
4.797AlaArg: 4.797 ± 0.669
4.206AlaSer: 4.206 ± 0.623
4.133AlaThr: 4.133 ± 0.741
5.535AlaVal: 5.535 ± 0.735
0.812AlaTrp: 0.812 ± 0.306
2.804AlaTyr: 2.804 ± 0.54
0.0AlaXaa: 0.0 ± 0.0
Cys
0.369CysAla: 0.369 ± 0.133
0.0CysCys: 0.0 ± 0.0
0.369CysAsp: 0.369 ± 0.196
0.664CysGlu: 0.664 ± 0.267
0.221CysPhe: 0.221 ± 0.117
0.517CysGly: 0.517 ± 0.201
0.221CysHis: 0.221 ± 0.126
0.664CysIle: 0.664 ± 0.176
0.886CysLys: 0.886 ± 0.257
0.886CysLeu: 0.886 ± 0.265
0.148CysMet: 0.148 ± 0.101
0.59CysAsn: 0.59 ± 0.183
0.664CysPro: 0.664 ± 0.218
0.295CysGln: 0.295 ± 0.124
0.59CysArg: 0.59 ± 0.275
0.59CysSer: 0.59 ± 0.204
0.664CysThr: 0.664 ± 0.289
0.738CysVal: 0.738 ± 0.201
0.148CysTrp: 0.148 ± 0.088
0.369CysTyr: 0.369 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
5.461AspAla: 5.461 ± 0.586
0.664AspCys: 0.664 ± 0.192
3.911AspAsp: 3.911 ± 0.394
4.944AspGlu: 4.944 ± 0.646
2.804AspPhe: 2.804 ± 0.402
4.944AspGly: 4.944 ± 0.754
0.738AspHis: 0.738 ± 0.216
4.502AspIle: 4.502 ± 0.615
6.273AspLys: 6.273 ± 0.728
4.649AspLeu: 4.649 ± 0.601
1.55AspMet: 1.55 ± 0.342
2.952AspAsn: 2.952 ± 0.43
2.435AspPro: 2.435 ± 0.428
1.107AspGln: 1.107 ± 0.311
2.657AspArg: 2.657 ± 0.402
3.69AspSer: 3.69 ± 0.531
3.69AspThr: 3.69 ± 0.506
4.87AspVal: 4.87 ± 0.562
1.402AspTrp: 1.402 ± 0.429
2.952AspTyr: 2.952 ± 0.416
0.0AspXaa: 0.0 ± 0.0
Glu
6.125GluAla: 6.125 ± 0.856
0.443GluCys: 0.443 ± 0.17
4.575GluAsp: 4.575 ± 0.588
7.601GluGlu: 7.601 ± 1.084
3.616GluPhe: 3.616 ± 0.474
4.649GluGly: 4.649 ± 0.622
1.476GluHis: 1.476 ± 0.41
3.099GluIle: 3.099 ± 0.392
4.428GluLys: 4.428 ± 0.57
7.527GluLeu: 7.527 ± 0.866
2.583GluMet: 2.583 ± 0.379
2.73GluAsn: 2.73 ± 0.381
2.878GluPro: 2.878 ± 0.581
4.502GluGln: 4.502 ± 0.734
3.837GluArg: 3.837 ± 0.578
4.133GluSer: 4.133 ± 0.618
2.952GluThr: 2.952 ± 0.288
5.166GluVal: 5.166 ± 0.59
1.623GluTrp: 1.623 ± 0.363
2.509GluTyr: 2.509 ± 0.36
0.0GluXaa: 0.0 ± 0.0
Phe
2.73PheAla: 2.73 ± 0.356
0.517PheCys: 0.517 ± 0.211
3.764PheAsp: 3.764 ± 0.629
2.657PheGlu: 2.657 ± 0.353
1.476PhePhe: 1.476 ± 0.281
2.509PheGly: 2.509 ± 0.385
0.886PheHis: 0.886 ± 0.198
2.066PheIle: 2.066 ± 0.316
2.435PheLys: 2.435 ± 0.46
2.657PheLeu: 2.657 ± 0.468
1.55PheMet: 1.55 ± 0.353
2.14PheAsn: 2.14 ± 0.286
1.771PhePro: 1.771 ± 0.36
0.959PheGln: 0.959 ± 0.246
1.919PheArg: 1.919 ± 0.356
2.435PheSer: 2.435 ± 0.407
1.992PheThr: 1.992 ± 0.36
2.509PheVal: 2.509 ± 0.352
0.664PheTrp: 0.664 ± 0.266
0.886PheTyr: 0.886 ± 0.231
0.0PheXaa: 0.0 ± 0.0
Gly
5.166GlyAla: 5.166 ± 0.69
0.886GlyCys: 0.886 ± 0.287
4.575GlyAsp: 4.575 ± 0.416
5.166GlyGlu: 5.166 ± 0.662
2.435GlyPhe: 2.435 ± 0.388
6.051GlyGly: 6.051 ± 0.961
1.55GlyHis: 1.55 ± 0.401
3.985GlyIle: 3.985 ± 0.538
7.084GlyLys: 7.084 ± 0.65
5.166GlyLeu: 5.166 ± 0.653
2.657GlyMet: 2.657 ± 0.396
3.468GlyAsn: 3.468 ± 0.476
0.148GlyPro: 0.148 ± 0.119
2.066GlyGln: 2.066 ± 0.372
3.542GlyArg: 3.542 ± 0.445
4.575GlySer: 4.575 ± 0.635
4.649GlyThr: 4.649 ± 0.807
3.247GlyVal: 3.247 ± 0.508
1.255GlyTrp: 1.255 ± 0.285
3.173GlyTyr: 3.173 ± 0.509
0.0GlyXaa: 0.0 ± 0.0
His
1.107HisAla: 1.107 ± 0.335
0.221HisCys: 0.221 ± 0.162
1.328HisAsp: 1.328 ± 0.301
1.328HisGlu: 1.328 ± 0.307
0.59HisPhe: 0.59 ± 0.184
1.033HisGly: 1.033 ± 0.343
0.517HisHis: 0.517 ± 0.246
1.255HisIle: 1.255 ± 0.267
1.623HisLys: 1.623 ± 0.271
2.288HisLeu: 2.288 ± 0.475
0.443HisMet: 0.443 ± 0.168
0.886HisAsn: 0.886 ± 0.228
0.664HisPro: 0.664 ± 0.24
0.812HisGln: 0.812 ± 0.27
0.886HisArg: 0.886 ± 0.275
1.255HisSer: 1.255 ± 0.242
0.886HisThr: 0.886 ± 0.273
0.812HisVal: 0.812 ± 0.278
0.148HisTrp: 0.148 ± 0.115
0.886HisTyr: 0.886 ± 0.396
0.0HisXaa: 0.0 ± 0.0
Ile
4.133IleAla: 4.133 ± 0.63
0.517IleCys: 0.517 ± 0.202
4.87IleAsp: 4.87 ± 0.549
3.985IleGlu: 3.985 ± 0.473
1.919IlePhe: 1.919 ± 0.421
3.985IleGly: 3.985 ± 0.506
1.328IleHis: 1.328 ± 0.352
2.952IleIle: 2.952 ± 0.639
4.354IleLys: 4.354 ± 0.611
3.542IleLeu: 3.542 ± 0.479
1.402IleMet: 1.402 ± 0.272
2.435IleAsn: 2.435 ± 0.361
2.361IlePro: 2.361 ± 0.327
2.509IleGln: 2.509 ± 0.488
2.583IleArg: 2.583 ± 0.465
2.657IleSer: 2.657 ± 0.449
3.764IleThr: 3.764 ± 0.54
3.173IleVal: 3.173 ± 0.532
0.886IleTrp: 0.886 ± 0.269
1.919IleTyr: 1.919 ± 0.46
0.0IleXaa: 0.0 ± 0.0
Lys
6.642LysAla: 6.642 ± 0.969
0.812LysCys: 0.812 ± 0.235
5.461LysAsp: 5.461 ± 0.774
6.051LysGlu: 6.051 ± 0.64
3.026LysPhe: 3.026 ± 0.408
5.166LysGly: 5.166 ± 0.899
1.402LysHis: 1.402 ± 0.328
2.509LysIle: 2.509 ± 0.377
3.616LysLys: 3.616 ± 0.594
5.682LysLeu: 5.682 ± 0.646
1.771LysMet: 1.771 ± 0.396
3.026LysAsn: 3.026 ± 0.379
3.321LysPro: 3.321 ± 0.611
3.985LysGln: 3.985 ± 0.565
4.575LysArg: 4.575 ± 0.696
2.952LysSer: 2.952 ± 0.4
3.837LysThr: 3.837 ± 0.552
3.69LysVal: 3.69 ± 0.543
0.959LysTrp: 0.959 ± 0.237
2.73LysTyr: 2.73 ± 0.376
0.0LysXaa: 0.0 ± 0.0
Leu
6.346LeuAla: 6.346 ± 0.676
0.369LeuCys: 0.369 ± 0.214
5.535LeuAsp: 5.535 ± 0.592
5.904LeuGlu: 5.904 ± 0.688
1.919LeuPhe: 1.919 ± 0.315
5.977LeuGly: 5.977 ± 0.415
2.214LeuHis: 2.214 ± 0.434
4.797LeuIle: 4.797 ± 0.627
5.461LeuLys: 5.461 ± 0.699
5.682LeuLeu: 5.682 ± 0.613
3.099LeuMet: 3.099 ± 0.413
3.247LeuAsn: 3.247 ± 0.424
3.247LeuPro: 3.247 ± 0.424
3.099LeuGln: 3.099 ± 0.395
4.354LeuArg: 4.354 ± 0.825
4.797LeuSer: 4.797 ± 0.871
4.428LeuThr: 4.428 ± 0.531
5.756LeuVal: 5.756 ± 0.738
0.664LeuTrp: 0.664 ± 0.193
3.321LeuTyr: 3.321 ± 0.521
0.0LeuXaa: 0.0 ± 0.0
Met
2.73MetAla: 2.73 ± 0.319
0.074MetCys: 0.074 ± 0.063
1.255MetAsp: 1.255 ± 0.339
1.919MetGlu: 1.919 ± 0.425
1.402MetPhe: 1.402 ± 0.375
2.214MetGly: 2.214 ± 0.415
0.517MetHis: 0.517 ± 0.196
1.476MetIle: 1.476 ± 0.288
2.878MetLys: 2.878 ± 0.468
3.395MetLeu: 3.395 ± 0.432
0.59MetMet: 0.59 ± 0.192
1.255MetAsn: 1.255 ± 0.275
1.255MetPro: 1.255 ± 0.266
1.697MetGln: 1.697 ± 0.417
1.992MetArg: 1.992 ± 0.422
2.14MetSer: 2.14 ± 0.443
1.771MetThr: 1.771 ± 0.464
1.255MetVal: 1.255 ± 0.264
0.074MetTrp: 0.074 ± 0.066
1.107MetTyr: 1.107 ± 0.277
0.0MetXaa: 0.0 ± 0.0
Asn
3.985AsnAla: 3.985 ± 0.548
0.664AsnCys: 0.664 ± 0.362
2.361AsnAsp: 2.361 ± 0.473
2.509AsnGlu: 2.509 ± 0.31
1.845AsnPhe: 1.845 ± 0.26
3.321AsnGly: 3.321 ± 0.587
0.517AsnHis: 0.517 ± 0.16
2.583AsnIle: 2.583 ± 0.489
3.837AsnLys: 3.837 ± 0.695
5.092AsnLeu: 5.092 ± 0.658
1.328AsnMet: 1.328 ± 0.27
2.583AsnAsn: 2.583 ± 0.447
2.361AsnPro: 2.361 ± 0.454
1.919AsnGln: 1.919 ± 0.345
2.288AsnArg: 2.288 ± 0.366
2.361AsnSer: 2.361 ± 0.391
2.804AsnThr: 2.804 ± 0.431
3.321AsnVal: 3.321 ± 0.428
0.443AsnTrp: 0.443 ± 0.183
1.402AsnTyr: 1.402 ± 0.32
0.0AsnXaa: 0.0 ± 0.0
Pro
3.026ProAla: 3.026 ± 0.405
0.443ProCys: 0.443 ± 0.179
2.583ProAsp: 2.583 ± 0.482
4.28ProGlu: 4.28 ± 0.663
1.476ProPhe: 1.476 ± 0.309
0.148ProGly: 0.148 ± 0.101
0.812ProHis: 0.812 ± 0.232
1.845ProIle: 1.845 ± 0.381
1.992ProLys: 1.992 ± 0.362
2.878ProLeu: 2.878 ± 0.424
0.959ProMet: 0.959 ± 0.19
2.288ProAsn: 2.288 ± 0.353
1.255ProPro: 1.255 ± 0.297
1.402ProGln: 1.402 ± 0.302
1.255ProArg: 1.255 ± 0.35
2.73ProSer: 2.73 ± 0.486
1.919ProThr: 1.919 ± 0.312
2.878ProVal: 2.878 ± 0.423
0.738ProTrp: 0.738 ± 0.199
1.402ProTyr: 1.402 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
4.575GlnAla: 4.575 ± 0.555
0.369GlnCys: 0.369 ± 0.148
1.697GlnAsp: 1.697 ± 0.334
4.28GlnGlu: 4.28 ± 0.706
1.845GlnPhe: 1.845 ± 0.302
2.066GlnGly: 2.066 ± 0.406
0.443GlnHis: 0.443 ± 0.173
1.992GlnIle: 1.992 ± 0.289
1.845GlnLys: 1.845 ± 0.37
3.468GlnLeu: 3.468 ± 0.382
1.476GlnMet: 1.476 ± 0.232
2.288GlnAsn: 2.288 ± 0.33
1.181GlnPro: 1.181 ± 0.361
2.657GlnGln: 2.657 ± 0.539
2.73GlnArg: 2.73 ± 0.695
2.361GlnSer: 2.361 ± 0.411
1.845GlnThr: 1.845 ± 0.4
2.435GlnVal: 2.435 ± 0.422
0.221GlnTrp: 0.221 ± 0.164
1.402GlnTyr: 1.402 ± 0.296
0.0GlnXaa: 0.0 ± 0.0
Arg
4.206ArgAla: 4.206 ± 0.608
0.443ArgCys: 0.443 ± 0.204
3.247ArgAsp: 3.247 ± 0.484
3.764ArgGlu: 3.764 ± 0.51
1.476ArgPhe: 1.476 ± 0.322
3.837ArgGly: 3.837 ± 0.411
0.959ArgHis: 0.959 ± 0.235
3.321ArgIle: 3.321 ± 0.446
3.468ArgLys: 3.468 ± 0.606
4.354ArgLeu: 4.354 ± 0.564
1.992ArgMet: 1.992 ± 0.297
2.288ArgAsn: 2.288 ± 0.435
1.771ArgPro: 1.771 ± 0.351
1.919ArgGln: 1.919 ± 0.279
2.804ArgArg: 2.804 ± 0.484
2.288ArgSer: 2.288 ± 0.433
2.657ArgThr: 2.657 ± 0.253
2.952ArgVal: 2.952 ± 0.351
1.033ArgTrp: 1.033 ± 0.189
2.435ArgTyr: 2.435 ± 0.354
0.0ArgXaa: 0.0 ± 0.0
Ser
4.133SerAla: 4.133 ± 0.704
0.295SerCys: 0.295 ± 0.157
3.395SerAsp: 3.395 ± 0.417
3.468SerGlu: 3.468 ± 0.49
2.435SerPhe: 2.435 ± 0.418
5.608SerGly: 5.608 ± 0.739
1.033SerHis: 1.033 ± 0.274
3.985SerIle: 3.985 ± 0.542
4.649SerLys: 4.649 ± 0.552
5.018SerLeu: 5.018 ± 0.635
1.919SerMet: 1.919 ± 0.41
2.952SerAsn: 2.952 ± 0.483
1.919SerPro: 1.919 ± 0.354
1.697SerGln: 1.697 ± 0.26
2.066SerArg: 2.066 ± 0.436
3.173SerSer: 3.173 ± 0.738
2.804SerThr: 2.804 ± 0.528
3.321SerVal: 3.321 ± 0.566
0.664SerTrp: 0.664 ± 0.196
2.361SerTyr: 2.361 ± 0.574
0.0SerXaa: 0.0 ± 0.0
Thr
3.764ThrAla: 3.764 ± 0.517
0.664ThrCys: 0.664 ± 0.221
4.28ThrAsp: 4.28 ± 0.637
3.985ThrGlu: 3.985 ± 0.552
2.952ThrPhe: 2.952 ± 0.433
5.387ThrGly: 5.387 ± 0.562
0.812ThrHis: 0.812 ± 0.214
3.321ThrIle: 3.321 ± 0.376
3.173ThrLys: 3.173 ± 0.414
4.428ThrLeu: 4.428 ± 0.516
1.328ThrMet: 1.328 ± 0.356
2.657ThrAsn: 2.657 ± 0.499
2.509ThrPro: 2.509 ± 0.457
2.214ThrGln: 2.214 ± 0.418
1.919ThrArg: 1.919 ± 0.343
2.657ThrSer: 2.657 ± 0.563
2.878ThrThr: 2.878 ± 0.449
3.173ThrVal: 3.173 ± 0.447
0.443ThrTrp: 0.443 ± 0.2
1.402ThrTyr: 1.402 ± 0.337
0.0ThrXaa: 0.0 ± 0.0
Val
5.682ValAla: 5.682 ± 0.653
0.517ValCys: 0.517 ± 0.197
3.985ValAsp: 3.985 ± 0.502
3.69ValGlu: 3.69 ± 0.656
2.361ValPhe: 2.361 ± 0.461
4.723ValGly: 4.723 ± 0.474
0.886ValHis: 0.886 ± 0.278
3.173ValIle: 3.173 ± 0.442
3.985ValLys: 3.985 ± 0.47
4.28ValLeu: 4.28 ± 0.53
1.919ValMet: 1.919 ± 0.389
3.321ValAsn: 3.321 ± 0.5
1.771ValPro: 1.771 ± 0.319
2.361ValGln: 2.361 ± 0.424
4.206ValArg: 4.206 ± 0.764
4.28ValSer: 4.28 ± 0.711
3.616ValThr: 3.616 ± 0.653
5.018ValVal: 5.018 ± 0.698
0.738ValTrp: 0.738 ± 0.281
1.476ValTyr: 1.476 ± 0.396
0.0ValXaa: 0.0 ± 0.0
Trp
0.959TrpAla: 0.959 ± 0.258
0.517TrpCys: 0.517 ± 0.194
0.59TrpAsp: 0.59 ± 0.214
1.181TrpGlu: 1.181 ± 0.313
0.664TrpPhe: 0.664 ± 0.206
0.664TrpGly: 0.664 ± 0.226
0.369TrpHis: 0.369 ± 0.198
1.033TrpIle: 1.033 ± 0.249
1.033TrpLys: 1.033 ± 0.313
1.255TrpLeu: 1.255 ± 0.393
0.517TrpMet: 0.517 ± 0.15
0.369TrpAsn: 0.369 ± 0.151
0.369TrpPro: 0.369 ± 0.173
0.664TrpGln: 0.664 ± 0.229
0.443TrpArg: 0.443 ± 0.217
1.255TrpSer: 1.255 ± 0.311
0.812TrpThr: 0.812 ± 0.232
0.369TrpVal: 0.369 ± 0.121
0.221TrpTrp: 0.221 ± 0.135
0.738TrpTyr: 0.738 ± 0.167
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.657TyrAla: 2.657 ± 0.469
0.517TyrCys: 0.517 ± 0.196
2.214TyrAsp: 2.214 ± 0.348
2.435TyrGlu: 2.435 ± 0.384
1.476TyrPhe: 1.476 ± 0.299
2.509TyrGly: 2.509 ± 0.409
0.812TyrHis: 0.812 ± 0.243
2.066TyrIle: 2.066 ± 0.446
2.583TyrLys: 2.583 ± 0.369
2.361TyrLeu: 2.361 ± 0.316
1.255TyrMet: 1.255 ± 0.271
2.361TyrAsn: 2.361 ± 0.402
1.55TyrPro: 1.55 ± 0.416
1.845TyrGln: 1.845 ± 0.321
1.771TyrArg: 1.771 ± 0.299
2.361TyrSer: 2.361 ± 0.392
1.845TyrThr: 1.845 ± 0.323
1.771TyrVal: 1.771 ± 0.365
0.886TyrTrp: 0.886 ± 0.274
1.107TyrTyr: 1.107 ± 0.325
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (13552 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski