Amino acid dipepetide frequency for Thermodesulfitimonas autotrophica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.352AlaAla: 17.352 ± 0.289	1.491AlaCys: 1.491 ± 0.055	4.51AlaAsp: 4.51 ± 0.092	7.359AlaGlu: 7.359 ± 0.121	3.852AlaPhe: 3.852 ± 0.083	10.888AlaGly: 10.888 ± 0.173	1.698AlaHis: 1.698 ± 0.05	4.771AlaIle: 4.771 ± 0.09	4.116AlaLys: 4.116 ± 0.086	12.927AlaLeu: 12.927 ± 0.169	1.945AlaMet: 1.945 ± 0.06	2.328AlaAsn: 2.328 ± 0.057	4.353AlaPro: 4.353 ± 0.097	3.29AlaGln: 3.29 ± 0.073	8.584AlaArg: 8.584 ± 0.138	3.787AlaSer: 3.787 ± 0.079	5.082AlaThr: 5.082 ± 0.097	11.412AlaVal: 11.412 ± 0.168	1.169AlaTrp: 1.169 ± 0.043	2.89AlaTyr: 2.89 ± 0.076	0.0AlaXaa: 0.0 ± 0.0
Cys	1.242CysAla: 1.242 ± 0.053	0.249CysCys: 0.249 ± 0.022	0.524CysAsp: 0.524 ± 0.032	0.551CysGlu: 0.551 ± 0.029	0.496CysPhe: 0.496 ± 0.03	1.694CysGly: 1.694 ± 0.064	0.453CysHis: 0.453 ± 0.057	0.466CysIle: 0.466 ± 0.033	0.32CysLys: 0.32 ± 0.026	1.302CysLeu: 1.302 ± 0.05	0.168CysMet: 0.168 ± 0.017	0.326CysAsn: 0.326 ± 0.024	1.018CysPro: 1.018 ± 0.045	0.354CysGln: 0.354 ± 0.022	1.172CysArg: 1.172 ± 0.042	0.595CysSer: 0.595 ± 0.036	0.565CysThr: 0.565 ± 0.033	0.822CysVal: 0.822 ± 0.036	0.17CysTrp: 0.17 ± 0.016	0.437CysTyr: 0.437 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.408AspAla: 4.408 ± 0.082	0.572AspCys: 0.572 ± 0.032	1.559AspAsp: 1.559 ± 0.046	2.664AspGlu: 2.664 ± 0.077	2.116AspPhe: 2.116 ± 0.057	3.548AspGly: 3.548 ± 0.085	0.65AspHis: 0.65 ± 0.033	2.521AspIle: 2.521 ± 0.065	1.517AspLys: 1.517 ± 0.048	4.988AspLeu: 4.988 ± 0.083	0.684AspMet: 0.684 ± 0.032	0.965AspAsn: 0.965 ± 0.04	3.109AspPro: 3.109 ± 0.087	1.002AspGln: 1.002 ± 0.039	3.088AspArg: 3.088 ± 0.066	1.288AspSer: 1.288 ± 0.046	1.849AspThr: 1.849 ± 0.06	3.455AspVal: 3.455 ± 0.07	0.639AspTrp: 0.639 ± 0.032	1.586AspTyr: 1.586 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	8.548GluAla: 8.548 ± 0.128	0.587GluCys: 0.587 ± 0.032	2.581GluAsp: 2.581 ± 0.073	6.659GluGlu: 6.659 ± 0.112	2.311GluPhe: 2.311 ± 0.055	5.156GluGly: 5.156 ± 0.097	1.092GluHis: 1.092 ± 0.04	4.799GluIle: 4.799 ± 0.096	4.501GluLys: 4.501 ± 0.092	7.501GluLeu: 7.501 ± 0.127	1.647GluMet: 1.647 ± 0.053	1.968GluAsn: 1.968 ± 0.056	2.581GluPro: 2.581 ± 0.069	1.966GluGln: 1.966 ± 0.062	5.737GluArg: 5.737 ± 0.108	2.096GluSer: 2.096 ± 0.062	3.217GluThr: 3.217 ± 0.064	5.951GluVal: 5.951 ± 0.115	0.667GluTrp: 0.667 ± 0.034	1.597GluTyr: 1.597 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	4.11PheAla: 4.11 ± 0.088	0.686PheCys: 0.686 ± 0.035	1.781PheAsp: 1.781 ± 0.057	1.861PheGlu: 1.861 ± 0.054	1.982PhePhe: 1.982 ± 0.065	3.38PheGly: 3.38 ± 0.065	0.666PheHis: 0.666 ± 0.031	1.963PheIle: 1.963 ± 0.062	1.441PheLys: 1.441 ± 0.046	4.645PheLeu: 4.645 ± 0.103	0.636PheMet: 0.636 ± 0.031	1.05PheAsn: 1.05 ± 0.039	1.994PhePro: 1.994 ± 0.065	0.925PheGln: 0.925 ± 0.039	2.536PheArg: 2.536 ± 0.067	1.937PheSer: 1.937 ± 0.059	2.224PheThr: 2.224 ± 0.055	2.791PheVal: 2.791 ± 0.073	0.596PheTrp: 0.596 ± 0.031	1.341PheTyr: 1.341 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	8.468GlyAla: 8.468 ± 0.134	1.308GlyCys: 1.308 ± 0.053	3.533GlyAsp: 3.533 ± 0.075	5.86GlyGlu: 5.86 ± 0.096	3.437GlyPhe: 3.437 ± 0.08	6.858GlyGly: 6.858 ± 0.128	1.509GlyHis: 1.509 ± 0.055	4.929GlyIle: 4.929 ± 0.093	4.259GlyLys: 4.259 ± 0.094	8.883GlyLeu: 8.883 ± 0.139	2.033GlyMet: 2.033 ± 0.059	2.096GlyAsn: 2.096 ± 0.069	3.344GlyPro: 3.344 ± 0.077	2.53GlyGln: 2.53 ± 0.067	6.651GlyArg: 6.651 ± 0.103	3.786GlySer: 3.786 ± 0.076	4.52GlyThr: 4.52 ± 0.087	7.38GlyVal: 7.38 ± 0.112	1.002GlyTrp: 1.002 ± 0.044	2.887GlyTyr: 2.887 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.444HisAla: 1.444 ± 0.046	0.281HisCys: 0.281 ± 0.021	0.683HisAsp: 0.683 ± 0.032	0.802HisGlu: 0.802 ± 0.035	0.816HisPhe: 0.816 ± 0.04	1.447HisGly: 1.447 ± 0.053	0.463HisHis: 0.463 ± 0.026	0.836HisIle: 0.836 ± 0.036	0.519HisLys: 0.519 ± 0.032	2.142HisLeu: 2.142 ± 0.056	0.249HisMet: 0.249 ± 0.021	0.5HisAsn: 0.5 ± 0.029	1.395HisPro: 1.395 ± 0.052	0.562HisGln: 0.562 ± 0.028	1.406HisArg: 1.406 ± 0.043	0.714HisSer: 0.714 ± 0.031	0.843HisThr: 0.843 ± 0.042	1.106HisVal: 1.106 ± 0.042	0.215HisTrp: 0.215 ± 0.019	0.635HisTyr: 0.635 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.436IleAla: 5.436 ± 0.088	0.66IleCys: 0.66 ± 0.033	2.399IleAsp: 2.399 ± 0.067	3.428IleGlu: 3.428 ± 0.082	2.034IlePhe: 2.034 ± 0.062	4.172IleGly: 4.172 ± 0.088	0.82IleHis: 0.82 ± 0.037	2.881IleIle: 2.881 ± 0.078	2.201IleLys: 2.201 ± 0.06	5.352IleLeu: 5.352 ± 0.092	0.802IleMet: 0.802 ± 0.036	1.399IleAsn: 1.399 ± 0.045	2.726IlePro: 2.726 ± 0.065	1.155IleGln: 1.155 ± 0.041	3.479IleArg: 3.479 ± 0.08	2.229IleSer: 2.229 ± 0.061	2.77IleThr: 2.77 ± 0.065	3.685IleVal: 3.685 ± 0.075	0.479IleTrp: 0.479 ± 0.025	1.528IleTyr: 1.528 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.055LysAla: 4.055 ± 0.099	0.426LysCys: 0.426 ± 0.026	1.775LysAsp: 1.775 ± 0.051	4.272LysGlu: 4.272 ± 0.11	1.2LysPhe: 1.2 ± 0.055	3.363LysGly: 3.363 ± 0.075	0.661LysHis: 0.661 ± 0.031	2.521LysIle: 2.521 ± 0.063	2.58LysLys: 2.58 ± 0.081	3.868LysLeu: 3.868 ± 0.086	0.976LysMet: 0.976 ± 0.035	1.273LysAsn: 1.273 ± 0.042	2.116LysPro: 2.116 ± 0.051	1.208LysGln: 1.208 ± 0.046	3.027LysArg: 3.027 ± 0.083	1.651LysSer: 1.651 ± 0.05	2.142LysThr: 2.142 ± 0.06	3.896LysVal: 3.896 ± 0.086	0.348LysTrp: 0.348 ± 0.023	1.078LysTyr: 1.078 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	13.224LeuAla: 13.224 ± 0.179	1.457LeuCys: 1.457 ± 0.053	4.376LeuAsp: 4.376 ± 0.077	6.623LeuGlu: 6.623 ± 0.114	4.011LeuPhe: 4.011 ± 0.094	8.905LeuGly: 8.905 ± 0.126	1.708LeuHis: 1.708 ± 0.052	4.832LeuIle: 4.832 ± 0.091	5.414LeuLys: 5.414 ± 0.103	12.516LeuLeu: 12.516 ± 0.202	1.815LeuMet: 1.815 ± 0.059	2.746LeuAsn: 2.746 ± 0.07	6.216LeuPro: 6.216 ± 0.107	3.001LeuGln: 3.001 ± 0.074	8.56LeuArg: 8.56 ± 0.121	5.792LeuSer: 5.792 ± 0.104	5.951LeuThr: 5.951 ± 0.124	9.007LeuVal: 9.007 ± 0.122	1.196LeuTrp: 1.196 ± 0.052	2.96LeuTyr: 2.96 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.278MetAla: 2.278 ± 0.061	0.15MetCys: 0.15 ± 0.016	0.717MetAsp: 0.717 ± 0.038	1.196MetGlu: 1.196 ± 0.042	0.504MetPhe: 0.504 ± 0.029	1.521MetGly: 1.521 ± 0.05	0.309MetHis: 0.309 ± 0.021	0.833MetIle: 0.833 ± 0.04	0.897MetLys: 0.897 ± 0.038	1.959MetLeu: 1.959 ± 0.055	0.352MetMet: 0.352 ± 0.022	0.483MetAsn: 0.483 ± 0.025	0.989MetPro: 0.989 ± 0.047	0.521MetGln: 0.521 ± 0.028	1.518MetArg: 1.518 ± 0.056	0.828MetSer: 0.828 ± 0.037	0.837MetThr: 0.837 ± 0.033	1.722MetVal: 1.722 ± 0.054	0.162MetTrp: 0.162 ± 0.016	0.306MetTyr: 0.306 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.314AsnAla: 2.314 ± 0.066	0.334AsnCys: 0.334 ± 0.023	0.879AsnAsp: 0.879 ± 0.04	1.327AsnGlu: 1.327 ± 0.052	1.043AsnPhe: 1.043 ± 0.041	2.107AsnGly: 2.107 ± 0.073	0.431AsnHis: 0.431 ± 0.027	1.495AsnIle: 1.495 ± 0.056	0.837AsnLys: 0.837 ± 0.037	3.16AsnLeu: 3.16 ± 0.075	0.445AsnMet: 0.445 ± 0.026	0.658AsnAsn: 0.658 ± 0.034	2.042AsnPro: 2.042 ± 0.058	0.703AsnGln: 0.703 ± 0.038	1.989AsnArg: 1.989 ± 0.053	0.899AsnSer: 0.899 ± 0.039	1.179AsnThr: 1.179 ± 0.048	1.886AsnVal: 1.886 ± 0.052	0.361AsnTrp: 0.361 ± 0.025	0.819AsnTyr: 0.819 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	6.016ProAla: 6.016 ± 0.108	0.553ProCys: 0.553 ± 0.031	2.884ProAsp: 2.884 ± 0.067	5.227ProGlu: 5.227 ± 0.102	1.943ProPhe: 1.943 ± 0.067	5.275ProGly: 5.275 ± 0.11	0.987ProHis: 0.987 ± 0.041	1.318ProIle: 1.318 ± 0.048	1.531ProLys: 1.531 ± 0.056	4.94ProLeu: 4.94 ± 0.099	0.615ProMet: 0.615 ± 0.032	1.177ProAsn: 1.177 ± 0.045	3.038ProPro: 3.038 ± 0.081	1.63ProGln: 1.63 ± 0.049	3.137ProArg: 3.137 ± 0.067	1.766ProSer: 1.766 ± 0.06	1.969ProThr: 1.969 ± 0.061	5.644ProVal: 5.644 ± 0.089	0.605ProTrp: 0.605 ± 0.036	1.549ProTyr: 1.549 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	3.475GlnAla: 3.475 ± 0.082	0.235GlnCys: 0.235 ± 0.019	1.226GlnAsp: 1.226 ± 0.043	2.734GlnGlu: 2.734 ± 0.067	0.748GlnPhe: 0.748 ± 0.039	2.286GlnGly: 2.286 ± 0.052	0.463GlnHis: 0.463 ± 0.026	1.423GlnIle: 1.423 ± 0.049	1.535GlnLys: 1.535 ± 0.05	2.527GlnLeu: 2.527 ± 0.07	0.627GlnMet: 0.627 ± 0.034	0.819GlnAsn: 0.819 ± 0.035	1.375GlnPro: 1.375 ± 0.047	1.069GlnGln: 1.069 ± 0.046	2.125GlnArg: 2.125 ± 0.044	0.968GlnSer: 0.968 ± 0.042	1.285GlnThr: 1.285 ± 0.046	2.714GlnVal: 2.714 ± 0.065	0.267GlnTrp: 0.267 ± 0.021	0.556GlnTyr: 0.556 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.135ArgAla: 7.135 ± 0.117	1.009ArgCys: 1.009 ± 0.052	3.327ArgAsp: 3.327 ± 0.079	7.369ArgGlu: 7.369 ± 0.12	3.129ArgPhe: 3.129 ± 0.069	5.161ArgGly: 5.161 ± 0.091	1.484ArgHis: 1.484 ± 0.048	3.525ArgIle: 3.525 ± 0.083	2.862ArgLys: 2.862 ± 0.076	9.242ArgLeu: 9.242 ± 0.15	1.569ArgMet: 1.569 ± 0.051	1.67ArgAsn: 1.67 ± 0.054	3.415ArgPro: 3.415 ± 0.072	2.788ArgGln: 2.788 ± 0.064	6.569ArgArg: 6.569 ± 0.125	2.601ArgSer: 2.601 ± 0.054	2.953ArgThr: 2.953 ± 0.076	6.789ArgVal: 6.789 ± 0.123	0.962ArgTrp: 0.962 ± 0.047	2.431ArgTyr: 2.431 ± 0.07	0.0ArgXaa: 0.0 ± 0.0
Ser	3.529SerAla: 3.529 ± 0.081	0.602SerCys: 0.602 ± 0.034	1.555SerAsp: 1.555 ± 0.055	2.308SerGlu: 2.308 ± 0.063	2.13SerPhe: 2.13 ± 0.057	4.265SerGly: 4.265 ± 0.08	0.7SerHis: 0.7 ± 0.035	1.73SerIle: 1.73 ± 0.057	1.225SerLys: 1.225 ± 0.042	4.904SerLeu: 4.904 ± 0.095	0.723SerMet: 0.723 ± 0.038	0.822SerAsn: 0.822 ± 0.036	2.513SerPro: 2.513 ± 0.057	1.152SerGln: 1.152 ± 0.042	3.204SerArg: 3.204 ± 0.07	1.881SerSer: 1.881 ± 0.06	1.796SerThr: 1.796 ± 0.061	3.194SerVal: 3.194 ± 0.082	0.587SerTrp: 0.587 ± 0.036	1.267SerTyr: 1.267 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.69ThrAla: 5.69 ± 0.113	0.592ThrCys: 0.592 ± 0.031	2.053ThrAsp: 2.053 ± 0.066	2.887ThrGlu: 2.887 ± 0.063	1.82ThrPhe: 1.82 ± 0.05	5.595ThrGly: 5.595 ± 0.099	0.85ThrHis: 0.85 ± 0.037	2.393ThrIle: 2.393 ± 0.067	1.565ThrLys: 1.565 ± 0.055	5.054ThrLeu: 5.054 ± 0.096	0.695ThrMet: 0.695 ± 0.032	1.165ThrAsn: 1.165 ± 0.047	2.905ThrPro: 2.905 ± 0.071	1.084ThrGln: 1.084 ± 0.046	3.052ThrArg: 3.052 ± 0.071	1.806ThrSer: 1.806 ± 0.055	2.609ThrThr: 2.609 ± 0.081	5.102ThrVal: 5.102 ± 0.109	0.548ThrTrp: 0.548 ± 0.028	1.293ThrTyr: 1.293 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	11.243ValAla: 11.243 ± 0.162	1.126ValCys: 1.126 ± 0.043	3.858ValAsp: 3.858 ± 0.086	5.536ValGlu: 5.536 ± 0.098	3.191ValPhe: 3.191 ± 0.078	6.216ValGly: 6.216 ± 0.095	1.267ValHis: 1.267 ± 0.052	4.626ValIle: 4.626 ± 0.09	3.882ValLys: 3.882 ± 0.081	9.436ValLeu: 9.436 ± 0.12	1.546ValMet: 1.546 ± 0.045	2.379ValAsn: 2.379 ± 0.068	4.501ValPro: 4.501 ± 0.099	2.084ValGln: 2.084 ± 0.069	6.33ValArg: 6.33 ± 0.113	3.911ValSer: 3.911 ± 0.076	5.117ValThr: 5.117 ± 0.105	8.789ValVal: 8.789 ± 0.161	0.894ValTrp: 0.894 ± 0.033	2.328ValTyr: 2.328 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	1.063TrpAla: 1.063 ± 0.047	0.164TrpCys: 0.164 ± 0.016	0.525TrpAsp: 0.525 ± 0.032	0.953TrpGlu: 0.953 ± 0.04	0.436TrpPhe: 0.436 ± 0.026	0.935TrpGly: 0.935 ± 0.037	0.226TrpHis: 0.226 ± 0.017	0.431TrpIle: 0.431 ± 0.029	0.368TrpLys: 0.368 ± 0.024	1.398TrpLeu: 1.398 ± 0.056	0.193TrpMet: 0.193 ± 0.016	0.292TrpAsn: 0.292 ± 0.024	0.612TrpPro: 0.612 ± 0.027	0.473TrpGln: 0.473 ± 0.031	1.111TrpArg: 1.111 ± 0.044	0.409TrpSer: 0.409 ± 0.023	0.406TrpThr: 0.406 ± 0.03	0.916TrpVal: 0.916 ± 0.039	0.213TrpTrp: 0.213 ± 0.02	0.34TrpTyr: 0.34 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.063	0.445TyrCys: 0.445 ± 0.029	1.466TyrAsp: 1.466 ± 0.081	1.546TyrGlu: 1.546 ± 0.047	1.348TyrPhe: 1.348 ± 0.046	2.502TyrGly: 2.502 ± 0.074	0.621TyrHis: 0.621 ± 0.031	1.342TyrIle: 1.342 ± 0.051	0.867TyrLys: 0.867 ± 0.034	3.567TyrLeu: 3.567 ± 0.074	0.36TyrMet: 0.36 ± 0.025	0.791TyrAsn: 0.791 ± 0.035	1.562TyrPro: 1.562 ± 0.049	0.961TyrGln: 0.961 ± 0.035	2.715TyrArg: 2.715 ± 0.074	1.143TyrSer: 1.143 ± 0.045	1.44TyrThr: 1.44 ± 0.05	1.999TyrVal: 1.999 ± 0.05	0.378TyrTrp: 0.378 ± 0.024	1.007TyrTyr: 1.007 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2146 proteins (647403 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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