Amino acid dipepetide frequency for Porphyromonas sp. HMSC077F02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.313AlaAla: 4.313 ± 0.085
0.627AlaCys: 0.627 ± 0.035
3.717AlaAsp: 3.717 ± 0.093
5.233AlaGlu: 5.233 ± 0.102
2.98AlaPhe: 2.98 ± 0.066
4.618AlaGly: 4.618 ± 0.104
1.419AlaHis: 1.419 ± 0.044
5.163AlaIle: 5.163 ± 0.093
4.761AlaLys: 4.761 ± 0.092
7.997AlaLeu: 7.997 ± 0.121
2.013AlaMet: 2.013 ± 0.058
2.907AlaAsn: 2.907 ± 0.071
2.826AlaPro: 2.826 ± 0.061
2.685AlaGln: 2.685 ± 0.064
3.367AlaArg: 3.367 ± 0.073
4.479AlaSer: 4.479 ± 0.089
4.734AlaThr: 4.734 ± 0.081
4.424AlaVal: 4.424 ± 0.089
0.75AlaTrp: 0.75 ± 0.032
2.797AlaTyr: 2.797 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.514CysAla: 0.514 ± 0.031
0.113CysCys: 0.113 ± 0.016
0.553CysAsp: 0.553 ± 0.028
0.502CysGlu: 0.502 ± 0.029
0.369CysPhe: 0.369 ± 0.024
0.79CysGly: 0.79 ± 0.038
0.288CysHis: 0.288 ± 0.023
0.53CysIle: 0.53 ± 0.027
0.472CysLys: 0.472 ± 0.03
0.663CysLeu: 0.663 ± 0.031
0.169CysMet: 0.169 ± 0.017
0.376CysAsn: 0.376 ± 0.022
0.401CysPro: 0.401 ± 0.026
0.327CysGln: 0.327 ± 0.021
0.455CysArg: 0.455 ± 0.03
0.539CysSer: 0.539 ± 0.03
0.468CysThr: 0.468 ± 0.028
0.492CysVal: 0.492 ± 0.03
0.082CysTrp: 0.082 ± 0.012
0.359CysTyr: 0.359 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.571AspAla: 3.571 ± 0.076
0.437AspCys: 0.437 ± 0.025
2.492AspAsp: 2.492 ± 0.076
3.769AspGlu: 3.769 ± 0.084
2.603AspPhe: 2.603 ± 0.066
3.754AspGly: 3.754 ± 0.088
1.182AspHis: 1.182 ± 0.045
3.604AspIle: 3.604 ± 0.076
3.444AspLys: 3.444 ± 0.079
5.481AspLeu: 5.481 ± 0.094
1.33AspMet: 1.33 ± 0.048
2.228AspAsn: 2.228 ± 0.065
2.5AspPro: 2.5 ± 0.068
1.883AspGln: 1.883 ± 0.049
2.82AspArg: 2.82 ± 0.068
2.898AspSer: 2.898 ± 0.079
2.619AspThr: 2.619 ± 0.071
2.942AspVal: 2.942 ± 0.07
0.695AspTrp: 0.695 ± 0.032
2.602AspTyr: 2.602 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.795GluAla: 5.795 ± 0.109
0.545GluCys: 0.545 ± 0.031
3.116GluAsp: 3.116 ± 0.083
6.913GluGlu: 6.913 ± 0.138
2.001GluPhe: 2.001 ± 0.06
5.352GluGly: 5.352 ± 0.093
1.338GluHis: 1.338 ± 0.046
4.649GluIle: 4.649 ± 0.097
4.28GluLys: 4.28 ± 0.101
7.602GluLeu: 7.602 ± 0.123
2.252GluMet: 2.252 ± 0.065
2.417GluAsn: 2.417 ± 0.058
2.168GluPro: 2.168 ± 0.06
3.288GluGln: 3.288 ± 0.08
4.074GluArg: 4.074 ± 0.086
3.517GluSer: 3.517 ± 0.075
3.133GluThr: 3.133 ± 0.079
6.164GluVal: 6.164 ± 0.104
0.932GluTrp: 0.932 ± 0.044
2.732GluTyr: 2.732 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.913PheAla: 2.913 ± 0.06
0.448PheCys: 0.448 ± 0.028
2.552PheAsp: 2.552 ± 0.061
2.476PheGlu: 2.476 ± 0.064
1.817PhePhe: 1.817 ± 0.064
3.184PheGly: 3.184 ± 0.07
0.763PheHis: 0.763 ± 0.033
2.588PheIle: 2.588 ± 0.069
2.016PheLys: 2.016 ± 0.065
3.463PheLeu: 3.463 ± 0.094
0.999PheMet: 0.999 ± 0.042
1.953PheAsn: 1.953 ± 0.06
1.62PhePro: 1.62 ± 0.054
1.257PheGln: 1.257 ± 0.04
1.883PheArg: 1.883 ± 0.058
3.032PheSer: 3.032 ± 0.08
2.534PheThr: 2.534 ± 0.063
2.868PheVal: 2.868 ± 0.07
0.446PheTrp: 0.446 ± 0.026
1.538PheTyr: 1.538 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
5.389GlyAla: 5.389 ± 0.118
0.684GlyCys: 0.684 ± 0.03
3.618GlyAsp: 3.618 ± 0.074
4.787GlyGlu: 4.787 ± 0.1
2.908GlyPhe: 2.908 ± 0.071
5.442GlyGly: 5.442 ± 0.098
1.408GlyHis: 1.408 ± 0.05
4.946GlyIle: 4.946 ± 0.083
4.726GlyLys: 4.726 ± 0.101
6.597GlyLeu: 6.597 ± 0.116
2.002GlyMet: 2.002 ± 0.062
2.772GlyAsn: 2.772 ± 0.075
1.318GlyPro: 1.318 ± 0.051
2.227GlyGln: 2.227 ± 0.056
3.642GlyArg: 3.642 ± 0.081
4.191GlySer: 4.191 ± 0.082
3.912GlyThr: 3.912 ± 0.074
5.608GlyVal: 5.608 ± 0.095
0.931GlyTrp: 0.931 ± 0.042
3.489GlyTyr: 3.489 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
1.161HisAla: 1.161 ± 0.044
0.218HisCys: 0.218 ± 0.02
1.033HisAsp: 1.033 ± 0.04
1.073HisGlu: 1.073 ± 0.045
1.191HisPhe: 1.191 ± 0.042
1.242HisGly: 1.242 ± 0.043
0.592HisHis: 0.592 ± 0.032
1.527HisIle: 1.527 ± 0.043
1.113HisLys: 1.113 ± 0.038
2.396HisLeu: 2.396 ± 0.063
0.325HisMet: 0.325 ± 0.021
0.906HisAsn: 0.906 ± 0.038
1.163HisPro: 1.163 ± 0.042
0.886HisGln: 0.886 ± 0.042
1.177HisArg: 1.177 ± 0.044
1.338HisSer: 1.338 ± 0.051
1.242HisThr: 1.242 ± 0.044
0.914HisVal: 0.914 ± 0.042
0.231HisTrp: 0.231 ± 0.024
0.996HisTyr: 0.996 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.23IleAla: 5.23 ± 0.088
0.646IleCys: 0.646 ± 0.034
4.14IleAsp: 4.14 ± 0.09
4.761IleGlu: 4.761 ± 0.089
2.295IlePhe: 2.295 ± 0.062
4.761IleGly: 4.761 ± 0.09
1.282IleHis: 1.282 ± 0.046
4.067IleIle: 4.067 ± 0.086
3.946IleLys: 3.946 ± 0.089
5.608IleLeu: 5.608 ± 0.106
1.203IleMet: 1.203 ± 0.042
3.066IleAsn: 3.066 ± 0.075
3.173IlePro: 3.173 ± 0.067
2.317IleGln: 2.317 ± 0.063
3.23IleArg: 3.23 ± 0.079
4.48IleSer: 4.48 ± 0.088
3.855IleThr: 3.855 ± 0.075
4.205IleVal: 4.205 ± 0.086
0.564IleTrp: 0.564 ± 0.027
2.609IleTyr: 2.609 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.72LysAla: 4.72 ± 0.099
0.364LysCys: 0.364 ± 0.025
3.176LysAsp: 3.176 ± 0.069
5.945LysGlu: 5.945 ± 0.115
1.556LysPhe: 1.556 ± 0.051
4.801LysGly: 4.801 ± 0.103
1.126LysHis: 1.126 ± 0.041
3.404LysIle: 3.404 ± 0.084
3.82LysLys: 3.82 ± 0.099
5.431LysLeu: 5.431 ± 0.089
1.868LysMet: 1.868 ± 0.045
2.208LysAsn: 2.208 ± 0.063
2.137LysPro: 2.137 ± 0.06
2.38LysGln: 2.38 ± 0.067
3.268LysArg: 3.268 ± 0.071
3.616LysSer: 3.616 ± 0.083
2.554LysThr: 2.554 ± 0.069
4.737LysVal: 4.737 ± 0.088
0.736LysTrp: 0.736 ± 0.035
2.515LysTyr: 2.515 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
7.056LeuAla: 7.056 ± 0.138
0.943LeuCys: 0.943 ± 0.039
4.962LeuAsp: 4.962 ± 0.095
6.404LeuGlu: 6.404 ± 0.127
4.607LeuPhe: 4.607 ± 0.095
6.509LeuGly: 6.509 ± 0.118
1.922LeuHis: 1.922 ± 0.056
5.863LeuIle: 5.863 ± 0.119
5.705LeuLys: 5.705 ± 0.096
11.297LeuLeu: 11.297 ± 0.219
2.447LeuMet: 2.447 ± 0.06
4.045LeuAsn: 4.045 ± 0.091
5.052LeuPro: 5.052 ± 0.11
4.124LeuGln: 4.124 ± 0.088
5.194LeuArg: 5.194 ± 0.085
8.242LeuSer: 8.242 ± 0.144
5.776LeuThr: 5.776 ± 0.099
5.993LeuVal: 5.993 ± 0.12
1.089LeuTrp: 1.089 ± 0.042
3.937LeuTyr: 3.937 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
2.081MetAla: 2.081 ± 0.064
0.172MetCys: 0.172 ± 0.019
1.423MetAsp: 1.423 ± 0.048
1.9MetGlu: 1.9 ± 0.054
0.585MetPhe: 0.585 ± 0.03
2.005MetGly: 2.005 ± 0.059
0.461MetHis: 0.461 ± 0.027
1.597MetIle: 1.597 ± 0.05
2.004MetLys: 2.004 ± 0.05
2.43MetLeu: 2.43 ± 0.065
0.833MetMet: 0.833 ± 0.037
1.149MetAsn: 1.149 ± 0.044
1.188MetPro: 1.188 ± 0.044
0.996MetGln: 0.996 ± 0.04
1.31MetArg: 1.31 ± 0.043
1.553MetSer: 1.553 ± 0.048
1.381MetThr: 1.381 ± 0.046
1.739MetVal: 1.739 ± 0.045
0.217MetTrp: 0.217 ± 0.019
0.66MetTyr: 0.66 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.95AsnAla: 2.95 ± 0.071
0.297AsnCys: 0.297 ± 0.025
2.184AsnAsp: 2.184 ± 0.065
2.558AsnGlu: 2.558 ± 0.067
1.721AsnPhe: 1.721 ± 0.044
2.961AsnGly: 2.961 ± 0.081
0.954AsnHis: 0.954 ± 0.044
2.972AsnIle: 2.972 ± 0.074
2.554AsnLys: 2.554 ± 0.065
3.737AsnLeu: 3.737 ± 0.086
1.041AsnMet: 1.041 ± 0.037
2.154AsnAsn: 2.154 ± 0.068
2.168AsnPro: 2.168 ± 0.056
1.494AsnGln: 1.494 ± 0.048
2.281AsnArg: 2.281 ± 0.065
2.54AsnSer: 2.54 ± 0.056
2.177AsnThr: 2.177 ± 0.065
2.405AsnVal: 2.405 ± 0.074
0.5AsnTrp: 0.5 ± 0.031
1.931AsnTyr: 1.931 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.464ProAla: 2.464 ± 0.058
0.238ProCys: 0.238 ± 0.019
2.348ProAsp: 2.348 ± 0.06
3.582ProGlu: 3.582 ± 0.088
1.923ProPhe: 1.923 ± 0.056
2.14ProGly: 2.14 ± 0.056
0.948ProHis: 0.948 ± 0.039
2.908ProIle: 2.908 ± 0.071
2.605ProLys: 2.605 ± 0.07
4.081ProLeu: 4.081 ± 0.096
1.081ProMet: 1.081 ± 0.039
2.029ProAsn: 2.029 ± 0.059
1.016ProPro: 1.016 ± 0.043
1.553ProGln: 1.553 ± 0.054
1.744ProArg: 1.744 ± 0.052
2.761ProSer: 2.761 ± 0.064
2.71ProThr: 2.71 ± 0.059
2.284ProVal: 2.284 ± 0.068
0.441ProTrp: 0.441 ± 0.025
1.841ProTyr: 1.841 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
2.654GlnAla: 2.654 ± 0.072
0.252GlnCys: 0.252 ± 0.021
1.655GlnAsp: 1.655 ± 0.054
2.952GlnGlu: 2.952 ± 0.067
1.408GlnPhe: 1.408 ± 0.051
2.335GlnGly: 2.335 ± 0.066
0.748GlnHis: 0.748 ± 0.037
2.34GlnIle: 2.34 ± 0.06
2.421GlnLys: 2.421 ± 0.066
4.767GlnLeu: 4.767 ± 0.098
1.152GlnMet: 1.152 ± 0.038
1.482GlnAsn: 1.482 ± 0.043
1.536GlnPro: 1.536 ± 0.052
1.731GlnGln: 1.731 ± 0.065
2.081GlnArg: 2.081 ± 0.058
2.408GlnSer: 2.408 ± 0.058
1.702GlnThr: 1.702 ± 0.058
2.478GlnVal: 2.478 ± 0.055
0.542GlnTrp: 0.542 ± 0.029
1.518GlnTyr: 1.518 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
3.344ArgAla: 3.344 ± 0.071
0.376ArgCys: 0.376 ± 0.024
2.574ArgAsp: 2.574 ± 0.068
3.906ArgGlu: 3.906 ± 0.086
2.252ArgPhe: 2.252 ± 0.061
3.282ArgGly: 3.282 ± 0.069
1.115ArgHis: 1.115 ± 0.042
3.364ArgIle: 3.364 ± 0.068
3.147ArgLys: 3.147 ± 0.067
5.177ArgLeu: 5.177 ± 0.09
1.45ArgMet: 1.45 ± 0.048
2.097ArgAsn: 2.097 ± 0.058
1.88ArgPro: 1.88 ± 0.06
2.001ArgGln: 2.001 ± 0.057
2.839ArgArg: 2.839 ± 0.081
2.894ArgSer: 2.894 ± 0.069
2.424ArgThr: 2.424 ± 0.065
3.412ArgVal: 3.412 ± 0.07
0.692ArgTrp: 0.692 ± 0.036
2.478ArgTyr: 2.478 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
4.2SerAla: 4.2 ± 0.087
0.66SerCys: 0.66 ± 0.03
3.559SerAsp: 3.559 ± 0.071
4.146SerGlu: 4.146 ± 0.085
3.119SerPhe: 3.119 ± 0.077
4.869SerGly: 4.869 ± 0.081
1.412SerHis: 1.412 ± 0.053
4.421SerIle: 4.421 ± 0.092
3.752SerLys: 3.752 ± 0.082
6.651SerLeu: 6.651 ± 0.113
1.411SerMet: 1.411 ± 0.048
2.597SerAsn: 2.597 ± 0.074
2.591SerPro: 2.591 ± 0.068
2.385SerGln: 2.385 ± 0.065
2.939SerArg: 2.939 ± 0.063
4.35SerSer: 4.35 ± 0.091
3.415SerThr: 3.415 ± 0.081
4.043SerVal: 4.043 ± 0.088
0.711SerTrp: 0.711 ± 0.03
2.958SerTyr: 2.958 ± 0.091
0.0SerXaa: 0.0 ± 0.0
Thr
4.026ThrAla: 4.026 ± 0.088
0.401ThrCys: 0.401 ± 0.027
2.901ThrAsp: 2.901 ± 0.061
3.39ThrGlu: 3.39 ± 0.076
2.479ThrPhe: 2.479 ± 0.064
3.67ThrGly: 3.67 ± 0.077
1.236ThrHis: 1.236 ± 0.051
4.099ThrIle: 4.099 ± 0.08
3.156ThrLys: 3.156 ± 0.072
6.126ThrLeu: 6.126 ± 0.097
1.163ThrMet: 1.163 ± 0.041
2.202ThrAsn: 2.202 ± 0.068
3.181ThrPro: 3.181 ± 0.073
1.826ThrGln: 1.826 ± 0.048
2.153ThrArg: 2.153 ± 0.054
3.514ThrSer: 3.514 ± 0.072
3.579ThrThr: 3.579 ± 0.084
3.238ThrVal: 3.238 ± 0.075
0.531ThrTrp: 0.531 ± 0.03
2.349ThrTyr: 2.349 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
5.897ValAla: 5.897 ± 0.099
0.568ValCys: 0.568 ± 0.027
3.7ValAsp: 3.7 ± 0.077
4.962ValGlu: 4.962 ± 0.099
2.129ValPhe: 2.129 ± 0.06
4.887ValGly: 4.887 ± 0.11
1.112ValHis: 1.112 ± 0.041
4.153ValIle: 4.153 ± 0.078
3.63ValLys: 3.63 ± 0.083
6.075ValLeu: 6.075 ± 0.101
1.762ValMet: 1.762 ± 0.051
2.527ValAsn: 2.527 ± 0.065
2.692ValPro: 2.692 ± 0.07
2.228ValGln: 2.228 ± 0.066
3.212ValArg: 3.212 ± 0.071
4.276ValSer: 4.276 ± 0.088
4.076ValThr: 4.076 ± 0.098
5.467ValVal: 5.467 ± 0.104
0.733ValTrp: 0.733 ± 0.031
2.202ValTyr: 2.202 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.652TrpAla: 0.652 ± 0.035
0.122TrpCys: 0.122 ± 0.013
0.635TrpAsp: 0.635 ± 0.032
0.711TrpGlu: 0.711 ± 0.031
0.378TrpPhe: 0.378 ± 0.029
0.983TrpGly: 0.983 ± 0.049
0.325TrpHis: 0.325 ± 0.024
0.688TrpIle: 0.688 ± 0.036
0.593TrpLys: 0.593 ± 0.03
1.284TrpLeu: 1.284 ± 0.045
0.348TrpMet: 0.348 ± 0.025
0.534TrpAsn: 0.534 ± 0.032
0.256TrpPro: 0.256 ± 0.02
0.612TrpGln: 0.612 ± 0.032
0.68TrpArg: 0.68 ± 0.032
0.799TrpSer: 0.799 ± 0.039
0.536TrpThr: 0.536 ± 0.028
0.737TrpVal: 0.737 ± 0.038
0.183TrpTrp: 0.183 ± 0.016
0.441TrpTyr: 0.441 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.877TyrAla: 2.877 ± 0.072
0.348TyrCys: 0.348 ± 0.023
2.518TyrAsp: 2.518 ± 0.073
2.3TyrGlu: 2.3 ± 0.059
2.03TyrPhe: 2.03 ± 0.066
3.012TyrGly: 3.012 ± 0.082
1.093TyrHis: 1.093 ± 0.047
2.554TyrIle: 2.554 ± 0.068
2.216TyrLys: 2.216 ± 0.067
4.304TyrLeu: 4.304 ± 0.093
0.835TyrMet: 0.835 ± 0.037
1.928TyrAsn: 1.928 ± 0.069
1.834TyrPro: 1.834 ± 0.051
1.962TyrGln: 1.962 ± 0.06
2.351TyrArg: 2.351 ± 0.068
2.763TyrSer: 2.763 ± 0.076
2.396TyrThr: 2.396 ± 0.059
2.139TyrVal: 2.139 ± 0.057
0.492TyrTrp: 0.492 ± 0.032
1.995TyrTyr: 1.995 ± 0.076
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1770 proteins (645730 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski