Amino acid dipepetide frequency for Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.715AlaAla: 3.715 ± 0.634
1.454AlaCys: 1.454 ± 0.43
3.392AlaAsp: 3.392 ± 0.61
2.423AlaGlu: 2.423 ± 0.603
2.746AlaPhe: 2.746 ± 0.655
2.1AlaGly: 2.1 ± 0.607
0.485AlaHis: 0.485 ± 0.214
3.392AlaIle: 3.392 ± 0.494
3.069AlaLys: 3.069 ± 0.972
4.361AlaLeu: 4.361 ± 0.727
0.969AlaMet: 0.969 ± 0.239
5.007AlaAsn: 5.007 ± 0.763
1.938AlaPro: 1.938 ± 0.482
1.777AlaGln: 1.777 ± 0.44
2.423AlaArg: 2.423 ± 0.688
4.038AlaSer: 4.038 ± 0.929
3.877AlaThr: 3.877 ± 0.687
4.523AlaVal: 4.523 ± 0.838
0.162AlaTrp: 0.162 ± 0.131
1.615AlaTyr: 1.615 ± 0.507
0.0AlaXaa: 0.0 ± 0.0
Cys
0.485CysAla: 0.485 ± 0.322
0.485CysCys: 0.485 ± 0.236
0.646CysAsp: 0.646 ± 0.319
0.323CysGlu: 0.323 ± 0.252
0.646CysPhe: 0.646 ± 0.32
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.969CysIle: 0.969 ± 0.353
1.131CysLys: 1.131 ± 0.549
1.292CysLeu: 1.292 ± 0.535
0.646CysMet: 0.646 ± 0.278
0.808CysAsn: 0.808 ± 0.278
0.323CysPro: 0.323 ± 0.244
0.808CysGln: 0.808 ± 0.413
0.969CysArg: 0.969 ± 0.434
1.131CysSer: 1.131 ± 0.399
1.131CysThr: 1.131 ± 0.536
0.323CysVal: 0.323 ± 0.176
0.0CysTrp: 0.0 ± 0.0
0.485CysTyr: 0.485 ± 0.234
0.0CysXaa: 0.0 ± 0.0
Asp
2.907AspAla: 2.907 ± 0.761
0.646AspCys: 0.646 ± 0.304
3.877AspAsp: 3.877 ± 0.894
4.038AspGlu: 4.038 ± 0.47
3.392AspPhe: 3.392 ± 0.681
2.746AspGly: 2.746 ± 0.582
0.969AspHis: 0.969 ± 0.43
4.361AspIle: 4.361 ± 0.509
2.423AspLys: 2.423 ± 0.542
4.038AspLeu: 4.038 ± 0.57
1.938AspMet: 1.938 ± 0.373
2.584AspAsn: 2.584 ± 0.648
1.454AspPro: 1.454 ± 0.338
3.069AspGln: 3.069 ± 0.693
2.584AspArg: 2.584 ± 0.747
4.684AspSer: 4.684 ± 0.902
3.877AspThr: 3.877 ± 0.852
4.846AspVal: 4.846 ± 0.889
0.808AspTrp: 0.808 ± 0.327
4.523AspTyr: 4.523 ± 0.634
0.0AspXaa: 0.0 ± 0.0
Glu
2.907GluAla: 2.907 ± 0.685
0.0GluCys: 0.0 ± 0.0
3.23GluAsp: 3.23 ± 0.587
2.907GluGlu: 2.907 ± 0.824
1.615GluPhe: 1.615 ± 0.575
1.292GluGly: 1.292 ± 0.373
1.131GluHis: 1.131 ± 0.417
4.361GluIle: 4.361 ± 0.787
4.2GluLys: 4.2 ± 0.847
5.33GluLeu: 5.33 ± 0.905
2.423GluMet: 2.423 ± 0.461
3.554GluAsn: 3.554 ± 0.738
2.423GluPro: 2.423 ± 0.597
1.938GluGln: 1.938 ± 0.509
2.261GluArg: 2.261 ± 0.452
3.554GluSer: 3.554 ± 0.54
3.069GluThr: 3.069 ± 0.394
4.038GluVal: 4.038 ± 0.922
1.777GluTrp: 1.777 ± 0.665
4.361GluTyr: 4.361 ± 0.841
0.0GluXaa: 0.0 ± 0.0
Phe
1.777PheAla: 1.777 ± 0.631
0.323PheCys: 0.323 ± 0.196
3.069PheAsp: 3.069 ± 0.604
2.1PheGlu: 2.1 ± 0.404
0.808PhePhe: 0.808 ± 0.364
1.777PheGly: 1.777 ± 0.439
1.131PheHis: 1.131 ± 0.354
4.2PheIle: 4.2 ± 1.055
4.2PheLys: 4.2 ± 0.992
3.23PheLeu: 3.23 ± 0.888
0.485PheMet: 0.485 ± 0.285
3.392PheAsn: 3.392 ± 0.561
1.615PhePro: 1.615 ± 0.728
1.615PheGln: 1.615 ± 0.48
2.261PheArg: 2.261 ± 0.469
3.554PheSer: 3.554 ± 0.548
2.584PheThr: 2.584 ± 0.57
1.615PheVal: 1.615 ± 0.621
0.162PheTrp: 0.162 ± 0.121
1.777PheTyr: 1.777 ± 0.509
0.0PheXaa: 0.0 ± 0.0
Gly
1.777GlyAla: 1.777 ± 0.47
0.969GlyCys: 0.969 ± 0.3
1.292GlyAsp: 1.292 ± 0.437
1.131GlyGlu: 1.131 ± 0.365
1.131GlyPhe: 1.131 ± 0.356
1.777GlyGly: 1.777 ± 0.632
0.808GlyHis: 0.808 ± 0.429
4.2GlyIle: 4.2 ± 0.616
2.746GlyLys: 2.746 ± 0.557
2.261GlyLeu: 2.261 ± 0.512
1.131GlyMet: 1.131 ± 0.426
1.615GlyAsn: 1.615 ± 0.422
1.454GlyPro: 1.454 ± 0.539
1.131GlyGln: 1.131 ± 0.265
2.1GlyArg: 2.1 ± 0.687
3.23GlySer: 3.23 ± 0.737
1.938GlyThr: 1.938 ± 0.719
2.907GlyVal: 2.907 ± 0.704
0.808GlyTrp: 0.808 ± 0.244
1.292GlyTyr: 1.292 ± 0.45
0.0GlyXaa: 0.0 ± 0.0
His
0.485HisAla: 0.485 ± 0.234
0.0HisCys: 0.0 ± 0.0
1.454HisAsp: 1.454 ± 0.414
0.969HisGlu: 0.969 ± 0.443
0.162HisPhe: 0.162 ± 0.142
0.162HisGly: 0.162 ± 0.178
0.323HisHis: 0.323 ± 0.309
0.485HisIle: 0.485 ± 0.197
1.131HisLys: 1.131 ± 0.466
1.938HisLeu: 1.938 ± 0.656
0.323HisMet: 0.323 ± 0.176
0.646HisAsn: 0.646 ± 0.294
0.646HisPro: 0.646 ± 0.299
1.292HisGln: 1.292 ± 0.589
0.0HisArg: 0.0 ± 0.0
1.454HisSer: 1.454 ± 0.495
0.646HisThr: 0.646 ± 0.278
1.131HisVal: 1.131 ± 0.313
0.162HisTrp: 0.162 ± 0.154
1.454HisTyr: 1.454 ± 0.448
0.0HisXaa: 0.0 ± 0.0
Ile
5.007IleAla: 5.007 ± 0.74
0.646IleCys: 0.646 ± 0.381
3.392IleAsp: 3.392 ± 0.843
4.684IleGlu: 4.684 ± 0.768
2.584IlePhe: 2.584 ± 0.718
2.261IleGly: 2.261 ± 0.521
0.969IleHis: 0.969 ± 0.497
5.492IleIle: 5.492 ± 0.52
4.361IleLys: 4.361 ± 0.741
5.976IleLeu: 5.976 ± 0.872
1.454IleMet: 1.454 ± 0.235
5.815IleAsn: 5.815 ± 0.943
3.069IlePro: 3.069 ± 0.857
3.877IleGln: 3.877 ± 0.589
4.038IleArg: 4.038 ± 0.581
5.976IleSer: 5.976 ± 1.106
6.461IleThr: 6.461 ± 1.301
2.907IleVal: 2.907 ± 0.469
0.323IleTrp: 0.323 ± 0.22
4.2IleTyr: 4.2 ± 1.326
0.0IleXaa: 0.0 ± 0.0
Lys
2.1LysAla: 2.1 ± 0.47
1.454LysCys: 1.454 ± 0.443
2.746LysAsp: 2.746 ± 0.587
4.2LysGlu: 4.2 ± 1.246
3.23LysPhe: 3.23 ± 0.601
2.584LysGly: 2.584 ± 0.499
0.646LysHis: 0.646 ± 0.377
4.2LysIle: 4.2 ± 1.071
3.877LysLys: 3.877 ± 0.753
8.561LysLeu: 8.561 ± 1.227
2.584LysMet: 2.584 ± 0.658
3.23LysAsn: 3.23 ± 0.671
2.261LysPro: 2.261 ± 0.625
3.069LysGln: 3.069 ± 0.619
3.392LysArg: 3.392 ± 0.462
3.877LysSer: 3.877 ± 0.843
2.907LysThr: 2.907 ± 0.612
4.2LysVal: 4.2 ± 0.676
1.292LysTrp: 1.292 ± 0.638
3.715LysTyr: 3.715 ± 0.962
0.0LysXaa: 0.0 ± 0.0
Leu
4.2LeuAla: 4.2 ± 0.699
0.808LeuCys: 0.808 ± 0.473
5.169LeuAsp: 5.169 ± 0.675
5.815LeuGlu: 5.815 ± 1.427
4.038LeuPhe: 4.038 ± 0.73
2.423LeuGly: 2.423 ± 0.474
2.1LeuHis: 2.1 ± 0.583
7.269LeuIle: 7.269 ± 0.699
5.492LeuLys: 5.492 ± 0.851
8.076LeuLeu: 8.076 ± 1.39
3.715LeuMet: 3.715 ± 0.872
7.269LeuAsn: 7.269 ± 0.966
4.2LeuPro: 4.2 ± 0.769
3.23LeuGln: 3.23 ± 0.835
4.846LeuArg: 4.846 ± 0.557
7.915LeuSer: 7.915 ± 1.219
5.976LeuThr: 5.976 ± 0.831
5.007LeuVal: 5.007 ± 0.842
0.646LeuTrp: 0.646 ± 0.202
4.038LeuTyr: 4.038 ± 0.73
0.0LeuXaa: 0.0 ± 0.0
Met
1.938MetAla: 1.938 ± 0.392
0.162MetCys: 0.162 ± 0.131
3.877MetAsp: 3.877 ± 0.711
1.131MetGlu: 1.131 ± 0.675
1.615MetPhe: 1.615 ± 0.378
0.969MetGly: 0.969 ± 0.356
0.485MetHis: 0.485 ± 0.286
1.131MetIle: 1.131 ± 0.45
1.938MetLys: 1.938 ± 0.482
3.877MetLeu: 3.877 ± 0.617
0.969MetMet: 0.969 ± 0.448
1.938MetAsn: 1.938 ± 0.528
0.969MetPro: 0.969 ± 0.293
2.423MetGln: 2.423 ± 1.051
2.423MetArg: 2.423 ± 0.593
1.938MetSer: 1.938 ± 0.538
1.292MetThr: 1.292 ± 0.385
0.969MetVal: 0.969 ± 0.323
0.646MetTrp: 0.646 ± 0.249
1.292MetTyr: 1.292 ± 0.318
0.0MetXaa: 0.0 ± 0.0
Asn
4.684AsnAla: 4.684 ± 0.846
0.808AsnCys: 0.808 ± 0.401
4.361AsnAsp: 4.361 ± 1.018
4.523AsnGlu: 4.523 ± 0.587
2.1AsnPhe: 2.1 ± 0.583
3.392AsnGly: 3.392 ± 0.511
1.454AsnHis: 1.454 ± 0.663
2.584AsnIle: 2.584 ± 1.092
3.715AsnLys: 3.715 ± 0.939
7.269AsnLeu: 7.269 ± 0.615
2.261AsnMet: 2.261 ± 0.595
4.846AsnAsn: 4.846 ± 1.223
1.615AsnPro: 1.615 ± 0.72
2.1AsnGln: 2.1 ± 0.404
2.584AsnArg: 2.584 ± 0.55
5.976AsnSer: 5.976 ± 0.633
2.423AsnThr: 2.423 ± 0.656
5.169AsnVal: 5.169 ± 0.646
1.615AsnTrp: 1.615 ± 0.636
5.653AsnTyr: 5.653 ± 0.595
0.0AsnXaa: 0.0 ± 0.0
Pro
1.615ProAla: 1.615 ± 0.541
0.0ProCys: 0.0 ± 0.0
2.584ProAsp: 2.584 ± 0.449
0.485ProGlu: 0.485 ± 0.32
2.423ProPhe: 2.423 ± 0.33
1.615ProGly: 1.615 ± 0.472
0.646ProHis: 0.646 ± 0.342
3.715ProIle: 3.715 ± 0.326
1.292ProLys: 1.292 ± 0.369
1.615ProLeu: 1.615 ± 0.354
0.646ProMet: 0.646 ± 0.263
1.777ProAsn: 1.777 ± 0.669
0.969ProPro: 0.969 ± 0.483
1.454ProGln: 1.454 ± 0.578
1.454ProArg: 1.454 ± 0.271
2.1ProSer: 2.1 ± 0.601
2.746ProThr: 2.746 ± 0.45
3.392ProVal: 3.392 ± 0.901
0.0ProTrp: 0.0 ± 0.0
1.777ProTyr: 1.777 ± 0.532
0.0ProXaa: 0.0 ± 0.0
Gln
1.938GlnAla: 1.938 ± 0.622
0.646GlnCys: 0.646 ± 0.236
2.1GlnAsp: 2.1 ± 0.571
1.777GlnGlu: 1.777 ± 0.304
2.1GlnPhe: 2.1 ± 0.485
0.323GlnGly: 0.323 ± 0.207
0.808GlnHis: 0.808 ± 0.33
3.877GlnIle: 3.877 ± 0.692
2.584GlnLys: 2.584 ± 0.634
5.33GlnLeu: 5.33 ± 1.361
1.615GlnMet: 1.615 ± 0.593
2.584GlnAsn: 2.584 ± 0.835
1.131GlnPro: 1.131 ± 0.36
2.423GlnGln: 2.423 ± 0.873
2.261GlnArg: 2.261 ± 0.69
1.938GlnSer: 1.938 ± 0.309
4.038GlnThr: 4.038 ± 0.98
2.907GlnVal: 2.907 ± 0.854
0.646GlnTrp: 0.646 ± 0.244
2.261GlnTyr: 2.261 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
1.292ArgAla: 1.292 ± 0.475
0.646ArgCys: 0.646 ± 0.305
2.1ArgAsp: 2.1 ± 0.636
3.392ArgGlu: 3.392 ± 0.412
2.423ArgPhe: 2.423 ± 0.574
1.777ArgGly: 1.777 ± 0.388
0.646ArgHis: 0.646 ± 0.251
3.392ArgIle: 3.392 ± 0.378
2.907ArgLys: 2.907 ± 0.645
4.361ArgLeu: 4.361 ± 1.102
2.261ArgMet: 2.261 ± 0.473
4.361ArgAsn: 4.361 ± 1.149
1.292ArgPro: 1.292 ± 0.509
2.1ArgGln: 2.1 ± 0.686
2.261ArgArg: 2.261 ± 0.402
3.877ArgSer: 3.877 ± 0.953
2.584ArgThr: 2.584 ± 0.546
3.392ArgVal: 3.392 ± 0.732
0.969ArgTrp: 0.969 ± 0.297
1.938ArgTyr: 1.938 ± 0.471
0.0ArgXaa: 0.0 ± 0.0
Ser
3.23SerAla: 3.23 ± 0.786
0.646SerCys: 0.646 ± 0.324
4.2SerAsp: 4.2 ± 1.115
4.361SerGlu: 4.361 ± 0.897
2.907SerPhe: 2.907 ± 0.764
3.069SerGly: 3.069 ± 0.839
0.808SerHis: 0.808 ± 0.332
6.138SerIle: 6.138 ± 1.166
5.169SerLys: 5.169 ± 0.646
5.976SerLeu: 5.976 ± 0.954
2.746SerMet: 2.746 ± 0.555
5.653SerAsn: 5.653 ± 1.287
1.938SerPro: 1.938 ± 0.547
4.2SerGln: 4.2 ± 0.63
3.715SerArg: 3.715 ± 0.518
6.299SerSer: 6.299 ± 1.615
5.976SerThr: 5.976 ± 0.625
5.815SerVal: 5.815 ± 0.82
0.323SerTrp: 0.323 ± 0.242
2.907SerTyr: 2.907 ± 1.069
0.0SerXaa: 0.0 ± 0.0
Thr
3.877ThrAla: 3.877 ± 1.158
0.646ThrCys: 0.646 ± 0.378
4.361ThrAsp: 4.361 ± 0.662
3.715ThrGlu: 3.715 ± 0.636
3.392ThrPhe: 3.392 ± 0.79
1.938ThrGly: 1.938 ± 0.468
0.485ThrHis: 0.485 ± 0.245
4.038ThrIle: 4.038 ± 0.821
3.715ThrLys: 3.715 ± 0.572
7.753ThrLeu: 7.753 ± 1.568
2.423ThrMet: 2.423 ± 0.686
3.715ThrAsn: 3.715 ± 0.681
1.292ThrPro: 1.292 ± 0.292
2.746ThrGln: 2.746 ± 0.656
2.584ThrArg: 2.584 ± 0.683
4.523ThrSer: 4.523 ± 0.407
4.684ThrThr: 4.684 ± 0.773
5.169ThrVal: 5.169 ± 0.609
0.808ThrTrp: 0.808 ± 0.335
2.1ThrTyr: 2.1 ± 0.757
0.0ThrXaa: 0.0 ± 0.0
Val
5.007ValAla: 5.007 ± 0.559
0.969ValCys: 0.969 ± 0.418
4.2ValAsp: 4.2 ± 0.715
4.846ValGlu: 4.846 ± 0.773
1.938ValPhe: 1.938 ± 0.578
2.907ValGly: 2.907 ± 0.409
0.323ValHis: 0.323 ± 0.19
4.361ValIle: 4.361 ± 0.52
4.523ValLys: 4.523 ± 0.867
6.623ValLeu: 6.623 ± 0.907
1.777ValMet: 1.777 ± 0.53
5.653ValAsn: 5.653 ± 1.077
2.1ValPro: 2.1 ± 0.654
1.777ValGln: 1.777 ± 0.463
2.907ValArg: 2.907 ± 0.485
4.846ValSer: 4.846 ± 0.975
4.523ValThr: 4.523 ± 0.599
5.653ValVal: 5.653 ± 1.095
0.162ValTrp: 0.162 ± 0.139
2.423ValTyr: 2.423 ± 0.458
0.0ValXaa: 0.0 ± 0.0
Trp
0.485TrpAla: 0.485 ± 0.248
0.485TrpCys: 0.485 ± 0.417
0.969TrpAsp: 0.969 ± 0.339
0.485TrpGlu: 0.485 ± 0.332
0.162TrpPhe: 0.162 ± 0.139
0.323TrpGly: 0.323 ± 0.262
0.162TrpHis: 0.162 ± 0.142
1.131TrpIle: 1.131 ± 0.479
1.938TrpLys: 1.938 ± 0.459
1.292TrpLeu: 1.292 ± 0.248
0.323TrpMet: 0.323 ± 0.202
0.808TrpAsn: 0.808 ± 0.443
0.485TrpPro: 0.485 ± 0.278
0.646TrpGln: 0.646 ± 0.445
0.323TrpArg: 0.323 ± 0.188
0.162TrpSer: 0.162 ± 0.121
0.323TrpThr: 0.323 ± 0.209
0.485TrpVal: 0.485 ± 0.227
0.323TrpTrp: 0.323 ± 0.244
0.808TrpTyr: 0.808 ± 0.334
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.038TyrAla: 4.038 ± 0.682
0.808TyrCys: 0.808 ± 0.413
2.746TyrAsp: 2.746 ± 0.807
3.069TyrGlu: 3.069 ± 0.529
2.261TyrPhe: 2.261 ± 0.394
2.261TyrGly: 2.261 ± 0.615
0.485TyrHis: 0.485 ± 0.292
4.2TyrIle: 4.2 ± 0.889
3.715TyrLys: 3.715 ± 0.676
3.069TyrLeu: 3.069 ± 1.115
1.131TyrMet: 1.131 ± 0.363
3.877TyrAsn: 3.877 ± 0.598
1.131TyrPro: 1.131 ± 0.367
1.615TyrGln: 1.615 ± 0.432
2.584TyrArg: 2.584 ± 0.603
5.007TyrSer: 5.007 ± 1.729
2.907TyrThr: 2.907 ± 0.832
3.23TyrVal: 3.23 ± 0.57
0.485TyrTrp: 0.485 ± 0.204
2.746TyrTyr: 2.746 ± 0.852
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (6192 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski