Amino acid dipepetide frequency for Bacteroides caccae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.417AlaAla: 5.417 ± 0.077	0.92AlaCys: 0.92 ± 0.026	4.036AlaAsp: 4.036 ± 0.051	4.674AlaGlu: 4.674 ± 0.06	3.046AlaPhe: 3.046 ± 0.051	4.921AlaGly: 4.921 ± 0.065	1.176AlaHis: 1.176 ± 0.025	4.625AlaIle: 4.625 ± 0.061	4.104AlaLys: 4.104 ± 0.06	6.302AlaLeu: 6.302 ± 0.075	1.893AlaMet: 1.893 ± 0.04	3.168AlaAsn: 3.168 ± 0.044	2.175AlaPro: 2.175 ± 0.035	2.555AlaGln: 2.555 ± 0.045	2.923AlaArg: 2.923 ± 0.046	4.135AlaSer: 4.135 ± 0.057	3.902AlaThr: 3.902 ± 0.052	4.532AlaVal: 4.532 ± 0.064	0.798AlaTrp: 0.798 ± 0.025	2.866AlaTyr: 2.866 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.708CysAla: 0.708 ± 0.022	0.231CysCys: 0.231 ± 0.014	0.657CysAsp: 0.657 ± 0.019	0.677CysGlu: 0.677 ± 0.022	0.645CysPhe: 0.645 ± 0.022	0.968CysGly: 0.968 ± 0.025	0.286CysHis: 0.286 ± 0.015	0.98CysIle: 0.98 ± 0.029	0.754CysLys: 0.754 ± 0.024	1.118CysLeu: 1.118 ± 0.025	0.339CysMet: 0.339 ± 0.016	0.59CysAsn: 0.59 ± 0.02	0.51CysPro: 0.51 ± 0.021	0.33CysGln: 0.33 ± 0.015	0.631CysArg: 0.631 ± 0.022	0.795CysSer: 0.795 ± 0.024	0.684CysThr: 0.684 ± 0.023	0.73CysVal: 0.73 ± 0.022	0.162CysTrp: 0.162 ± 0.01	0.605CysTyr: 0.605 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.624AspAla: 3.624 ± 0.056	0.63AspCys: 0.63 ± 0.021	2.671AspAsp: 2.671 ± 0.045	3.935AspGlu: 3.935 ± 0.05	2.954AspPhe: 2.954 ± 0.044	3.863AspGly: 3.863 ± 0.059	0.746AspHis: 0.746 ± 0.023	4.184AspIle: 4.184 ± 0.052	4.135AspLys: 4.135 ± 0.049	4.579AspLeu: 4.579 ± 0.058	1.665AspMet: 1.665 ± 0.028	2.881AspAsn: 2.881 ± 0.042	1.838AspPro: 1.838 ± 0.037	1.224AspGln: 1.224 ± 0.026	2.448AspArg: 2.448 ± 0.039	3.113AspSer: 3.113 ± 0.049	2.852AspThr: 2.852 ± 0.05	3.431AspVal: 3.431 ± 0.046	0.905AspTrp: 0.905 ± 0.025	2.972AspTyr: 2.972 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.746GluAla: 4.746 ± 0.069	0.648GluCys: 0.648 ± 0.023	3.328GluAsp: 3.328 ± 0.048	5.322GluGlu: 5.322 ± 0.078	2.468GluPhe: 2.468 ± 0.033	4.174GluGly: 4.174 ± 0.063	1.247GluHis: 1.247 ± 0.029	4.715GluIle: 4.715 ± 0.06	5.451GluLys: 5.451 ± 0.055	6.3GluLeu: 6.3 ± 0.071	2.044GluMet: 2.044 ± 0.032	3.674GluAsn: 3.674 ± 0.042	1.791GluPro: 1.791 ± 0.036	2.742GluGln: 2.742 ± 0.041	3.318GluArg: 3.318 ± 0.055	3.284GluSer: 3.284 ± 0.045	3.348GluThr: 3.348 ± 0.043	4.303GluVal: 4.303 ± 0.052	0.883GluTrp: 0.883 ± 0.026	2.921GluTyr: 2.921 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.009PheAla: 3.009 ± 0.049	0.681PheCys: 0.681 ± 0.023	2.734PheAsp: 2.734 ± 0.04	2.498PheGlu: 2.498 ± 0.038	2.287PhePhe: 2.287 ± 0.044	3.18PheGly: 3.18 ± 0.049	0.921PheHis: 0.921 ± 0.024	3.34PheIle: 3.34 ± 0.051	2.487PheLys: 2.487 ± 0.045	4.021PheLeu: 4.021 ± 0.054	1.275PheMet: 1.275 ± 0.024	2.46PheAsn: 2.46 ± 0.035	1.803PhePro: 1.803 ± 0.035	1.316PheGln: 1.316 ± 0.029	2.214PheArg: 2.214 ± 0.038	3.507PheSer: 3.507 ± 0.049	2.782PheThr: 2.782 ± 0.044	2.823PheVal: 2.823 ± 0.041	0.569PheTrp: 0.569 ± 0.021	2.03PheTyr: 2.03 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.133GlyAla: 4.133 ± 0.064	0.841GlyCys: 0.841 ± 0.024	3.444GlyAsp: 3.444 ± 0.047	4.189GlyGlu: 4.189 ± 0.059	3.126GlyPhe: 3.126 ± 0.047	4.627GlyGly: 4.627 ± 0.075	1.18GlyHis: 1.18 ± 0.03	5.343GlyIle: 5.343 ± 0.064	5.296GlyLys: 5.296 ± 0.058	5.752GlyLeu: 5.752 ± 0.072	2.11GlyMet: 2.11 ± 0.038	3.729GlyAsn: 3.729 ± 0.059	1.248GlyPro: 1.248 ± 0.029	2.042GlyGln: 2.042 ± 0.034	2.858GlyArg: 2.858 ± 0.043	3.941GlySer: 3.941 ± 0.058	4.221GlyThr: 4.221 ± 0.061	4.617GlyVal: 4.617 ± 0.065	0.991GlyTrp: 0.991 ± 0.027	3.465GlyTyr: 3.465 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.101HisAla: 1.101 ± 0.027	0.3HisCys: 0.3 ± 0.014	0.858HisAsp: 0.858 ± 0.026	1.025HisGlu: 1.025 ± 0.027	1.0HisPhe: 1.0 ± 0.027	1.139HisGly: 1.139 ± 0.03	0.444HisHis: 0.444 ± 0.02	1.455HisIle: 1.455 ± 0.033	1.007HisLys: 1.007 ± 0.025	1.694HisLeu: 1.694 ± 0.035	0.335HisMet: 0.335 ± 0.014	0.885HisAsn: 0.885 ± 0.025	1.029HisPro: 1.029 ± 0.028	0.61HisGln: 0.61 ± 0.02	0.946HisArg: 0.946 ± 0.029	1.155HisSer: 1.155 ± 0.027	1.053HisThr: 1.053 ± 0.026	0.955HisVal: 0.955 ± 0.025	0.279HisTrp: 0.279 ± 0.014	0.915HisTyr: 0.915 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.172IleAla: 5.172 ± 0.069	1.041IleCys: 1.041 ± 0.03	4.216IleAsp: 4.216 ± 0.054	4.499IleGlu: 4.499 ± 0.053	2.867IlePhe: 2.867 ± 0.044	4.679IleGly: 4.679 ± 0.058	1.349IleHis: 1.349 ± 0.033	4.709IleIle: 4.709 ± 0.072	4.079IleLys: 4.079 ± 0.057	6.165IleLeu: 6.165 ± 0.079	1.496IleMet: 1.496 ± 0.033	3.572IleAsn: 3.572 ± 0.055	3.215IlePro: 3.215 ± 0.047	2.265IleGln: 2.265 ± 0.04	3.516IleArg: 3.516 ± 0.049	4.814IleSer: 4.814 ± 0.061	4.147IleThr: 4.147 ± 0.053	4.35IleVal: 4.35 ± 0.067	0.734IleTrp: 0.734 ± 0.022	2.945IleTyr: 2.945 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.887LysAla: 4.887 ± 0.058	0.557LysCys: 0.557 ± 0.019	4.161LysAsp: 4.161 ± 0.053	6.099LysGlu: 6.099 ± 0.069	2.28LysPhe: 2.28 ± 0.043	4.578LysGly: 4.578 ± 0.057	1.191LysHis: 1.191 ± 0.029	4.191LysIle: 4.191 ± 0.052	5.421LysLys: 5.421 ± 0.066	5.487LysLeu: 5.487 ± 0.056	2.114LysMet: 2.114 ± 0.036	3.672LysAsn: 3.672 ± 0.055	2.119LysPro: 2.119 ± 0.039	2.641LysGln: 2.641 ± 0.043	3.202LysArg: 3.202 ± 0.05	3.482LysSer: 3.482 ± 0.054	3.642LysThr: 3.642 ± 0.057	4.493LysVal: 4.493 ± 0.054	0.838LysTrp: 0.838 ± 0.025	3.118LysTyr: 3.118 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.163LeuAla: 6.163 ± 0.081	1.334LeuCys: 1.334 ± 0.027	4.557LeuAsp: 4.557 ± 0.06	5.163LeuGlu: 5.163 ± 0.061	4.671LeuPhe: 4.671 ± 0.067	5.433LeuGly: 5.433 ± 0.074	1.692LeuHis: 1.692 ± 0.033	5.619LeuIle: 5.619 ± 0.065	6.456LeuLys: 6.456 ± 0.076	9.063LeuLeu: 9.063 ± 0.103	2.393LeuMet: 2.393 ± 0.042	4.783LeuAsn: 4.783 ± 0.063	4.19LeuPro: 4.19 ± 0.058	3.309LeuGln: 3.309 ± 0.053	4.24LeuArg: 4.24 ± 0.06	6.643LeuSer: 6.643 ± 0.078	5.274LeuThr: 5.274 ± 0.063	5.116LeuVal: 5.116 ± 0.068	1.043LeuTrp: 1.043 ± 0.024	3.751LeuTyr: 3.751 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.908MetAla: 1.908 ± 0.035	0.245MetCys: 0.245 ± 0.013	1.445MetAsp: 1.445 ± 0.031	1.815MetGlu: 1.815 ± 0.033	1.043MetPhe: 1.043 ± 0.028	1.759MetGly: 1.759 ± 0.038	0.461MetHis: 0.461 ± 0.016	1.698MetIle: 1.698 ± 0.032	2.689MetLys: 2.689 ± 0.04	2.47MetLeu: 2.47 ± 0.044	0.728MetMet: 0.728 ± 0.023	1.681MetAsn: 1.681 ± 0.028	1.102MetPro: 1.102 ± 0.029	1.067MetGln: 1.067 ± 0.026	1.342MetArg: 1.342 ± 0.027	1.601MetSer: 1.601 ± 0.027	1.465MetThr: 1.465 ± 0.028	1.501MetVal: 1.501 ± 0.031	0.262MetTrp: 0.262 ± 0.014	0.908MetTyr: 0.908 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.434AsnAla: 3.434 ± 0.046	0.569AsnCys: 0.569 ± 0.022	2.641AsnAsp: 2.641 ± 0.039	3.28AsnGlu: 3.28 ± 0.04	2.307AsnPhe: 2.307 ± 0.041	4.044AsnGly: 4.044 ± 0.062	0.939AsnHis: 0.939 ± 0.025	3.944AsnIle: 3.944 ± 0.065	3.398AsnLys: 3.398 ± 0.045	4.513AsnLeu: 4.513 ± 0.065	1.367AsnMet: 1.367 ± 0.031	2.851AsnAsn: 2.851 ± 0.056	2.504AsnPro: 2.504 ± 0.038	1.752AsnGln: 1.752 ± 0.034	2.591AsnArg: 2.591 ± 0.046	2.896AsnSer: 2.896 ± 0.042	2.863AsnThr: 2.863 ± 0.041	3.316AsnVal: 3.316 ± 0.047	0.73AsnTrp: 0.73 ± 0.021	2.431AsnTyr: 2.431 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.695ProAla: 2.695 ± 0.043	0.362ProCys: 0.362 ± 0.017	2.506ProAsp: 2.506 ± 0.044	3.417ProGlu: 3.417 ± 0.046	1.84ProPhe: 1.84 ± 0.035	2.434ProGly: 2.434 ± 0.043	0.695ProHis: 0.695 ± 0.022	2.358ProIle: 2.358 ± 0.042	2.116ProLys: 2.116 ± 0.038	3.252ProLeu: 3.252 ± 0.046	0.897ProMet: 0.897 ± 0.024	1.696ProAsn: 1.696 ± 0.033	0.812ProPro: 0.812 ± 0.022	1.442ProGln: 1.442 ± 0.033	1.292ProArg: 1.292 ± 0.028	2.276ProSer: 2.276 ± 0.044	1.989ProThr: 1.989 ± 0.034	2.932ProVal: 2.932 ± 0.043	0.432ProTrp: 0.432 ± 0.016	1.737ProTyr: 1.737 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.399GlnAla: 2.399 ± 0.039	0.318GlnCys: 0.318 ± 0.014	1.584GlnAsp: 1.584 ± 0.034	2.443GlnGlu: 2.443 ± 0.043	1.321GlnPhe: 1.321 ± 0.029	2.07GlnGly: 2.07 ± 0.034	0.612GlnHis: 0.612 ± 0.02	2.384GlnIle: 2.384 ± 0.042	2.59GlnLys: 2.59 ± 0.039	3.365GlnLeu: 3.365 ± 0.047	1.062GlnMet: 1.062 ± 0.025	1.819GlnAsn: 1.819 ± 0.037	1.292GlnPro: 1.292 ± 0.032	1.655GlnGln: 1.655 ± 0.042	1.728GlnArg: 1.728 ± 0.038	1.982GlnSer: 1.982 ± 0.035	2.018GlnThr: 2.018 ± 0.033	2.076GlnVal: 2.076 ± 0.035	0.485GlnTrp: 0.485 ± 0.018	1.499GlnTyr: 1.499 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.676ArgAla: 2.676 ± 0.044	0.505ArgCys: 0.505 ± 0.02	2.151ArgAsp: 2.151 ± 0.035	3.073ArgGlu: 3.073 ± 0.054	2.37ArgPhe: 2.37 ± 0.038	2.447ArgGly: 2.447 ± 0.041	0.907ArgHis: 0.907 ± 0.025	3.662ArgIle: 3.662 ± 0.056	3.557ArgLys: 3.557 ± 0.056	4.414ArgLeu: 4.414 ± 0.051	1.567ArgMet: 1.567 ± 0.033	2.529ArgAsn: 2.529 ± 0.041	1.647ArgPro: 1.647 ± 0.042	1.867ArgGln: 1.867 ± 0.039	2.251ArgArg: 2.251 ± 0.05	2.438ArgSer: 2.438 ± 0.037	2.528ArgThr: 2.528 ± 0.044	2.66ArgVal: 2.66 ± 0.041	0.665ArgTrp: 0.665 ± 0.021	2.258ArgTyr: 2.258 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.993SerAla: 3.993 ± 0.052	0.922SerCys: 0.922 ± 0.026	3.355SerAsp: 3.355 ± 0.045	3.684SerGlu: 3.684 ± 0.049	3.347SerPhe: 3.347 ± 0.047	4.477SerGly: 4.477 ± 0.058	1.078SerHis: 1.078 ± 0.026	4.49SerIle: 4.49 ± 0.055	3.527SerLys: 3.527 ± 0.05	6.085SerLeu: 6.085 ± 0.069	1.513SerMet: 1.513 ± 0.032	2.857SerAsn: 2.857 ± 0.052	2.305SerPro: 2.305 ± 0.043	1.934SerGln: 1.934 ± 0.036	2.635SerArg: 2.635 ± 0.041	4.14SerSer: 4.14 ± 0.07	3.315SerThr: 3.315 ± 0.046	4.273SerVal: 4.273 ± 0.062	0.84SerTrp: 0.84 ± 0.024	2.966SerTyr: 2.966 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.948ThrAla: 3.948 ± 0.048	0.598ThrCys: 0.598 ± 0.019	3.439ThrAsp: 3.439 ± 0.048	3.502ThrGlu: 3.502 ± 0.046	2.823ThrPhe: 2.823 ± 0.052	4.448ThrGly: 4.448 ± 0.054	1.004ThrHis: 1.004 ± 0.026	3.874ThrIle: 3.874 ± 0.056	3.023ThrLys: 3.023 ± 0.053	5.381ThrLeu: 5.381 ± 0.067	1.163ThrMet: 1.163 ± 0.03	2.657ThrAsn: 2.657 ± 0.05	2.838ThrPro: 2.838 ± 0.045	1.766ThrGln: 1.766 ± 0.036	2.223ThrArg: 2.223 ± 0.037	3.502ThrSer: 3.502 ± 0.044	3.147ThrThr: 3.147 ± 0.054	4.067ThrVal: 4.067 ± 0.048	0.69ThrTrp: 0.69 ± 0.023	2.524ThrTyr: 2.524 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.422ValAla: 4.422 ± 0.061	0.929ValCys: 0.929 ± 0.026	3.594ValAsp: 3.594 ± 0.056	4.016ValGlu: 4.016 ± 0.052	2.822ValPhe: 2.822 ± 0.046	3.974ValGly: 3.974 ± 0.058	1.081ValHis: 1.081 ± 0.027	4.434ValIle: 4.434 ± 0.06	4.21ValLys: 4.21 ± 0.059	5.62ValLeu: 5.62 ± 0.069	1.648ValMet: 1.648 ± 0.033	3.366ValAsn: 3.366 ± 0.046	2.497ValPro: 2.497 ± 0.044	1.952ValGln: 1.952 ± 0.037	3.001ValArg: 3.001 ± 0.042	4.476ValSer: 4.476 ± 0.052	3.901ValThr: 3.901 ± 0.054	4.245ValVal: 4.245 ± 0.057	0.742ValTrp: 0.742 ± 0.022	2.704ValTyr: 2.704 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.788TrpAla: 0.788 ± 0.025	0.185TrpCys: 0.185 ± 0.01	0.7TrpAsp: 0.7 ± 0.024	0.856TrpGlu: 0.856 ± 0.022	0.596TrpPhe: 0.596 ± 0.02	0.962TrpGly: 0.962 ± 0.027	0.254TrpHis: 0.254 ± 0.013	0.893TrpIle: 0.893 ± 0.025	0.992TrpLys: 0.992 ± 0.026	1.176TrpLeu: 1.176 ± 0.027	0.427TrpMet: 0.427 ± 0.018	0.836TrpAsn: 0.836 ± 0.026	0.275TrpPro: 0.275 ± 0.014	0.512TrpGln: 0.512 ± 0.019	0.571TrpArg: 0.571 ± 0.02	0.689TrpSer: 0.689 ± 0.022	0.71TrpThr: 0.71 ± 0.022	0.711TrpVal: 0.711 ± 0.026	0.219TrpTrp: 0.219 ± 0.013	0.549TrpTyr: 0.549 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.947TyrAla: 2.947 ± 0.043	0.582TyrCys: 0.582 ± 0.019	2.572TyrAsp: 2.572 ± 0.045	2.54TyrGlu: 2.54 ± 0.047	2.124TyrPhe: 2.124 ± 0.042	2.977TyrGly: 2.977 ± 0.041	0.922TyrHis: 0.922 ± 0.025	2.931TyrIle: 2.931 ± 0.045	2.883TyrLys: 2.883 ± 0.045	4.137TyrLeu: 4.137 ± 0.056	1.155TyrMet: 1.155 ± 0.027	2.662TyrAsn: 2.662 ± 0.049	1.99TyrPro: 1.99 ± 0.035	1.718TyrGln: 1.718 ± 0.036	2.244TyrArg: 2.244 ± 0.042	2.867TyrSer: 2.867 ± 0.047	2.776TyrThr: 2.776 ± 0.06	2.503TyrVal: 2.503 ± 0.041	0.634TyrTrp: 0.634 ± 0.022	2.234TyrTyr: 2.234 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4410 proteins (1589254 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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