Amino acid dipepetide frequency for Lacinutrix sp. CAU 1491

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.635AlaAla: 3.635 ± 0.068
0.538AlaCys: 0.538 ± 0.026
2.963AlaAsp: 2.963 ± 0.061
3.596AlaGlu: 3.596 ± 0.068
3.343AlaPhe: 3.343 ± 0.063
3.564AlaGly: 3.564 ± 0.078
1.067AlaHis: 1.067 ± 0.038
5.502AlaIle: 5.502 ± 0.082
4.766AlaLys: 4.766 ± 0.076
6.001AlaLeu: 6.001 ± 0.091
1.441AlaMet: 1.441 ± 0.048
3.683AlaAsn: 3.683 ± 0.061
1.79AlaPro: 1.79 ± 0.045
2.241AlaGln: 2.241 ± 0.048
1.851AlaArg: 1.851 ± 0.049
3.98AlaSer: 3.98 ± 0.068
3.529AlaThr: 3.529 ± 0.07
3.63AlaVal: 3.63 ± 0.071
0.58AlaTrp: 0.58 ± 0.022
2.543AlaTyr: 2.543 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.425CysAla: 0.425 ± 0.02
0.097CysCys: 0.097 ± 0.01
0.449CysAsp: 0.449 ± 0.026
0.419CysGlu: 0.419 ± 0.023
0.407CysPhe: 0.407 ± 0.023
0.608CysGly: 0.608 ± 0.039
0.165CysHis: 0.165 ± 0.013
0.527CysIle: 0.527 ± 0.023
0.523CysLys: 0.523 ± 0.026
0.593CysLeu: 0.593 ± 0.023
0.154CysMet: 0.154 ± 0.015
0.481CysAsn: 0.481 ± 0.022
0.309CysPro: 0.309 ± 0.022
0.205CysGln: 0.205 ± 0.014
0.171CysArg: 0.171 ± 0.013
0.51CysSer: 0.51 ± 0.024
0.362CysThr: 0.362 ± 0.019
0.414CysVal: 0.414 ± 0.02
0.064CysTrp: 0.064 ± 0.008
0.306CysTyr: 0.306 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.646AspAla: 3.646 ± 0.07
0.404AspCys: 0.404 ± 0.026
3.203AspAsp: 3.203 ± 0.076
3.767AspGlu: 3.767 ± 0.074
3.49AspPhe: 3.49 ± 0.063
3.657AspGly: 3.657 ± 0.085
0.802AspHis: 0.802 ± 0.028
5.003AspIle: 5.003 ± 0.076
4.345AspLys: 4.345 ± 0.067
4.984AspLeu: 4.984 ± 0.063
1.188AspMet: 1.188 ± 0.034
3.637AspAsn: 3.637 ± 0.067
1.505AspPro: 1.505 ± 0.043
1.218AspGln: 1.218 ± 0.037
1.721AspArg: 1.721 ± 0.043
3.319AspSer: 3.319 ± 0.058
2.909AspThr: 2.909 ± 0.056
3.837AspVal: 3.837 ± 0.07
0.684AspTrp: 0.684 ± 0.025
2.925AspTyr: 2.925 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.494GluAla: 4.494 ± 0.082
0.366GluCys: 0.366 ± 0.027
3.69GluAsp: 3.69 ± 0.074
4.493GluGlu: 4.493 ± 0.107
3.127GluPhe: 3.127 ± 0.055
3.515GluGly: 3.515 ± 0.071
1.273GluHis: 1.273 ± 0.038
5.183GluIle: 5.183 ± 0.07
5.446GluLys: 5.446 ± 0.086
6.209GluLeu: 6.209 ± 0.09
1.395GluMet: 1.395 ± 0.039
4.525GluAsn: 4.525 ± 0.076
1.547GluPro: 1.547 ± 0.034
2.308GluGln: 2.308 ± 0.053
2.444GluArg: 2.444 ± 0.054
3.354GluSer: 3.354 ± 0.061
3.716GluThr: 3.716 ± 0.064
4.207GluVal: 4.207 ± 0.079
0.591GluTrp: 0.591 ± 0.024
2.323GluTyr: 2.323 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
2.853PheAla: 2.853 ± 0.061
0.382PheCys: 0.382 ± 0.02
3.222PheAsp: 3.222 ± 0.067
3.397PheGlu: 3.397 ± 0.057
2.65PhePhe: 2.65 ± 0.061
3.608PheGly: 3.608 ± 0.069
0.815PheHis: 0.815 ± 0.028
4.12PheIle: 4.12 ± 0.073
4.34PheLys: 4.34 ± 0.081
4.525PheLeu: 4.525 ± 0.086
1.123PheMet: 1.123 ± 0.032
3.753PheAsn: 3.753 ± 0.071
1.618PhePro: 1.618 ± 0.04
1.431PheGln: 1.431 ± 0.039
1.542PheArg: 1.542 ± 0.038
3.881PheSer: 3.881 ± 0.068
3.042PheThr: 3.042 ± 0.055
3.032PheVal: 3.032 ± 0.057
0.598PheTrp: 0.598 ± 0.023
2.14PheTyr: 2.14 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
3.803GlyAla: 3.803 ± 0.075
0.554GlyCys: 0.554 ± 0.025
3.293GlyAsp: 3.293 ± 0.065
3.526GlyGlu: 3.526 ± 0.06
3.476GlyPhe: 3.476 ± 0.066
4.33GlyGly: 4.33 ± 0.089
1.184GlyHis: 1.184 ± 0.039
5.041GlyIle: 5.041 ± 0.076
5.002GlyLys: 5.002 ± 0.071
5.626GlyLeu: 5.626 ± 0.096
1.54GlyMet: 1.54 ± 0.041
3.738GlyAsn: 3.738 ± 0.07
1.263GlyPro: 1.263 ± 0.04
1.682GlyGln: 1.682 ± 0.042
2.064GlyArg: 2.064 ± 0.043
3.845GlySer: 3.845 ± 0.065
3.789GlyThr: 3.789 ± 0.07
4.134GlyVal: 4.134 ± 0.073
0.693GlyTrp: 0.693 ± 0.028
2.737GlyTyr: 2.737 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
0.914HisAla: 0.914 ± 0.03
0.171HisCys: 0.171 ± 0.013
0.954HisAsp: 0.954 ± 0.032
0.976HisGlu: 0.976 ± 0.033
1.101HisPhe: 1.101 ± 0.04
1.091HisGly: 1.091 ± 0.036
0.478HisHis: 0.478 ± 0.026
1.516HisIle: 1.516 ± 0.044
1.338HisLys: 1.338 ± 0.038
1.846HisLeu: 1.846 ± 0.042
0.331HisMet: 0.331 ± 0.019
1.081HisAsn: 1.081 ± 0.032
0.876HisPro: 0.876 ± 0.036
0.66HisGln: 0.66 ± 0.026
0.627HisArg: 0.627 ± 0.025
1.119HisSer: 1.119 ± 0.032
0.983HisThr: 0.983 ± 0.033
1.007HisVal: 1.007 ± 0.034
0.239HisTrp: 0.239 ± 0.018
0.862HisTyr: 0.862 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.489IleAla: 5.489 ± 0.082
0.596IleCys: 0.596 ± 0.025
5.36IleAsp: 5.36 ± 0.073
5.794IleGlu: 5.794 ± 0.089
3.56IlePhe: 3.56 ± 0.061
5.15IleGly: 5.15 ± 0.09
1.342IleHis: 1.342 ± 0.043
6.769IleIle: 6.769 ± 0.106
6.582IleLys: 6.582 ± 0.094
7.036IleLeu: 7.036 ± 0.108
1.449IleMet: 1.449 ± 0.037
5.459IleAsn: 5.459 ± 0.082
3.163IlePro: 3.163 ± 0.052
2.336IleGln: 2.336 ± 0.05
2.435IleArg: 2.435 ± 0.048
5.853IleSer: 5.853 ± 0.076
5.114IleThr: 5.114 ± 0.082
5.031IleVal: 5.031 ± 0.081
0.694IleTrp: 0.694 ± 0.028
2.933IleTyr: 2.933 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.211LysAla: 5.211 ± 0.084
0.371LysCys: 0.371 ± 0.02
4.707LysAsp: 4.707 ± 0.078
6.34LysGlu: 6.34 ± 0.11
3.018LysPhe: 3.018 ± 0.059
4.597LysGly: 4.597 ± 0.071
1.744LysHis: 1.744 ± 0.051
6.152LysIle: 6.152 ± 0.085
7.238LysLys: 7.238 ± 0.121
7.157LysLeu: 7.157 ± 0.091
1.97LysMet: 1.97 ± 0.049
5.668LysAsn: 5.668 ± 0.089
2.604LysPro: 2.604 ± 0.052
3.263LysGln: 3.263 ± 0.054
3.161LysArg: 3.161 ± 0.065
5.048LysSer: 5.048 ± 0.083
5.055LysThr: 5.055 ± 0.079
4.943LysVal: 4.943 ± 0.078
0.845LysTrp: 0.845 ± 0.031
3.17LysTyr: 3.17 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
5.361LeuAla: 5.361 ± 0.076
0.642LeuCys: 0.642 ± 0.026
5.152LeuAsp: 5.152 ± 0.077
6.052LeuGlu: 6.052 ± 0.083
4.865LeuPhe: 4.865 ± 0.094
5.632LeuGly: 5.632 ± 0.086
1.556LeuHis: 1.556 ± 0.038
7.424LeuIle: 7.424 ± 0.114
8.229LeuLys: 8.229 ± 0.106
8.627LeuLeu: 8.627 ± 0.127
2.098LeuMet: 2.098 ± 0.056
6.089LeuAsn: 6.089 ± 0.093
3.329LeuPro: 3.329 ± 0.066
2.987LeuGln: 2.987 ± 0.06
3.009LeuArg: 3.009 ± 0.062
6.65LeuSer: 6.65 ± 0.083
5.072LeuThr: 5.072 ± 0.076
5.358LeuVal: 5.358 ± 0.078
0.794LeuTrp: 0.794 ± 0.031
3.226LeuTyr: 3.226 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
1.48MetAla: 1.48 ± 0.042
0.143MetCys: 0.143 ± 0.012
1.113MetAsp: 1.113 ± 0.036
1.235MetGlu: 1.235 ± 0.036
1.008MetPhe: 1.008 ± 0.033
1.14MetGly: 1.14 ± 0.037
0.447MetHis: 0.447 ± 0.02
1.549MetIle: 1.549 ± 0.039
2.219MetLys: 2.219 ± 0.048
2.068MetLeu: 2.068 ± 0.048
0.551MetMet: 0.551 ± 0.025
1.373MetAsn: 1.373 ± 0.038
0.856MetPro: 0.856 ± 0.03
0.8MetGln: 0.8 ± 0.032
0.848MetArg: 0.848 ± 0.027
1.6MetSer: 1.6 ± 0.039
1.201MetThr: 1.201 ± 0.035
1.34MetVal: 1.34 ± 0.036
0.163MetTrp: 0.163 ± 0.012
0.768MetTyr: 0.768 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.891AsnAla: 3.891 ± 0.071
0.509AsnCys: 0.509 ± 0.028
3.81AsnAsp: 3.81 ± 0.069
3.954AsnGlu: 3.954 ± 0.061
3.102AsnPhe: 3.102 ± 0.065
4.079AsnGly: 4.079 ± 0.071
1.143AsnHis: 1.143 ± 0.035
5.615AsnIle: 5.615 ± 0.08
5.27AsnLys: 5.27 ± 0.086
5.683AsnLeu: 5.683 ± 0.079
1.522AsnMet: 1.522 ± 0.039
4.833AsnAsn: 4.833 ± 0.083
2.762AsnPro: 2.762 ± 0.054
2.238AsnGln: 2.238 ± 0.052
2.232AsnArg: 2.232 ± 0.045
4.268AsnSer: 4.268 ± 0.073
4.1AsnThr: 4.1 ± 0.076
3.88AsnVal: 3.88 ± 0.064
0.8AsnTrp: 0.8 ± 0.029
3.151AsnTyr: 3.151 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
1.487ProAla: 1.487 ± 0.044
0.192ProCys: 0.192 ± 0.015
1.929ProAsp: 1.929 ± 0.048
2.705ProGlu: 2.705 ± 0.055
1.833ProPhe: 1.833 ± 0.043
1.719ProGly: 1.719 ± 0.041
0.616ProHis: 0.616 ± 0.022
2.766ProIle: 2.766 ± 0.051
2.748ProLys: 2.748 ± 0.051
2.837ProLeu: 2.837 ± 0.055
0.721ProMet: 0.721 ± 0.028
2.386ProAsn: 2.386 ± 0.054
0.771ProPro: 0.771 ± 0.035
1.073ProGln: 1.073 ± 0.038
0.981ProArg: 0.981 ± 0.031
2.157ProSer: 2.157 ± 0.049
1.955ProThr: 1.955 ± 0.049
2.011ProVal: 2.011 ± 0.043
0.326ProTrp: 0.326 ± 0.021
1.397ProTyr: 1.397 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
1.798GlnAla: 1.798 ± 0.045
0.169GlnCys: 0.169 ± 0.012
1.671GlnAsp: 1.671 ± 0.047
2.247GlnGlu: 2.247 ± 0.048
1.672GlnPhe: 1.672 ± 0.044
1.748GlnGly: 1.748 ± 0.043
0.636GlnHis: 0.636 ± 0.024
2.591GlnIle: 2.591 ± 0.049
2.635GlnLys: 2.635 ± 0.059
3.505GlnLeu: 3.505 ± 0.069
0.755GlnMet: 0.755 ± 0.032
2.094GlnAsn: 2.094 ± 0.057
1.137GlnPro: 1.137 ± 0.031
1.425GlnGln: 1.425 ± 0.047
1.216GlnArg: 1.216 ± 0.029
1.895GlnSer: 1.895 ± 0.041
1.796GlnThr: 1.796 ± 0.042
1.851GlnVal: 1.851 ± 0.044
0.357GlnTrp: 0.357 ± 0.02
1.356GlnTyr: 1.356 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.016ArgAla: 2.016 ± 0.045
0.174ArgCys: 0.174 ± 0.013
1.892ArgAsp: 1.892 ± 0.047
2.037ArgGlu: 2.037 ± 0.051
1.829ArgPhe: 1.829 ± 0.046
1.95ArgGly: 1.95 ± 0.045
0.625ArgHis: 0.625 ± 0.026
2.824ArgIle: 2.824 ± 0.048
2.596ArgLys: 2.596 ± 0.056
3.144ArgLeu: 3.144 ± 0.053
0.841ArgMet: 0.841 ± 0.033
2.109ArgAsn: 2.109 ± 0.042
1.029ArgPro: 1.029 ± 0.031
1.118ArgGln: 1.118 ± 0.037
1.302ArgArg: 1.302 ± 0.039
1.825ArgSer: 1.825 ± 0.046
1.854ArgThr: 1.854 ± 0.042
2.124ArgVal: 2.124 ± 0.054
0.404ArgTrp: 0.404 ± 0.02
1.514ArgTyr: 1.514 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
3.544SerAla: 3.544 ± 0.055
0.632SerCys: 0.632 ± 0.024
3.415SerAsp: 3.415 ± 0.061
3.697SerGlu: 3.697 ± 0.068
3.855SerPhe: 3.855 ± 0.068
4.542SerGly: 4.542 ± 0.077
1.114SerHis: 1.114 ± 0.037
5.542SerIle: 5.542 ± 0.079
5.664SerLys: 5.664 ± 0.085
6.039SerLeu: 6.039 ± 0.081
1.311SerMet: 1.311 ± 0.039
4.503SerAsn: 4.503 ± 0.086
2.036SerPro: 2.036 ± 0.049
2.191SerGln: 2.191 ± 0.049
2.126SerArg: 2.126 ± 0.052
4.304SerSer: 4.304 ± 0.083
3.494SerThr: 3.494 ± 0.057
3.973SerVal: 3.973 ± 0.069
0.734SerTrp: 0.734 ± 0.027
2.835SerTyr: 2.835 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
3.338ThrAla: 3.338 ± 0.074
0.353ThrCys: 0.353 ± 0.02
3.086ThrAsp: 3.086 ± 0.058
3.153ThrGlu: 3.153 ± 0.062
3.132ThrPhe: 3.132 ± 0.066
3.549ThrGly: 3.549 ± 0.063
1.084ThrHis: 1.084 ± 0.034
5.25ThrIle: 5.25 ± 0.084
4.419ThrLys: 4.419 ± 0.065
5.521ThrLeu: 5.521 ± 0.076
1.028ThrMet: 1.028 ± 0.034
3.852ThrAsn: 3.852 ± 0.068
2.353ThrPro: 2.353 ± 0.046
1.838ThrGln: 1.838 ± 0.042
1.652ThrArg: 1.652 ± 0.046
3.987ThrSer: 3.987 ± 0.067
3.572ThrThr: 3.572 ± 0.08
3.628ThrVal: 3.628 ± 0.072
0.694ThrTrp: 0.694 ± 0.032
2.5ThrTyr: 2.5 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
3.924ValAla: 3.924 ± 0.067
0.473ValCys: 0.473 ± 0.024
3.414ValAsp: 3.414 ± 0.056
3.998ValGlu: 3.998 ± 0.072
3.556ValPhe: 3.556 ± 0.06
3.647ValGly: 3.647 ± 0.064
0.992ValHis: 0.992 ± 0.031
5.018ValIle: 5.018 ± 0.083
4.611ValLys: 4.611 ± 0.069
5.918ValLeu: 5.918 ± 0.082
1.386ValMet: 1.386 ± 0.037
3.772ValAsn: 3.772 ± 0.064
2.003ValPro: 2.003 ± 0.046
1.658ValGln: 1.658 ± 0.04
1.948ValArg: 1.948 ± 0.043
4.477ValSer: 4.477 ± 0.072
3.543ValThr: 3.543 ± 0.067
4.178ValVal: 4.178 ± 0.076
0.605ValTrp: 0.605 ± 0.025
2.332ValTyr: 2.332 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.591TrpAla: 0.591 ± 0.026
0.097TrpCys: 0.097 ± 0.01
0.576TrpAsp: 0.576 ± 0.026
0.617TrpGlu: 0.617 ± 0.025
0.551TrpPhe: 0.551 ± 0.022
0.573TrpGly: 0.573 ± 0.023
0.232TrpHis: 0.232 ± 0.017
0.781TrpIle: 0.781 ± 0.029
0.833TrpLys: 0.833 ± 0.033
1.019TrpLeu: 1.019 ± 0.031
0.308TrpMet: 0.308 ± 0.018
0.765TrpAsn: 0.765 ± 0.031
0.224TrpPro: 0.224 ± 0.016
0.436TrpGln: 0.436 ± 0.018
0.409TrpArg: 0.409 ± 0.021
0.702TrpSer: 0.702 ± 0.029
0.563TrpThr: 0.563 ± 0.029
0.608TrpVal: 0.608 ± 0.025
0.145TrpTrp: 0.145 ± 0.012
0.458TrpTyr: 0.458 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.344TyrAla: 2.344 ± 0.047
0.326TyrCys: 0.326 ± 0.018
2.347TyrAsp: 2.347 ± 0.052
2.203TyrGlu: 2.203 ± 0.05
2.499TyrPhe: 2.499 ± 0.061
2.622TyrGly: 2.622 ± 0.061
0.858TyrHis: 0.858 ± 0.031
2.969TyrIle: 2.969 ± 0.062
3.457TyrLys: 3.457 ± 0.063
3.817TyrLeu: 3.817 ± 0.064
0.789TyrMet: 0.789 ± 0.024
3.042TyrAsn: 3.042 ± 0.065
1.434TyrPro: 1.434 ± 0.039
1.443TyrGln: 1.443 ± 0.039
1.466TyrArg: 1.466 ± 0.046
2.779TyrSer: 2.779 ± 0.057
2.336TyrThr: 2.336 ± 0.054
2.266TyrVal: 2.266 ± 0.05
0.477TyrTrp: 0.477 ± 0.02
1.927TyrTyr: 1.927 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2986 proteins (998528 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski