Amino acid dipepetide frequency for Kutzneria sp. 744

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.223AlaAla: 19.223 ± 0.119	1.08AlaCys: 1.08 ± 0.018	8.403AlaAsp: 8.403 ± 0.054	7.752AlaGlu: 7.752 ± 0.067	3.512AlaPhe: 3.512 ± 0.03	12.357AlaGly: 12.357 ± 0.071	2.533AlaHis: 2.533 ± 0.026	4.23AlaIle: 4.23 ± 0.047	2.907AlaLys: 2.907 ± 0.036	13.295AlaLeu: 13.295 ± 0.086	2.679AlaMet: 2.679 ± 0.03	2.69AlaAsn: 2.69 ± 0.039	5.605AlaPro: 5.605 ± 0.054	3.972AlaGln: 3.972 ± 0.035	8.737AlaArg: 8.737 ± 0.073	6.116AlaSer: 6.116 ± 0.046	7.516AlaThr: 7.516 ± 0.057	12.046AlaVal: 12.046 ± 0.077	1.868AlaTrp: 1.868 ± 0.024	2.44AlaTyr: 2.44 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.038CysAla: 1.038 ± 0.018	0.135CysCys: 0.135 ± 0.006	0.521CysAsp: 0.521 ± 0.012	0.417CysGlu: 0.417 ± 0.012	0.223CysPhe: 0.223 ± 0.009	0.971CysGly: 0.971 ± 0.018	0.233CysHis: 0.233 ± 0.01	0.178CysIle: 0.178 ± 0.008	0.123CysLys: 0.123 ± 0.006	0.808CysLeu: 0.808 ± 0.018	0.143CysMet: 0.143 ± 0.006	0.182CysAsn: 0.182 ± 0.008	0.524CysPro: 0.524 ± 0.013	0.245CysGln: 0.245 ± 0.009	0.697CysArg: 0.697 ± 0.017	0.534CysSer: 0.534 ± 0.014	0.517CysThr: 0.517 ± 0.016	0.719CysVal: 0.719 ± 0.014	0.179CysTrp: 0.179 ± 0.007	0.197CysTyr: 0.197 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.156AspAla: 7.156 ± 0.053	0.461AspCys: 0.461 ± 0.012	3.726AspAsp: 3.726 ± 0.037	3.649AspGlu: 3.649 ± 0.042	1.755AspPhe: 1.755 ± 0.026	6.299AspGly: 6.299 ± 0.056	1.56AspHis: 1.56 ± 0.024	2.032AspIle: 2.032 ± 0.028	1.254AspLys: 1.254 ± 0.026	6.481AspLeu: 6.481 ± 0.045	0.881AspMet: 0.881 ± 0.019	1.434AspAsn: 1.434 ± 0.025	4.306AspPro: 4.306 ± 0.038	2.017AspGln: 2.017 ± 0.026	5.019AspArg: 5.019 ± 0.051	2.754AspSer: 2.754 ± 0.034	3.235AspThr: 3.235 ± 0.034	5.343AspVal: 5.343 ± 0.046	1.005AspTrp: 1.005 ± 0.021	1.32AspTyr: 1.32 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.829GluAla: 5.829 ± 0.058	0.352GluCys: 0.352 ± 0.011	2.402GluAsp: 2.402 ± 0.028	2.292GluGlu: 2.292 ± 0.027	1.648GluPhe: 1.648 ± 0.025	3.066GluGly: 3.066 ± 0.034	1.621GluHis: 1.621 ± 0.023	2.25GluIle: 2.25 ± 0.026	0.976GluLys: 0.976 ± 0.019	6.956GluLeu: 6.956 ± 0.063	0.848GluMet: 0.848 ± 0.016	0.978GluAsn: 0.978 ± 0.017	2.96GluPro: 2.96 ± 0.031	2.275GluGln: 2.275 ± 0.031	4.453GluArg: 4.453 ± 0.047	2.324GluSer: 2.324 ± 0.027	2.401GluThr: 2.401 ± 0.029	4.301GluVal: 4.301 ± 0.039	0.775GluTrp: 0.775 ± 0.016	0.933GluTyr: 0.933 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.891PheAla: 3.891 ± 0.037	0.286PheCys: 0.286 ± 0.009	2.345PheAsp: 2.345 ± 0.029	1.387PheGlu: 1.387 ± 0.021	0.888PhePhe: 0.888 ± 0.016	3.214PheGly: 3.214 ± 0.037	0.667PheHis: 0.667 ± 0.015	0.708PheIle: 0.708 ± 0.014	0.467PheLys: 0.467 ± 0.012	2.638PheLeu: 2.638 ± 0.036	0.429PheMet: 0.429 ± 0.013	0.65PheAsn: 0.65 ± 0.015	1.49PhePro: 1.49 ± 0.018	0.787PheGln: 0.787 ± 0.015	1.85PheArg: 1.85 ± 0.025	1.598PheSer: 1.598 ± 0.023	2.085PheThr: 2.085 ± 0.029	2.562PheVal: 2.562 ± 0.03	0.445PheTrp: 0.445 ± 0.014	0.653PheTyr: 0.653 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	9.633GlyAla: 9.633 ± 0.068	0.876GlyCys: 0.876 ± 0.016	5.113GlyAsp: 5.113 ± 0.048	4.36GlyGlu: 4.36 ± 0.043	2.99GlyPhe: 2.99 ± 0.033	8.27GlyGly: 8.27 ± 0.077	2.309GlyHis: 2.309 ± 0.028	3.564GlyIle: 3.564 ± 0.037	2.378GlyLys: 2.378 ± 0.032	9.166GlyLeu: 9.166 ± 0.053	1.99GlyMet: 1.99 ± 0.025	2.153GlyAsn: 2.153 ± 0.044	4.639GlyPro: 4.639 ± 0.043	3.184GlyGln: 3.184 ± 0.032	6.988GlyArg: 6.988 ± 0.058	5.381GlySer: 5.381 ± 0.052	5.446GlyThr: 5.446 ± 0.05	7.971GlyVal: 7.971 ± 0.065	1.774GlyTrp: 1.774 ± 0.024	2.389GlyTyr: 2.389 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.674HisAla: 2.674 ± 0.033	0.23HisCys: 0.23 ± 0.01	1.474HisAsp: 1.474 ± 0.028	1.223HisGlu: 1.223 ± 0.019	0.658HisPhe: 0.658 ± 0.016	2.404HisGly: 2.404 ± 0.027	0.722HisHis: 0.722 ± 0.017	0.727HisIle: 0.727 ± 0.016	0.36HisLys: 0.36 ± 0.011	2.36HisLeu: 2.36 ± 0.029	0.353HisMet: 0.353 ± 0.01	0.537HisAsn: 0.537 ± 0.014	1.682HisPro: 1.682 ± 0.024	0.727HisGln: 0.727 ± 0.016	2.129HisArg: 2.129 ± 0.031	1.15HisSer: 1.15 ± 0.019	1.25HisThr: 1.25 ± 0.019	1.981HisVal: 1.981 ± 0.023	0.393HisTrp: 0.393 ± 0.01	0.525HisTyr: 0.525 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.346IleAla: 5.346 ± 0.044	0.306IleCys: 0.306 ± 0.011	2.621IleAsp: 2.621 ± 0.033	2.064IleGlu: 2.064 ± 0.027	0.739IlePhe: 0.739 ± 0.018	3.964IleGly: 3.964 ± 0.04	0.638IleHis: 0.638 ± 0.013	0.988IleIle: 0.988 ± 0.018	0.719IleLys: 0.719 ± 0.016	2.425IleLeu: 2.425 ± 0.027	0.49IleMet: 0.49 ± 0.011	0.829IleAsn: 0.829 ± 0.018	1.865IlePro: 1.865 ± 0.026	0.857IleGln: 0.857 ± 0.015	2.424IleArg: 2.424 ± 0.029	1.948IleSer: 1.948 ± 0.026	2.619IleThr: 2.619 ± 0.027	3.202IleVal: 3.202 ± 0.034	0.423IleTrp: 0.423 ± 0.014	0.621IleTyr: 0.621 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.809LysAla: 2.809 ± 0.035	0.139LysCys: 0.139 ± 0.007	1.111LysAsp: 1.111 ± 0.022	0.834LysGlu: 0.834 ± 0.018	0.563LysPhe: 0.563 ± 0.015	1.484LysGly: 1.484 ± 0.022	0.46LysHis: 0.46 ± 0.013	0.919LysIle: 0.919 ± 0.016	0.497LysLys: 0.497 ± 0.015	2.173LysLeu: 2.173 ± 0.029	0.383LysMet: 0.383 ± 0.012	0.456LysAsn: 0.456 ± 0.012	1.389LysPro: 1.389 ± 0.023	0.752LysGln: 0.752 ± 0.016	1.361LysArg: 1.361 ± 0.021	1.048LysSer: 1.048 ± 0.021	1.213LysThr: 1.213 ± 0.024	1.914LysVal: 1.914 ± 0.025	0.301LysTrp: 0.301 ± 0.01	0.42LysTyr: 0.42 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.305LeuAla: 15.305 ± 0.09	0.879LeuCys: 0.879 ± 0.017	6.936LeuAsp: 6.936 ± 0.057	3.968LeuGlu: 3.968 ± 0.043	2.751LeuPhe: 2.751 ± 0.032	9.169LeuGly: 9.169 ± 0.055	2.382LeuHis: 2.382 ± 0.031	3.536LeuIle: 3.536 ± 0.042	1.737LeuLys: 1.737 ± 0.027	10.849LeuLeu: 10.849 ± 0.082	1.598LeuMet: 1.598 ± 0.021	1.934LeuAsn: 1.934 ± 0.025	6.416LeuPro: 6.416 ± 0.058	2.196LeuGln: 2.196 ± 0.023	8.576LeuArg: 8.576 ± 0.068	5.917LeuSer: 5.917 ± 0.037	6.723LeuThr: 6.723 ± 0.053	9.599LeuVal: 9.599 ± 0.065	1.377LeuTrp: 1.377 ± 0.023	1.742LeuTyr: 1.742 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.344MetAla: 2.344 ± 0.028	0.151MetCys: 0.151 ± 0.007	0.913MetAsp: 0.913 ± 0.016	0.631MetGlu: 0.631 ± 0.013	0.503MetPhe: 0.503 ± 0.012	1.266MetGly: 1.266 ± 0.021	0.397MetHis: 0.397 ± 0.012	0.78MetIle: 0.78 ± 0.016	0.357MetLys: 0.357 ± 0.011	1.895MetLeu: 1.895 ± 0.027	0.33MetMet: 0.33 ± 0.01	0.411MetAsn: 0.411 ± 0.012	1.21MetPro: 1.21 ± 0.019	0.485MetGln: 0.485 ± 0.013	1.511MetArg: 1.511 ± 0.023	1.319MetSer: 1.319 ± 0.019	1.557MetThr: 1.557 ± 0.023	1.527MetVal: 1.527 ± 0.022	0.228MetTrp: 0.228 ± 0.009	0.316MetTyr: 0.316 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.697AsnAla: 2.697 ± 0.027	0.203AsnCys: 0.203 ± 0.008	1.176AsnAsp: 1.176 ± 0.022	0.867AsnGlu: 0.867 ± 0.016	0.607AsnPhe: 0.607 ± 0.013	2.55AsnGly: 2.55 ± 0.046	0.492AsnHis: 0.492 ± 0.013	0.706AsnIle: 0.706 ± 0.016	0.441AsnLys: 0.441 ± 0.014	2.035AsnLeu: 2.035 ± 0.03	0.345AsnMet: 0.345 ± 0.011	0.67AsnAsn: 0.67 ± 0.023	1.638AsnPro: 1.638 ± 0.025	0.737AsnGln: 0.737 ± 0.017	1.474AsnArg: 1.474 ± 0.019	1.245AsnSer: 1.245 ± 0.021	1.424AsnThr: 1.424 ± 0.027	1.666AsnVal: 1.666 ± 0.028	0.386AsnTrp: 0.386 ± 0.011	0.547AsnTyr: 0.547 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.757ProAla: 7.757 ± 0.056	0.421ProCys: 0.421 ± 0.012	4.31ProAsp: 4.31 ± 0.039	3.442ProGlu: 3.442 ± 0.037	1.595ProPhe: 1.595 ± 0.02	5.801ProGly: 5.801 ± 0.041	1.243ProHis: 1.243 ± 0.023	1.756ProIle: 1.756 ± 0.024	1.191ProLys: 1.191 ± 0.021	5.07ProLeu: 5.07 ± 0.05	1.132ProMet: 1.132 ± 0.018	1.284ProAsn: 1.284 ± 0.023	3.32ProPro: 3.32 ± 0.048	1.74ProGln: 1.74 ± 0.026	3.554ProArg: 3.554 ± 0.039	3.447ProSer: 3.447 ± 0.036	3.662ProThr: 3.662 ± 0.034	5.318ProVal: 5.318 ± 0.045	0.899ProTrp: 0.899 ± 0.018	1.151ProTyr: 1.151 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.15GlnAla: 4.15 ± 0.041	0.234GlnCys: 0.234 ± 0.008	1.43GlnAsp: 1.43 ± 0.018	1.204GlnGlu: 1.204 ± 0.022	0.918GlnPhe: 0.918 ± 0.017	2.216GlnGly: 2.216 ± 0.028	0.882GlnHis: 0.882 ± 0.018	1.195GlnIle: 1.195 ± 0.019	0.544GlnLys: 0.544 ± 0.014	3.856GlnLeu: 3.856 ± 0.039	0.525GlnMet: 0.525 ± 0.012	0.656GlnAsn: 0.656 ± 0.016	1.994GlnPro: 1.994 ± 0.029	1.553GlnGln: 1.553 ± 0.03	2.716GlnArg: 2.716 ± 0.032	1.459GlnSer: 1.459 ± 0.023	1.566GlnThr: 1.566 ± 0.027	2.834GlnVal: 2.834 ± 0.033	0.618GlnTrp: 0.618 ± 0.016	0.673GlnTyr: 0.673 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	8.64ArgAla: 8.64 ± 0.071	0.715ArgCys: 0.715 ± 0.017	4.192ArgAsp: 4.192 ± 0.04	3.993ArgGlu: 3.993 ± 0.043	2.407ArgPhe: 2.407 ± 0.026	5.325ArgGly: 5.325 ± 0.05	2.133ArgHis: 2.133 ± 0.032	3.102ArgIle: 3.102 ± 0.035	1.618ArgLys: 1.618 ± 0.023	8.517ArgLeu: 8.517 ± 0.069	1.726ArgMet: 1.726 ± 0.023	1.525ArgAsn: 1.525 ± 0.024	4.725ArgPro: 4.725 ± 0.043	2.62ArgGln: 2.62 ± 0.035	7.667ArgArg: 7.667 ± 0.083	4.093ArgSer: 4.093 ± 0.042	4.561ArgThr: 4.561 ± 0.04	5.795ArgVal: 5.795 ± 0.054	1.461ArgTrp: 1.461 ± 0.024	1.762ArgTyr: 1.762 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.705SerAla: 6.705 ± 0.052	0.526SerCys: 0.526 ± 0.014	2.99SerAsp: 2.99 ± 0.037	2.282SerGlu: 2.282 ± 0.026	1.661SerPhe: 1.661 ± 0.022	5.773SerGly: 5.773 ± 0.056	1.106SerHis: 1.106 ± 0.02	1.803SerIle: 1.803 ± 0.028	1.087SerLys: 1.087 ± 0.02	5.068SerLeu: 5.068 ± 0.04	1.226SerMet: 1.226 ± 0.018	1.155SerAsn: 1.155 ± 0.021	3.241SerPro: 3.241 ± 0.035	1.523SerGln: 1.523 ± 0.024	3.859SerArg: 3.859 ± 0.04	3.287SerSer: 3.287 ± 0.035	3.851SerThr: 3.851 ± 0.047	4.729SerVal: 4.729 ± 0.043	1.095SerTrp: 1.095 ± 0.018	1.353SerTyr: 1.353 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.392ThrAla: 8.392 ± 0.059	0.51ThrCys: 0.51 ± 0.011	3.639ThrAsp: 3.639 ± 0.043	2.975ThrGlu: 2.975 ± 0.032	1.745ThrPhe: 1.745 ± 0.028	6.247ThrGly: 6.247 ± 0.047	1.155ThrHis: 1.155 ± 0.019	2.212ThrIle: 2.212 ± 0.029	1.287ThrLys: 1.287 ± 0.021	5.606ThrLeu: 5.606 ± 0.039	1.117ThrMet: 1.117 ± 0.016	1.322ThrAsn: 1.322 ± 0.026	4.047ThrPro: 4.047 ± 0.044	1.588ThrGln: 1.588 ± 0.025	3.739ThrArg: 3.739 ± 0.037	3.636ThrSer: 3.636 ± 0.049	4.506ThrThr: 4.506 ± 0.075	6.406ThrVal: 6.406 ± 0.05	1.048ThrTrp: 1.048 ± 0.019	1.302ThrTyr: 1.302 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.303ValAla: 11.303 ± 0.075	0.725ValCys: 0.725 ± 0.012	6.089ValAsp: 6.089 ± 0.044	4.67ValGlu: 4.67 ± 0.049	2.635ValPhe: 2.635 ± 0.03	7.105ValGly: 7.105 ± 0.061	2.081ValHis: 2.081 ± 0.029	3.31ValIle: 3.31 ± 0.033	1.657ValLys: 1.657 ± 0.028	10.143ValLeu: 10.143 ± 0.072	1.378ValMet: 1.378 ± 0.022	2.057ValAsn: 2.057 ± 0.028	4.998ValPro: 4.998 ± 0.042	2.431ValGln: 2.431 ± 0.031	6.585ValArg: 6.585 ± 0.049	4.847ValSer: 4.847 ± 0.039	5.939ValThr: 5.939 ± 0.046	8.729ValVal: 8.729 ± 0.069	1.165ValTrp: 1.165 ± 0.021	1.532ValTyr: 1.532 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.666TrpAla: 1.666 ± 0.025	0.166TrpCys: 0.166 ± 0.007	0.853TrpAsp: 0.853 ± 0.02	0.634TrpGlu: 0.634 ± 0.012	0.553TrpPhe: 0.553 ± 0.014	1.074TrpGly: 1.074 ± 0.018	0.456TrpHis: 0.456 ± 0.012	0.604TrpIle: 0.604 ± 0.015	0.278TrpLys: 0.278 ± 0.009	1.989TrpLeu: 1.989 ± 0.03	0.31TrpMet: 0.31 ± 0.009	0.474TrpAsn: 0.474 ± 0.013	0.942TrpPro: 0.942 ± 0.017	0.753TrpGln: 0.753 ± 0.016	1.424TrpArg: 1.424 ± 0.023	1.091TrpSer: 1.091 ± 0.02	1.184TrpThr: 1.184 ± 0.021	1.035TrpVal: 1.035 ± 0.019	0.376TrpTrp: 0.376 ± 0.011	0.35TrpTyr: 0.35 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.405TyrAla: 2.405 ± 0.029	0.188TyrCys: 0.188 ± 0.007	1.441TyrAsp: 1.441 ± 0.033	0.996TyrGlu: 0.996 ± 0.018	0.69TyrPhe: 0.69 ± 0.016	2.016TyrGly: 2.016 ± 0.025	0.489TyrHis: 0.489 ± 0.014	0.489TyrIle: 0.489 ± 0.013	0.348TyrLys: 0.348 ± 0.011	2.261TyrLeu: 2.261 ± 0.029	0.247TyrMet: 0.247 ± 0.01	0.506TyrAsn: 0.506 ± 0.015	1.103TyrPro: 1.103 ± 0.019	0.78TyrGln: 0.78 ± 0.016	1.815TyrArg: 1.815 ± 0.028	1.124TyrSer: 1.124 ± 0.02	1.224TyrThr: 1.224 ± 0.022	1.701TyrVal: 1.701 ± 0.023	0.398TyrTrp: 0.398 ± 0.011	0.514TyrTyr: 0.514 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10148 proteins (3322608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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