Amino acid dipepetide frequency for Streptococcus satellite phage Javan731

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.964AlaAla: 1.964 ± 1.077
1.309AlaCys: 1.309 ± 0.856
3.273AlaAsp: 3.273 ± 0.796
6.874AlaGlu: 6.874 ± 1.879
3.601AlaPhe: 3.601 ± 0.922
2.619AlaGly: 2.619 ± 0.96
0.655AlaHis: 0.655 ± 0.399
3.601AlaIle: 3.601 ± 1.029
5.565AlaLys: 5.565 ± 1.082
4.583AlaLeu: 4.583 ± 1.063
2.619AlaMet: 2.619 ± 1.017
1.964AlaAsn: 1.964 ± 0.835
1.309AlaPro: 1.309 ± 0.573
2.619AlaGln: 2.619 ± 0.691
2.946AlaArg: 2.946 ± 0.843
2.619AlaSer: 2.619 ± 0.805
2.946AlaThr: 2.946 ± 0.928
3.601AlaVal: 3.601 ± 0.906
0.0AlaTrp: 0.0 ± 0.0
2.619AlaTyr: 2.619 ± 1.284
0.0AlaXaa: 0.0 ± 0.0
Cys
0.655CysAla: 0.655 ± 0.41
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.327CysGlu: 0.327 ± 0.262
0.655CysPhe: 0.655 ± 0.482
0.327CysGly: 0.327 ± 0.337
0.655CysHis: 0.655 ± 0.378
0.0CysIle: 0.0 ± 0.0
0.655CysLys: 0.655 ± 0.436
1.309CysLeu: 1.309 ± 0.573
0.327CysMet: 0.327 ± 0.346
0.655CysAsn: 0.655 ± 0.494
0.327CysPro: 0.327 ± 0.262
1.637CysGln: 1.637 ± 1.034
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.327CysThr: 0.327 ± 0.356
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.946AspAla: 2.946 ± 0.749
0.327AspCys: 0.327 ± 0.262
4.91AspAsp: 4.91 ± 1.277
4.583AspGlu: 4.583 ± 1.194
2.291AspPhe: 2.291 ± 0.59
2.291AspGly: 2.291 ± 0.85
0.0AspHis: 0.0 ± 0.0
7.856AspIle: 7.856 ± 1.715
4.255AspLys: 4.255 ± 0.785
6.547AspLeu: 6.547 ± 1.846
0.982AspMet: 0.982 ± 0.525
3.928AspAsn: 3.928 ± 0.863
0.655AspPro: 0.655 ± 0.378
1.309AspGln: 1.309 ± 0.498
2.291AspArg: 2.291 ± 0.736
0.982AspSer: 0.982 ± 0.432
2.619AspThr: 2.619 ± 1.04
1.637AspVal: 1.637 ± 0.476
0.327AspTrp: 0.327 ± 0.302
3.601AspTyr: 3.601 ± 1.102
0.0AspXaa: 0.0 ± 0.0
Glu
4.583GluAla: 4.583 ± 1.32
0.982GluCys: 0.982 ± 0.468
2.946GluAsp: 2.946 ± 1.39
4.91GluGlu: 4.91 ± 1.622
1.964GluPhe: 1.964 ± 0.816
1.309GluGly: 1.309 ± 0.502
0.982GluHis: 0.982 ± 0.514
6.219GluIle: 6.219 ± 1.413
8.838GluLys: 8.838 ± 1.869
12.111GluLeu: 12.111 ± 2.51
3.273GluMet: 3.273 ± 1.0
6.547GluAsn: 6.547 ± 1.352
3.273GluPro: 3.273 ± 1.051
3.273GluGln: 3.273 ± 0.66
3.928GluArg: 3.928 ± 1.302
4.583GluSer: 4.583 ± 1.359
2.619GluThr: 2.619 ± 0.723
4.583GluVal: 4.583 ± 1.453
0.327GluTrp: 0.327 ± 0.302
4.583GluTyr: 4.583 ± 1.044
0.0GluXaa: 0.0 ± 0.0
Phe
0.655PheAla: 0.655 ± 0.482
0.327PheCys: 0.327 ± 0.356
3.273PheAsp: 3.273 ± 1.099
2.619PheGlu: 2.619 ± 0.98
2.946PhePhe: 2.946 ± 1.077
2.291PheGly: 2.291 ± 0.96
1.309PheHis: 1.309 ± 0.502
3.273PheIle: 3.273 ± 1.095
3.273PheLys: 3.273 ± 1.11
2.946PheLeu: 2.946 ± 0.908
0.655PheMet: 0.655 ± 0.49
3.928PheAsn: 3.928 ± 1.011
1.309PhePro: 1.309 ± 0.571
0.655PheGln: 0.655 ± 0.381
1.309PheArg: 1.309 ± 0.678
3.601PheSer: 3.601 ± 0.862
1.637PheThr: 1.637 ± 0.616
2.619PheVal: 2.619 ± 1.23
0.327PheTrp: 0.327 ± 0.281
2.291PheTyr: 2.291 ± 0.617
0.0PheXaa: 0.0 ± 0.0
Gly
2.291GlyAla: 2.291 ± 1.255
0.327GlyCys: 0.327 ± 0.31
3.273GlyAsp: 3.273 ± 0.823
2.291GlyGlu: 2.291 ± 0.649
1.637GlyPhe: 1.637 ± 0.865
0.982GlyGly: 0.982 ± 0.477
0.655GlyHis: 0.655 ± 0.409
5.237GlyIle: 5.237 ± 1.253
3.601GlyLys: 3.601 ± 1.259
4.91GlyLeu: 4.91 ± 1.394
1.309GlyMet: 1.309 ± 0.541
1.637GlyAsn: 1.637 ± 0.665
0.0GlyPro: 0.0 ± 0.0
2.946GlyGln: 2.946 ± 1.332
2.619GlyArg: 2.619 ± 1.081
2.619GlySer: 2.619 ± 0.9
1.964GlyThr: 1.964 ± 0.848
4.255GlyVal: 4.255 ± 1.196
1.309GlyTrp: 1.309 ± 0.84
3.928GlyTyr: 3.928 ± 1.307
0.0GlyXaa: 0.0 ± 0.0
His
1.637HisAla: 1.637 ± 0.677
0.0HisCys: 0.0 ± 0.0
0.327HisAsp: 0.327 ± 0.35
2.619HisGlu: 2.619 ± 0.899
0.655HisPhe: 0.655 ± 0.477
1.637HisGly: 1.637 ± 0.61
0.655HisHis: 0.655 ± 0.453
0.0HisIle: 0.0 ± 0.0
1.637HisLys: 1.637 ± 0.588
1.637HisLeu: 1.637 ± 1.021
0.327HisMet: 0.327 ± 0.371
1.309HisAsn: 1.309 ± 0.711
1.309HisPro: 1.309 ± 0.607
0.327HisGln: 0.327 ± 0.295
1.309HisArg: 1.309 ± 0.56
0.327HisSer: 0.327 ± 0.262
1.309HisThr: 1.309 ± 0.661
0.655HisVal: 0.655 ± 0.443
0.0HisTrp: 0.0 ± 0.0
1.309HisTyr: 1.309 ± 0.863
0.0HisXaa: 0.0 ± 0.0
Ile
5.237IleAla: 5.237 ± 1.55
0.327IleCys: 0.327 ± 0.374
2.946IleAsp: 2.946 ± 1.138
6.219IleGlu: 6.219 ± 1.278
2.619IlePhe: 2.619 ± 0.791
4.583IleGly: 4.583 ± 1.065
1.309IleHis: 1.309 ± 0.603
5.237IleIle: 5.237 ± 1.31
9.82IleLys: 9.82 ± 1.591
6.219IleLeu: 6.219 ± 1.407
1.637IleMet: 1.637 ± 0.613
2.619IleAsn: 2.619 ± 0.742
3.273IlePro: 3.273 ± 0.972
4.255IleGln: 4.255 ± 1.238
2.946IleArg: 2.946 ± 0.793
4.255IleSer: 4.255 ± 1.081
4.91IleThr: 4.91 ± 0.948
4.583IleVal: 4.583 ± 0.792
0.982IleTrp: 0.982 ± 0.496
2.291IleTyr: 2.291 ± 0.83
0.0IleXaa: 0.0 ± 0.0
Lys
7.529LysAla: 7.529 ± 1.095
0.655LysCys: 0.655 ± 0.41
5.565LysAsp: 5.565 ± 1.363
8.838LysGlu: 8.838 ± 1.311
2.291LysPhe: 2.291 ± 0.85
5.892LysGly: 5.892 ± 1.399
2.619LysHis: 2.619 ± 0.874
6.219LysIle: 6.219 ± 1.11
7.856LysLys: 7.856 ± 2.135
7.529LysLeu: 7.529 ± 1.624
3.601LysMet: 3.601 ± 1.042
5.892LysAsn: 5.892 ± 0.921
2.619LysPro: 2.619 ± 1.137
3.928LysGln: 3.928 ± 1.276
4.255LysArg: 4.255 ± 0.97
6.547LysSer: 6.547 ± 1.449
5.892LysThr: 5.892 ± 2.031
3.273LysVal: 3.273 ± 0.839
1.964LysTrp: 1.964 ± 0.842
3.273LysTyr: 3.273 ± 0.961
0.0LysXaa: 0.0 ± 0.0
Leu
6.547LeuAla: 6.547 ± 0.936
0.327LeuCys: 0.327 ± 0.31
7.201LeuAsp: 7.201 ± 1.915
9.82LeuGlu: 9.82 ± 1.98
4.91LeuPhe: 4.91 ± 1.635
5.892LeuGly: 5.892 ± 1.045
2.291LeuHis: 2.291 ± 0.935
6.219LeuIle: 6.219 ± 1.199
10.475LeuLys: 10.475 ± 1.676
8.183LeuLeu: 8.183 ± 1.487
1.309LeuMet: 1.309 ± 0.594
6.874LeuAsn: 6.874 ± 1.417
4.255LeuPro: 4.255 ± 1.029
3.928LeuGln: 3.928 ± 1.257
4.583LeuArg: 4.583 ± 1.012
3.928LeuSer: 3.928 ± 1.05
7.529LeuThr: 7.529 ± 1.735
2.946LeuVal: 2.946 ± 0.762
0.655LeuTrp: 0.655 ± 0.496
4.583LeuTyr: 4.583 ± 1.145
0.0LeuXaa: 0.0 ± 0.0
Met
0.982MetAla: 0.982 ± 0.573
0.0MetCys: 0.0 ± 0.0
1.964MetAsp: 1.964 ± 0.873
3.273MetGlu: 3.273 ± 0.815
1.309MetPhe: 1.309 ± 0.568
1.309MetGly: 1.309 ± 0.592
0.327MetHis: 0.327 ± 0.295
0.655MetIle: 0.655 ± 0.439
0.982MetLys: 0.982 ± 0.497
1.637MetLeu: 1.637 ± 0.77
1.309MetMet: 1.309 ± 0.863
1.964MetAsn: 1.964 ± 0.666
0.982MetPro: 0.982 ± 0.557
0.655MetGln: 0.655 ± 0.398
2.291MetArg: 2.291 ± 0.738
0.982MetSer: 0.982 ± 0.597
3.273MetThr: 3.273 ± 1.211
0.327MetVal: 0.327 ± 0.305
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.291AsnAla: 2.291 ± 0.621
0.327AsnCys: 0.327 ± 0.262
3.601AsnAsp: 3.601 ± 1.197
3.273AsnGlu: 3.273 ± 0.929
1.309AsnPhe: 1.309 ± 0.772
4.91AsnGly: 4.91 ± 1.348
1.637AsnHis: 1.637 ± 0.831
1.964AsnIle: 1.964 ± 0.802
8.838AsnLys: 8.838 ± 2.0
5.565AsnLeu: 5.565 ± 1.149
1.964AsnMet: 1.964 ± 0.866
1.964AsnAsn: 1.964 ± 0.686
2.291AsnPro: 2.291 ± 0.73
2.619AsnGln: 2.619 ± 0.84
2.619AsnArg: 2.619 ± 0.644
3.601AsnSer: 3.601 ± 1.105
2.291AsnThr: 2.291 ± 0.891
2.291AsnVal: 2.291 ± 0.872
0.655AsnTrp: 0.655 ± 0.335
1.637AsnTyr: 1.637 ± 0.651
0.0AsnXaa: 0.0 ± 0.0
Pro
2.619ProAla: 2.619 ± 0.966
0.0ProCys: 0.0 ± 0.0
2.291ProAsp: 2.291 ± 0.628
3.928ProGlu: 3.928 ± 1.067
1.309ProPhe: 1.309 ± 0.507
0.327ProGly: 0.327 ± 0.295
0.327ProHis: 0.327 ± 0.281
0.982ProIle: 0.982 ± 0.489
2.291ProLys: 2.291 ± 0.94
2.946ProLeu: 2.946 ± 0.915
0.0ProMet: 0.0 ± 0.0
2.619ProAsn: 2.619 ± 0.767
1.309ProPro: 1.309 ± 0.785
0.655ProGln: 0.655 ± 0.342
1.964ProArg: 1.964 ± 0.74
1.964ProSer: 1.964 ± 1.082
2.291ProThr: 2.291 ± 1.099
1.964ProVal: 1.964 ± 0.666
0.0ProTrp: 0.0 ± 0.0
2.291ProTyr: 2.291 ± 0.788
0.0ProXaa: 0.0 ± 0.0
Gln
4.583GlnAla: 4.583 ± 1.426
0.655GlnCys: 0.655 ± 0.463
2.619GlnAsp: 2.619 ± 1.099
2.946GlnGlu: 2.946 ± 0.768
1.309GlnPhe: 1.309 ± 0.712
2.291GlnGly: 2.291 ± 0.724
0.982GlnHis: 0.982 ± 0.478
3.273GlnIle: 3.273 ± 1.108
2.619GlnLys: 2.619 ± 0.852
6.547GlnLeu: 6.547 ± 1.259
1.309GlnMet: 1.309 ± 0.645
1.309GlnAsn: 1.309 ± 0.465
0.655GlnPro: 0.655 ± 0.404
1.637GlnGln: 1.637 ± 0.682
1.637GlnArg: 1.637 ± 0.61
1.309GlnSer: 1.309 ± 0.601
1.637GlnThr: 1.637 ± 0.769
3.601GlnVal: 3.601 ± 1.025
0.327GlnTrp: 0.327 ± 0.262
0.655GlnTyr: 0.655 ± 0.621
0.0GlnXaa: 0.0 ± 0.0
Arg
3.273ArgAla: 3.273 ± 1.351
0.327ArgCys: 0.327 ± 0.337
2.291ArgAsp: 2.291 ± 0.803
4.583ArgGlu: 4.583 ± 1.054
2.619ArgPhe: 2.619 ± 0.894
0.982ArgGly: 0.982 ± 0.533
0.655ArgHis: 0.655 ± 0.478
3.928ArgIle: 3.928 ± 1.128
4.91ArgLys: 4.91 ± 1.432
5.892ArgLeu: 5.892 ± 1.396
0.655ArgMet: 0.655 ± 0.404
1.637ArgAsn: 1.637 ± 0.966
0.655ArgPro: 0.655 ± 0.562
3.928ArgGln: 3.928 ± 1.003
2.946ArgArg: 2.946 ± 0.694
1.964ArgSer: 1.964 ± 0.615
2.291ArgThr: 2.291 ± 0.782
3.273ArgVal: 3.273 ± 0.873
0.327ArgTrp: 0.327 ± 0.356
1.964ArgTyr: 1.964 ± 0.839
0.0ArgXaa: 0.0 ± 0.0
Ser
2.619SerAla: 2.619 ± 1.055
0.327SerCys: 0.327 ± 0.295
2.291SerAsp: 2.291 ± 0.809
3.601SerGlu: 3.601 ± 1.265
1.309SerPhe: 1.309 ± 0.593
1.964SerGly: 1.964 ± 0.837
0.655SerHis: 0.655 ± 0.386
4.91SerIle: 4.91 ± 0.962
5.565SerLys: 5.565 ± 1.395
5.565SerLeu: 5.565 ± 1.27
1.309SerMet: 1.309 ± 0.492
3.601SerAsn: 3.601 ± 0.956
1.309SerPro: 1.309 ± 0.582
1.637SerGln: 1.637 ± 0.646
3.601SerArg: 3.601 ± 0.945
3.273SerSer: 3.273 ± 0.911
2.619SerThr: 2.619 ± 0.71
2.619SerVal: 2.619 ± 0.913
0.655SerTrp: 0.655 ± 0.443
1.964SerTyr: 1.964 ± 0.632
0.0SerXaa: 0.0 ± 0.0
Thr
1.309ThrAla: 1.309 ± 0.617
0.0ThrCys: 0.0 ± 0.0
2.291ThrAsp: 2.291 ± 0.774
3.601ThrGlu: 3.601 ± 0.709
1.964ThrPhe: 1.964 ± 0.813
3.601ThrGly: 3.601 ± 0.81
1.964ThrHis: 1.964 ± 0.993
6.219ThrIle: 6.219 ± 1.081
3.928ThrLys: 3.928 ± 0.978
5.237ThrLeu: 5.237 ± 1.062
0.327ThrMet: 0.327 ± 0.262
0.655ThrAsn: 0.655 ± 0.453
3.273ThrPro: 3.273 ± 0.824
2.946ThrGln: 2.946 ± 1.35
3.273ThrArg: 3.273 ± 0.779
2.619ThrSer: 2.619 ± 0.511
4.583ThrThr: 4.583 ± 0.996
4.91ThrVal: 4.91 ± 1.855
0.327ThrTrp: 0.327 ± 0.353
3.928ThrTyr: 3.928 ± 1.484
0.0ThrXaa: 0.0 ± 0.0
Val
3.273ValAla: 3.273 ± 1.215
0.327ValCys: 0.327 ± 0.281
1.964ValAsp: 1.964 ± 0.94
4.91ValGlu: 4.91 ± 1.252
2.619ValPhe: 2.619 ± 0.977
3.273ValGly: 3.273 ± 1.349
0.0ValHis: 0.0 ± 0.0
4.91ValIle: 4.91 ± 1.015
4.255ValLys: 4.255 ± 0.924
4.255ValLeu: 4.255 ± 0.987
0.655ValMet: 0.655 ± 0.496
2.946ValAsn: 2.946 ± 0.91
1.964ValPro: 1.964 ± 0.889
1.637ValGln: 1.637 ± 0.813
2.619ValArg: 2.619 ± 0.987
3.601ValSer: 3.601 ± 1.148
3.601ValThr: 3.601 ± 0.943
2.291ValVal: 2.291 ± 1.12
0.655ValTrp: 0.655 ± 0.509
1.964ValTyr: 1.964 ± 0.984
0.0ValXaa: 0.0 ± 0.0
Trp
0.327TrpAla: 0.327 ± 0.262
0.327TrpCys: 0.327 ± 0.302
0.0TrpAsp: 0.0 ± 0.0
0.982TrpGlu: 0.982 ± 0.597
0.327TrpPhe: 0.327 ± 0.371
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.309TrpIle: 1.309 ± 0.671
1.637TrpLys: 1.637 ± 0.699
1.964TrpLeu: 1.964 ± 0.7
0.0TrpMet: 0.0 ± 0.0
0.327TrpAsn: 0.327 ± 0.356
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.327TrpSer: 0.327 ± 0.262
0.327TrpThr: 0.327 ± 0.345
0.655TrpVal: 0.655 ± 0.521
0.0TrpTrp: 0.0 ± 0.0
0.327TrpTyr: 0.327 ± 0.371
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.964TyrAla: 1.964 ± 0.58
0.982TyrCys: 0.982 ± 0.497
1.309TyrAsp: 1.309 ± 0.43
1.964TyrGlu: 1.964 ± 0.636
3.601TyrPhe: 3.601 ± 1.227
1.309TyrGly: 1.309 ± 0.616
1.309TyrHis: 1.309 ± 0.684
4.255TyrIle: 4.255 ± 1.003
5.237TyrLys: 5.237 ± 1.703
6.874TyrLeu: 6.874 ± 1.602
0.327TyrMet: 0.327 ± 0.305
3.273TyrAsn: 3.273 ± 1.024
1.309TyrPro: 1.309 ± 0.571
1.309TyrGln: 1.309 ± 0.633
1.964TyrArg: 1.964 ± 0.918
2.291TyrSer: 2.291 ± 0.849
2.291TyrThr: 2.291 ± 0.643
1.637TyrVal: 1.637 ± 0.855
0.0TyrTrp: 0.0 ± 0.0
0.655TyrTyr: 0.655 ± 0.404
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3056 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski