Amino acid dipepetide frequency for Fibrella sp. ES10-3-2-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.185AlaAla: 8.185 ± 0.093
0.753AlaCys: 0.753 ± 0.022
5.683AlaAsp: 5.683 ± 0.062
4.64AlaGlu: 4.64 ± 0.069
3.669AlaPhe: 3.669 ± 0.052
7.25AlaGly: 7.25 ± 0.083
1.443AlaHis: 1.443 ± 0.036
5.193AlaIle: 5.193 ± 0.057
3.901AlaLys: 3.901 ± 0.056
8.676AlaLeu: 8.676 ± 0.086
2.017AlaMet: 2.017 ± 0.037
4.099AlaAsn: 4.099 ± 0.06
3.556AlaPro: 3.556 ± 0.059
4.006AlaGln: 4.006 ± 0.051
4.3AlaArg: 4.3 ± 0.054
5.468AlaSer: 5.468 ± 0.074
6.446AlaThr: 6.446 ± 0.123
6.161AlaVal: 6.161 ± 0.071
1.049AlaTrp: 1.049 ± 0.028
3.172AlaTyr: 3.172 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.592CysAla: 0.592 ± 0.023
0.109CysCys: 0.109 ± 0.008
0.346CysAsp: 0.346 ± 0.016
0.337CysGlu: 0.337 ± 0.015
0.353CysPhe: 0.353 ± 0.015
0.568CysGly: 0.568 ± 0.021
0.186CysHis: 0.186 ± 0.012
0.437CysIle: 0.437 ± 0.014
0.269CysLys: 0.269 ± 0.012
0.834CysLeu: 0.834 ± 0.021
0.147CysMet: 0.147 ± 0.01
0.263CysAsn: 0.263 ± 0.013
0.364CysPro: 0.364 ± 0.016
0.36CysGln: 0.36 ± 0.015
0.406CysArg: 0.406 ± 0.018
0.48CysSer: 0.48 ± 0.023
0.48CysThr: 0.48 ± 0.025
0.501CysVal: 0.501 ± 0.018
0.119CysTrp: 0.119 ± 0.008
0.264CysTyr: 0.264 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.542AspAla: 4.542 ± 0.055
0.366AspCys: 0.366 ± 0.014
2.672AspAsp: 2.672 ± 0.047
3.274AspGlu: 3.274 ± 0.046
2.514AspPhe: 2.514 ± 0.038
4.152AspGly: 4.152 ± 0.063
0.918AspHis: 0.918 ± 0.023
2.79AspIle: 2.79 ± 0.041
2.649AspLys: 2.649 ± 0.045
5.401AspLeu: 5.401 ± 0.061
1.12AspMet: 1.12 ± 0.025
2.284AspAsn: 2.284 ± 0.041
2.532AspPro: 2.532 ± 0.039
2.317AspGln: 2.317 ± 0.039
3.072AspArg: 3.072 ± 0.046
2.831AspSer: 2.831 ± 0.044
2.877AspThr: 2.877 ± 0.04
3.914AspVal: 3.914 ± 0.051
0.911AspTrp: 0.911 ± 0.022
2.29AspTyr: 2.29 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
4.854GluAla: 4.854 ± 0.067
0.253GluCys: 0.253 ± 0.012
1.883GluAsp: 1.883 ± 0.036
2.45GluGlu: 2.45 ± 0.052
1.901GluPhe: 1.901 ± 0.032
3.189GluGly: 3.189 ± 0.049
0.896GluHis: 0.896 ± 0.024
2.493GluIle: 2.493 ± 0.041
2.797GluLys: 2.797 ± 0.052
5.193GluLeu: 5.193 ± 0.069
1.121GluMet: 1.121 ± 0.024
1.998GluAsn: 1.998 ± 0.036
1.977GluPro: 1.977 ± 0.034
2.603GluGln: 2.603 ± 0.042
3.087GluArg: 3.087 ± 0.051
2.639GluSer: 2.639 ± 0.043
3.071GluThr: 3.071 ± 0.044
3.505GluVal: 3.505 ± 0.055
0.641GluTrp: 0.641 ± 0.02
1.611GluTyr: 1.611 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.544PheAla: 3.544 ± 0.043
0.392PheCys: 0.392 ± 0.017
2.778PheAsp: 2.778 ± 0.034
1.95PheGlu: 1.95 ± 0.034
1.993PhePhe: 1.993 ± 0.044
3.439PheGly: 3.439 ± 0.052
0.686PheHis: 0.686 ± 0.022
2.283PheIle: 2.283 ± 0.038
1.666PheLys: 1.666 ± 0.03
3.889PheLeu: 3.889 ± 0.058
1.016PheMet: 1.016 ± 0.027
2.009PheAsn: 2.009 ± 0.039
1.708PhePro: 1.708 ± 0.034
1.572PheGln: 1.572 ± 0.035
2.392PheArg: 2.392 ± 0.04
3.091PheSer: 3.091 ± 0.047
3.118PheThr: 3.118 ± 0.055
2.984PheVal: 2.984 ± 0.04
0.652PheTrp: 0.652 ± 0.02
1.657PheTyr: 1.657 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.494GlyAla: 5.494 ± 0.057
0.704GlyCys: 0.704 ± 0.028
3.598GlyAsp: 3.598 ± 0.051
3.341GlyGlu: 3.341 ± 0.045
3.38GlyPhe: 3.38 ± 0.047
5.712GlyGly: 5.712 ± 0.087
1.331GlyHis: 1.331 ± 0.034
4.484GlyIle: 4.484 ± 0.053
4.096GlyLys: 4.096 ± 0.058
7.602GlyLeu: 7.602 ± 0.084
1.712GlyMet: 1.712 ± 0.034
3.384GlyAsn: 3.384 ± 0.061
2.418GlyPro: 2.418 ± 0.047
3.661GlyGln: 3.661 ± 0.051
3.885GlyArg: 3.885 ± 0.049
4.823GlySer: 4.823 ± 0.08
5.634GlyThr: 5.634 ± 0.112
5.243GlyVal: 5.243 ± 0.061
1.207GlyTrp: 1.207 ± 0.03
3.117GlyTyr: 3.117 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.252HisAla: 1.252 ± 0.029
0.183HisCys: 0.183 ± 0.01
0.908HisAsp: 0.908 ± 0.027
0.959HisGlu: 0.959 ± 0.029
0.906HisPhe: 0.906 ± 0.023
1.188HisGly: 1.188 ± 0.026
0.456HisHis: 0.456 ± 0.016
0.999HisIle: 0.999 ± 0.023
0.669HisLys: 0.669 ± 0.019
1.761HisLeu: 1.761 ± 0.033
0.338HisMet: 0.338 ± 0.014
0.704HisAsn: 0.704 ± 0.019
1.119HisPro: 1.119 ± 0.027
0.816HisGln: 0.816 ± 0.023
1.021HisArg: 1.021 ± 0.028
0.895HisSer: 0.895 ± 0.024
1.117HisThr: 1.117 ± 0.023
1.101HisVal: 1.101 ± 0.024
0.282HisTrp: 0.282 ± 0.012
0.769HisTyr: 0.769 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.95IleAla: 4.95 ± 0.068
0.515IleCys: 0.515 ± 0.019
3.793IleAsp: 3.793 ± 0.045
2.984IleGlu: 2.984 ± 0.047
1.855IlePhe: 1.855 ± 0.034
4.55IleGly: 4.55 ± 0.062
0.967IleHis: 0.967 ± 0.025
2.663IleIle: 2.663 ± 0.048
2.389IleLys: 2.389 ± 0.039
4.309IleLeu: 4.309 ± 0.052
1.0IleMet: 1.0 ± 0.026
2.76IleAsn: 2.76 ± 0.045
2.699IlePro: 2.699 ± 0.039
2.162IleGln: 2.162 ± 0.032
3.464IleArg: 3.464 ± 0.045
3.586IleSer: 3.586 ± 0.05
3.801IleThr: 3.801 ± 0.048
3.539IleVal: 3.539 ± 0.055
0.67IleTrp: 0.67 ± 0.018
1.784IleTyr: 1.784 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.551LysAla: 4.551 ± 0.071
0.174LysCys: 0.174 ± 0.01
2.162LysAsp: 2.162 ± 0.042
2.391LysGlu: 2.391 ± 0.05
1.395LysPhe: 1.395 ± 0.029
3.217LysGly: 3.217 ± 0.048
0.759LysHis: 0.759 ± 0.019
2.312LysIle: 2.312 ± 0.038
2.634LysLys: 2.634 ± 0.045
4.55LysLeu: 4.55 ± 0.06
1.174LysMet: 1.174 ± 0.03
2.027LysAsn: 2.027 ± 0.034
2.75LysPro: 2.75 ± 0.043
2.274LysGln: 2.274 ± 0.039
2.524LysArg: 2.524 ± 0.043
2.581LysSer: 2.581 ± 0.039
3.201LysThr: 3.201 ± 0.045
2.935LysVal: 2.935 ± 0.049
0.502LysTrp: 0.502 ± 0.016
1.481LysTyr: 1.481 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
9.587LeuAla: 9.587 ± 0.091
0.778LeuCys: 0.778 ± 0.023
4.989LeuAsp: 4.989 ± 0.052
3.965LeuGlu: 3.965 ± 0.055
4.57LeuPhe: 4.57 ± 0.056
6.665LeuGly: 6.665 ± 0.075
1.76LeuHis: 1.76 ± 0.031
5.694LeuIle: 5.694 ± 0.066
4.524LeuLys: 4.524 ± 0.066
11.268LeuLeu: 11.268 ± 0.124
2.179LeuMet: 2.179 ± 0.035
4.56LeuAsn: 4.56 ± 0.057
5.319LeuPro: 5.319 ± 0.061
3.555LeuGln: 3.555 ± 0.042
5.363LeuArg: 5.363 ± 0.057
6.922LeuSer: 6.922 ± 0.057
8.138LeuThr: 8.138 ± 0.086
6.846LeuVal: 6.846 ± 0.072
1.098LeuTrp: 1.098 ± 0.027
3.331LeuTyr: 3.331 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.237MetAla: 2.237 ± 0.042
0.112MetCys: 0.112 ± 0.008
0.92MetAsp: 0.92 ± 0.025
0.911MetGlu: 0.911 ± 0.026
0.591MetPhe: 0.591 ± 0.018
1.591MetGly: 1.591 ± 0.029
0.447MetHis: 0.447 ± 0.018
1.039MetIle: 1.039 ± 0.026
1.363MetLys: 1.363 ± 0.03
2.196MetLeu: 2.196 ± 0.036
0.528MetMet: 0.528 ± 0.018
1.177MetAsn: 1.177 ± 0.023
1.204MetPro: 1.204 ± 0.025
0.946MetGln: 0.946 ± 0.022
1.198MetArg: 1.198 ± 0.025
1.264MetSer: 1.264 ± 0.03
1.499MetThr: 1.499 ± 0.028
1.327MetVal: 1.327 ± 0.03
0.19MetTrp: 0.19 ± 0.011
0.579MetTyr: 0.579 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.831AsnAla: 3.831 ± 0.053
0.325AsnCys: 0.325 ± 0.015
2.315AsnAsp: 2.315 ± 0.047
2.233AsnGlu: 2.233 ± 0.036
1.763AsnPhe: 1.763 ± 0.032
3.865AsnGly: 3.865 ± 0.071
0.748AsnHis: 0.748 ± 0.019
2.18AsnIle: 2.18 ± 0.042
1.836AsnLys: 1.836 ± 0.036
4.27AsnLeu: 4.27 ± 0.06
0.873AsnMet: 0.873 ± 0.024
2.11AsnAsn: 2.11 ± 0.049
2.736AsnPro: 2.736 ± 0.045
2.167AsnGln: 2.167 ± 0.032
2.844AsnArg: 2.844 ± 0.036
2.516AsnSer: 2.516 ± 0.047
2.858AsnThr: 2.858 ± 0.053
3.211AsnVal: 3.211 ± 0.045
0.746AsnTrp: 0.746 ± 0.021
1.805AsnTyr: 1.805 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
5.202ProAla: 5.202 ± 0.071
0.217ProCys: 0.217 ± 0.011
3.372ProAsp: 3.372 ± 0.051
2.717ProGlu: 2.717 ± 0.041
2.088ProPhe: 2.088 ± 0.034
3.675ProGly: 3.675 ± 0.056
0.778ProHis: 0.778 ± 0.022
2.663ProIle: 2.663 ± 0.039
1.865ProLys: 1.865 ± 0.039
4.198ProLeu: 4.198 ± 0.054
0.909ProMet: 0.909 ± 0.025
2.282ProAsn: 2.282 ± 0.034
1.562ProPro: 1.562 ± 0.032
1.65ProGln: 1.65 ± 0.032
1.815ProArg: 1.815 ± 0.036
2.581ProSer: 2.581 ± 0.045
3.666ProThr: 3.666 ± 0.055
4.027ProVal: 4.027 ± 0.054
0.5ProTrp: 0.5 ± 0.018
1.67ProTyr: 1.67 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.11GlnAla: 4.11 ± 0.068
0.227GlnCys: 0.227 ± 0.012
1.529GlnAsp: 1.529 ± 0.031
1.939GlnGlu: 1.939 ± 0.034
1.998GlnPhe: 1.998 ± 0.032
2.531GlnGly: 2.531 ± 0.038
0.871GlnHis: 0.871 ± 0.026
2.277GlnIle: 2.277 ± 0.035
2.034GlnLys: 2.034 ± 0.037
5.025GlnLeu: 5.025 ± 0.062
0.876GlnMet: 0.876 ± 0.024
1.805GlnAsn: 1.805 ± 0.036
2.537GlnPro: 2.537 ± 0.041
2.707GlnGln: 2.707 ± 0.049
2.576GlnArg: 2.576 ± 0.042
2.489GlnSer: 2.489 ± 0.038
3.201GlnThr: 3.201 ± 0.048
3.069GlnVal: 3.069 ± 0.045
0.495GlnTrp: 0.495 ± 0.018
1.649GlnTyr: 1.649 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
4.101ArgAla: 4.101 ± 0.054
0.301ArgCys: 0.301 ± 0.014
2.662ArgAsp: 2.662 ± 0.047
2.801ArgGlu: 2.801 ± 0.052
2.666ArgPhe: 2.666 ± 0.046
3.105ArgGly: 3.105 ± 0.051
1.002ArgHis: 1.002 ± 0.028
3.36ArgIle: 3.36 ± 0.044
2.525ArgLys: 2.525 ± 0.041
5.859ArgLeu: 5.859 ± 0.069
1.339ArgMet: 1.339 ± 0.026
2.419ArgAsn: 2.419 ± 0.035
2.507ArgPro: 2.507 ± 0.043
2.977ArgGln: 2.977 ± 0.042
3.021ArgArg: 3.021 ± 0.049
3.028ArgSer: 3.028 ± 0.046
3.489ArgThr: 3.489 ± 0.045
3.829ArgVal: 3.829 ± 0.053
0.847ArgTrp: 0.847 ± 0.024
2.313ArgTyr: 2.313 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.453SerAla: 5.453 ± 0.08
0.496SerCys: 0.496 ± 0.017
3.048SerAsp: 3.048 ± 0.046
2.549SerGlu: 2.549 ± 0.038
2.987SerPhe: 2.987 ± 0.047
5.103SerGly: 5.103 ± 0.074
0.979SerHis: 0.979 ± 0.023
3.505SerIle: 3.505 ± 0.053
2.414SerLys: 2.414 ± 0.042
6.665SerLeu: 6.665 ± 0.068
1.269SerMet: 1.269 ± 0.028
2.46SerAsn: 2.46 ± 0.05
3.051SerPro: 3.051 ± 0.049
2.368SerGln: 2.368 ± 0.039
3.093SerArg: 3.093 ± 0.038
3.845SerSer: 3.845 ± 0.07
4.156SerThr: 4.156 ± 0.065
4.639SerVal: 4.639 ± 0.067
0.786SerTrp: 0.786 ± 0.022
2.361SerTyr: 2.361 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.389ThrAla: 6.389 ± 0.119
0.449ThrCys: 0.449 ± 0.025
4.198ThrAsp: 4.198 ± 0.056
3.043ThrGlu: 3.043 ± 0.041
3.001ThrPhe: 3.001 ± 0.043
5.957ThrGly: 5.957 ± 0.092
1.107ThrHis: 1.107 ± 0.027
3.924ThrIle: 3.924 ± 0.057
2.718ThrLys: 2.718 ± 0.044
7.181ThrLeu: 7.181 ± 0.083
1.156ThrMet: 1.156 ± 0.022
3.247ThrAsn: 3.247 ± 0.054
3.768ThrPro: 3.768 ± 0.054
2.574ThrGln: 2.574 ± 0.036
2.958ThrArg: 2.958 ± 0.049
4.148ThrSer: 4.148 ± 0.071
5.007ThrThr: 5.007 ± 0.122
5.293ThrVal: 5.293 ± 0.105
0.805ThrTrp: 0.805 ± 0.026
3.134ThrTyr: 3.134 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
6.662ValAla: 6.662 ± 0.072
0.634ValCys: 0.634 ± 0.018
3.839ValAsp: 3.839 ± 0.044
3.267ValGlu: 3.267 ± 0.051
2.848ValPhe: 2.848 ± 0.044
5.352ValGly: 5.352 ± 0.066
1.144ValHis: 1.144 ± 0.029
3.78ValIle: 3.78 ± 0.048
3.057ValLys: 3.057 ± 0.042
6.865ValLeu: 6.865 ± 0.066
1.516ValMet: 1.516 ± 0.029
3.262ValAsn: 3.262 ± 0.049
3.411ValPro: 3.411 ± 0.038
2.673ValGln: 2.673 ± 0.045
4.001ValArg: 4.001 ± 0.054
4.908ValSer: 4.908 ± 0.057
4.949ValThr: 4.949 ± 0.106
5.494ValVal: 5.494 ± 0.068
0.888ValTrp: 0.888 ± 0.021
2.497ValTyr: 2.497 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.035TrpAla: 1.035 ± 0.024
0.099TrpCys: 0.099 ± 0.008
0.59TrpAsp: 0.59 ± 0.021
0.582TrpGlu: 0.582 ± 0.017
0.595TrpPhe: 0.595 ± 0.019
0.936TrpGly: 0.936 ± 0.022
0.32TrpHis: 0.32 ± 0.015
0.615TrpIle: 0.615 ± 0.019
0.571TrpLys: 0.571 ± 0.019
1.64TrpLeu: 1.64 ± 0.037
0.332TrpMet: 0.332 ± 0.014
0.594TrpAsn: 0.594 ± 0.021
0.512TrpPro: 0.512 ± 0.017
0.78TrpGln: 0.78 ± 0.023
0.763TrpArg: 0.763 ± 0.023
0.787TrpSer: 0.787 ± 0.025
0.815TrpThr: 0.815 ± 0.024
0.876TrpVal: 0.876 ± 0.026
0.222TrpTrp: 0.222 ± 0.012
0.476TrpTyr: 0.476 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.095TyrAla: 3.095 ± 0.045
0.328TyrCys: 0.328 ± 0.013
2.14TyrAsp: 2.14 ± 0.038
1.825TyrGlu: 1.825 ± 0.033
1.744TyrPhe: 1.744 ± 0.034
2.779TyrGly: 2.779 ± 0.043
0.645TyrHis: 0.645 ± 0.02
1.75TyrIle: 1.75 ± 0.036
1.621TyrLys: 1.621 ± 0.036
3.73TyrLeu: 3.73 ± 0.049
0.7TyrMet: 0.7 ± 0.024
1.784TyrAsn: 1.784 ± 0.038
1.706TyrPro: 1.706 ± 0.034
1.779TyrGln: 1.779 ± 0.034
2.369TyrArg: 2.369 ± 0.034
2.343TyrSer: 2.343 ± 0.048
2.536TyrThr: 2.536 ± 0.044
2.554TyrVal: 2.554 ± 0.04
0.532TyrTrp: 0.532 ± 0.018
1.572TyrTyr: 1.572 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5038 proteins (1868441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski