Amino acid dipepetide frequency for Bacteroides sp. AM16-15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.673AlaAla: 5.673 ± 0.09	0.995AlaCys: 0.995 ± 0.029	4.159AlaAsp: 4.159 ± 0.061	4.89AlaGlu: 4.89 ± 0.067	3.05AlaPhe: 3.05 ± 0.054	5.122AlaGly: 5.122 ± 0.074	1.243AlaHis: 1.243 ± 0.03	4.779AlaIle: 4.779 ± 0.068	4.187AlaLys: 4.187 ± 0.071	6.629AlaLeu: 6.629 ± 0.088	2.023AlaMet: 2.023 ± 0.049	3.123AlaAsn: 3.123 ± 0.056	2.192AlaPro: 2.192 ± 0.043	2.627AlaGln: 2.627 ± 0.053	3.044AlaArg: 3.044 ± 0.047	4.113AlaSer: 4.113 ± 0.054	3.747AlaThr: 3.747 ± 0.066	4.805AlaVal: 4.805 ± 0.075	0.778AlaTrp: 0.778 ± 0.026	2.997AlaTyr: 2.997 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.755CysAla: 0.755 ± 0.025	0.219CysCys: 0.219 ± 0.013	0.617CysAsp: 0.617 ± 0.023	0.672CysGlu: 0.672 ± 0.023	0.677CysPhe: 0.677 ± 0.026	1.042CysGly: 1.042 ± 0.031	0.301CysHis: 0.301 ± 0.016	1.003CysIle: 1.003 ± 0.03	0.76CysLys: 0.76 ± 0.027	1.138CysLeu: 1.138 ± 0.032	0.375CysMet: 0.375 ± 0.018	0.583CysAsn: 0.583 ± 0.022	0.562CysPro: 0.562 ± 0.023	0.332CysGln: 0.332 ± 0.016	0.682CysArg: 0.682 ± 0.027	0.805CysSer: 0.805 ± 0.027	0.743CysThr: 0.743 ± 0.029	0.722CysVal: 0.722 ± 0.028	0.154CysTrp: 0.154 ± 0.012	0.59CysTyr: 0.59 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.775AspAla: 3.775 ± 0.067	0.68AspCys: 0.68 ± 0.028	2.594AspAsp: 2.594 ± 0.049	3.829AspGlu: 3.829 ± 0.062	2.968AspPhe: 2.968 ± 0.053	3.953AspGly: 3.953 ± 0.065	0.78AspHis: 0.78 ± 0.024	4.122AspIle: 4.122 ± 0.053	4.207AspLys: 4.207 ± 0.067	4.456AspLeu: 4.456 ± 0.077	1.685AspMet: 1.685 ± 0.034	2.869AspAsn: 2.869 ± 0.054	1.602AspPro: 1.602 ± 0.04	1.047AspGln: 1.047 ± 0.034	2.43AspArg: 2.43 ± 0.046	3.027AspSer: 3.027 ± 0.062	2.84AspThr: 2.84 ± 0.054	3.351AspVal: 3.351 ± 0.059	0.85AspTrp: 0.85 ± 0.025	2.912AspTyr: 2.912 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.989GluAla: 4.989 ± 0.085	0.669GluCys: 0.669 ± 0.023	3.293GluAsp: 3.293 ± 0.06	5.555GluGlu: 5.555 ± 0.083	2.505GluPhe: 2.505 ± 0.048	4.103GluGly: 4.103 ± 0.058	1.361GluHis: 1.361 ± 0.032	4.703GluIle: 4.703 ± 0.068	5.518GluLys: 5.518 ± 0.078	6.455GluLeu: 6.455 ± 0.076	2.147GluMet: 2.147 ± 0.042	3.674GluAsn: 3.674 ± 0.06	1.708GluPro: 1.708 ± 0.04	2.828GluGln: 2.828 ± 0.054	3.362GluArg: 3.362 ± 0.06	3.078GluSer: 3.078 ± 0.051	3.493GluThr: 3.493 ± 0.056	4.445GluVal: 4.445 ± 0.065	0.891GluTrp: 0.891 ± 0.026	2.881GluTyr: 2.881 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.959PheAla: 2.959 ± 0.052	0.7PheCys: 0.7 ± 0.025	2.654PheAsp: 2.654 ± 0.05	2.465PheGlu: 2.465 ± 0.046	2.261PhePhe: 2.261 ± 0.051	3.15PheGly: 3.15 ± 0.063	0.944PheHis: 0.944 ± 0.031	3.395PheIle: 3.395 ± 0.058	2.524PheLys: 2.524 ± 0.049	4.081PheLeu: 4.081 ± 0.07	1.327PheMet: 1.327 ± 0.038	2.359PheAsn: 2.359 ± 0.046	1.743PhePro: 1.743 ± 0.038	1.282PheGln: 1.282 ± 0.03	2.1PheArg: 2.1 ± 0.041	3.274PheSer: 3.274 ± 0.056	2.786PheThr: 2.786 ± 0.04	2.827PheVal: 2.827 ± 0.053	0.554PheTrp: 0.554 ± 0.023	2.036PheTyr: 2.036 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.262GlyAla: 4.262 ± 0.074	0.963GlyCys: 0.963 ± 0.032	3.275GlyAsp: 3.275 ± 0.059	4.193GlyGlu: 4.193 ± 0.062	3.131GlyPhe: 3.131 ± 0.053	4.45GlyGly: 4.45 ± 0.076	1.305GlyHis: 1.305 ± 0.037	5.351GlyIle: 5.351 ± 0.084	5.621GlyLys: 5.621 ± 0.07	5.626GlyLeu: 5.626 ± 0.069	2.284GlyMet: 2.284 ± 0.042	3.693GlyAsn: 3.693 ± 0.061	1.229GlyPro: 1.229 ± 0.034	1.993GlyGln: 1.993 ± 0.043	2.828GlyArg: 2.828 ± 0.05	3.808GlySer: 3.808 ± 0.067	3.981GlyThr: 3.981 ± 0.062	4.63GlyVal: 4.63 ± 0.066	0.932GlyTrp: 0.932 ± 0.03	3.37GlyTyr: 3.37 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.131HisAla: 1.131 ± 0.032	0.312HisCys: 0.312 ± 0.016	0.924HisAsp: 0.924 ± 0.029	1.092HisGlu: 1.092 ± 0.031	1.052HisPhe: 1.052 ± 0.03	1.167HisGly: 1.167 ± 0.032	0.517HisHis: 0.517 ± 0.025	1.606HisIle: 1.606 ± 0.037	1.122HisLys: 1.122 ± 0.031	1.812HisLeu: 1.812 ± 0.044	0.35HisMet: 0.35 ± 0.017	0.97HisAsn: 0.97 ± 0.029	1.138HisPro: 1.138 ± 0.031	0.656HisGln: 0.656 ± 0.025	0.952HisArg: 0.952 ± 0.029	1.179HisSer: 1.179 ± 0.033	1.191HisThr: 1.191 ± 0.036	1.076HisVal: 1.076 ± 0.03	0.293HisTrp: 0.293 ± 0.014	0.968HisTyr: 0.968 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.278IleAla: 5.278 ± 0.084	1.015IleCys: 1.015 ± 0.03	4.131IleAsp: 4.131 ± 0.056	4.612IleGlu: 4.612 ± 0.073	2.853IlePhe: 2.853 ± 0.059	4.712IleGly: 4.712 ± 0.073	1.457IleHis: 1.457 ± 0.035	4.935IleIle: 4.935 ± 0.073	4.356IleLys: 4.356 ± 0.07	6.176IleLeu: 6.176 ± 0.087	1.678IleMet: 1.678 ± 0.035	3.639IleAsn: 3.639 ± 0.058	3.18IlePro: 3.18 ± 0.053	2.273IleGln: 2.273 ± 0.042	3.491IleArg: 3.491 ± 0.055	4.661IleSer: 4.661 ± 0.067	4.124IleThr: 4.124 ± 0.058	4.314IleVal: 4.314 ± 0.067	0.7IleTrp: 0.7 ± 0.024	2.929IleTyr: 2.929 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.057LysAla: 5.057 ± 0.078	0.608LysCys: 0.608 ± 0.026	4.141LysAsp: 4.141 ± 0.066	6.474LysGlu: 6.474 ± 0.091	2.274LysPhe: 2.274 ± 0.044	4.766LysGly: 4.766 ± 0.062	1.284LysHis: 1.284 ± 0.033	4.383LysIle: 4.383 ± 0.07	5.585LysLys: 5.585 ± 0.08	5.636LysLeu: 5.636 ± 0.078	2.078LysMet: 2.078 ± 0.042	3.658LysAsn: 3.658 ± 0.059	2.214LysPro: 2.214 ± 0.052	2.766LysGln: 2.766 ± 0.048	3.334LysArg: 3.334 ± 0.056	3.386LysSer: 3.386 ± 0.05	3.61LysThr: 3.61 ± 0.056	4.454LysVal: 4.454 ± 0.064	0.74LysTrp: 0.74 ± 0.025	3.045LysTyr: 3.045 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.304LeuAla: 6.304 ± 0.081	1.415LeuCys: 1.415 ± 0.036	4.479LeuAsp: 4.479 ± 0.065	5.16LeuGlu: 5.16 ± 0.071	4.549LeuPhe: 4.549 ± 0.061	5.579LeuGly: 5.579 ± 0.063	1.854LeuHis: 1.854 ± 0.039	5.68LeuIle: 5.68 ± 0.075	6.588LeuLys: 6.588 ± 0.081	9.178LeuLeu: 9.178 ± 0.124	2.564LeuMet: 2.564 ± 0.044	4.735LeuAsn: 4.735 ± 0.067	4.111LeuPro: 4.111 ± 0.064	3.42LeuGln: 3.42 ± 0.058	4.059LeuArg: 4.059 ± 0.063	6.712LeuSer: 6.712 ± 0.084	5.21LeuThr: 5.21 ± 0.068	4.945LeuVal: 4.945 ± 0.069	1.027LeuTrp: 1.027 ± 0.033	3.751LeuTyr: 3.751 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.139MetAla: 2.139 ± 0.045	0.289MetCys: 0.289 ± 0.015	1.567MetAsp: 1.567 ± 0.034	2.075MetGlu: 2.075 ± 0.041	0.998MetPhe: 0.998 ± 0.031	1.896MetGly: 1.896 ± 0.038	0.481MetHis: 0.481 ± 0.021	1.711MetIle: 1.711 ± 0.039	2.75MetLys: 2.75 ± 0.046	2.497MetLeu: 2.497 ± 0.048	0.834MetMet: 0.834 ± 0.03	1.755MetAsn: 1.755 ± 0.04	1.132MetPro: 1.132 ± 0.03	1.1MetGln: 1.1 ± 0.03	1.296MetArg: 1.296 ± 0.037	1.522MetSer: 1.522 ± 0.035	1.49MetThr: 1.49 ± 0.037	1.626MetVal: 1.626 ± 0.035	0.253MetTrp: 0.253 ± 0.014	0.875MetTyr: 0.875 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.392AsnAla: 3.392 ± 0.056	0.513AsnCys: 0.513 ± 0.024	2.614AsnAsp: 2.614 ± 0.052	3.328AsnGlu: 3.328 ± 0.06	2.212AsnPhe: 2.212 ± 0.053	3.972AsnGly: 3.972 ± 0.065	0.994AsnHis: 0.994 ± 0.028	4.028AsnIle: 4.028 ± 0.065	3.525AsnLys: 3.525 ± 0.057	4.393AsnLeu: 4.393 ± 0.058	1.391AsnMet: 1.391 ± 0.033	2.751AsnAsn: 2.751 ± 0.061	2.49AsnPro: 2.49 ± 0.049	1.553AsnGln: 1.553 ± 0.037	2.596AsnArg: 2.596 ± 0.046	2.698AsnSer: 2.698 ± 0.05	2.713AsnThr: 2.713 ± 0.05	3.141AsnVal: 3.141 ± 0.049	0.644AsnTrp: 0.644 ± 0.025	2.408AsnTyr: 2.408 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.736ProAla: 2.736 ± 0.046	0.375ProCys: 0.375 ± 0.018	2.522ProAsp: 2.522 ± 0.049	3.292ProGlu: 3.292 ± 0.055	1.824ProPhe: 1.824 ± 0.042	2.417ProGly: 2.417 ± 0.049	0.771ProHis: 0.771 ± 0.025	2.352ProIle: 2.352 ± 0.047	2.074ProLys: 2.074 ± 0.041	3.267ProLeu: 3.267 ± 0.052	0.926ProMet: 0.926 ± 0.027	1.652ProAsn: 1.652 ± 0.043	0.799ProPro: 0.799 ± 0.031	1.46ProGln: 1.46 ± 0.033	1.321ProArg: 1.321 ± 0.031	2.149ProSer: 2.149 ± 0.041	1.937ProThr: 1.937 ± 0.041	2.929ProVal: 2.929 ± 0.055	0.409ProTrp: 0.409 ± 0.02	1.654ProTyr: 1.654 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.53GlnAla: 2.53 ± 0.051	0.322GlnCys: 0.322 ± 0.017	1.596GlnAsp: 1.596 ± 0.038	2.494GlnGlu: 2.494 ± 0.054	1.307GlnPhe: 1.307 ± 0.036	2.024GlnGly: 2.024 ± 0.046	0.651GlnHis: 0.651 ± 0.022	2.401GlnIle: 2.401 ± 0.045	2.604GlnLys: 2.604 ± 0.055	3.241GlnLeu: 3.241 ± 0.058	1.044GlnMet: 1.044 ± 0.03	1.731GlnAsn: 1.731 ± 0.039	1.244GlnPro: 1.244 ± 0.031	1.616GlnGln: 1.616 ± 0.047	1.604GlnArg: 1.604 ± 0.039	1.96GlnSer: 1.96 ± 0.038	1.963GlnThr: 1.963 ± 0.047	2.098GlnVal: 2.098 ± 0.04	0.471GlnTrp: 0.471 ± 0.019	1.478GlnTyr: 1.478 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.681ArgAla: 2.681 ± 0.051	0.518ArgCys: 0.518 ± 0.021	2.11ArgAsp: 2.11 ± 0.044	3.138ArgGlu: 3.138 ± 0.06	2.293ArgPhe: 2.293 ± 0.041	2.352ArgGly: 2.352 ± 0.044	1.018ArgHis: 1.018 ± 0.031	3.695ArgIle: 3.695 ± 0.06	3.588ArgLys: 3.588 ± 0.059	4.398ArgLeu: 4.398 ± 0.067	1.61ArgMet: 1.61 ± 0.04	2.396ArgAsn: 2.396 ± 0.046	1.638ArgPro: 1.638 ± 0.04	1.911ArgGln: 1.911 ± 0.041	2.181ArgArg: 2.181 ± 0.043	2.412ArgSer: 2.412 ± 0.049	2.449ArgThr: 2.449 ± 0.049	2.607ArgVal: 2.607 ± 0.046	0.636ArgTrp: 0.636 ± 0.022	2.225ArgTyr: 2.225 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.038SerAla: 4.038 ± 0.059	0.861SerCys: 0.861 ± 0.026	3.17SerAsp: 3.17 ± 0.055	3.559SerGlu: 3.559 ± 0.051	3.287SerPhe: 3.287 ± 0.061	4.3SerGly: 4.3 ± 0.074	1.172SerHis: 1.172 ± 0.038	4.263SerIle: 4.263 ± 0.064	3.358SerLys: 3.358 ± 0.056	5.898SerLeu: 5.898 ± 0.087	1.436SerMet: 1.436 ± 0.037	2.753SerAsn: 2.753 ± 0.053	2.339SerPro: 2.339 ± 0.038	1.832SerGln: 1.832 ± 0.042	2.656SerArg: 2.656 ± 0.048	3.743SerSer: 3.743 ± 0.068	3.187SerThr: 3.187 ± 0.059	4.171SerVal: 4.171 ± 0.056	0.744SerTrp: 0.744 ± 0.029	2.718SerTyr: 2.718 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.119ThrAla: 4.119 ± 0.069	0.543ThrCys: 0.543 ± 0.022	3.554ThrAsp: 3.554 ± 0.052	3.473ThrGlu: 3.473 ± 0.066	2.669ThrPhe: 2.669 ± 0.047	4.21ThrGly: 4.21 ± 0.062	1.068ThrHis: 1.068 ± 0.031	3.907ThrIle: 3.907 ± 0.065	2.788ThrLys: 2.788 ± 0.04	5.533ThrLeu: 5.533 ± 0.073	1.188ThrMet: 1.188 ± 0.03	2.472ThrAsn: 2.472 ± 0.045	2.787ThrPro: 2.787 ± 0.045	1.773ThrGln: 1.773 ± 0.036	2.167ThrArg: 2.167 ± 0.046	3.166ThrSer: 3.166 ± 0.05	3.088ThrThr: 3.088 ± 0.054	4.061ThrVal: 4.061 ± 0.075	0.664ThrTrp: 0.664 ± 0.023	2.41ThrTyr: 2.41 ± 0.046	0.001ThrXaa: 0.001 ± 0.001
Val	4.566ValAla: 4.566 ± 0.071	1.012ValCys: 1.012 ± 0.027	3.447ValAsp: 3.447 ± 0.055	3.998ValGlu: 3.998 ± 0.061	2.825ValPhe: 2.825 ± 0.052	3.909ValGly: 3.909 ± 0.057	1.061ValHis: 1.061 ± 0.034	4.363ValIle: 4.363 ± 0.07	4.477ValLys: 4.477 ± 0.066	5.782ValLeu: 5.782 ± 0.072	1.75ValMet: 1.75 ± 0.038	3.259ValAsn: 3.259 ± 0.052	2.55ValPro: 2.55 ± 0.044	1.883ValGln: 1.883 ± 0.042	2.885ValArg: 2.885 ± 0.053	4.381ValSer: 4.381 ± 0.068	3.809ValThr: 3.809 ± 0.062	4.286ValVal: 4.286 ± 0.063	0.736ValTrp: 0.736 ± 0.024	2.64ValTyr: 2.64 ± 0.047	0.002ValXaa: 0.002 ± 0.001
Trp	0.759TrpAla: 0.759 ± 0.025	0.148TrpCys: 0.148 ± 0.011	0.635TrpAsp: 0.635 ± 0.026	0.788TrpGlu: 0.788 ± 0.026	0.567TrpPhe: 0.567 ± 0.023	0.935TrpGly: 0.935 ± 0.032	0.264TrpHis: 0.264 ± 0.014	0.828TrpIle: 0.828 ± 0.03	0.939TrpLys: 0.939 ± 0.027	1.132TrpLeu: 1.132 ± 0.031	0.465TrpMet: 0.465 ± 0.02	0.79TrpAsn: 0.79 ± 0.026	0.265TrpPro: 0.265 ± 0.016	0.499TrpGln: 0.499 ± 0.019	0.569TrpArg: 0.569 ± 0.023	0.682TrpSer: 0.682 ± 0.024	0.627TrpThr: 0.627 ± 0.025	0.68TrpVal: 0.68 ± 0.029	0.168TrpTrp: 0.168 ± 0.013	0.491TrpTyr: 0.491 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.034TyrAla: 3.034 ± 0.055	0.576TyrCys: 0.576 ± 0.023	2.491TyrAsp: 2.491 ± 0.049	2.571TyrGlu: 2.571 ± 0.042	2.117TyrPhe: 2.117 ± 0.041	2.866TyrGly: 2.866 ± 0.052	0.982TyrHis: 0.982 ± 0.032	3.011TyrIle: 3.011 ± 0.051	2.922TyrLys: 2.922 ± 0.047	3.99TyrLeu: 3.99 ± 0.071	1.133TyrMet: 1.133 ± 0.028	2.492TyrAsn: 2.492 ± 0.046	1.941TyrPro: 1.941 ± 0.046	1.527TyrGln: 1.527 ± 0.034	2.298TyrArg: 2.298 ± 0.045	2.73TyrSer: 2.73 ± 0.056	2.654TyrThr: 2.654 ± 0.052	2.453TyrVal: 2.453 ± 0.047	0.587TyrTrp: 0.587 ± 0.022	2.172TyrTyr: 2.172 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.003

Statistics based on 3417 proteins (1213394 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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