Amino acid dipepetide frequency for Streptococcus satellite phage Javan175

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.372AlaAla: 1.372 ± 0.59
0.343AlaCys: 0.343 ± 0.343
3.086AlaAsp: 3.086 ± 1.044
8.573AlaGlu: 8.573 ± 2.153
1.372AlaPhe: 1.372 ± 0.884
2.743AlaGly: 2.743 ± 0.821
1.029AlaHis: 1.029 ± 0.597
3.772AlaIle: 3.772 ± 1.505
3.429AlaLys: 3.429 ± 0.921
6.173AlaLeu: 6.173 ± 1.251
2.058AlaMet: 2.058 ± 0.963
2.401AlaAsn: 2.401 ± 0.738
1.715AlaPro: 1.715 ± 0.778
4.801AlaGln: 4.801 ± 1.149
4.801AlaArg: 4.801 ± 1.293
2.401AlaSer: 2.401 ± 0.693
4.115AlaThr: 4.115 ± 1.006
5.144AlaVal: 5.144 ± 1.29
1.029AlaTrp: 1.029 ± 0.536
3.772AlaTyr: 3.772 ± 0.963
0.0AlaXaa: 0.0 ± 0.0
Cys
0.686CysAla: 0.686 ± 0.49
0.343CysCys: 0.343 ± 0.323
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.029CysPhe: 1.029 ± 0.713
0.343CysGly: 0.343 ± 0.323
0.0CysHis: 0.0 ± 0.0
0.343CysIle: 0.343 ± 0.273
1.029CysLys: 1.029 ± 1.028
0.343CysLeu: 0.343 ± 0.318
0.0CysMet: 0.0 ± 0.0
1.029CysAsn: 1.029 ± 0.841
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.686CysArg: 0.686 ± 0.346
0.686CysSer: 0.686 ± 0.45
0.343CysThr: 0.343 ± 0.323
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.686CysTyr: 0.686 ± 0.729
0.0CysXaa: 0.0 ± 0.0
Asp
2.401AspAla: 2.401 ± 0.834
0.343AspCys: 0.343 ± 0.273
4.801AspAsp: 4.801 ± 1.738
1.372AspGlu: 1.372 ± 0.563
4.801AspPhe: 4.801 ± 1.182
2.058AspGly: 2.058 ± 0.723
0.686AspHis: 0.686 ± 0.525
6.516AspIle: 6.516 ± 1.498
5.487AspLys: 5.487 ± 1.32
9.259AspLeu: 9.259 ± 1.738
2.401AspMet: 2.401 ± 0.94
3.086AspAsn: 3.086 ± 0.866
1.372AspPro: 1.372 ± 0.863
2.743AspGln: 2.743 ± 1.313
4.115AspArg: 4.115 ± 1.017
2.743AspSer: 2.743 ± 0.874
4.458AspThr: 4.458 ± 1.001
2.058AspVal: 2.058 ± 1.012
0.686AspTrp: 0.686 ± 0.346
5.487AspTyr: 5.487 ± 1.308
0.0AspXaa: 0.0 ± 0.0
Glu
2.401GluAla: 2.401 ± 1.151
0.686GluCys: 0.686 ± 0.434
5.83GluAsp: 5.83 ± 1.466
6.516GluGlu: 6.516 ± 1.666
4.115GluPhe: 4.115 ± 1.421
2.058GluGly: 2.058 ± 0.663
1.029GluHis: 1.029 ± 0.6
3.086GluIle: 3.086 ± 1.121
12.003GluLys: 12.003 ± 2.113
14.403GluLeu: 14.403 ± 2.144
1.029GluMet: 1.029 ± 0.641
3.086GluAsn: 3.086 ± 1.444
1.029GluPro: 1.029 ± 0.659
5.83GluGln: 5.83 ± 1.568
6.173GluArg: 6.173 ± 1.768
2.058GluSer: 2.058 ± 0.778
2.058GluThr: 2.058 ± 0.627
4.801GluVal: 4.801 ± 1.218
0.343GluTrp: 0.343 ± 0.362
2.401GluTyr: 2.401 ± 0.951
0.0GluXaa: 0.0 ± 0.0
Phe
2.058PheAla: 2.058 ± 0.863
0.686PheCys: 0.686 ± 0.471
3.429PheAsp: 3.429 ± 1.269
3.086PheGlu: 3.086 ± 0.931
2.401PhePhe: 2.401 ± 0.735
1.715PheGly: 1.715 ± 0.867
0.343PheHis: 0.343 ± 0.323
3.429PheIle: 3.429 ± 1.317
2.401PheLys: 2.401 ± 0.886
5.144PheLeu: 5.144 ± 1.113
0.0PheMet: 0.0 ± 0.0
0.686PheAsn: 0.686 ± 0.559
1.029PhePro: 1.029 ± 0.618
0.343PheGln: 0.343 ± 0.335
1.029PheArg: 1.029 ± 0.533
4.458PheSer: 4.458 ± 1.615
1.715PheThr: 1.715 ± 0.844
2.401PheVal: 2.401 ± 0.898
1.372PheTrp: 1.372 ± 0.623
1.372PheTyr: 1.372 ± 0.656
0.0PheXaa: 0.0 ± 0.0
Gly
3.086GlyAla: 3.086 ± 0.836
0.343GlyCys: 0.343 ± 0.323
2.401GlyAsp: 2.401 ± 0.86
3.429GlyGlu: 3.429 ± 0.942
2.401GlyPhe: 2.401 ± 0.654
1.029GlyGly: 1.029 ± 0.636
0.686GlyHis: 0.686 ± 0.53
3.086GlyIle: 3.086 ± 0.953
3.772GlyLys: 3.772 ± 1.25
6.173GlyLeu: 6.173 ± 1.93
1.029GlyMet: 1.029 ± 0.556
1.372GlyAsn: 1.372 ± 0.53
0.343GlyPro: 0.343 ± 0.431
2.401GlyGln: 2.401 ± 0.843
1.372GlyArg: 1.372 ± 0.535
1.029GlySer: 1.029 ± 0.732
1.715GlyThr: 1.715 ± 0.706
4.458GlyVal: 4.458 ± 1.329
1.372GlyTrp: 1.372 ± 0.64
2.058GlyTyr: 2.058 ± 0.845
0.0GlyXaa: 0.0 ± 0.0
His
1.029HisAla: 1.029 ± 0.666
0.0HisCys: 0.0 ± 0.0
0.343HisAsp: 0.343 ± 0.273
0.343HisGlu: 0.343 ± 0.419
0.343HisPhe: 0.343 ± 0.323
1.715HisGly: 1.715 ± 0.754
0.343HisHis: 0.343 ± 0.323
1.029HisIle: 1.029 ± 0.614
2.058HisLys: 2.058 ± 0.679
1.372HisLeu: 1.372 ± 0.531
0.0HisMet: 0.0 ± 0.0
2.058HisAsn: 2.058 ± 0.875
0.343HisPro: 0.343 ± 0.362
2.401HisGln: 2.401 ± 0.865
1.029HisArg: 1.029 ± 0.562
0.343HisSer: 0.343 ± 0.323
1.029HisThr: 1.029 ± 0.686
0.343HisVal: 0.343 ± 0.328
0.343HisTrp: 0.343 ± 0.323
0.686HisTyr: 0.686 ± 0.435
0.0HisXaa: 0.0 ± 0.0
Ile
3.086IleAla: 3.086 ± 0.931
0.343IleCys: 0.343 ± 0.409
4.801IleAsp: 4.801 ± 1.321
3.429IleGlu: 3.429 ± 0.919
1.715IlePhe: 1.715 ± 0.949
3.086IleGly: 3.086 ± 0.727
1.029IleHis: 1.029 ± 0.686
4.115IleIle: 4.115 ± 0.938
5.83IleLys: 5.83 ± 1.517
5.144IleLeu: 5.144 ± 1.439
1.029IleMet: 1.029 ± 0.457
3.429IleAsn: 3.429 ± 1.075
2.058IlePro: 2.058 ± 1.003
1.029IleGln: 1.029 ± 0.436
2.058IleArg: 2.058 ± 0.898
2.743IleSer: 2.743 ± 1.174
3.429IleThr: 3.429 ± 1.009
1.715IleVal: 1.715 ± 0.806
0.686IleTrp: 0.686 ± 0.462
2.743IleTyr: 2.743 ± 0.73
0.0IleXaa: 0.0 ± 0.0
Lys
10.631LysAla: 10.631 ± 2.259
0.343LysCys: 0.343 ± 0.343
5.487LysAsp: 5.487 ± 1.616
9.259LysGlu: 9.259 ± 2.515
1.029LysPhe: 1.029 ± 0.482
4.801LysGly: 4.801 ± 1.546
1.372LysHis: 1.372 ± 0.566
4.458LysIle: 4.458 ± 1.284
9.602LysLys: 9.602 ± 2.836
8.23LysLeu: 8.23 ± 1.523
2.401LysMet: 2.401 ± 0.799
4.458LysAsn: 4.458 ± 1.47
3.429LysPro: 3.429 ± 1.415
3.086LysGln: 3.086 ± 0.583
7.202LysArg: 7.202 ± 1.369
2.743LysSer: 2.743 ± 1.423
6.859LysThr: 6.859 ± 1.61
2.743LysVal: 2.743 ± 0.74
0.686LysTrp: 0.686 ± 0.45
1.029LysTyr: 1.029 ± 0.564
0.0LysXaa: 0.0 ± 0.0
Leu
9.945LeuAla: 9.945 ± 1.437
0.343LeuCys: 0.343 ± 0.323
10.288LeuAsp: 10.288 ± 1.817
9.945LeuGlu: 9.945 ± 1.887
2.743LeuPhe: 2.743 ± 1.165
6.859LeuGly: 6.859 ± 1.693
1.372LeuHis: 1.372 ± 0.68
5.144LeuIle: 5.144 ± 1.289
7.545LeuLys: 7.545 ± 1.952
12.346LeuLeu: 12.346 ± 1.501
1.372LeuMet: 1.372 ± 0.791
5.144LeuAsn: 5.144 ± 1.152
5.487LeuPro: 5.487 ± 1.333
5.144LeuGln: 5.144 ± 1.17
4.801LeuArg: 4.801 ± 1.559
4.458LeuSer: 4.458 ± 1.213
8.916LeuThr: 8.916 ± 2.124
8.23LeuVal: 8.23 ± 1.533
1.715LeuTrp: 1.715 ± 0.671
2.743LeuTyr: 2.743 ± 0.645
0.0LeuXaa: 0.0 ± 0.0
Met
2.058MetAla: 2.058 ± 0.786
0.0MetCys: 0.0 ± 0.0
0.343MetAsp: 0.343 ± 0.323
0.686MetGlu: 0.686 ± 0.503
1.372MetPhe: 1.372 ± 0.657
0.686MetGly: 0.686 ± 0.427
0.0MetHis: 0.0 ± 0.0
0.343MetIle: 0.343 ± 0.323
2.743MetLys: 2.743 ± 1.081
3.086MetLeu: 3.086 ± 0.781
0.343MetMet: 0.343 ± 0.343
1.372MetAsn: 1.372 ± 0.934
1.715MetPro: 1.715 ± 0.739
0.343MetGln: 0.343 ± 0.362
0.686MetArg: 0.686 ± 0.501
0.686MetSer: 0.686 ± 0.489
3.429MetThr: 3.429 ± 0.975
1.029MetVal: 1.029 ± 0.573
0.0MetTrp: 0.0 ± 0.0
0.343MetTyr: 0.343 ± 0.343
0.0MetXaa: 0.0 ± 0.0
Asn
2.058AsnAla: 2.058 ± 0.8
0.0AsnCys: 0.0 ± 0.0
2.743AsnAsp: 2.743 ± 1.083
3.429AsnGlu: 3.429 ± 0.759
2.058AsnPhe: 2.058 ± 1.089
1.715AsnGly: 1.715 ± 0.727
2.058AsnHis: 2.058 ± 0.603
2.058AsnIle: 2.058 ± 0.71
3.086AsnLys: 3.086 ± 1.338
3.429AsnLeu: 3.429 ± 1.054
0.686AsnMet: 0.686 ± 0.567
2.058AsnAsn: 2.058 ± 0.659
2.743AsnPro: 2.743 ± 0.779
3.772AsnGln: 3.772 ± 1.325
6.173AsnArg: 6.173 ± 0.975
1.372AsnSer: 1.372 ± 0.729
2.743AsnThr: 2.743 ± 0.911
1.029AsnVal: 1.029 ± 0.646
0.0AsnTrp: 0.0 ± 0.0
3.429AsnTyr: 3.429 ± 1.235
0.0AsnXaa: 0.0 ± 0.0
Pro
2.743ProAla: 2.743 ± 0.84
0.0ProCys: 0.0 ± 0.0
2.058ProAsp: 2.058 ± 0.828
3.086ProGlu: 3.086 ± 1.148
1.372ProPhe: 1.372 ± 0.563
1.029ProGly: 1.029 ± 0.548
0.343ProHis: 0.343 ± 0.273
2.743ProIle: 2.743 ± 1.201
3.429ProLys: 3.429 ± 1.132
3.086ProLeu: 3.086 ± 0.831
0.686ProMet: 0.686 ± 0.496
2.743ProAsn: 2.743 ± 1.272
0.686ProPro: 0.686 ± 0.444
1.372ProGln: 1.372 ± 0.607
1.715ProArg: 1.715 ± 0.588
1.029ProSer: 1.029 ± 0.561
1.372ProThr: 1.372 ± 0.593
1.372ProVal: 1.372 ± 0.863
0.343ProTrp: 0.343 ± 0.343
2.058ProTyr: 2.058 ± 0.864
0.0ProXaa: 0.0 ± 0.0
Gln
4.115GlnAla: 4.115 ± 1.251
0.0GlnCys: 0.0 ± 0.0
3.772GlnAsp: 3.772 ± 0.874
7.545GlnGlu: 7.545 ± 1.114
1.715GlnPhe: 1.715 ± 0.71
4.115GlnGly: 4.115 ± 0.934
1.372GlnHis: 1.372 ± 0.616
1.715GlnIle: 1.715 ± 0.918
3.086GlnLys: 3.086 ± 1.44
6.173GlnLeu: 6.173 ± 1.376
0.343GlnMet: 0.343 ± 0.318
1.715GlnAsn: 1.715 ± 0.659
0.686GlnPro: 0.686 ± 0.49
4.458GlnGln: 4.458 ± 1.363
1.372GlnArg: 1.372 ± 0.54
1.029GlnSer: 1.029 ± 0.819
3.429GlnThr: 3.429 ± 1.14
4.115GlnVal: 4.115 ± 0.94
0.343GlnTrp: 0.343 ± 0.374
1.715GlnTyr: 1.715 ± 0.664
0.0GlnXaa: 0.0 ± 0.0
Arg
5.144ArgAla: 5.144 ± 1.298
0.686ArgCys: 0.686 ± 0.495
4.801ArgAsp: 4.801 ± 1.576
4.115ArgGlu: 4.115 ± 1.265
3.086ArgPhe: 3.086 ± 1.275
2.058ArgGly: 2.058 ± 0.761
1.029ArgHis: 1.029 ± 0.441
2.401ArgIle: 2.401 ± 1.186
4.115ArgLys: 4.115 ± 1.042
5.487ArgLeu: 5.487 ± 1.892
1.715ArgMet: 1.715 ± 0.751
2.058ArgAsn: 2.058 ± 0.784
1.372ArgPro: 1.372 ± 0.56
5.487ArgGln: 5.487 ± 0.909
4.115ArgArg: 4.115 ± 1.595
1.029ArgSer: 1.029 ± 0.52
4.801ArgThr: 4.801 ± 1.869
2.058ArgVal: 2.058 ± 1.0
0.686ArgTrp: 0.686 ± 0.535
3.086ArgTyr: 3.086 ± 1.078
0.0ArgXaa: 0.0 ± 0.0
Ser
2.743SerAla: 2.743 ± 0.8
0.343SerCys: 0.343 ± 0.364
3.429SerAsp: 3.429 ± 0.783
2.401SerGlu: 2.401 ± 0.99
2.058SerPhe: 2.058 ± 0.736
1.029SerGly: 1.029 ± 0.542
1.029SerHis: 1.029 ± 0.588
1.372SerIle: 1.372 ± 0.492
3.772SerLys: 3.772 ± 0.98
4.801SerLeu: 4.801 ± 1.124
1.715SerMet: 1.715 ± 0.773
2.743SerAsn: 2.743 ± 0.809
2.743SerPro: 2.743 ± 0.781
1.715SerGln: 1.715 ± 0.613
1.715SerArg: 1.715 ± 1.101
1.372SerSer: 1.372 ± 0.725
2.058SerThr: 2.058 ± 1.039
3.429SerVal: 3.429 ± 0.796
1.029SerTrp: 1.029 ± 0.556
1.372SerTyr: 1.372 ± 0.644
0.0SerXaa: 0.0 ± 0.0
Thr
2.743ThrAla: 2.743 ± 0.929
0.686ThrCys: 0.686 ± 0.474
2.058ThrAsp: 2.058 ± 0.727
3.772ThrGlu: 3.772 ± 1.227
1.029ThrPhe: 1.029 ± 0.495
3.086ThrGly: 3.086 ± 0.73
1.372ThrHis: 1.372 ± 0.895
2.743ThrIle: 2.743 ± 1.037
8.23ThrLys: 8.23 ± 1.021
8.573ThrLeu: 8.573 ± 1.208
1.372ThrMet: 1.372 ± 0.57
2.058ThrAsn: 2.058 ± 0.802
3.086ThrPro: 3.086 ± 0.89
1.372ThrGln: 1.372 ± 0.555
2.743ThrArg: 2.743 ± 0.897
3.772ThrSer: 3.772 ± 0.948
3.086ThrThr: 3.086 ± 1.194
4.801ThrVal: 4.801 ± 2.009
0.0ThrTrp: 0.0 ± 0.0
3.086ThrTyr: 3.086 ± 0.87
0.0ThrXaa: 0.0 ± 0.0
Val
4.801ValAla: 4.801 ± 1.064
1.029ValCys: 1.029 ± 0.516
2.058ValAsp: 2.058 ± 0.824
5.144ValGlu: 5.144 ± 1.773
2.401ValPhe: 2.401 ± 0.806
2.058ValGly: 2.058 ± 1.019
1.029ValHis: 1.029 ± 0.471
4.115ValIle: 4.115 ± 0.935
3.429ValLys: 3.429 ± 1.018
3.772ValLeu: 3.772 ± 1.362
2.743ValMet: 2.743 ± 1.444
2.743ValAsn: 2.743 ± 1.137
0.686ValPro: 0.686 ± 0.586
1.715ValGln: 1.715 ± 0.575
2.743ValArg: 2.743 ± 0.793
5.487ValSer: 5.487 ± 0.912
2.058ValThr: 2.058 ± 1.181
2.743ValVal: 2.743 ± 0.783
0.343ValTrp: 0.343 ± 0.342
2.401ValTyr: 2.401 ± 0.572
0.0ValXaa: 0.0 ± 0.0
Trp
0.343TrpAla: 0.343 ± 0.356
0.343TrpCys: 0.343 ± 0.273
0.0TrpAsp: 0.0 ± 0.0
3.086TrpGlu: 3.086 ± 0.884
0.686TrpPhe: 0.686 ± 0.41
0.0TrpGly: 0.0 ± 0.0
0.343TrpHis: 0.343 ± 0.356
0.686TrpIle: 0.686 ± 0.5
0.0TrpLys: 0.0 ± 0.0
2.401TrpLeu: 2.401 ± 0.919
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.686TrpGln: 0.686 ± 0.346
0.686TrpArg: 0.686 ± 0.44
0.686TrpSer: 0.686 ± 0.481
0.686TrpThr: 0.686 ± 0.497
0.343TrpVal: 0.343 ± 0.343
0.686TrpTrp: 0.686 ± 0.346
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.686TyrAla: 0.686 ± 0.399
0.686TyrCys: 0.686 ± 0.501
5.144TyrAsp: 5.144 ± 1.449
2.058TyrGlu: 2.058 ± 0.798
1.372TyrPhe: 1.372 ± 0.566
1.372TyrGly: 1.372 ± 0.663
0.686TyrHis: 0.686 ± 0.39
0.343TyrIle: 0.343 ± 0.273
4.801TyrLys: 4.801 ± 1.45
5.144TyrLeu: 5.144 ± 1.466
0.0TyrMet: 0.0 ± 0.0
2.401TyrAsn: 2.401 ± 0.814
2.743TyrPro: 2.743 ± 0.856
4.115TyrGln: 4.115 ± 1.185
4.115TyrArg: 4.115 ± 0.966
2.743TyrSer: 2.743 ± 0.927
1.372TyrThr: 1.372 ± 0.454
0.686TyrVal: 0.686 ± 0.41
0.0TyrTrp: 0.0 ± 0.0
1.372TyrTyr: 1.372 ± 0.654
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (2917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski