Amino acid dipepetide frequency for Methylobacter tundripaludum (strain ATCC BAA-1195 / DSM 17260 / SV96)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.866AlaAla: 9.866 ± 0.145
1.045AlaCys: 1.045 ± 0.031
5.413AlaAsp: 5.413 ± 0.086
6.453AlaGlu: 6.453 ± 0.098
3.467AlaPhe: 3.467 ± 0.059
7.022AlaGly: 7.022 ± 0.094
1.984AlaHis: 1.984 ± 0.042
5.962AlaIle: 5.962 ± 0.065
4.665AlaLys: 4.665 ± 0.084
10.428AlaLeu: 10.428 ± 0.156
2.439AlaMet: 2.439 ± 0.05
3.448AlaAsn: 3.448 ± 0.074
3.219AlaPro: 3.219 ± 0.054
3.818AlaGln: 3.818 ± 0.071
4.202AlaArg: 4.202 ± 0.084
4.924AlaSer: 4.924 ± 0.063
4.8AlaThr: 4.8 ± 0.109
6.625AlaVal: 6.625 ± 0.072
1.204AlaTrp: 1.204 ± 0.034
2.613AlaTyr: 2.613 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.926CysAla: 0.926 ± 0.027
0.175CysCys: 0.175 ± 0.011
0.561CysAsp: 0.561 ± 0.021
0.584CysGlu: 0.584 ± 0.023
0.451CysPhe: 0.451 ± 0.016
0.904CysGly: 0.904 ± 0.032
0.321CysHis: 0.321 ± 0.02
0.655CysIle: 0.655 ± 0.024
0.426CysLys: 0.426 ± 0.018
1.133CysLeu: 1.133 ± 0.032
0.241CysMet: 0.241 ± 0.014
0.386CysAsn: 0.386 ± 0.018
0.521CysPro: 0.521 ± 0.02
0.394CysGln: 0.394 ± 0.018
0.651CysArg: 0.651 ± 0.022
0.731CysSer: 0.731 ± 0.022
0.537CysThr: 0.537 ± 0.022
0.695CysVal: 0.695 ± 0.025
0.146CysTrp: 0.146 ± 0.012
0.345CysTyr: 0.345 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.217AspAla: 5.217 ± 0.073
0.654AspCys: 0.654 ± 0.023
3.158AspAsp: 3.158 ± 0.063
3.543AspGlu: 3.543 ± 0.063
2.575AspPhe: 2.575 ± 0.044
3.864AspGly: 3.864 ± 0.061
1.177AspHis: 1.177 ± 0.032
3.812AspIle: 3.812 ± 0.058
3.049AspLys: 3.049 ± 0.062
5.509AspLeu: 5.509 ± 0.083
1.354AspMet: 1.354 ± 0.032
2.27AspAsn: 2.27 ± 0.047
2.31AspPro: 2.31 ± 0.044
2.149AspGln: 2.149 ± 0.039
2.79AspArg: 2.79 ± 0.046
3.139AspSer: 3.139 ± 0.048
2.766AspThr: 2.766 ± 0.071
3.587AspVal: 3.587 ± 0.066
0.917AspTrp: 0.917 ± 0.032
1.9AspTyr: 1.9 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.578GluAla: 5.578 ± 0.091
0.501GluCys: 0.501 ± 0.022
2.834GluAsp: 2.834 ± 0.053
3.231GluGlu: 3.231 ± 0.068
2.229GluPhe: 2.229 ± 0.046
3.313GluGly: 3.313 ± 0.056
1.608GluHis: 1.608 ± 0.039
4.162GluIle: 4.162 ± 0.066
3.471GluLys: 3.471 ± 0.065
6.785GluLeu: 6.785 ± 0.085
1.502GluMet: 1.502 ± 0.033
2.463GluAsn: 2.463 ± 0.047
2.09GluPro: 2.09 ± 0.04
3.913GluGln: 3.913 ± 0.068
3.437GluArg: 3.437 ± 0.059
3.286GluSer: 3.286 ± 0.049
3.261GluThr: 3.261 ± 0.056
3.772GluVal: 3.772 ± 0.067
0.716GluTrp: 0.716 ± 0.024
1.585GluTyr: 1.585 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.405PheAla: 3.405 ± 0.054
0.523PheCys: 0.523 ± 0.022
2.65PheAsp: 2.65 ± 0.045
2.236PheGlu: 2.236 ± 0.039
1.838PhePhe: 1.838 ± 0.043
2.934PheGly: 2.934 ± 0.044
0.813PheHis: 0.813 ± 0.024
2.67PheIle: 2.67 ± 0.047
1.972PheLys: 1.972 ± 0.044
3.688PheLeu: 3.688 ± 0.059
0.958PheMet: 0.958 ± 0.031
1.905PheAsn: 1.905 ± 0.038
1.591PhePro: 1.591 ± 0.032
1.355PheGln: 1.355 ± 0.032
1.762PheArg: 1.762 ± 0.034
3.053PheSer: 3.053 ± 0.06
2.21PheThr: 2.21 ± 0.054
2.566PheVal: 2.566 ± 0.051
0.535PheTrp: 0.535 ± 0.023
1.305PheTyr: 1.305 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.667GlyAla: 5.667 ± 0.109
0.946GlyCys: 0.946 ± 0.026
3.652GlyAsp: 3.652 ± 0.053
3.975GlyGlu: 3.975 ± 0.069
3.332GlyPhe: 3.332 ± 0.055
5.144GlyGly: 5.144 ± 0.107
1.651GlyHis: 1.651 ± 0.037
4.968GlyIle: 4.968 ± 0.076
4.059GlyLys: 4.059 ± 0.06
7.458GlyLeu: 7.458 ± 0.076
1.955GlyMet: 1.955 ± 0.046
2.947GlyAsn: 2.947 ± 0.081
1.77GlyPro: 1.77 ± 0.04
2.839GlyGln: 2.839 ± 0.051
3.593GlyArg: 3.593 ± 0.057
4.259GlySer: 4.259 ± 0.096
3.781GlyThr: 3.781 ± 0.123
5.048GlyVal: 5.048 ± 0.074
1.014GlyTrp: 1.014 ± 0.032
2.519GlyTyr: 2.519 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.971HisAla: 1.971 ± 0.044
0.338HisCys: 0.338 ± 0.017
1.295HisAsp: 1.295 ± 0.029
1.324HisGlu: 1.324 ± 0.035
1.111HisPhe: 1.111 ± 0.032
1.64HisGly: 1.64 ± 0.036
0.742HisHis: 0.742 ± 0.028
1.44HisIle: 1.44 ± 0.031
0.993HisLys: 0.993 ± 0.026
2.371HisLeu: 2.371 ± 0.048
0.454HisMet: 0.454 ± 0.018
0.843HisAsn: 0.843 ± 0.025
1.373HisPro: 1.373 ± 0.034
1.111HisGln: 1.111 ± 0.033
1.226HisArg: 1.226 ± 0.035
1.387HisSer: 1.387 ± 0.031
1.073HisThr: 1.073 ± 0.029
1.249HisVal: 1.249 ± 0.033
0.399HisTrp: 0.399 ± 0.018
0.871HisTyr: 0.871 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.706IleAla: 6.706 ± 0.084
0.664IleCys: 0.664 ± 0.021
4.325IleAsp: 4.325 ± 0.068
4.232IleGlu: 4.232 ± 0.066
2.195IlePhe: 2.195 ± 0.045
4.747IleGly: 4.747 ± 0.068
1.415IleHis: 1.415 ± 0.033
3.954IleIle: 3.954 ± 0.073
3.56IleLys: 3.56 ± 0.057
5.576IleLeu: 5.576 ± 0.074
1.307IleMet: 1.307 ± 0.035
3.08IleAsn: 3.08 ± 0.047
2.889IlePro: 2.889 ± 0.047
2.154IleGln: 2.154 ± 0.042
3.12IleArg: 3.12 ± 0.044
4.037IleSer: 4.037 ± 0.057
3.816IleThr: 3.816 ± 0.075
4.115IleVal: 4.115 ± 0.067
0.622IleTrp: 0.622 ± 0.022
1.727IleTyr: 1.727 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.707LysAla: 4.707 ± 0.075
0.317LysCys: 0.317 ± 0.016
2.628LysAsp: 2.628 ± 0.054
2.915LysGlu: 2.915 ± 0.058
1.427LysPhe: 1.427 ± 0.037
2.99LysGly: 2.99 ± 0.053
1.229LysHis: 1.229 ± 0.031
3.464LysIle: 3.464 ± 0.059
3.006LysLys: 3.006 ± 0.061
5.155LysLeu: 5.155 ± 0.071
1.271LysMet: 1.271 ± 0.033
2.378LysAsn: 2.378 ± 0.049
2.519LysPro: 2.519 ± 0.048
2.814LysGln: 2.814 ± 0.051
2.595LysArg: 2.595 ± 0.043
2.887LysSer: 2.887 ± 0.047
3.211LysThr: 3.211 ± 0.053
3.136LysVal: 3.136 ± 0.067
0.466LysTrp: 0.466 ± 0.02
1.223LysTyr: 1.223 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
10.484LeuAla: 10.484 ± 0.125
1.155LeuCys: 1.155 ± 0.03
5.897LeuAsp: 5.897 ± 0.079
6.148LeuGlu: 6.148 ± 0.085
4.316LeuPhe: 4.316 ± 0.067
7.108LeuGly: 7.108 ± 0.089
2.272LeuHis: 2.272 ± 0.049
6.566LeuIle: 6.566 ± 0.076
5.539LeuLys: 5.539 ± 0.07
11.607LeuLeu: 11.607 ± 0.132
2.606LeuMet: 2.606 ± 0.044
4.416LeuAsn: 4.416 ± 0.065
5.294LeuPro: 5.294 ± 0.092
4.168LeuGln: 4.168 ± 0.068
5.279LeuArg: 5.279 ± 0.067
7.337LeuSer: 7.337 ± 0.09
6.105LeuThr: 6.105 ± 0.083
6.49LeuVal: 6.49 ± 0.081
1.206LeuTrp: 1.206 ± 0.038
2.616LeuTyr: 2.616 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.33MetAla: 2.33 ± 0.047
0.189MetCys: 0.189 ± 0.012
1.282MetAsp: 1.282 ± 0.036
1.279MetGlu: 1.279 ± 0.035
0.705MetPhe: 0.705 ± 0.023
1.571MetGly: 1.571 ± 0.038
0.563MetHis: 0.563 ± 0.021
1.387MetIle: 1.387 ± 0.035
1.286MetLys: 1.286 ± 0.034
2.592MetLeu: 2.592 ± 0.047
0.639MetMet: 0.639 ± 0.025
1.121MetAsn: 1.121 ± 0.028
1.331MetPro: 1.331 ± 0.036
1.16MetGln: 1.16 ± 0.03
1.2MetArg: 1.2 ± 0.03
1.574MetSer: 1.574 ± 0.04
1.59MetThr: 1.59 ± 0.036
1.439MetVal: 1.439 ± 0.035
0.15MetTrp: 0.15 ± 0.011
0.426MetTyr: 0.426 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.774AsnAla: 3.774 ± 0.069
0.439AsnCys: 0.439 ± 0.017
2.228AsnAsp: 2.228 ± 0.059
2.189AsnGlu: 2.189 ± 0.04
1.452AsnPhe: 1.452 ± 0.031
2.907AsnGly: 2.907 ± 0.07
0.915AsnHis: 0.915 ± 0.025
2.746AsnIle: 2.746 ± 0.047
2.064AsnLys: 2.064 ± 0.042
4.034AsnLeu: 4.034 ± 0.064
0.908AsnMet: 0.908 ± 0.025
1.819AsnAsn: 1.819 ± 0.053
2.314AsnPro: 2.314 ± 0.041
1.795AsnGln: 1.795 ± 0.037
2.281AsnArg: 2.281 ± 0.042
2.421AsnSer: 2.421 ± 0.059
2.217AsnThr: 2.217 ± 0.052
2.385AsnVal: 2.385 ± 0.057
0.589AsnTrp: 0.589 ± 0.022
1.218AsnTyr: 1.218 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
3.958ProAla: 3.958 ± 0.065
0.444ProCys: 0.444 ± 0.021
2.948ProAsp: 2.948 ± 0.058
3.577ProGlu: 3.577 ± 0.057
1.737ProPhe: 1.737 ± 0.039
3.201ProGly: 3.201 ± 0.058
0.928ProHis: 0.928 ± 0.03
2.476ProIle: 2.476 ± 0.042
1.836ProLys: 1.836 ± 0.043
4.521ProLeu: 4.521 ± 0.071
0.962ProMet: 0.962 ± 0.03
1.572ProAsn: 1.572 ± 0.033
1.75ProPro: 1.75 ± 0.042
1.596ProGln: 1.596 ± 0.036
1.649ProArg: 1.649 ± 0.034
2.404ProSer: 2.404 ± 0.054
2.095ProThr: 2.095 ± 0.045
3.674ProVal: 3.674 ± 0.051
0.517ProTrp: 0.517 ± 0.024
1.209ProTyr: 1.209 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.615GlnAla: 4.615 ± 0.08
0.399GlnCys: 0.399 ± 0.019
2.025GlnAsp: 2.025 ± 0.042
2.293GlnGlu: 2.293 ± 0.045
1.558GlnPhe: 1.558 ± 0.031
2.954GlnGly: 2.954 ± 0.057
1.185GlnHis: 1.185 ± 0.034
2.628GlnIle: 2.628 ± 0.049
2.053GlnLys: 2.053 ± 0.042
4.869GlnLeu: 4.869 ± 0.078
0.941GlnMet: 0.941 ± 0.026
1.58GlnAsn: 1.58 ± 0.039
1.926GlnPro: 1.926 ± 0.041
2.948GlnGln: 2.948 ± 0.071
2.506GlnArg: 2.506 ± 0.058
2.609GlnSer: 2.609 ± 0.046
2.413GlnThr: 2.413 ± 0.048
2.809GlnVal: 2.809 ± 0.046
0.587GlnTrp: 0.587 ± 0.02
1.131GlnTyr: 1.131 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
3.779ArgAla: 3.779 ± 0.053
0.564ArgCys: 0.564 ± 0.019
2.613ArgAsp: 2.613 ± 0.04
2.984ArgGlu: 2.984 ± 0.049
2.391ArgPhe: 2.391 ± 0.045
2.819ArgGly: 2.819 ± 0.055
1.351ArgHis: 1.351 ± 0.035
3.592ArgIle: 3.592 ± 0.051
2.489ArgLys: 2.489 ± 0.047
6.164ArgLeu: 6.164 ± 0.079
1.305ArgMet: 1.305 ± 0.026
2.046ArgAsn: 2.046 ± 0.04
2.012ArgPro: 2.012 ± 0.047
2.591ArgGln: 2.591 ± 0.044
2.802ArgArg: 2.802 ± 0.051
2.841ArgSer: 2.841 ± 0.055
2.281ArgThr: 2.281 ± 0.045
3.242ArgVal: 3.242 ± 0.06
0.784ArgTrp: 0.784 ± 0.027
1.862ArgTyr: 1.862 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.75SerAla: 5.75 ± 0.081
0.663SerCys: 0.663 ± 0.023
3.092SerAsp: 3.092 ± 0.052
3.401SerGlu: 3.401 ± 0.054
2.548SerPhe: 2.548 ± 0.044
5.233SerGly: 5.233 ± 0.105
1.397SerHis: 1.397 ± 0.034
3.756SerIle: 3.756 ± 0.057
2.681SerLys: 2.681 ± 0.047
6.403SerLeu: 6.403 ± 0.074
1.428SerMet: 1.428 ± 0.038
2.319SerAsn: 2.319 ± 0.058
2.71SerPro: 2.71 ± 0.05
2.281SerGln: 2.281 ± 0.039
3.155SerArg: 3.155 ± 0.042
3.981SerSer: 3.981 ± 0.068
3.185SerThr: 3.185 ± 0.07
4.209SerVal: 4.209 ± 0.061
0.805SerTrp: 0.805 ± 0.027
1.803SerTyr: 1.803 ± 0.045
0.001SerXaa: 0.001 ± 0.001
Thr
5.347ThrAla: 5.347 ± 0.1
0.499ThrCys: 0.499 ± 0.021
3.054ThrAsp: 3.054 ± 0.061
3.157ThrGlu: 3.157 ± 0.048
1.888ThrPhe: 1.888 ± 0.046
4.927ThrGly: 4.927 ± 0.12
1.295ThrHis: 1.295 ± 0.033
3.212ThrIle: 3.212 ± 0.07
2.07ThrLys: 2.07 ± 0.042
6.39ThrLeu: 6.39 ± 0.101
0.981ThrMet: 0.981 ± 0.029
1.753ThrAsn: 1.753 ± 0.052
2.91ThrPro: 2.91 ± 0.06
2.223ThrGln: 2.223 ± 0.041
2.414ThrArg: 2.414 ± 0.037
3.003ThrSer: 3.003 ± 0.081
2.93ThrThr: 2.93 ± 0.091
4.123ThrVal: 4.123 ± 0.088
0.608ThrTrp: 0.608 ± 0.025
1.467ThrTyr: 1.467 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.114ValAla: 6.114 ± 0.074
0.722ValCys: 0.722 ± 0.026
3.843ValAsp: 3.843 ± 0.057
4.129ValGlu: 4.129 ± 0.062
2.883ValPhe: 2.883 ± 0.05
4.365ValGly: 4.365 ± 0.067
1.33ValHis: 1.33 ± 0.032
4.561ValIle: 4.561 ± 0.065
3.321ValLys: 3.321 ± 0.059
6.952ValLeu: 6.952 ± 0.086
1.716ValMet: 1.716 ± 0.038
2.826ValAsn: 2.826 ± 0.056
2.639ValPro: 2.639 ± 0.048
2.285ValGln: 2.285 ± 0.042
3.124ValArg: 3.124 ± 0.044
4.358ValSer: 4.358 ± 0.063
3.9ValThr: 3.9 ± 0.078
4.678ValVal: 4.678 ± 0.08
0.828ValTrp: 0.828 ± 0.025
1.813ValTyr: 1.813 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.854TrpAla: 0.854 ± 0.026
0.142TrpCys: 0.142 ± 0.01
0.643TrpAsp: 0.643 ± 0.028
0.651TrpGlu: 0.651 ± 0.022
0.537TrpPhe: 0.537 ± 0.02
0.764TrpGly: 0.764 ± 0.025
0.357TrpHis: 0.357 ± 0.017
0.705TrpIle: 0.705 ± 0.023
0.576TrpLys: 0.576 ± 0.022
1.831TrpLeu: 1.831 ± 0.046
0.344TrpMet: 0.344 ± 0.016
0.519TrpAsn: 0.519 ± 0.022
0.529TrpPro: 0.529 ± 0.023
0.824TrpGln: 0.824 ± 0.025
0.795TrpArg: 0.795 ± 0.026
0.699TrpSer: 0.699 ± 0.025
0.599TrpThr: 0.599 ± 0.025
0.848TrpVal: 0.848 ± 0.027
0.195TrpTrp: 0.195 ± 0.012
0.322TrpTyr: 0.322 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.547TyrAla: 2.547 ± 0.042
0.405TyrCys: 0.405 ± 0.016
1.599TyrAsp: 1.599 ± 0.041
1.435TyrGlu: 1.435 ± 0.037
1.33TyrPhe: 1.33 ± 0.034
2.169TyrGly: 2.169 ± 0.045
0.676TyrHis: 0.676 ± 0.021
1.525TyrIle: 1.525 ± 0.033
1.224TyrLys: 1.224 ± 0.038
3.143TyrLeu: 3.143 ± 0.047
0.506TyrMet: 0.506 ± 0.02
1.006TyrAsn: 1.006 ± 0.032
1.356TyrPro: 1.356 ± 0.032
1.61TyrGln: 1.61 ± 0.035
1.93TyrArg: 1.93 ± 0.042
1.867TyrSer: 1.867 ± 0.038
1.483TyrThr: 1.483 ± 0.04
1.697TyrVal: 1.697 ± 0.039
0.448TyrTrp: 0.448 ± 0.02
0.959TyrTyr: 0.959 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.001XaaCys: 0.001 ± 0.001
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 4194 proteins (1362415 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski