Amino acid dipepetide frequency for Culex-associated Tombus-like virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.612AlaAla: 5.612 ± 1.534
2.245AlaCys: 2.245 ± 0.449
2.245AlaAsp: 2.245 ± 0.449
3.367AlaGlu: 3.367 ± 3.331
2.245AlaPhe: 2.245 ± 1.322
1.122AlaGly: 1.122 ± 0.661
2.245AlaHis: 2.245 ± 1.322
1.122AlaIle: 1.122 ± 0.661
3.367AlaLys: 3.367 ± 0.212
5.612AlaLeu: 5.612 ± 1.534
0.0AlaMet: 0.0 ± 0.0
3.367AlaAsn: 3.367 ± 0.212
1.122AlaPro: 1.122 ± 0.661
1.122AlaGln: 1.122 ± 1.11
2.245AlaArg: 2.245 ± 0.449
1.122AlaSer: 1.122 ± 1.11
1.122AlaThr: 1.122 ± 1.11
2.245AlaVal: 2.245 ± 2.22
1.122AlaTrp: 1.122 ± 1.11
6.734AlaTyr: 6.734 ± 3.119
0.0AlaXaa: 0.0 ± 0.0
Cys
3.367CysAla: 3.367 ± 1.983
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.122CysPhe: 1.122 ± 0.661
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
2.245CysArg: 2.245 ± 1.322
1.122CysSer: 1.122 ± 1.11
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.122CysTyr: 1.122 ± 0.661
0.0CysXaa: 0.0 ± 0.0
Asp
4.489AspAla: 4.489 ± 0.873
0.0AspCys: 0.0 ± 0.0
2.245AspAsp: 2.245 ± 1.322
4.489AspGlu: 4.489 ± 0.873
2.245AspPhe: 2.245 ± 0.449
2.245AspGly: 2.245 ± 0.449
2.245AspHis: 2.245 ± 0.449
4.489AspIle: 4.489 ± 0.898
1.122AspLys: 1.122 ± 0.661
2.245AspLeu: 2.245 ± 0.449
0.0AspMet: 0.0 ± 0.0
2.245AspAsn: 2.245 ± 0.449
0.0AspPro: 0.0 ± 0.0
1.122AspGln: 1.122 ± 0.661
2.245AspArg: 2.245 ± 1.322
1.122AspSer: 1.122 ± 1.11
6.734AspThr: 6.734 ± 0.423
1.122AspVal: 1.122 ± 1.11
1.122AspTrp: 1.122 ± 1.11
3.367AspTyr: 3.367 ± 0.212
0.0AspXaa: 0.0 ± 0.0
Glu
2.245GluAla: 2.245 ± 1.322
1.122GluCys: 1.122 ± 0.661
0.0GluAsp: 0.0 ± 0.0
2.245GluGlu: 2.245 ± 0.449
3.367GluPhe: 3.367 ± 0.212
2.245GluGly: 2.245 ± 0.449
2.245GluHis: 2.245 ± 1.322
5.612GluIle: 5.612 ± 0.238
4.489GluLys: 4.489 ± 0.873
5.612GluLeu: 5.612 ± 0.238
1.122GluMet: 1.122 ± 0.661
5.612GluAsn: 5.612 ± 0.238
0.0GluPro: 0.0 ± 0.0
1.122GluGln: 1.122 ± 0.661
2.245GluArg: 2.245 ± 0.449
1.122GluSer: 1.122 ± 1.11
6.734GluThr: 6.734 ± 1.348
4.489GluVal: 4.489 ± 0.898
2.245GluTrp: 2.245 ± 0.449
4.489GluTyr: 4.489 ± 0.873
0.0GluXaa: 0.0 ± 0.0
Phe
2.245PheAla: 2.245 ± 2.22
1.122PheCys: 1.122 ± 0.661
1.122PheAsp: 1.122 ± 0.661
0.0PheGlu: 0.0 ± 0.0
1.122PhePhe: 1.122 ± 1.11
3.367PheGly: 3.367 ± 0.212
0.0PheHis: 0.0 ± 0.0
2.245PheIle: 2.245 ± 0.449
4.489PheLys: 4.489 ± 2.644
2.245PheLeu: 2.245 ± 0.449
0.0PheMet: 0.0 ± 0.0
2.245PheAsn: 2.245 ± 1.322
3.367PhePro: 3.367 ± 0.212
0.0PheGln: 0.0 ± 0.0
2.245PheArg: 2.245 ± 2.22
1.122PheSer: 1.122 ± 0.661
4.489PheThr: 4.489 ± 0.873
0.0PheVal: 0.0 ± 0.0
1.122PheTrp: 1.122 ± 1.11
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
0.0GlyAla: 0.0 ± 0.0
0.0GlyCys: 0.0 ± 0.0
2.245GlyAsp: 2.245 ± 1.322
3.367GlyGlu: 3.367 ± 1.983
2.245GlyPhe: 2.245 ± 2.22
0.0GlyGly: 0.0 ± 0.0
0.0GlyHis: 0.0 ± 0.0
4.489GlyIle: 4.489 ± 0.898
5.612GlyLys: 5.612 ± 0.238
5.612GlyLeu: 5.612 ± 1.534
2.245GlyMet: 2.245 ± 0.449
1.122GlyAsn: 1.122 ± 0.661
3.367GlyPro: 3.367 ± 1.559
5.612GlyGln: 5.612 ± 0.238
3.367GlyArg: 3.367 ± 0.212
2.245GlySer: 2.245 ± 1.322
5.612GlyThr: 5.612 ± 2.009
0.0GlyVal: 0.0 ± 0.0
2.245GlyTrp: 2.245 ± 2.22
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
1.122HisAsp: 1.122 ± 0.661
0.0HisGlu: 0.0 ± 0.0
1.122HisPhe: 1.122 ± 0.661
1.122HisGly: 1.122 ± 0.661
1.122HisHis: 1.122 ± 0.661
4.489HisIle: 4.489 ± 0.873
4.489HisLys: 4.489 ± 2.644
2.245HisLeu: 2.245 ± 0.449
1.122HisMet: 1.122 ± 0.661
0.0HisAsn: 0.0 ± 0.0
1.122HisPro: 1.122 ± 0.661
3.367HisGln: 3.367 ± 1.983
2.245HisArg: 2.245 ± 0.449
1.122HisSer: 1.122 ± 1.11
1.122HisThr: 1.122 ± 0.661
2.245HisVal: 2.245 ± 1.322
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.245IleAla: 2.245 ± 1.322
1.122IleCys: 1.122 ± 0.661
2.245IleAsp: 2.245 ± 0.449
3.367IleGlu: 3.367 ± 0.212
2.245IlePhe: 2.245 ± 0.449
4.489IleGly: 4.489 ± 2.644
1.122IleHis: 1.122 ± 0.661
3.367IleIle: 3.367 ± 0.212
7.856IleLys: 7.856 ± 0.687
11.223IleLeu: 11.223 ± 0.475
4.489IleMet: 4.489 ± 0.898
4.489IleAsn: 4.489 ± 0.873
2.245IlePro: 2.245 ± 0.449
5.612IleGln: 5.612 ± 2.009
3.367IleArg: 3.367 ± 0.212
5.612IleSer: 5.612 ± 0.238
1.122IleThr: 1.122 ± 1.11
0.0IleVal: 0.0 ± 0.0
0.0IleTrp: 0.0 ± 0.0
6.734IleTyr: 6.734 ± 2.195
0.0IleXaa: 0.0 ± 0.0
Lys
3.367LysAla: 3.367 ± 0.212
1.122LysCys: 1.122 ± 0.661
5.612LysAsp: 5.612 ± 0.238
7.856LysGlu: 7.856 ± 2.855
3.367LysPhe: 3.367 ± 0.212
3.367LysGly: 3.367 ± 1.983
2.245LysHis: 2.245 ± 0.449
4.489LysIle: 4.489 ± 0.873
4.489LysLys: 4.489 ± 0.873
8.979LysLeu: 8.979 ± 1.745
2.245LysMet: 2.245 ± 1.689
4.489LysAsn: 4.489 ± 2.644
3.367LysPro: 3.367 ± 1.983
3.367LysGln: 3.367 ± 0.212
5.612LysArg: 5.612 ± 1.534
3.367LysSer: 3.367 ± 0.212
5.612LysThr: 5.612 ± 3.305
2.245LysVal: 2.245 ± 2.22
1.122LysTrp: 1.122 ± 0.661
6.734LysTyr: 6.734 ± 2.195
0.0LysXaa: 0.0 ± 0.0
Leu
5.612LeuAla: 5.612 ± 0.238
1.122LeuCys: 1.122 ± 0.661
3.367LeuAsp: 3.367 ± 0.212
5.612LeuGlu: 5.612 ± 0.238
4.489LeuPhe: 4.489 ± 2.644
3.367LeuGly: 3.367 ± 0.212
1.122LeuHis: 1.122 ± 0.661
4.489LeuIle: 4.489 ± 0.873
8.979LeuLys: 8.979 ± 3.516
5.612LeuLeu: 5.612 ± 1.534
2.245LeuMet: 2.245 ± 1.322
3.367LeuAsn: 3.367 ± 3.331
5.612LeuPro: 5.612 ± 2.009
3.367LeuGln: 3.367 ± 1.983
3.367LeuArg: 3.367 ± 0.212
2.245LeuSer: 2.245 ± 0.449
12.346LeuThr: 12.346 ± 3.356
2.245LeuVal: 2.245 ± 2.22
0.0LeuTrp: 0.0 ± 0.0
3.367LeuTyr: 3.367 ± 0.212
0.0LeuXaa: 0.0 ± 0.0
Met
1.122MetAla: 1.122 ± 1.11
0.0MetCys: 0.0 ± 0.0
2.245MetAsp: 2.245 ± 0.449
3.367MetGlu: 3.367 ± 1.983
0.0MetPhe: 0.0 ± 0.0
2.245MetGly: 2.245 ± 0.449
3.367MetHis: 3.367 ± 0.212
1.122MetIle: 1.122 ± 1.11
3.367MetLys: 3.367 ± 1.983
1.122MetLeu: 1.122 ± 1.11
3.367MetMet: 3.367 ± 0.212
1.122MetAsn: 1.122 ± 0.661
2.245MetPro: 2.245 ± 2.22
2.245MetGln: 2.245 ± 0.449
0.0MetArg: 0.0 ± 0.0
1.122MetSer: 1.122 ± 1.11
2.245MetThr: 2.245 ± 1.322
1.122MetVal: 1.122 ± 0.661
0.0MetTrp: 0.0 ± 0.0
1.122MetTyr: 1.122 ± 0.661
0.0MetXaa: 0.0 ± 0.0
Asn
3.367AsnAla: 3.367 ± 3.331
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
3.367AsnGlu: 3.367 ± 1.559
0.0AsnPhe: 0.0 ± 0.0
2.245AsnGly: 2.245 ± 0.449
0.0AsnHis: 0.0 ± 0.0
7.856AsnIle: 7.856 ± 2.855
6.734AsnLys: 6.734 ± 2.195
2.245AsnLeu: 2.245 ± 2.22
1.122AsnMet: 1.122 ± 0.661
1.122AsnAsn: 1.122 ± 0.661
0.0AsnPro: 0.0 ± 0.0
1.122AsnGln: 1.122 ± 1.11
4.489AsnArg: 4.489 ± 0.873
3.367AsnSer: 3.367 ± 0.212
2.245AsnThr: 2.245 ± 1.322
2.245AsnVal: 2.245 ± 1.322
1.122AsnTrp: 1.122 ± 0.661
3.367AsnTyr: 3.367 ± 1.983
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
4.489ProAsp: 4.489 ± 0.898
4.489ProGlu: 4.489 ± 0.898
3.367ProPhe: 3.367 ± 1.559
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
4.489ProIle: 4.489 ± 0.898
1.122ProLys: 1.122 ± 1.11
4.489ProLeu: 4.489 ± 0.898
1.122ProMet: 1.122 ± 0.667
0.0ProAsn: 0.0 ± 0.0
4.489ProPro: 4.489 ± 2.67
2.245ProGln: 2.245 ± 0.449
5.612ProArg: 5.612 ± 2.009
4.489ProSer: 4.489 ± 0.898
1.122ProThr: 1.122 ± 1.11
3.367ProVal: 3.367 ± 0.212
0.0ProTrp: 0.0 ± 0.0
5.612ProTyr: 5.612 ± 2.009
0.0ProXaa: 0.0 ± 0.0
Gln
4.489GlnAla: 4.489 ± 0.873
0.0GlnCys: 0.0 ± 0.0
3.367GlnAsp: 3.367 ± 1.559
4.489GlnGlu: 4.489 ± 0.898
0.0GlnPhe: 0.0 ± 0.0
1.122GlnGly: 1.122 ± 1.11
2.245GlnHis: 2.245 ± 1.322
1.122GlnIle: 1.122 ± 0.661
1.122GlnLys: 1.122 ± 0.661
5.612GlnLeu: 5.612 ± 0.238
0.0GlnMet: 0.0 ± 0.0
3.367GlnAsn: 3.367 ± 0.212
6.734GlnPro: 6.734 ± 1.348
1.122GlnGln: 1.122 ± 0.661
3.367GlnArg: 3.367 ± 1.983
3.367GlnSer: 3.367 ± 1.983
1.122GlnThr: 1.122 ± 1.11
3.367GlnVal: 3.367 ± 0.212
1.122GlnTrp: 1.122 ± 0.661
1.122GlnTyr: 1.122 ± 0.661
0.0GlnXaa: 0.0 ± 0.0
Arg
3.367ArgAla: 3.367 ± 3.331
1.122ArgCys: 1.122 ± 0.661
1.122ArgAsp: 1.122 ± 0.661
1.122ArgGlu: 1.122 ± 1.11
1.122ArgPhe: 1.122 ± 0.661
2.245ArgGly: 2.245 ± 2.22
4.489ArgHis: 4.489 ± 2.644
8.979ArgIle: 8.979 ± 1.745
2.245ArgLys: 2.245 ± 0.449
6.734ArgLeu: 6.734 ± 0.423
2.245ArgMet: 2.245 ± 0.449
2.245ArgAsn: 2.245 ± 1.322
6.734ArgPro: 6.734 ± 6.661
4.489ArgGln: 4.489 ± 0.873
4.489ArgArg: 4.489 ± 2.67
1.122ArgSer: 1.122 ± 0.661
6.734ArgThr: 6.734 ± 3.119
3.367ArgVal: 3.367 ± 1.983
0.0ArgTrp: 0.0 ± 0.0
1.122ArgTyr: 1.122 ± 0.661
0.0ArgXaa: 0.0 ± 0.0
Ser
0.0SerAla: 0.0 ± 0.0
0.0SerCys: 0.0 ± 0.0
0.0SerAsp: 0.0 ± 0.0
3.367SerGlu: 3.367 ± 0.212
0.0SerPhe: 0.0 ± 0.0
6.734SerGly: 6.734 ± 3.119
1.122SerHis: 1.122 ± 0.661
5.612SerIle: 5.612 ± 1.534
5.612SerLys: 5.612 ± 3.305
1.122SerLeu: 1.122 ± 0.661
4.489SerMet: 4.489 ± 0.898
4.489SerAsn: 4.489 ± 2.67
1.122SerPro: 1.122 ± 1.11
1.122SerGln: 1.122 ± 0.661
4.489SerArg: 4.489 ± 4.441
2.245SerSer: 2.245 ± 1.322
7.856SerThr: 7.856 ± 0.687
0.0SerVal: 0.0 ± 0.0
0.0SerTrp: 0.0 ± 0.0
2.245SerTyr: 2.245 ± 2.22
0.0SerXaa: 0.0 ± 0.0
Thr
5.612ThrAla: 5.612 ± 2.009
0.0ThrCys: 0.0 ± 0.0
5.612ThrAsp: 5.612 ± 2.009
4.489ThrGlu: 4.489 ± 0.873
1.122ThrPhe: 1.122 ± 0.661
5.612ThrGly: 5.612 ± 0.238
1.122ThrHis: 1.122 ± 0.661
4.489ThrIle: 4.489 ± 0.898
5.612ThrLys: 5.612 ± 1.534
1.122ThrLeu: 1.122 ± 0.661
2.245ThrMet: 2.245 ± 0.449
5.612ThrAsn: 5.612 ± 1.534
3.367ThrPro: 3.367 ± 1.559
3.367ThrGln: 3.367 ± 1.559
8.979ThrArg: 8.979 ± 5.339
6.734ThrSer: 6.734 ± 1.348
7.856ThrThr: 7.856 ± 4.229
5.612ThrVal: 5.612 ± 3.305
1.122ThrTrp: 1.122 ± 0.661
3.367ThrTyr: 3.367 ± 0.212
0.0ThrXaa: 0.0 ± 0.0
Val
2.245ValAla: 2.245 ± 2.22
0.0ValCys: 0.0 ± 0.0
3.367ValAsp: 3.367 ± 1.983
3.367ValGlu: 3.367 ± 0.212
0.0ValPhe: 0.0 ± 0.0
4.489ValGly: 4.489 ± 0.898
1.122ValHis: 1.122 ± 0.661
1.122ValIle: 1.122 ± 1.11
6.734ValLys: 6.734 ± 1.348
2.245ValLeu: 2.245 ± 1.322
1.122ValMet: 1.122 ± 1.11
0.0ValAsn: 0.0 ± 0.0
1.122ValPro: 1.122 ± 1.11
4.489ValGln: 4.489 ± 0.873
0.0ValArg: 0.0 ± 0.0
3.367ValSer: 3.367 ± 0.212
1.122ValThr: 1.122 ± 0.661
1.122ValVal: 1.122 ± 1.11
1.122ValTrp: 1.122 ± 0.661
1.122ValTyr: 1.122 ± 0.661
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
2.245TrpLys: 2.245 ± 1.322
0.0TrpLeu: 0.0 ± 0.0
1.122TrpMet: 1.122 ± 1.11
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.122TrpGln: 1.122 ± 0.661
0.0TrpArg: 0.0 ± 0.0
1.122TrpSer: 1.122 ± 1.11
4.489TrpThr: 4.489 ± 0.898
1.122TrpVal: 1.122 ± 1.11
0.0TrpTrp: 0.0 ± 0.0
2.245TrpTyr: 2.245 ± 0.449
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
4.489TyrAsp: 4.489 ± 0.898
0.0TyrGlu: 0.0 ± 0.0
3.367TyrPhe: 3.367 ± 1.559
3.367TyrGly: 3.367 ± 0.212
2.245TyrHis: 2.245 ± 0.449
3.367TyrIle: 3.367 ± 1.559
4.489TyrLys: 4.489 ± 2.644
7.856TyrLeu: 7.856 ± 0.687
1.122TyrMet: 1.122 ± 0.661
1.122TyrAsn: 1.122 ± 0.661
4.489TyrPro: 4.489 ± 0.873
2.245TyrGln: 2.245 ± 1.322
4.489TyrArg: 4.489 ± 2.644
4.489TyrSer: 4.489 ± 2.67
3.367TyrThr: 3.367 ± 1.983
3.367TyrVal: 3.367 ± 0.212
0.0TyrTrp: 0.0 ± 0.0
6.734TyrTyr: 6.734 ± 3.966
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski