Amino acid dipepetide frequency for Pedobacter changchengzhani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.192AlaAla: 4.192 ± 0.077	0.663AlaCys: 0.663 ± 0.023	4.284AlaAsp: 4.284 ± 0.07	4.381AlaGlu: 4.381 ± 0.075	3.544AlaPhe: 3.544 ± 0.053	4.785AlaGly: 4.785 ± 0.076	1.161AlaHis: 1.161 ± 0.038	5.759AlaIle: 5.759 ± 0.087	5.513AlaLys: 5.513 ± 0.081	6.789AlaLeu: 6.789 ± 0.092	1.603AlaMet: 1.603 ± 0.044	3.983AlaAsn: 3.983 ± 0.06	2.026AlaPro: 2.026 ± 0.053	2.784AlaGln: 2.784 ± 0.049	2.001AlaArg: 2.001 ± 0.045	4.392AlaSer: 4.392 ± 0.07	4.034AlaThr: 4.034 ± 0.058	4.545AlaVal: 4.545 ± 0.062	0.675AlaTrp: 0.675 ± 0.027	2.688AlaTyr: 2.688 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.552CysAla: 0.552 ± 0.025	0.134CysCys: 0.134 ± 0.012	0.405CysAsp: 0.405 ± 0.019	0.41CysGlu: 0.41 ± 0.023	0.458CysPhe: 0.458 ± 0.02	0.661CysGly: 0.661 ± 0.029	0.172CysHis: 0.172 ± 0.016	0.705CysIle: 0.705 ± 0.026	0.549CysLys: 0.549 ± 0.022	0.712CysLeu: 0.712 ± 0.028	0.17CysMet: 0.17 ± 0.012	0.43CysAsn: 0.43 ± 0.023	0.307CysPro: 0.307 ± 0.02	0.188CysGln: 0.188 ± 0.014	0.268CysArg: 0.268 ± 0.015	0.481CysSer: 0.481 ± 0.022	0.44CysThr: 0.44 ± 0.022	0.477CysVal: 0.477 ± 0.024	0.07CysTrp: 0.07 ± 0.008	0.304CysTyr: 0.304 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.907AspAla: 3.907 ± 0.061	0.422AspCys: 0.422 ± 0.02	2.843AspAsp: 2.843 ± 0.063	3.903AspGlu: 3.903 ± 0.063	3.606AspPhe: 3.606 ± 0.053	3.874AspGly: 3.874 ± 0.079	0.909AspHis: 0.909 ± 0.028	3.937AspIle: 3.937 ± 0.059	4.409AspLys: 4.409 ± 0.065	5.364AspLeu: 5.364 ± 0.071	1.087AspMet: 1.087 ± 0.031	2.765AspAsn: 2.765 ± 0.052	1.712AspPro: 1.712 ± 0.045	1.729AspGln: 1.729 ± 0.038	1.938AspArg: 1.938 ± 0.041	2.846AspSer: 2.846 ± 0.063	2.375AspThr: 2.375 ± 0.046	3.731AspVal: 3.731 ± 0.06	0.7AspTrp: 0.7 ± 0.027	2.655AspTyr: 2.655 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.013GluAla: 4.013 ± 0.077	0.324GluCys: 0.324 ± 0.017	2.94GluAsp: 2.94 ± 0.058	3.835GluGlu: 3.835 ± 0.079	2.646GluPhe: 2.646 ± 0.047	3.137GluGly: 3.137 ± 0.058	1.08GluHis: 1.08 ± 0.031	5.293GluIle: 5.293 ± 0.079	5.618GluLys: 5.618 ± 0.084	5.518GluLeu: 5.518 ± 0.097	1.482GluMet: 1.482 ± 0.047	4.124GluAsn: 4.124 ± 0.076	1.484GluPro: 1.484 ± 0.04	2.183GluGln: 2.183 ± 0.046	2.295GluArg: 2.295 ± 0.051	2.9GluSer: 2.9 ± 0.052	3.09GluThr: 3.09 ± 0.055	3.958GluVal: 3.958 ± 0.064	0.591GluTrp: 0.591 ± 0.025	1.995GluTyr: 1.995 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.643PheAla: 3.643 ± 0.058	0.533PheCys: 0.533 ± 0.022	3.209PheAsp: 3.209 ± 0.048	3.182PheGlu: 3.182 ± 0.057	2.712PhePhe: 2.712 ± 0.066	3.766PheGly: 3.766 ± 0.072	0.777PheHis: 0.777 ± 0.027	4.022PheIle: 4.022 ± 0.065	4.02PheLys: 4.02 ± 0.065	4.898PheLeu: 4.898 ± 0.091	1.121PheMet: 1.121 ± 0.029	3.367PheAsn: 3.367 ± 0.06	1.701PhePro: 1.701 ± 0.033	1.409PheGln: 1.409 ± 0.034	1.652PheArg: 1.652 ± 0.041	3.968PheSer: 3.968 ± 0.07	3.108PheThr: 3.108 ± 0.048	3.105PheVal: 3.105 ± 0.059	0.612PheTrp: 0.612 ± 0.026	2.337PheTyr: 2.337 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.434GlyAla: 4.434 ± 0.085	0.65GlyCys: 0.65 ± 0.031	3.403GlyAsp: 3.403 ± 0.077	3.386GlyGlu: 3.386 ± 0.057	3.718GlyPhe: 3.718 ± 0.062	4.661GlyGly: 4.661 ± 0.094	1.046GlyHis: 1.046 ± 0.032	5.458GlyIle: 5.458 ± 0.081	5.555GlyLys: 5.555 ± 0.077	6.08GlyLeu: 6.08 ± 0.082	1.609GlyMet: 1.609 ± 0.042	3.784GlyAsn: 3.784 ± 0.074	1.313GlyPro: 1.313 ± 0.044	1.85GlyGln: 1.85 ± 0.047	2.188GlyArg: 2.188 ± 0.05	3.94GlySer: 3.94 ± 0.073	3.856GlyThr: 3.856 ± 0.083	4.222GlyVal: 4.222 ± 0.077	0.748GlyTrp: 0.748 ± 0.026	2.903GlyTyr: 2.903 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.019HisAla: 1.019 ± 0.03	0.169HisCys: 0.169 ± 0.012	0.807HisAsp: 0.807 ± 0.026	0.881HisGlu: 0.881 ± 0.031	1.07HisPhe: 1.07 ± 0.033	1.019HisGly: 1.019 ± 0.028	0.469HisHis: 0.469 ± 0.021	1.312HisIle: 1.312 ± 0.033	1.156HisLys: 1.156 ± 0.034	1.798HisLeu: 1.798 ± 0.045	0.239HisMet: 0.239 ± 0.015	0.909HisAsn: 0.909 ± 0.026	0.886HisPro: 0.886 ± 0.033	0.725HisGln: 0.725 ± 0.028	0.618HisArg: 0.618 ± 0.023	0.92HisSer: 0.92 ± 0.026	0.857HisThr: 0.857 ± 0.029	0.892HisVal: 0.892 ± 0.033	0.206HisTrp: 0.206 ± 0.014	0.786HisTyr: 0.786 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.113IleAla: 6.113 ± 0.093	0.752IleCys: 0.752 ± 0.031	4.862IleAsp: 4.862 ± 0.074	4.857IleGlu: 4.857 ± 0.078	3.95IlePhe: 3.95 ± 0.076	5.245IleGly: 5.245 ± 0.085	1.251IleHis: 1.251 ± 0.039	6.229IleIle: 6.229 ± 0.095	6.301IleLys: 6.301 ± 0.087	7.276IleLeu: 7.276 ± 0.102	1.416IleMet: 1.416 ± 0.037	5.081IleAsn: 5.081 ± 0.077	3.064IlePro: 3.064 ± 0.056	2.326IleGln: 2.326 ± 0.046	2.567IleArg: 2.567 ± 0.049	5.527IleSer: 5.527 ± 0.08	4.659IleThr: 4.659 ± 0.062	4.731IleVal: 4.731 ± 0.068	0.785IleTrp: 0.785 ± 0.029	2.976IleTyr: 2.976 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.5LysAla: 5.5 ± 0.083	0.418LysCys: 0.418 ± 0.02	4.618LysAsp: 4.618 ± 0.068	4.967LysGlu: 4.967 ± 0.085	3.497LysPhe: 3.497 ± 0.06	4.684LysGly: 4.684 ± 0.071	1.325LysHis: 1.325 ± 0.034	6.771LysIle: 6.771 ± 0.085	6.508LysLys: 6.508 ± 0.086	7.537LysLeu: 7.537 ± 0.093	2.13LysMet: 2.13 ± 0.051	5.662LysAsn: 5.662 ± 0.078	2.862LysPro: 2.862 ± 0.058	2.957LysGln: 2.957 ± 0.063	2.718LysArg: 2.718 ± 0.047	4.809LysSer: 4.809 ± 0.072	4.967LysThr: 4.967 ± 0.061	4.901LysVal: 4.901 ± 0.071	0.815LysTrp: 0.815 ± 0.027	3.347LysTyr: 3.347 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.894LeuAla: 6.894 ± 0.086	0.731LeuCys: 0.731 ± 0.029	4.868LeuAsp: 4.868 ± 0.078	5.013LeuGlu: 5.013 ± 0.087	4.888LeuPhe: 4.888 ± 0.091	5.732LeuGly: 5.732 ± 0.087	1.543LeuHis: 1.543 ± 0.04	7.489LeuIle: 7.489 ± 0.107	8.364LeuLys: 8.364 ± 0.098	8.996LeuLeu: 8.996 ± 0.139	2.186LeuMet: 2.186 ± 0.047	6.392LeuAsn: 6.392 ± 0.074	3.896LeuPro: 3.896 ± 0.069	3.319LeuGln: 3.319 ± 0.056	3.102LeuArg: 3.102 ± 0.056	6.874LeuSer: 6.874 ± 0.069	5.549LeuThr: 5.549 ± 0.07	5.455LeuVal: 5.455 ± 0.08	0.84LeuTrp: 0.84 ± 0.028	3.133LeuTyr: 3.133 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.735MetAla: 1.735 ± 0.043	0.158MetCys: 0.158 ± 0.011	1.164MetAsp: 1.164 ± 0.04	1.294MetGlu: 1.294 ± 0.035	0.9MetPhe: 0.9 ± 0.034	1.53MetGly: 1.53 ± 0.038	0.4MetHis: 0.4 ± 0.021	1.5MetIle: 1.5 ± 0.038	1.976MetLys: 1.976 ± 0.042	2.017MetLeu: 2.017 ± 0.045	0.618MetMet: 0.618 ± 0.023	1.223MetAsn: 1.223 ± 0.034	1.001MetPro: 1.001 ± 0.031	0.943MetGln: 0.943 ± 0.03	0.877MetArg: 0.877 ± 0.03	1.313MetSer: 1.313 ± 0.035	0.933MetThr: 0.933 ± 0.033	1.486MetVal: 1.486 ± 0.038	0.171MetTrp: 0.171 ± 0.013	0.646MetTyr: 0.646 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.294AsnAla: 4.294 ± 0.067	0.428AsnCys: 0.428 ± 0.024	3.246AsnAsp: 3.246 ± 0.057	3.543AsnGlu: 3.543 ± 0.057	3.462AsnPhe: 3.462 ± 0.066	4.232AsnGly: 4.232 ± 0.081	1.027AsnHis: 1.027 ± 0.034	4.882AsnIle: 4.882 ± 0.073	4.58AsnLys: 4.58 ± 0.066	5.959AsnLeu: 5.959 ± 0.071	1.247AsnMet: 1.247 ± 0.038	3.883AsnAsn: 3.883 ± 0.074	2.696AsnPro: 2.696 ± 0.044	2.283AsnGln: 2.283 ± 0.047	2.209AsnArg: 2.209 ± 0.049	3.555AsnSer: 3.555 ± 0.067	3.596AsnThr: 3.596 ± 0.063	3.567AsnVal: 3.567 ± 0.058	0.805AsnTrp: 0.805 ± 0.03	2.918AsnTyr: 2.918 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.417ProAla: 2.417 ± 0.055	0.222ProCys: 0.222 ± 0.016	2.103ProAsp: 2.103 ± 0.048	2.429ProGlu: 2.429 ± 0.057	1.915ProPhe: 1.915 ± 0.042	2.095ProGly: 2.095 ± 0.074	0.55ProHis: 0.55 ± 0.022	2.807ProIle: 2.807 ± 0.05	2.692ProLys: 2.692 ± 0.043	3.069ProLeu: 3.069 ± 0.047	0.726ProMet: 0.726 ± 0.031	2.299ProAsn: 2.299 ± 0.049	0.859ProPro: 0.859 ± 0.033	1.236ProGln: 1.236 ± 0.034	0.901ProArg: 0.901 ± 0.031	2.123ProSer: 2.123 ± 0.045	2.085ProThr: 2.085 ± 0.051	2.4ProVal: 2.4 ± 0.053	0.322ProTrp: 0.322 ± 0.017	1.376ProTyr: 1.376 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.31GlnAla: 2.31 ± 0.046	0.168GlnCys: 0.168 ± 0.012	1.641GlnAsp: 1.641 ± 0.039	1.793GlnGlu: 1.793 ± 0.044	1.731GlnPhe: 1.731 ± 0.043	1.709GlnGly: 1.709 ± 0.04	0.671GlnHis: 0.671 ± 0.029	2.807GlnIle: 2.807 ± 0.049	3.006GlnLys: 3.006 ± 0.056	3.46GlnLeu: 3.46 ± 0.065	0.773GlnMet: 0.773 ± 0.028	2.346GlnAsn: 2.346 ± 0.049	1.217GlnPro: 1.217 ± 0.039	1.644GlnGln: 1.644 ± 0.059	1.278GlnArg: 1.278 ± 0.042	2.095GlnSer: 2.095 ± 0.043	1.987GlnThr: 1.987 ± 0.046	1.986GlnVal: 1.986 ± 0.045	0.305GlnTrp: 0.305 ± 0.015	1.332GlnTyr: 1.332 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.073ArgAla: 2.073 ± 0.049	0.206ArgCys: 0.206 ± 0.014	1.742ArgAsp: 1.742 ± 0.049	1.955ArgGlu: 1.955 ± 0.053	1.89ArgPhe: 1.89 ± 0.041	1.899ArgGly: 1.899 ± 0.047	0.535ArgHis: 0.535 ± 0.021	2.802ArgIle: 2.802 ± 0.05	2.806ArgLys: 2.806 ± 0.056	3.356ArgLeu: 3.356 ± 0.056	0.893ArgMet: 0.893 ± 0.031	2.112ArgAsn: 2.112 ± 0.048	1.104ArgPro: 1.104 ± 0.034	1.061ArgGln: 1.061 ± 0.036	1.224ArgArg: 1.224 ± 0.039	1.882ArgSer: 1.882 ± 0.042	1.798ArgThr: 1.798 ± 0.041	2.067ArgVal: 2.067 ± 0.046	0.38ArgTrp: 0.38 ± 0.02	1.541ArgTyr: 1.541 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.459SerAla: 4.459 ± 0.069	0.536SerCys: 0.536 ± 0.02	3.018SerAsp: 3.018 ± 0.057	3.154SerGlu: 3.154 ± 0.059	3.809SerPhe: 3.809 ± 0.059	4.419SerGly: 4.419 ± 0.075	0.976SerHis: 0.976 ± 0.032	5.29SerIle: 5.29 ± 0.076	4.78SerLys: 4.78 ± 0.061	6.162SerLeu: 6.162 ± 0.077	1.241SerMet: 1.241 ± 0.036	3.654SerAsn: 3.654 ± 0.07	2.122SerPro: 2.122 ± 0.041	1.826SerGln: 1.826 ± 0.046	1.969SerArg: 1.969 ± 0.044	4.095SerSer: 4.095 ± 0.072	3.576SerThr: 3.576 ± 0.068	4.01SerVal: 4.01 ± 0.067	0.628SerTrp: 0.628 ± 0.028	2.615SerTyr: 2.615 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.177ThrAla: 4.177 ± 0.059	0.349ThrCys: 0.349 ± 0.019	3.269ThrAsp: 3.269 ± 0.054	3.311ThrGlu: 3.311 ± 0.06	2.908ThrPhe: 2.908 ± 0.057	4.109ThrGly: 4.109 ± 0.069	0.944ThrHis: 0.944 ± 0.03	4.52ThrIle: 4.52 ± 0.071	4.128ThrLys: 4.128 ± 0.062	5.39ThrLeu: 5.39 ± 0.066	0.967ThrMet: 0.967 ± 0.029	3.27ThrAsn: 3.27 ± 0.067	2.405ThrPro: 2.405 ± 0.054	1.927ThrGln: 1.927 ± 0.044	1.535ThrArg: 1.535 ± 0.037	3.428ThrSer: 3.428 ± 0.07	3.343ThrThr: 3.343 ± 0.075	3.628ThrVal: 3.628 ± 0.074	0.565ThrTrp: 0.565 ± 0.023	2.258ThrTyr: 2.258 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.649ValAla: 4.649 ± 0.063	0.57ValCys: 0.57 ± 0.024	3.528ValAsp: 3.528 ± 0.062	3.611ValGlu: 3.611 ± 0.063	3.231ValPhe: 3.231 ± 0.065	3.903ValGly: 3.903 ± 0.068	0.922ValHis: 0.922 ± 0.028	4.924ValIle: 4.924 ± 0.074	5.047ValLys: 5.047 ± 0.072	5.865ValLeu: 5.865 ± 0.087	1.358ValMet: 1.358 ± 0.036	3.914ValAsn: 3.914 ± 0.065	2.156ValPro: 2.156 ± 0.048	1.851ValGln: 1.851 ± 0.042	1.967ValArg: 1.967 ± 0.047	4.062ValSer: 4.062 ± 0.061	3.338ValThr: 3.338 ± 0.067	4.127ValVal: 4.127 ± 0.064	0.62ValTrp: 0.62 ± 0.023	2.372ValTyr: 2.372 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.7TrpAla: 0.7 ± 0.022	0.101TrpCys: 0.101 ± 0.01	0.583TrpAsp: 0.583 ± 0.026	0.596TrpGlu: 0.596 ± 0.025	0.603TrpPhe: 0.603 ± 0.026	0.71TrpGly: 0.71 ± 0.023	0.22TrpHis: 0.22 ± 0.014	0.737TrpIle: 0.737 ± 0.027	0.818TrpLys: 0.818 ± 0.026	1.076TrpLeu: 1.076 ± 0.037	0.312TrpMet: 0.312 ± 0.016	0.591TrpAsn: 0.591 ± 0.027	0.286TrpPro: 0.286 ± 0.017	0.434TrpGln: 0.434 ± 0.018	0.454TrpArg: 0.454 ± 0.021	0.529TrpSer: 0.529 ± 0.024	0.516TrpThr: 0.516 ± 0.027	0.635TrpVal: 0.635 ± 0.025	0.17TrpTrp: 0.17 ± 0.013	0.382TrpTyr: 0.382 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.72TyrAla: 2.72 ± 0.053	0.36TyrCys: 0.36 ± 0.019	2.178TyrAsp: 2.178 ± 0.047	2.005TyrGlu: 2.005 ± 0.049	2.603TyrPhe: 2.603 ± 0.057	2.636TyrGly: 2.636 ± 0.058	0.761TyrHis: 0.761 ± 0.027	2.725TyrIle: 2.725 ± 0.055	3.165TyrLys: 3.165 ± 0.059	3.942TyrLeu: 3.942 ± 0.073	0.705TyrMet: 0.705 ± 0.028	2.622TyrAsn: 2.622 ± 0.059	1.529TyrPro: 1.529 ± 0.034	1.588TyrGln: 1.588 ± 0.041	1.566TyrArg: 1.566 ± 0.043	2.599TyrSer: 2.599 ± 0.053	2.322TyrThr: 2.322 ± 0.054	2.092TyrVal: 2.092 ± 0.047	0.445TyrTrp: 0.445 ± 0.02	1.875TyrTyr: 1.875 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3293 proteins (1105995 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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