Amino acid dipepetide frequency for Gordonia phage Coeur

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.566AlaAla: 24.566 ± 2.95
0.195AlaCys: 0.195 ± 0.207
9.164AlaAsp: 9.164 ± 0.994
7.799AlaGlu: 7.799 ± 1.083
2.925AlaPhe: 2.925 ± 0.716
16.962AlaGly: 16.962 ± 2.538
4.094AlaHis: 4.094 ± 0.734
9.164AlaIle: 9.164 ± 2.073
2.535AlaLys: 2.535 ± 0.638
10.333AlaLeu: 10.333 ± 1.728
4.484AlaMet: 4.484 ± 0.949
4.484AlaAsn: 4.484 ± 1.044
7.019AlaPro: 7.019 ± 1.201
5.264AlaGln: 5.264 ± 0.766
9.748AlaArg: 9.748 ± 2.082
4.679AlaSer: 4.679 ± 1.058
8.579AlaThr: 8.579 ± 1.339
10.528AlaVal: 10.528 ± 2.218
3.314AlaTrp: 3.314 ± 0.789
3.12AlaTyr: 3.12 ± 0.601
0.0AlaXaa: 0.0 ± 0.0
Cys
0.975CysAla: 0.975 ± 0.39
0.195CysCys: 0.195 ± 0.176
0.975CysAsp: 0.975 ± 0.516
0.39CysGlu: 0.39 ± 0.23
0.195CysPhe: 0.195 ± 0.212
1.17CysGly: 1.17 ± 0.599
0.195CysHis: 0.195 ± 0.264
0.195CysIle: 0.195 ± 0.209
0.195CysLys: 0.195 ± 0.178
0.39CysLeu: 0.39 ± 0.324
0.0CysMet: 0.0 ± 0.0
0.39CysAsn: 0.39 ± 0.345
0.195CysPro: 0.195 ± 0.262
0.195CysGln: 0.195 ± 0.211
0.585CysArg: 0.585 ± 0.467
0.195CysSer: 0.195 ± 0.188
0.585CysThr: 0.585 ± 0.3
0.975CysVal: 0.975 ± 0.352
0.0CysTrp: 0.0 ± 0.0
0.195CysTyr: 0.195 ± 0.187
0.0CysXaa: 0.0 ± 0.0
Asp
6.629AspAla: 6.629 ± 0.918
0.39AspCys: 0.39 ± 0.243
6.044AspAsp: 6.044 ± 1.146
2.34AspGlu: 2.34 ± 0.678
0.975AspPhe: 0.975 ± 0.506
4.874AspGly: 4.874 ± 0.931
0.975AspHis: 0.975 ± 0.539
3.314AspIle: 3.314 ± 1.042
1.365AspLys: 1.365 ± 0.508
6.044AspLeu: 6.044 ± 1.259
1.17AspMet: 1.17 ± 0.69
1.755AspAsn: 1.755 ± 0.502
6.044AspPro: 6.044 ± 1.002
0.78AspGln: 0.78 ± 0.406
4.484AspArg: 4.484 ± 1.069
2.925AspSer: 2.925 ± 0.835
4.289AspThr: 4.289 ± 0.832
5.459AspVal: 5.459 ± 1.216
1.56AspTrp: 1.56 ± 0.584
1.95AspTyr: 1.95 ± 0.393
0.0AspXaa: 0.0 ± 0.0
Glu
7.604GluAla: 7.604 ± 1.295
0.78GluCys: 0.78 ± 0.392
2.145GluAsp: 2.145 ± 0.781
0.975GluGlu: 0.975 ± 0.43
1.755GluPhe: 1.755 ± 0.693
2.73GluGly: 2.73 ± 0.654
0.78GluHis: 0.78 ± 0.368
0.78GluIle: 0.78 ± 0.421
0.39GluLys: 0.39 ± 0.238
4.094GluLeu: 4.094 ± 0.836
1.56GluMet: 1.56 ± 0.523
1.755GluAsn: 1.755 ± 0.512
1.56GluPro: 1.56 ± 0.578
1.365GluGln: 1.365 ± 0.612
2.535GluArg: 2.535 ± 0.532
3.509GluSer: 3.509 ± 1.041
2.925GluThr: 2.925 ± 0.892
2.73GluVal: 2.73 ± 0.595
0.585GluTrp: 0.585 ± 0.401
1.365GluTyr: 1.365 ± 0.582
0.0GluXaa: 0.0 ± 0.0
Phe
2.73PheAla: 2.73 ± 1.031
0.0PheCys: 0.0 ± 0.0
3.12PheAsp: 3.12 ± 0.881
1.17PheGlu: 1.17 ± 0.429
0.39PhePhe: 0.39 ± 0.247
3.899PheGly: 3.899 ± 0.809
0.585PheHis: 0.585 ± 0.355
0.975PheIle: 0.975 ± 0.403
0.39PheLys: 0.39 ± 0.322
1.56PheLeu: 1.56 ± 0.719
0.975PheMet: 0.975 ± 0.414
0.78PheAsn: 0.78 ± 0.594
0.975PhePro: 0.975 ± 0.316
0.39PheGln: 0.39 ± 0.25
1.56PheArg: 1.56 ± 0.545
0.975PheSer: 0.975 ± 0.491
1.95PheThr: 1.95 ± 0.661
1.755PheVal: 1.755 ± 0.605
0.39PheTrp: 0.39 ± 0.278
1.17PheTyr: 1.17 ± 0.557
0.0PheXaa: 0.0 ± 0.0
Gly
9.164GlyAla: 9.164 ± 1.42
0.585GlyCys: 0.585 ± 0.312
4.484GlyAsp: 4.484 ± 0.856
3.704GlyGlu: 3.704 ± 1.18
3.12GlyPhe: 3.12 ± 0.717
7.994GlyGly: 7.994 ± 1.397
2.925GlyHis: 2.925 ± 1.101
4.289GlyIle: 4.289 ± 1.187
1.56GlyLys: 1.56 ± 0.443
8.189GlyLeu: 8.189 ± 1.383
1.56GlyMet: 1.56 ± 0.602
2.73GlyAsn: 2.73 ± 0.871
4.094GlyPro: 4.094 ± 0.794
2.535GlyGln: 2.535 ± 0.773
5.654GlyArg: 5.654 ± 0.811
3.899GlySer: 3.899 ± 0.713
4.679GlyThr: 4.679 ± 0.927
7.214GlyVal: 7.214 ± 1.008
3.509GlyTrp: 3.509 ± 0.883
2.145GlyTyr: 2.145 ± 0.687
0.0GlyXaa: 0.0 ± 0.0
His
1.95HisAla: 1.95 ± 0.796
0.0HisCys: 0.0 ± 0.0
1.755HisAsp: 1.755 ± 0.772
0.78HisGlu: 0.78 ± 0.43
0.195HisPhe: 0.195 ± 0.161
1.56HisGly: 1.56 ± 0.559
0.39HisHis: 0.39 ± 0.303
0.975HisIle: 0.975 ± 0.553
0.585HisLys: 0.585 ± 0.285
3.314HisLeu: 3.314 ± 0.79
0.585HisMet: 0.585 ± 0.361
0.39HisAsn: 0.39 ± 0.283
1.95HisPro: 1.95 ± 0.802
0.78HisGln: 0.78 ± 0.438
2.145HisArg: 2.145 ± 0.624
1.17HisSer: 1.17 ± 0.494
1.755HisThr: 1.755 ± 0.56
0.975HisVal: 0.975 ± 0.458
0.585HisTrp: 0.585 ± 0.346
0.39HisTyr: 0.39 ± 0.282
0.0HisXaa: 0.0 ± 0.0
Ile
7.799IleAla: 7.799 ± 1.077
0.39IleCys: 0.39 ± 0.241
3.12IleAsp: 3.12 ± 0.644
3.704IleGlu: 3.704 ± 0.686
0.78IlePhe: 0.78 ± 0.265
2.34IleGly: 2.34 ± 0.827
0.585IleHis: 0.585 ± 0.303
2.73IleIle: 2.73 ± 0.926
1.17IleLys: 1.17 ± 0.509
1.755IleLeu: 1.755 ± 0.629
0.0IleMet: 0.0 ± 0.0
2.145IleAsn: 2.145 ± 0.523
2.34IlePro: 2.34 ± 0.67
0.975IleGln: 0.975 ± 0.442
4.484IleArg: 4.484 ± 0.871
3.12IleSer: 3.12 ± 0.721
5.849IleThr: 5.849 ± 1.048
4.679IleVal: 4.679 ± 1.434
0.585IleTrp: 0.585 ± 0.284
0.78IleTyr: 0.78 ± 0.389
0.0IleXaa: 0.0 ± 0.0
Lys
2.925LysAla: 2.925 ± 0.707
0.0LysCys: 0.0 ± 0.0
0.78LysAsp: 0.78 ± 0.463
0.39LysGlu: 0.39 ± 0.422
0.39LysPhe: 0.39 ± 0.212
0.78LysGly: 0.78 ± 0.398
0.195LysHis: 0.195 ± 0.161
0.195LysIle: 0.195 ± 0.178
0.195LysLys: 0.195 ± 0.211
1.17LysLeu: 1.17 ± 0.371
0.195LysMet: 0.195 ± 0.191
0.39LysAsn: 0.39 ± 0.26
0.78LysPro: 0.78 ± 0.377
0.585LysGln: 0.585 ± 0.303
0.78LysArg: 0.78 ± 0.472
1.755LysSer: 1.755 ± 0.465
1.755LysThr: 1.755 ± 0.547
1.365LysVal: 1.365 ± 0.414
0.78LysTrp: 0.78 ± 0.361
0.78LysTyr: 0.78 ± 0.38
0.0LysXaa: 0.0 ± 0.0
Leu
13.258LeuAla: 13.258 ± 1.455
1.17LeuCys: 1.17 ± 0.701
7.019LeuAsp: 7.019 ± 1.461
2.535LeuGlu: 2.535 ± 0.962
1.95LeuPhe: 1.95 ± 0.515
7.799LeuGly: 7.799 ± 2.005
1.95LeuHis: 1.95 ± 0.675
3.704LeuIle: 3.704 ± 0.818
0.78LeuLys: 0.78 ± 0.429
5.654LeuLeu: 5.654 ± 0.86
1.17LeuMet: 1.17 ± 0.495
1.755LeuAsn: 1.755 ± 0.585
6.434LeuPro: 6.434 ± 0.762
1.56LeuGln: 1.56 ± 0.595
4.289LeuArg: 4.289 ± 1.264
5.459LeuSer: 5.459 ± 0.796
4.874LeuThr: 4.874 ± 1.042
5.849LeuVal: 5.849 ± 0.852
1.17LeuTrp: 1.17 ± 0.429
0.39LeuTyr: 0.39 ± 0.247
0.0LeuXaa: 0.0 ± 0.0
Met
2.34MetAla: 2.34 ± 0.867
0.195MetCys: 0.195 ± 0.174
0.78MetAsp: 0.78 ± 0.39
0.78MetGlu: 0.78 ± 0.45
0.585MetPhe: 0.585 ± 0.33
1.365MetGly: 1.365 ± 0.322
0.585MetHis: 0.585 ± 0.33
0.78MetIle: 0.78 ± 0.367
0.195MetLys: 0.195 ± 0.178
1.56MetLeu: 1.56 ± 0.496
0.195MetMet: 0.195 ± 0.207
0.975MetAsn: 0.975 ± 0.526
1.56MetPro: 1.56 ± 0.561
0.585MetGln: 0.585 ± 0.344
1.755MetArg: 1.755 ± 0.667
2.925MetSer: 2.925 ± 0.762
2.145MetThr: 2.145 ± 0.486
1.17MetVal: 1.17 ± 0.475
0.39MetTrp: 0.39 ± 0.281
0.195MetTyr: 0.195 ± 0.221
0.0MetXaa: 0.0 ± 0.0
Asn
4.094AsnAla: 4.094 ± 0.777
0.195AsnCys: 0.195 ± 0.176
2.34AsnAsp: 2.34 ± 0.564
0.0AsnGlu: 0.0 ± 0.0
0.195AsnPhe: 0.195 ± 0.186
2.34AsnGly: 2.34 ± 0.538
0.78AsnHis: 0.78 ± 0.341
1.56AsnIle: 1.56 ± 0.587
0.39AsnLys: 0.39 ± 0.283
0.975AsnLeu: 0.975 ± 0.557
0.585AsnMet: 0.585 ± 0.441
0.78AsnAsn: 0.78 ± 0.375
2.535AsnPro: 2.535 ± 0.514
0.975AsnGln: 0.975 ± 0.447
4.094AsnArg: 4.094 ± 0.901
1.95AsnSer: 1.95 ± 0.494
2.34AsnThr: 2.34 ± 0.771
2.73AsnVal: 2.73 ± 0.715
0.39AsnTrp: 0.39 ± 0.25
0.975AsnTyr: 0.975 ± 0.454
0.0AsnXaa: 0.0 ± 0.0
Pro
14.623ProAla: 14.623 ± 1.435
0.39ProCys: 0.39 ± 0.312
3.314ProAsp: 3.314 ± 0.829
2.925ProGlu: 2.925 ± 1.111
1.95ProPhe: 1.95 ± 0.886
5.069ProGly: 5.069 ± 0.899
0.39ProHis: 0.39 ± 0.243
2.145ProIle: 2.145 ± 0.912
1.56ProLys: 1.56 ± 0.659
4.679ProLeu: 4.679 ± 0.794
1.17ProMet: 1.17 ± 0.421
0.78ProAsn: 0.78 ± 0.428
4.289ProPro: 4.289 ± 0.991
0.975ProGln: 0.975 ± 0.321
3.314ProArg: 3.314 ± 0.807
3.314ProSer: 3.314 ± 0.761
4.289ProThr: 4.289 ± 0.582
3.509ProVal: 3.509 ± 1.057
1.56ProTrp: 1.56 ± 0.497
1.755ProTyr: 1.755 ± 0.687
0.0ProXaa: 0.0 ± 0.0
Gln
4.289GlnAla: 4.289 ± 0.852
0.0GlnCys: 0.0 ± 0.0
1.95GlnAsp: 1.95 ± 0.551
0.39GlnGlu: 0.39 ± 0.295
0.39GlnPhe: 0.39 ± 0.348
1.56GlnGly: 1.56 ± 0.493
1.365GlnHis: 1.365 ± 0.459
1.17GlnIle: 1.17 ± 0.485
0.195GlnLys: 0.195 ± 0.161
2.925GlnLeu: 2.925 ± 0.611
0.975GlnMet: 0.975 ± 0.444
0.78GlnAsn: 0.78 ± 0.359
1.17GlnPro: 1.17 ± 0.502
0.585GlnGln: 0.585 ± 0.353
1.755GlnArg: 1.755 ± 0.682
1.56GlnSer: 1.56 ± 0.581
1.95GlnThr: 1.95 ± 0.471
1.365GlnVal: 1.365 ± 0.719
0.78GlnTrp: 0.78 ± 0.293
0.585GlnTyr: 0.585 ± 0.326
0.0GlnXaa: 0.0 ± 0.0
Arg
9.943ArgAla: 9.943 ± 1.597
1.17ArgCys: 1.17 ± 0.408
3.899ArgAsp: 3.899 ± 1.068
2.34ArgGlu: 2.34 ± 0.661
1.755ArgPhe: 1.755 ± 0.735
3.899ArgGly: 3.899 ± 0.93
2.535ArgHis: 2.535 ± 0.83
4.094ArgIle: 4.094 ± 0.87
0.975ArgLys: 0.975 ± 0.47
7.799ArgLeu: 7.799 ± 1.418
2.145ArgMet: 2.145 ± 0.566
2.73ArgAsn: 2.73 ± 0.711
5.459ArgPro: 5.459 ± 1.35
1.365ArgGln: 1.365 ± 0.522
9.554ArgArg: 9.554 ± 2.008
3.704ArgSer: 3.704 ± 1.161
3.899ArgThr: 3.899 ± 1.092
5.069ArgVal: 5.069 ± 1.128
1.755ArgTrp: 1.755 ± 0.618
1.17ArgTyr: 1.17 ± 0.413
0.0ArgXaa: 0.0 ± 0.0
Ser
10.528SerAla: 10.528 ± 1.373
0.195SerCys: 0.195 ± 0.211
1.755SerAsp: 1.755 ± 0.538
1.56SerGlu: 1.56 ± 0.43
2.925SerPhe: 2.925 ± 0.626
3.314SerGly: 3.314 ± 0.898
0.78SerHis: 0.78 ± 0.283
3.509SerIle: 3.509 ± 0.892
0.585SerLys: 0.585 ± 0.263
4.094SerLeu: 4.094 ± 0.657
1.17SerMet: 1.17 ± 0.389
2.535SerAsn: 2.535 ± 0.915
3.314SerPro: 3.314 ± 0.714
0.975SerGln: 0.975 ± 0.41
3.314SerArg: 3.314 ± 0.675
2.925SerSer: 2.925 ± 0.911
5.069SerThr: 5.069 ± 0.885
2.535SerVal: 2.535 ± 0.445
1.17SerTrp: 1.17 ± 0.533
1.365SerTyr: 1.365 ± 0.617
0.0SerXaa: 0.0 ± 0.0
Thr
10.333ThrAla: 10.333 ± 1.461
0.195ThrCys: 0.195 ± 0.176
3.314ThrAsp: 3.314 ± 0.878
4.484ThrGlu: 4.484 ± 1.342
2.145ThrPhe: 2.145 ± 0.57
6.239ThrGly: 6.239 ± 1.106
0.585ThrHis: 0.585 ± 0.362
3.704ThrIle: 3.704 ± 0.585
2.145ThrLys: 2.145 ± 0.571
5.264ThrLeu: 5.264 ± 1.013
1.56ThrMet: 1.56 ± 0.566
1.95ThrAsn: 1.95 ± 0.538
5.849ThrPro: 5.849 ± 0.926
1.755ThrGln: 1.755 ± 0.907
5.654ThrArg: 5.654 ± 1.364
2.535ThrSer: 2.535 ± 0.576
5.459ThrThr: 5.459 ± 1.434
6.044ThrVal: 6.044 ± 1.204
2.925ThrTrp: 2.925 ± 1.149
0.78ThrTyr: 0.78 ± 0.422
0.0ThrXaa: 0.0 ± 0.0
Val
10.918ValAla: 10.918 ± 1.403
1.17ValCys: 1.17 ± 0.687
5.069ValAsp: 5.069 ± 0.863
3.509ValGlu: 3.509 ± 0.854
1.755ValPhe: 1.755 ± 0.755
5.654ValGly: 5.654 ± 1.393
1.17ValHis: 1.17 ± 0.648
5.069ValIle: 5.069 ± 1.034
0.39ValLys: 0.39 ± 0.26
4.289ValLeu: 4.289 ± 1.039
0.78ValMet: 0.78 ± 0.377
1.56ValAsn: 1.56 ± 0.537
3.509ValPro: 3.509 ± 0.807
2.535ValGln: 2.535 ± 0.965
5.654ValArg: 5.654 ± 1.164
4.679ValSer: 4.679 ± 0.881
6.434ValThr: 6.434 ± 1.093
9.359ValVal: 9.359 ± 1.195
0.975ValTrp: 0.975 ± 0.327
1.17ValTyr: 1.17 ± 0.393
0.0ValXaa: 0.0 ± 0.0
Trp
1.755TrpAla: 1.755 ± 0.645
0.585TrpCys: 0.585 ± 0.38
1.755TrpAsp: 1.755 ± 0.596
0.975TrpGlu: 0.975 ± 0.33
1.17TrpPhe: 1.17 ± 0.485
1.755TrpGly: 1.755 ± 0.926
0.39TrpHis: 0.39 ± 0.262
0.78TrpIle: 0.78 ± 0.41
0.195TrpLys: 0.195 ± 0.211
3.509TrpLeu: 3.509 ± 0.788
0.195TrpMet: 0.195 ± 0.265
0.975TrpAsn: 0.975 ± 0.363
1.755TrpPro: 1.755 ± 0.68
0.78TrpGln: 0.78 ± 0.316
1.17TrpArg: 1.17 ± 0.48
1.755TrpSer: 1.755 ± 0.468
1.755TrpThr: 1.755 ± 0.413
1.755TrpVal: 1.755 ± 0.58
0.195TrpTrp: 0.195 ± 0.23
0.39TrpTyr: 0.39 ± 0.284
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.535TyrAla: 2.535 ± 0.934
0.39TyrCys: 0.39 ± 0.374
0.585TyrAsp: 0.585 ± 0.317
1.17TyrGlu: 1.17 ± 0.406
0.195TyrPhe: 0.195 ± 0.176
2.73TyrGly: 2.73 ± 0.591
0.975TyrHis: 0.975 ± 0.373
0.195TyrIle: 0.195 ± 0.188
0.39TyrLys: 0.39 ± 0.264
1.17TyrLeu: 1.17 ± 0.458
0.39TyrMet: 0.39 ± 0.234
0.585TyrAsn: 0.585 ± 0.281
1.17TyrPro: 1.17 ± 0.482
0.78TyrGln: 0.78 ± 0.474
2.925TyrArg: 2.925 ± 0.73
0.585TyrSer: 0.585 ± 0.309
2.34TyrThr: 2.34 ± 0.674
0.585TyrVal: 0.585 ± 0.343
0.975TyrTrp: 0.975 ± 0.479
0.585TyrTyr: 0.585 ± 0.331
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 26 proteins (5130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski