Amino acid dipepetide frequency for Ellagibacter isourolithinifaciens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.128AlaAla: 14.128 ± 0.225	2.35AlaCys: 2.35 ± 0.066	6.448AlaAsp: 6.448 ± 0.109	7.378AlaGlu: 7.378 ± 0.124	4.495AlaPhe: 4.495 ± 0.085	8.744AlaGly: 8.744 ± 0.138	2.079AlaHis: 2.079 ± 0.061	6.042AlaIle: 6.042 ± 0.11	4.962AlaLys: 4.962 ± 0.099	10.894AlaLeu: 10.894 ± 0.167	3.02AlaMet: 3.02 ± 0.073	3.232AlaAsn: 3.232 ± 0.073	4.269AlaPro: 4.269 ± 0.075	3.687AlaGln: 3.687 ± 0.08	6.933AlaArg: 6.933 ± 0.132	7.079AlaSer: 7.079 ± 0.129	5.465AlaThr: 5.465 ± 0.093	7.932AlaVal: 7.932 ± 0.116	1.156AlaTrp: 1.156 ± 0.042	2.84AlaTyr: 2.84 ± 0.072	0.0AlaXaa: 0.0 ± 0.0
Cys	2.074CysAla: 2.074 ± 0.064	0.304CysCys: 0.304 ± 0.019	1.083CysAsp: 1.083 ± 0.039	1.2CysGlu: 1.2 ± 0.043	0.647CysPhe: 0.647 ± 0.033	1.984CysGly: 1.984 ± 0.064	0.353CysHis: 0.353 ± 0.023	0.854CysIle: 0.854 ± 0.038	0.696CysLys: 0.696 ± 0.027	1.28CysLeu: 1.28 ± 0.041	0.443CysMet: 0.443 ± 0.025	0.483CysAsn: 0.483 ± 0.027	0.884CysPro: 0.884 ± 0.046	0.361CysGln: 0.361 ± 0.022	0.883CysArg: 0.883 ± 0.038	1.03CysSer: 1.03 ± 0.044	0.91CysThr: 0.91 ± 0.036	1.352CysVal: 1.352 ± 0.043	0.186CysTrp: 0.186 ± 0.018	0.479CysTyr: 0.479 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	7.519AspAla: 7.519 ± 0.126	0.859AspCys: 0.859 ± 0.039	3.725AspAsp: 3.725 ± 0.089	5.189AspGlu: 5.189 ± 0.085	2.612AspPhe: 2.612 ± 0.066	4.962AspGly: 4.962 ± 0.097	0.906AspHis: 0.906 ± 0.042	3.425AspIle: 3.425 ± 0.065	2.41AspLys: 2.41 ± 0.065	4.933AspLeu: 4.933 ± 0.103	1.634AspMet: 1.634 ± 0.042	1.603AspAsn: 1.603 ± 0.049	2.903AspPro: 2.903 ± 0.082	1.353AspGln: 1.353 ± 0.05	2.876AspArg: 2.876 ± 0.076	3.042AspSer: 3.042 ± 0.071	2.556AspThr: 2.556 ± 0.058	4.875AspVal: 4.875 ± 0.094	0.759AspTrp: 0.759 ± 0.033	1.977AspTyr: 1.977 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	7.465GluAla: 7.465 ± 0.139	0.881GluCys: 0.881 ± 0.033	3.66GluAsp: 3.66 ± 0.076	5.055GluGlu: 5.055 ± 0.099	2.364GluPhe: 2.364 ± 0.057	5.745GluGly: 5.745 ± 0.096	1.527GluHis: 1.527 ± 0.049	3.476GluIle: 3.476 ± 0.072	3.597GluLys: 3.597 ± 0.073	6.406GluLeu: 6.406 ± 0.107	1.883GluMet: 1.883 ± 0.052	2.382GluAsn: 2.382 ± 0.063	2.466GluPro: 2.466 ± 0.06	2.292GluGln: 2.292 ± 0.064	5.03GluArg: 5.03 ± 0.11	3.706GluSer: 3.706 ± 0.076	3.092GluThr: 3.092 ± 0.063	4.815GluVal: 4.815 ± 0.088	0.689GluTrp: 0.689 ± 0.037	1.853GluTyr: 1.853 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	4.5PheAla: 4.5 ± 0.09	0.757PheCys: 0.757 ± 0.031	2.826PheAsp: 2.826 ± 0.062	2.712PheGlu: 2.712 ± 0.065	1.594PhePhe: 1.594 ± 0.052	3.697PheGly: 3.697 ± 0.077	0.653PheHis: 0.653 ± 0.032	1.869PheIle: 1.869 ± 0.053	1.532PheLys: 1.532 ± 0.052	3.136PheLeu: 3.136 ± 0.083	1.006PheMet: 1.006 ± 0.043	1.262PheAsn: 1.262 ± 0.039	1.579PhePro: 1.579 ± 0.048	0.884PheGln: 0.884 ± 0.035	1.679PheArg: 1.679 ± 0.053	2.799PheSer: 2.799 ± 0.066	2.192PheThr: 2.192 ± 0.066	3.006PheVal: 3.006 ± 0.076	0.497PheTrp: 0.497 ± 0.031	1.042PheTyr: 1.042 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	8.298GlyAla: 8.298 ± 0.135	1.659GlyCys: 1.659 ± 0.057	4.443GlyAsp: 4.443 ± 0.092	5.458GlyGlu: 5.458 ± 0.091	3.463GlyPhe: 3.463 ± 0.069	6.168GlyGly: 6.168 ± 0.117	1.469GlyHis: 1.469 ± 0.047	5.086GlyIle: 5.086 ± 0.089	4.313GlyLys: 4.313 ± 0.087	6.755GlyLeu: 6.755 ± 0.107	2.446GlyMet: 2.446 ± 0.057	2.574GlyAsn: 2.574 ± 0.057	2.279GlyPro: 2.279 ± 0.055	2.066GlyGln: 2.066 ± 0.051	4.443GlyArg: 4.443 ± 0.082	5.112GlySer: 5.112 ± 0.1	4.69GlyThr: 4.69 ± 0.099	6.416GlyVal: 6.416 ± 0.088	0.967GlyTrp: 0.967 ± 0.037	2.542GlyTyr: 2.542 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.973HisAla: 1.973 ± 0.049	0.379HisCys: 0.379 ± 0.024	1.176HisAsp: 1.176 ± 0.044	1.229HisGlu: 1.229 ± 0.042	0.696HisPhe: 0.696 ± 0.03	1.539HisGly: 1.539 ± 0.047	0.394HisHis: 0.394 ± 0.024	1.002HisIle: 1.002 ± 0.035	0.594HisLys: 0.594 ± 0.028	1.486HisLeu: 1.486 ± 0.047	0.459HisMet: 0.459 ± 0.03	0.55HisAsn: 0.55 ± 0.029	1.06HisPro: 1.06 ± 0.047	0.381HisGln: 0.381 ± 0.022	1.04HisArg: 1.04 ± 0.038	1.104HisSer: 1.104 ± 0.039	0.871HisThr: 0.871 ± 0.035	1.54HisVal: 1.54 ± 0.047	0.2HisTrp: 0.2 ± 0.02	0.551HisTyr: 0.551 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.959IleAla: 6.959 ± 0.105	0.979IleCys: 0.979 ± 0.04	4.07IleAsp: 4.07 ± 0.071	4.219IleGlu: 4.219 ± 0.086	1.652IlePhe: 1.652 ± 0.059	4.207IleGly: 4.207 ± 0.088	0.77IleHis: 0.77 ± 0.035	2.643IleIle: 2.643 ± 0.073	1.872IleLys: 1.872 ± 0.059	3.889IleLeu: 3.889 ± 0.083	1.333IleMet: 1.333 ± 0.049	1.504IleAsn: 1.504 ± 0.051	2.599IlePro: 2.599 ± 0.067	1.169IleGln: 1.169 ± 0.04	2.479IleArg: 2.479 ± 0.066	3.09IleSer: 3.09 ± 0.065	2.923IleThr: 2.923 ± 0.069	5.032IleVal: 5.032 ± 0.086	0.501IleTrp: 0.501 ± 0.028	1.296IleTyr: 1.296 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.513LysAla: 4.513 ± 0.087	0.613LysCys: 0.613 ± 0.032	2.287LysAsp: 2.287 ± 0.068	2.784LysGlu: 2.784 ± 0.075	1.16LysPhe: 1.16 ± 0.039	3.209LysGly: 3.209 ± 0.078	0.863LysHis: 0.863 ± 0.036	2.087LysIle: 2.087 ± 0.059	2.689LysLys: 2.689 ± 0.075	3.929LysLeu: 3.929 ± 0.088	1.23LysMet: 1.23 ± 0.042	1.503LysAsn: 1.503 ± 0.045	2.05LysPro: 2.05 ± 0.053	1.364LysGln: 1.364 ± 0.047	3.23LysArg: 3.23 ± 0.071	2.652LysSer: 2.652 ± 0.065	2.683LysThr: 2.683 ± 0.063	3.065LysVal: 3.065 ± 0.071	0.469LysTrp: 0.469 ± 0.027	1.18LysTyr: 1.18 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	10.872LeuAla: 10.872 ± 0.15	1.592LeuCys: 1.592 ± 0.057	5.52LeuAsp: 5.52 ± 0.089	5.333LeuGlu: 5.333 ± 0.098	3.715LeuPhe: 3.715 ± 0.103	7.038LeuGly: 7.038 ± 0.103	1.509LeuHis: 1.509 ± 0.049	4.39LeuIle: 4.39 ± 0.095	3.423LeuLys: 3.423 ± 0.073	7.678LeuLeu: 7.678 ± 0.151	2.403LeuMet: 2.403 ± 0.067	2.31LeuAsn: 2.31 ± 0.065	4.116LeuPro: 4.116 ± 0.076	2.106LeuGln: 2.106 ± 0.061	5.11LeuArg: 5.11 ± 0.098	6.529LeuSer: 6.529 ± 0.122	4.502LeuThr: 4.502 ± 0.08	7.215LeuVal: 7.215 ± 0.13	0.839LeuTrp: 0.839 ± 0.039	2.264LeuTyr: 2.264 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.873MetAla: 2.873 ± 0.066	0.427MetCys: 0.427 ± 0.026	1.317MetAsp: 1.317 ± 0.043	1.572MetGlu: 1.572 ± 0.046	0.876MetPhe: 0.876 ± 0.035	2.34MetGly: 2.34 ± 0.061	0.483MetHis: 0.483 ± 0.024	1.316MetIle: 1.316 ± 0.05	1.282MetLys: 1.282 ± 0.044	2.53MetLeu: 2.53 ± 0.066	0.703MetMet: 0.703 ± 0.036	0.923MetAsn: 0.923 ± 0.031	1.372MetPro: 1.372 ± 0.045	0.797MetGln: 0.797 ± 0.029	1.864MetArg: 1.864 ± 0.053	1.862MetSer: 1.862 ± 0.058	1.573MetThr: 1.573 ± 0.054	1.852MetVal: 1.852 ± 0.05	0.237MetTrp: 0.237 ± 0.019	0.581MetTyr: 0.581 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.516AsnAla: 3.516 ± 0.074	0.481AsnCys: 0.481 ± 0.026	1.75AsnAsp: 1.75 ± 0.05	1.886AsnGlu: 1.886 ± 0.044	0.953AsnPhe: 0.953 ± 0.033	2.407AsnGly: 2.407 ± 0.065	0.6AsnHis: 0.6 ± 0.031	1.679AsnIle: 1.679 ± 0.05	1.159AsnLys: 1.159 ± 0.041	2.717AsnLeu: 2.717 ± 0.063	0.809AsnMet: 0.809 ± 0.038	0.934AsnAsn: 0.934 ± 0.041	1.993AsnPro: 1.993 ± 0.057	0.817AsnGln: 0.817 ± 0.036	1.66AsnArg: 1.66 ± 0.048	1.643AsnSer: 1.643 ± 0.054	1.546AsnThr: 1.546 ± 0.049	2.547AsnVal: 2.547 ± 0.064	0.391AsnTrp: 0.391 ± 0.022	0.94AsnTyr: 0.94 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	4.455ProAla: 4.455 ± 0.09	0.679ProCys: 0.679 ± 0.03	3.01ProAsp: 3.01 ± 0.069	3.686ProGlu: 3.686 ± 0.071	1.833ProPhe: 1.833 ± 0.054	3.173ProGly: 3.173 ± 0.087	0.914ProHis: 0.914 ± 0.033	2.124ProIle: 2.124 ± 0.058	1.767ProLys: 1.767 ± 0.048	3.669ProLeu: 3.669 ± 0.075	0.937ProMet: 0.937 ± 0.048	1.423ProAsn: 1.423 ± 0.054	1.126ProPro: 1.126 ± 0.042	1.356ProGln: 1.356 ± 0.046	2.26ProArg: 2.26 ± 0.063	2.634ProSer: 2.634 ± 0.058	2.244ProThr: 2.244 ± 0.06	3.422ProVal: 3.422 ± 0.072	0.513ProTrp: 0.513 ± 0.026	1.407ProTyr: 1.407 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	3.292GlnAla: 3.292 ± 0.074	0.383GlnCys: 0.383 ± 0.025	1.244GlnAsp: 1.244 ± 0.044	1.66GlnGlu: 1.66 ± 0.045	0.964GlnPhe: 0.964 ± 0.034	2.214GlnGly: 2.214 ± 0.055	0.506GlnHis: 0.506 ± 0.027	1.513GlnIle: 1.513 ± 0.049	1.303GlnLys: 1.303 ± 0.042	2.507GlnLeu: 2.507 ± 0.054	0.779GlnMet: 0.779 ± 0.032	0.867GlnAsn: 0.867 ± 0.038	1.12GlnPro: 1.12 ± 0.04	1.04GlnGln: 1.04 ± 0.046	1.789GlnArg: 1.789 ± 0.055	1.619GlnSer: 1.619 ± 0.056	1.533GlnThr: 1.533 ± 0.047	2.17GlnVal: 2.17 ± 0.059	0.311GlnTrp: 0.311 ± 0.02	0.689GlnTyr: 0.689 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	6.529ArgAla: 6.529 ± 0.137	0.964ArgCys: 0.964 ± 0.039	3.42ArgAsp: 3.42 ± 0.074	4.869ArgGlu: 4.869 ± 0.103	2.442ArgPhe: 2.442 ± 0.067	4.163ArgGly: 4.163 ± 0.07	1.062ArgHis: 1.062 ± 0.035	3.423ArgIle: 3.423 ± 0.075	2.84ArgLys: 2.84 ± 0.063	4.975ArgLeu: 4.975 ± 0.102	1.943ArgMet: 1.943 ± 0.051	1.836ArgAsn: 1.836 ± 0.055	2.189ArgPro: 2.189 ± 0.063	1.649ArgGln: 1.649 ± 0.051	4.146ArgArg: 4.146 ± 0.103	2.987ArgSer: 2.987 ± 0.061	2.85ArgThr: 2.85 ± 0.061	4.267ArgVal: 4.267 ± 0.084	0.571ArgTrp: 0.571 ± 0.032	1.839ArgTyr: 1.839 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	6.27SerAla: 6.27 ± 0.115	1.04SerCys: 1.04 ± 0.041	3.679SerAsp: 3.679 ± 0.08	3.755SerGlu: 3.755 ± 0.085	2.77SerPhe: 2.77 ± 0.058	5.268SerGly: 5.268 ± 0.099	1.097SerHis: 1.097 ± 0.04	3.435SerIle: 3.435 ± 0.077	2.542SerLys: 2.542 ± 0.067	5.763SerLeu: 5.763 ± 0.1	1.65SerMet: 1.65 ± 0.052	1.873SerAsn: 1.873 ± 0.051	2.577SerPro: 2.577 ± 0.066	1.877SerGln: 1.877 ± 0.051	3.676SerArg: 3.676 ± 0.098	4.559SerSer: 4.559 ± 0.121	3.163SerThr: 3.163 ± 0.073	4.516SerVal: 4.516 ± 0.075	0.773SerTrp: 0.773 ± 0.036	1.869SerTyr: 1.869 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.032ThrAla: 5.032 ± 0.092	0.962ThrCys: 0.962 ± 0.035	2.987ThrAsp: 2.987 ± 0.079	2.782ThrGlu: 2.782 ± 0.062	2.14ThrPhe: 2.14 ± 0.061	4.595ThrGly: 4.595 ± 0.089	0.986ThrHis: 0.986 ± 0.036	2.967ThrIle: 2.967 ± 0.072	1.973ThrLys: 1.973 ± 0.053	4.945ThrLeu: 4.945 ± 0.093	1.26ThrMet: 1.26 ± 0.049	1.523ThrAsn: 1.523 ± 0.049	2.856ThrPro: 2.856 ± 0.068	1.397ThrGln: 1.397 ± 0.046	2.662ThrArg: 2.662 ± 0.065	3.203ThrSer: 3.203 ± 0.07	2.925ThrThr: 2.925 ± 0.083	4.303ThrVal: 4.303 ± 0.087	0.637ThrTrp: 0.637 ± 0.032	1.612ThrTyr: 1.612 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	8.852ValAla: 8.852 ± 0.129	1.46ValCys: 1.46 ± 0.051	4.74ValAsp: 4.74 ± 0.09	5.035ValGlu: 5.035 ± 0.08	3.252ValPhe: 3.252 ± 0.079	5.865ValGly: 5.865 ± 0.106	1.33ValHis: 1.33 ± 0.044	4.085ValIle: 4.085 ± 0.075	3.109ValLys: 3.109 ± 0.066	7.168ValLeu: 7.168 ± 0.11	1.897ValMet: 1.897 ± 0.056	2.359ValAsn: 2.359 ± 0.059	3.577ValPro: 3.577 ± 0.072	1.789ValGln: 1.789 ± 0.052	4.673ValArg: 4.673 ± 0.089	5.269ValSer: 5.269 ± 0.104	4.026ValThr: 4.026 ± 0.088	6.993ValVal: 6.993 ± 0.117	0.777ValTrp: 0.777 ± 0.036	1.953ValTyr: 1.953 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.099TrpAla: 1.099 ± 0.042	0.241TrpCys: 0.241 ± 0.02	0.687TrpAsp: 0.687 ± 0.038	0.72TrpGlu: 0.72 ± 0.037	0.494TrpPhe: 0.494 ± 0.03	0.936TrpGly: 0.936 ± 0.043	0.217TrpHis: 0.217 ± 0.018	0.553TrpIle: 0.553 ± 0.032	0.444TrpLys: 0.444 ± 0.024	1.032TrpLeu: 1.032 ± 0.038	0.317TrpMet: 0.317 ± 0.025	0.39TrpAsn: 0.39 ± 0.026	0.39TrpPro: 0.39 ± 0.025	0.353TrpGln: 0.353 ± 0.024	0.687TrpArg: 0.687 ± 0.03	0.607TrpSer: 0.607 ± 0.034	0.494TrpThr: 0.494 ± 0.029	0.76TrpVal: 0.76 ± 0.037	0.184TrpTrp: 0.184 ± 0.017	0.33TrpTyr: 0.33 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.912TyrAla: 2.912 ± 0.067	0.477TyrCys: 0.477 ± 0.025	2.042TyrAsp: 2.042 ± 0.066	1.864TyrGlu: 1.864 ± 0.049	1.099TyrPhe: 1.099 ± 0.043	2.393TyrGly: 2.393 ± 0.071	0.507TyrHis: 0.507 ± 0.026	1.217TyrIle: 1.217 ± 0.045	1.054TyrLys: 1.054 ± 0.042	2.773TyrLeu: 2.773 ± 0.061	0.626TyrMet: 0.626 ± 0.027	0.899TyrAsn: 0.899 ± 0.033	1.229TyrPro: 1.229 ± 0.054	0.766TyrGln: 0.766 ± 0.034	1.843TyrArg: 1.843 ± 0.051	1.626TyrSer: 1.626 ± 0.054	1.507TyrThr: 1.507 ± 0.056	2.132TyrVal: 2.132 ± 0.052	0.279TyrTrp: 0.279 ± 0.021	0.986TyrTyr: 0.986 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2050 proteins (699948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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