Amino acid dipepetide frequency for Alysiella filiformis DSM 16848

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.271AlaAla: 11.271 ± 0.206
1.166AlaCys: 1.166 ± 0.044
5.355AlaAsp: 5.355 ± 0.092
6.208AlaGlu: 6.208 ± 0.178
3.83AlaPhe: 3.83 ± 0.079
6.072AlaGly: 6.072 ± 0.11
2.528AlaHis: 2.528 ± 0.063
5.66AlaIle: 5.66 ± 0.111
5.79AlaLys: 5.79 ± 0.132
10.198AlaLeu: 10.198 ± 0.135
2.895AlaMet: 2.895 ± 0.069
4.394AlaAsn: 4.394 ± 0.098
3.739AlaPro: 3.739 ± 0.093
6.822AlaGln: 6.822 ± 0.196
4.004AlaArg: 4.004 ± 0.079
4.537AlaSer: 4.537 ± 0.099
4.621AlaThr: 4.621 ± 0.087
6.33AlaVal: 6.33 ± 0.106
1.452AlaTrp: 1.452 ± 0.056
2.661AlaTyr: 2.661 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.954CysAla: 0.954 ± 0.044
0.155CysCys: 0.155 ± 0.015
0.537CysAsp: 0.537 ± 0.032
0.603CysGlu: 0.603 ± 0.032
0.364CysPhe: 0.364 ± 0.027
0.994CysGly: 0.994 ± 0.041
0.321CysHis: 0.321 ± 0.024
0.445CysIle: 0.445 ± 0.028
0.332CysLys: 0.332 ± 0.023
0.951CysLeu: 0.951 ± 0.035
0.19CysMet: 0.19 ± 0.017
0.304CysAsn: 0.304 ± 0.024
0.468CysPro: 0.468 ± 0.029
0.537CysGln: 0.537 ± 0.029
0.457CysArg: 0.457 ± 0.025
0.482CysSer: 0.482 ± 0.027
0.464CysThr: 0.464 ± 0.027
0.757CysVal: 0.757 ± 0.035
0.102CysTrp: 0.102 ± 0.013
0.275CysTyr: 0.275 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.152AspAla: 4.152 ± 0.101
0.54AspCys: 0.54 ± 0.03
3.147AspAsp: 3.147 ± 0.089
4.007AspGlu: 4.007 ± 0.089
2.939AspPhe: 2.939 ± 0.07
3.415AspGly: 3.415 ± 0.074
0.842AspHis: 0.842 ± 0.033
3.196AspIle: 3.196 ± 0.08
3.384AspLys: 3.384 ± 0.076
5.867AspLeu: 5.867 ± 0.09
1.226AspMet: 1.226 ± 0.047
2.482AspAsn: 2.482 ± 0.062
1.61AspPro: 1.61 ± 0.057
1.03AspGln: 1.03 ± 0.04
1.597AspArg: 1.597 ± 0.056
2.364AspSer: 2.364 ± 0.063
2.8AspThr: 2.8 ± 0.077
4.186AspVal: 4.186 ± 0.105
0.954AspTrp: 0.954 ± 0.038
2.059AspTyr: 2.059 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
3.955GluAla: 3.955 ± 0.096
0.479GluCys: 0.479 ± 0.025
2.115GluAsp: 2.115 ± 0.061
2.494GluGlu: 2.494 ± 0.072
2.178GluPhe: 2.178 ± 0.057
2.548GluGly: 2.548 ± 0.075
1.668GluHis: 1.668 ± 0.063
4.299GluIle: 4.299 ± 0.093
4.082GluLys: 4.082 ± 0.09
5.545GluLeu: 5.545 ± 0.102
1.844GluMet: 1.844 ± 0.05
4.155GluAsn: 4.155 ± 0.08
1.844GluPro: 1.844 ± 0.066
3.666GluGln: 3.666 ± 0.088
3.173GluArg: 3.173 ± 0.078
2.816GluSer: 2.816 ± 0.065
3.597GluThr: 3.597 ± 0.079
3.208GluVal: 3.208 ± 0.074
0.852GluTrp: 0.852 ± 0.034
1.759GluTyr: 1.759 ± 0.049
0.001GluXaa: 0.001 ± 0.001
Phe
4.465PheAla: 4.465 ± 0.092
0.461PheCys: 0.461 ± 0.028
2.651PheAsp: 2.651 ± 0.067
2.271PheGlu: 2.271 ± 0.06
1.742PhePhe: 1.742 ± 0.061
3.27PheGly: 3.27 ± 0.075
0.969PheHis: 0.969 ± 0.041
2.336PheIle: 2.336 ± 0.061
1.862PheLys: 1.862 ± 0.056
3.665PheLeu: 3.665 ± 0.088
1.011PheMet: 1.011 ± 0.043
1.913PheAsn: 1.913 ± 0.048
1.472PhePro: 1.472 ± 0.048
1.863PheGln: 1.863 ± 0.053
1.784PheArg: 1.784 ± 0.056
2.572PheSer: 2.572 ± 0.061
2.143PheThr: 2.143 ± 0.057
3.136PheVal: 3.136 ± 0.072
0.622PheTrp: 0.622 ± 0.034
1.38PheTyr: 1.38 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
5.923GlyAla: 5.923 ± 0.108
0.723GlyCys: 0.723 ± 0.036
3.513GlyAsp: 3.513 ± 0.09
4.154GlyGlu: 4.154 ± 0.085
3.09GlyPhe: 3.09 ± 0.066
5.14GlyGly: 5.14 ± 0.123
1.303GlyHis: 1.303 ± 0.05
4.05GlyIle: 4.05 ± 0.074
5.079GlyLys: 5.079 ± 0.079
6.513GlyLeu: 6.513 ± 0.115
2.018GlyMet: 2.018 ± 0.057
3.207GlyAsn: 3.207 ± 0.094
0.629GlyPro: 0.629 ± 0.034
2.408GlyGln: 2.408 ± 0.066
2.839GlyArg: 2.839 ± 0.074
4.502GlySer: 4.502 ± 0.103
3.363GlyThr: 3.363 ± 0.087
5.493GlyVal: 5.493 ± 0.113
0.919GlyTrp: 0.919 ± 0.043
2.069GlyTyr: 2.069 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.492HisAla: 2.492 ± 0.069
0.318HisCys: 0.318 ± 0.022
1.43HisAsp: 1.43 ± 0.047
1.434HisGlu: 1.434 ± 0.052
1.319HisPhe: 1.319 ± 0.051
1.862HisGly: 1.862 ± 0.055
0.986HisHis: 0.986 ± 0.049
2.201HisIle: 2.201 ± 0.067
1.19HisLys: 1.19 ± 0.045
2.697HisLeu: 2.697 ± 0.057
0.489HisMet: 0.489 ± 0.028
1.193HisAsn: 1.193 ± 0.047
1.08HisPro: 1.08 ± 0.04
1.3HisGln: 1.3 ± 0.04
1.123HisArg: 1.123 ± 0.039
1.426HisSer: 1.426 ± 0.044
1.588HisThr: 1.588 ± 0.053
1.3HisVal: 1.3 ± 0.043
0.366HisTrp: 0.366 ± 0.023
0.967HisTyr: 0.967 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.87IleAla: 6.87 ± 0.105
0.663IleCys: 0.663 ± 0.033
3.447IleAsp: 3.447 ± 0.076
3.552IleGlu: 3.552 ± 0.079
2.232IlePhe: 2.232 ± 0.061
4.432IleGly: 4.432 ± 0.1
1.518IleHis: 1.518 ± 0.049
3.483IleIle: 3.483 ± 0.075
3.038IleLys: 3.038 ± 0.074
6.151IleLeu: 6.151 ± 0.106
1.467IleMet: 1.467 ± 0.049
2.756IleAsn: 2.756 ± 0.069
2.21IlePro: 2.21 ± 0.059
2.839IleGln: 2.839 ± 0.07
2.756IleArg: 2.756 ± 0.064
3.42IleSer: 3.42 ± 0.071
3.221IleThr: 3.221 ± 0.077
4.306IleVal: 4.306 ± 0.093
0.764IleTrp: 0.764 ± 0.039
1.705IleTyr: 1.705 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.846LysAla: 4.846 ± 0.117
0.321LysCys: 0.321 ± 0.024
2.677LysAsp: 2.677 ± 0.073
2.604LysGlu: 2.604 ± 0.072
1.69LysPhe: 1.69 ± 0.056
3.155LysGly: 3.155 ± 0.074
1.453LysHis: 1.453 ± 0.05
3.998LysIle: 3.998 ± 0.08
3.359LysLys: 3.359 ± 0.1
5.529LysLeu: 5.529 ± 0.072
1.91LysMet: 1.91 ± 0.054
3.375LysAsn: 3.375 ± 0.08
2.441LysPro: 2.441 ± 0.07
3.335LysGln: 3.335 ± 0.078
2.697LysArg: 2.697 ± 0.066
2.934LysSer: 2.934 ± 0.07
3.327LysThr: 3.327 ± 0.087
3.144LysVal: 3.144 ± 0.073
0.817LysTrp: 0.817 ± 0.038
1.393LysTyr: 1.393 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
11.174LeuAla: 11.174 ± 0.147
1.042LeuCys: 1.042 ± 0.037
5.08LeuAsp: 5.08 ± 0.086
4.247LeuGlu: 4.247 ± 0.094
4.183LeuPhe: 4.183 ± 0.092
7.097LeuGly: 7.097 ± 0.116
2.614LeuHis: 2.614 ± 0.056
5.766LeuIle: 5.766 ± 0.111
5.442LeuLys: 5.442 ± 0.09
10.148LeuLeu: 10.148 ± 0.165
2.503LeuMet: 2.503 ± 0.066
5.68LeuAsn: 5.68 ± 0.102
6.146LeuPro: 6.146 ± 0.099
4.811LeuGln: 4.811 ± 0.095
4.9LeuArg: 4.9 ± 0.098
6.571LeuSer: 6.571 ± 0.104
4.872LeuThr: 4.872 ± 0.088
5.589LeuVal: 5.589 ± 0.092
1.199LeuTrp: 1.199 ± 0.047
2.443LeuTyr: 2.443 ± 0.061
0.001LeuXaa: 0.001 ± 0.001
Met
2.582MetAla: 2.582 ± 0.066
0.255MetCys: 0.255 ± 0.018
1.106MetAsp: 1.106 ± 0.036
0.998MetGlu: 0.998 ± 0.036
0.91MetPhe: 0.91 ± 0.042
1.884MetGly: 1.884 ± 0.054
0.487MetHis: 0.487 ± 0.029
1.499MetIle: 1.499 ± 0.05
1.692MetLys: 1.692 ± 0.052
2.74MetLeu: 2.74 ± 0.067
0.934MetMet: 0.934 ± 0.041
1.402MetAsn: 1.402 ± 0.047
1.25MetPro: 1.25 ± 0.043
1.273MetGln: 1.273 ± 0.04
1.238MetArg: 1.238 ± 0.046
1.556MetSer: 1.556 ± 0.048
1.414MetThr: 1.414 ± 0.049
1.666MetVal: 1.666 ± 0.053
0.263MetTrp: 0.263 ± 0.022
0.569MetTyr: 0.569 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.938AsnAla: 4.938 ± 0.111
0.354AsnCys: 0.354 ± 0.024
2.591AsnAsp: 2.591 ± 0.072
2.806AsnGlu: 2.806 ± 0.067
1.516AsnPhe: 1.516 ± 0.054
3.766AsnGly: 3.766 ± 0.086
1.467AsnHis: 1.467 ± 0.044
3.078AsnIle: 3.078 ± 0.072
2.639AsnLys: 2.639 ± 0.07
4.499AsnLeu: 4.499 ± 0.077
1.142AsnMet: 1.142 ± 0.04
2.263AsnAsn: 2.263 ± 0.072
2.854AsnPro: 2.854 ± 0.074
2.866AsnGln: 2.866 ± 0.067
2.266AsnArg: 2.266 ± 0.055
2.198AsnSer: 2.198 ± 0.074
2.595AsnThr: 2.595 ± 0.074
3.393AsnVal: 3.393 ± 0.085
0.691AsnTrp: 0.691 ± 0.037
1.288AsnTyr: 1.288 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.466ProAla: 3.466 ± 0.092
0.331ProCys: 0.331 ± 0.019
2.301ProAsp: 2.301 ± 0.056
3.936ProGlu: 3.936 ± 0.086
1.827ProPhe: 1.827 ± 0.06
0.724ProGly: 0.724 ± 0.035
1.513ProHis: 1.513 ± 0.045
2.806ProIle: 2.806 ± 0.064
2.43ProLys: 2.43 ± 0.068
3.58ProLeu: 3.58 ± 0.076
1.025ProMet: 1.025 ± 0.037
2.479ProAsn: 2.479 ± 0.066
1.607ProPro: 1.607 ± 0.073
2.389ProGln: 2.389 ± 0.069
1.525ProArg: 1.525 ± 0.047
2.305ProSer: 2.305 ± 0.055
2.507ProThr: 2.507 ± 0.071
2.718ProVal: 2.718 ± 0.068
0.297ProTrp: 0.297 ± 0.02
1.269ProTyr: 1.269 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
6.528GlnAla: 6.528 ± 0.17
0.375GlnCys: 0.375 ± 0.027
2.334GlnAsp: 2.334 ± 0.06
2.406GlnGlu: 2.406 ± 0.069
2.274GlnPhe: 2.274 ± 0.057
2.921GlnGly: 2.921 ± 0.075
1.788GlnHis: 1.788 ± 0.062
3.944GlnIle: 3.944 ± 0.092
3.091GlnLys: 3.091 ± 0.074
4.181GlnLeu: 4.181 ± 0.105
1.341GlnMet: 1.341 ± 0.036
3.447GlnAsn: 3.447 ± 0.086
2.192GlnPro: 2.192 ± 0.054
3.352GlnGln: 3.352 ± 0.111
2.539GlnArg: 2.539 ± 0.065
3.04GlnSer: 3.04 ± 0.065
3.022GlnThr: 3.022 ± 0.069
2.738GlnVal: 2.738 ± 0.065
0.635GlnTrp: 0.635 ± 0.034
1.556GlnTyr: 1.556 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.947ArgAla: 3.947 ± 0.084
0.326ArgCys: 0.326 ± 0.021
2.664ArgAsp: 2.664 ± 0.07
3.256ArgGlu: 3.256 ± 0.086
2.244ArgPhe: 2.244 ± 0.06
2.826ArgGly: 2.826 ± 0.074
1.428ArgHis: 1.428 ± 0.051
2.741ArgIle: 2.741 ± 0.07
2.242ArgLys: 2.242 ± 0.058
4.967ArgLeu: 4.967 ± 0.102
1.143ArgMet: 1.143 ± 0.041
1.926ArgAsn: 1.926 ± 0.054
1.668ArgPro: 1.668 ± 0.052
2.864ArgGln: 2.864 ± 0.067
2.046ArgArg: 2.046 ± 0.061
2.004ArgSer: 2.004 ± 0.06
1.967ArgThr: 1.967 ± 0.063
3.297ArgVal: 3.297 ± 0.079
0.52ArgTrp: 0.52 ± 0.028
1.581ArgTyr: 1.581 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.054SerAla: 5.054 ± 0.101
0.53SerCys: 0.53 ± 0.026
2.826SerAsp: 2.826 ± 0.064
3.087SerGlu: 3.087 ± 0.074
2.074SerPhe: 2.074 ± 0.059
5.043SerGly: 5.043 ± 0.091
1.622SerHis: 1.622 ± 0.054
2.689SerIle: 2.689 ± 0.073
2.478SerLys: 2.478 ± 0.063
5.841SerLeu: 5.841 ± 0.096
1.185SerMet: 1.185 ± 0.041
2.31SerAsn: 2.31 ± 0.08
2.662SerPro: 2.662 ± 0.058
2.936SerGln: 2.936 ± 0.063
2.629SerArg: 2.629 ± 0.067
3.107SerSer: 3.107 ± 0.077
2.57SerThr: 2.57 ± 0.069
3.763SerVal: 3.763 ± 0.082
0.685SerTrp: 0.685 ± 0.038
1.534SerTyr: 1.534 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.219ThrAla: 5.219 ± 0.102
0.395ThrCys: 0.395 ± 0.026
2.544ThrAsp: 2.544 ± 0.058
2.754ThrGlu: 2.754 ± 0.062
2.023ThrPhe: 2.023 ± 0.053
3.811ThrGly: 3.811 ± 0.09
1.496ThrHis: 1.496 ± 0.05
2.899ThrIle: 2.899 ± 0.07
1.828ThrLys: 1.828 ± 0.071
5.998ThrLeu: 5.998 ± 0.096
1.016ThrMet: 1.016 ± 0.042
1.698ThrAsn: 1.698 ± 0.06
3.078ThrPro: 3.078 ± 0.076
2.901ThrGln: 2.901 ± 0.062
2.349ThrArg: 2.349 ± 0.055
2.447ThrSer: 2.447 ± 0.063
2.64ThrThr: 2.64 ± 0.099
3.938ThrVal: 3.938 ± 0.092
0.711ThrTrp: 0.711 ± 0.034
1.3ThrTyr: 1.3 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
7.454ValAla: 7.454 ± 0.134
0.802ValCys: 0.802 ± 0.035
3.262ValAsp: 3.262 ± 0.079
3.384ValGlu: 3.384 ± 0.079
2.913ValPhe: 2.913 ± 0.067
4.865ValGly: 4.865 ± 0.099
1.37ValHis: 1.37 ± 0.044
3.704ValIle: 3.704 ± 0.075
3.568ValLys: 3.568 ± 0.084
7.387ValLeu: 7.387 ± 0.116
1.608ValMet: 1.608 ± 0.053
2.797ValAsn: 2.797 ± 0.079
2.599ValPro: 2.599 ± 0.062
3.396ValGln: 3.396 ± 0.078
3.125ValArg: 3.125 ± 0.076
4.413ValSer: 4.413 ± 0.091
2.23ValThr: 2.23 ± 0.069
4.877ValVal: 4.877 ± 0.092
0.883ValTrp: 0.883 ± 0.034
1.977ValTyr: 1.977 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.294TrpAla: 1.294 ± 0.051
0.126TrpCys: 0.126 ± 0.012
0.623TrpAsp: 0.623 ± 0.031
0.539TrpGlu: 0.539 ± 0.029
0.708TrpPhe: 0.708 ± 0.035
0.919TrpGly: 0.919 ± 0.045
0.537TrpHis: 0.537 ± 0.03
0.653TrpIle: 0.653 ± 0.037
0.468TrpLys: 0.468 ± 0.026
1.969TrpLeu: 1.969 ± 0.065
0.19TrpMet: 0.19 ± 0.017
0.363TrpAsn: 0.363 ± 0.023
0.063TrpPro: 0.063 ± 0.011
1.44TrpGln: 1.44 ± 0.049
0.874TrpArg: 0.874 ± 0.035
0.531TrpSer: 0.531 ± 0.028
0.52TrpThr: 0.52 ± 0.034
0.953TrpVal: 0.953 ± 0.038
0.243TrpTrp: 0.243 ± 0.022
0.372TrpTyr: 0.372 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.949TyrAla: 2.949 ± 0.068
0.332TyrCys: 0.332 ± 0.023
1.595TyrAsp: 1.595 ± 0.041
1.537TyrGlu: 1.537 ± 0.053
1.532TyrPhe: 1.532 ± 0.052
2.19TyrGly: 2.19 ± 0.062
0.85TyrHis: 0.85 ± 0.035
1.383TyrIle: 1.383 ± 0.047
1.014TyrLys: 1.014 ± 0.04
3.081TyrLeu: 3.081 ± 0.06
0.58TyrMet: 0.58 ± 0.027
1.063TyrAsn: 1.063 ± 0.038
1.418TyrPro: 1.418 ± 0.047
1.679TyrGln: 1.679 ± 0.048
1.739TyrArg: 1.739 ± 0.048
1.399TyrSer: 1.399 ± 0.04
1.584TyrThr: 1.584 ± 0.051
1.824TyrVal: 1.824 ± 0.055
0.41TyrTrp: 0.41 ± 0.027
0.909TyrTyr: 0.909 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.001
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.009XaaXaa: 0.009 ± 0.006
Statistics based on 2283 proteins (683258 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski