Amino acid dipepetide frequency for Lactobacillus brantae DSM 23927

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.89AlaAla: 9.89 ± 0.169
0.211AlaCys: 0.211 ± 0.02
5.965AlaAsp: 5.965 ± 0.115
4.636AlaGlu: 4.636 ± 0.116
3.752AlaPhe: 3.752 ± 0.084
7.099AlaGly: 7.099 ± 0.14
1.95AlaHis: 1.95 ± 0.061
6.697AlaIle: 6.697 ± 0.13
5.498AlaLys: 5.498 ± 0.1
9.748AlaLeu: 9.748 ± 0.157
2.756AlaMet: 2.756 ± 0.073
4.268AlaAsn: 4.268 ± 0.097
3.278AlaPro: 3.278 ± 0.093
4.984AlaGln: 4.984 ± 0.12
3.294AlaArg: 3.294 ± 0.072
5.007AlaSer: 5.007 ± 0.099
6.372AlaThr: 6.372 ± 0.148
7.024AlaVal: 7.024 ± 0.113
0.984AlaTrp: 0.984 ± 0.043
2.801AlaTyr: 2.801 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.175CysAla: 0.175 ± 0.016
0.023CysCys: 0.023 ± 0.006
0.107CysAsp: 0.107 ± 0.013
0.098CysGlu: 0.098 ± 0.013
0.096CysPhe: 0.096 ± 0.013
0.241CysGly: 0.241 ± 0.023
0.068CysHis: 0.068 ± 0.013
0.128CysIle: 0.128 ± 0.015
0.049CysLys: 0.049 ± 0.01
0.269CysLeu: 0.269 ± 0.022
0.047CysMet: 0.047 ± 0.009
0.075CysAsn: 0.075 ± 0.012
0.149CysPro: 0.149 ± 0.021
0.1CysGln: 0.1 ± 0.013
0.075CysArg: 0.075 ± 0.013
0.093CysSer: 0.093 ± 0.014
0.103CysThr: 0.103 ± 0.013
0.138CysVal: 0.138 ± 0.015
0.033CysTrp: 0.033 ± 0.007
0.077CysTyr: 0.077 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
5.463AspAla: 5.463 ± 0.102
0.096AspCys: 0.096 ± 0.012
3.616AspAsp: 3.616 ± 0.113
3.53AspGlu: 3.53 ± 0.092
3.02AspPhe: 3.02 ± 0.077
4.226AspGly: 4.226 ± 0.107
1.438AspHis: 1.438 ± 0.056
3.35AspIle: 3.35 ± 0.088
2.925AspLys: 2.925 ± 0.082
6.094AspLeu: 6.094 ± 0.123
1.557AspMet: 1.557 ± 0.056
2.429AspAsn: 2.429 ± 0.077
2.614AspPro: 2.614 ± 0.076
3.431AspGln: 3.431 ± 0.087
2.576AspArg: 2.576 ± 0.075
2.896AspSer: 2.896 ± 0.076
3.179AspThr: 3.179 ± 0.079
4.198AspVal: 4.198 ± 0.075
0.818AspTrp: 0.818 ± 0.039
2.497AspTyr: 2.497 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
5.159GluAla: 5.159 ± 0.118
0.072GluCys: 0.072 ± 0.014
2.599GluAsp: 2.599 ± 0.082
2.424GluGlu: 2.424 ± 0.084
1.842GluPhe: 1.842 ± 0.06
2.583GluGly: 2.583 ± 0.079
1.096GluHis: 1.096 ± 0.046
3.49GluIle: 3.49 ± 0.092
2.447GluLys: 2.447 ± 0.066
4.879GluLeu: 4.879 ± 0.11
1.562GluMet: 1.562 ± 0.053
1.991GluAsn: 1.991 ± 0.061
1.894GluPro: 1.894 ± 0.071
2.544GluGln: 2.544 ± 0.074
2.27GluArg: 2.27 ± 0.076
2.641GluSer: 2.641 ± 0.068
3.438GluThr: 3.438 ± 0.084
3.626GluVal: 3.626 ± 0.096
0.46GluTrp: 0.46 ± 0.03
1.384GluTyr: 1.384 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.981PheAla: 3.981 ± 0.087
0.121PheCys: 0.121 ± 0.012
3.03PheAsp: 3.03 ± 0.074
2.125PheGlu: 2.125 ± 0.07
1.928PhePhe: 1.928 ± 0.07
3.424PheGly: 3.424 ± 0.093
0.717PheHis: 0.717 ± 0.036
2.915PheIle: 2.915 ± 0.087
1.929PheLys: 1.929 ± 0.054
3.869PheLeu: 3.869 ± 0.094
1.134PheMet: 1.134 ± 0.045
2.053PheAsn: 2.053 ± 0.061
1.428PhePro: 1.428 ± 0.05
1.454PheGln: 1.454 ± 0.054
1.351PheArg: 1.351 ± 0.047
2.78PheSer: 2.78 ± 0.073
2.7PheThr: 2.7 ± 0.087
3.086PheVal: 3.086 ± 0.075
0.624PheTrp: 0.624 ± 0.038
1.391PheTyr: 1.391 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.585GlyAla: 5.585 ± 0.12
0.178GlyCys: 0.178 ± 0.018
4.016GlyAsp: 4.016 ± 0.098
3.327GlyGlu: 3.327 ± 0.087
3.336GlyPhe: 3.336 ± 0.086
4.823GlyGly: 4.823 ± 0.117
1.632GlyHis: 1.632 ± 0.057
5.092GlyIle: 5.092 ± 0.11
3.824GlyLys: 3.824 ± 0.088
7.626GlyLeu: 7.626 ± 0.126
1.945GlyMet: 1.945 ± 0.067
2.959GlyAsn: 2.959 ± 0.178
1.931GlyPro: 1.931 ± 0.068
3.815GlyGln: 3.815 ± 0.089
2.918GlyArg: 2.918 ± 0.072
3.995GlySer: 3.995 ± 0.158
4.591GlyThr: 4.591 ± 0.12
5.493GlyVal: 5.493 ± 0.115
0.806GlyTrp: 0.806 ± 0.046
2.704GlyTyr: 2.704 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.61HisAla: 1.61 ± 0.056
0.038HisCys: 0.038 ± 0.009
1.393HisAsp: 1.393 ± 0.059
1.061HisGlu: 1.061 ± 0.043
1.07HisPhe: 1.07 ± 0.044
1.562HisGly: 1.562 ± 0.061
0.598HisHis: 0.598 ± 0.035
1.16HisIle: 1.16 ± 0.051
0.746HisLys: 0.746 ± 0.033
2.26HisLeu: 2.26 ± 0.074
0.516HisMet: 0.516 ± 0.038
0.825HisAsn: 0.825 ± 0.038
1.103HisPro: 1.103 ± 0.049
1.297HisGln: 1.297 ± 0.053
0.979HisArg: 0.979 ± 0.042
0.973HisSer: 0.973 ± 0.042
1.0HisThr: 1.0 ± 0.038
1.473HisVal: 1.473 ± 0.054
0.344HisTrp: 0.344 ± 0.027
0.921HisTyr: 0.921 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.508IleAla: 6.508 ± 0.124
0.189IleCys: 0.189 ± 0.017
4.282IleAsp: 4.282 ± 0.095
3.249IleGlu: 3.249 ± 0.086
2.613IlePhe: 2.613 ± 0.088
5.169IleGly: 5.169 ± 0.12
1.188IleHis: 1.188 ± 0.043
3.998IleIle: 3.998 ± 0.097
2.987IleLys: 2.987 ± 0.081
6.117IleLeu: 6.117 ± 0.113
1.559IleMet: 1.559 ± 0.061
2.931IleAsn: 2.931 ± 0.086
2.863IlePro: 2.863 ± 0.069
2.691IleGln: 2.691 ± 0.069
2.476IleArg: 2.476 ± 0.073
3.843IleSer: 3.843 ± 0.079
4.068IleThr: 4.068 ± 0.081
5.154IleVal: 5.154 ± 0.108
0.662IleTrp: 0.662 ± 0.036
1.887IleTyr: 1.887 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
5.068LysAla: 5.068 ± 0.108
0.054LysCys: 0.054 ± 0.01
2.751LysAsp: 2.751 ± 0.068
2.244LysGlu: 2.244 ± 0.068
1.594LysPhe: 1.594 ± 0.052
2.641LysGly: 2.641 ± 0.07
0.973LysHis: 0.973 ± 0.041
2.927LysIle: 2.927 ± 0.074
2.681LysLys: 2.681 ± 0.079
4.282LysLeu: 4.282 ± 0.097
1.496LysMet: 1.496 ± 0.049
2.211LysAsn: 2.211 ± 0.062
2.289LysPro: 2.289 ± 0.07
2.952LysGln: 2.952 ± 0.08
2.578LysArg: 2.578 ± 0.071
2.69LysSer: 2.69 ± 0.076
3.638LysThr: 3.638 ± 0.095
3.296LysVal: 3.296 ± 0.088
0.465LysTrp: 0.465 ± 0.03
1.471LysTyr: 1.471 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
10.674LeuAla: 10.674 ± 0.161
0.252LeuCys: 0.252 ± 0.021
5.949LeuAsp: 5.949 ± 0.11
4.472LeuGlu: 4.472 ± 0.104
4.039LeuPhe: 4.039 ± 0.096
7.394LeuGly: 7.394 ± 0.136
1.817LeuHis: 1.817 ± 0.056
6.699LeuIle: 6.699 ± 0.138
4.982LeuLys: 4.982 ± 0.099
9.802LeuLeu: 9.802 ± 0.182
2.67LeuMet: 2.67 ± 0.076
4.759LeuAsn: 4.759 ± 0.095
4.708LeuPro: 4.708 ± 0.088
4.095LeuGln: 4.095 ± 0.09
3.981LeuArg: 3.981 ± 0.099
6.33LeuSer: 6.33 ± 0.124
7.668LeuThr: 7.668 ± 0.115
7.419LeuVal: 7.419 ± 0.133
1.052LeuTrp: 1.052 ± 0.043
2.63LeuTyr: 2.63 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.878MetAla: 2.878 ± 0.075
0.065MetCys: 0.065 ± 0.011
1.433MetAsp: 1.433 ± 0.056
0.944MetGlu: 0.944 ± 0.044
0.907MetPhe: 0.907 ± 0.042
1.667MetGly: 1.667 ± 0.058
0.454MetHis: 0.454 ± 0.031
1.812MetIle: 1.812 ± 0.054
1.374MetLys: 1.374 ± 0.047
2.665MetLeu: 2.665 ± 0.07
0.811MetMet: 0.811 ± 0.037
1.251MetAsn: 1.251 ± 0.052
1.129MetPro: 1.129 ± 0.046
1.382MetGln: 1.382 ± 0.041
1.152MetArg: 1.152 ± 0.05
1.529MetSer: 1.529 ± 0.05
2.164MetThr: 2.164 ± 0.063
1.868MetVal: 1.868 ± 0.065
0.218MetTrp: 0.218 ± 0.017
0.638MetTyr: 0.638 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.775AsnAla: 3.775 ± 0.108
0.096AsnCys: 0.096 ± 0.013
2.452AsnAsp: 2.452 ± 0.067
2.067AsnGlu: 2.067 ± 0.069
1.776AsnPhe: 1.776 ± 0.065
3.523AsnGly: 3.523 ± 0.133
1.148AsnHis: 1.148 ± 0.044
2.338AsnIle: 2.338 ± 0.062
1.826AsnLys: 1.826 ± 0.055
4.346AsnLeu: 4.346 ± 0.098
1.04AsnMet: 1.04 ± 0.045
1.804AsnAsn: 1.804 ± 0.127
2.326AsnPro: 2.326 ± 0.066
2.779AsnGln: 2.779 ± 0.08
2.198AsnArg: 2.198 ± 0.073
2.15AsnSer: 2.15 ± 0.152
2.447AsnThr: 2.447 ± 0.131
2.95AsnVal: 2.95 ± 0.082
0.566AsnTrp: 0.566 ± 0.033
1.578AsnTyr: 1.578 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
4.014ProAla: 4.014 ± 0.097
0.059ProCys: 0.059 ± 0.011
3.2ProAsp: 3.2 ± 0.093
3.064ProGlu: 3.064 ± 0.079
1.751ProPhe: 1.751 ± 0.064
2.833ProGly: 2.833 ± 0.073
0.725ProHis: 0.725 ± 0.038
2.537ProIle: 2.537 ± 0.067
2.209ProLys: 2.209 ± 0.06
3.792ProLeu: 3.792 ± 0.09
0.926ProMet: 0.926 ± 0.042
1.863ProAsn: 1.863 ± 0.057
0.799ProPro: 0.799 ± 0.045
1.805ProGln: 1.805 ± 0.06
1.298ProArg: 1.298 ± 0.048
2.179ProSer: 2.179 ± 0.071
2.95ProThr: 2.95 ± 0.076
3.59ProVal: 3.59 ± 0.088
0.44ProTrp: 0.44 ± 0.032
1.353ProTyr: 1.353 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
5.685GlnAla: 5.685 ± 0.118
0.059GlnCys: 0.059 ± 0.01
2.26GlnAsp: 2.26 ± 0.069
2.08GlnGlu: 2.08 ± 0.067
1.931GlnPhe: 1.931 ± 0.054
2.614GlnGly: 2.614 ± 0.07
1.118GlnHis: 1.118 ± 0.052
3.158GlnIle: 3.158 ± 0.078
2.405GlnLys: 2.405 ± 0.062
5.931GlnLeu: 5.931 ± 0.14
1.43GlnMet: 1.43 ± 0.058
2.059GlnAsn: 2.059 ± 0.066
2.34GlnPro: 2.34 ± 0.07
3.216GlnGln: 3.216 ± 0.106
2.169GlnArg: 2.169 ± 0.067
2.838GlnSer: 2.838 ± 0.081
3.624GlnThr: 3.624 ± 0.094
3.887GlnVal: 3.887 ± 0.081
0.68GlnTrp: 0.68 ± 0.038
1.7GlnTyr: 1.7 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.294ArgAla: 3.294 ± 0.08
0.077ArgCys: 0.077 ± 0.012
2.42ArgAsp: 2.42 ± 0.068
2.214ArgGlu: 2.214 ± 0.077
2.06ArgPhe: 2.06 ± 0.055
2.375ArgGly: 2.375 ± 0.067
1.022ArgHis: 1.022 ± 0.051
2.714ArgIle: 2.714 ± 0.071
1.877ArgLys: 1.877 ± 0.061
4.811ArgLeu: 4.811 ± 0.119
1.082ArgMet: 1.082 ± 0.043
1.634ArgAsn: 1.634 ± 0.049
1.667ArgPro: 1.667 ± 0.062
2.724ArgGln: 2.724 ± 0.075
2.249ArgArg: 2.249 ± 0.079
1.919ArgSer: 1.919 ± 0.059
2.102ArgThr: 2.102 ± 0.068
2.815ArgVal: 2.815 ± 0.078
0.446ArgTrp: 0.446 ± 0.029
1.734ArgTyr: 1.734 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.117SerAla: 5.117 ± 0.124
0.103SerCys: 0.103 ± 0.015
3.479SerAsp: 3.479 ± 0.089
2.733SerGlu: 2.733 ± 0.072
2.433SerPhe: 2.433 ± 0.077
4.907SerGly: 4.907 ± 0.141
1.16SerHis: 1.16 ± 0.043
3.065SerIle: 3.065 ± 0.084
2.412SerLys: 2.412 ± 0.073
5.798SerLeu: 5.798 ± 0.107
1.328SerMet: 1.328 ± 0.045
2.223SerAsn: 2.223 ± 0.127
2.155SerPro: 2.155 ± 0.057
3.03SerGln: 3.03 ± 0.071
2.391SerArg: 2.391 ± 0.073
3.476SerSer: 3.476 ± 0.148
3.504SerThr: 3.504 ± 0.097
4.318SerVal: 4.318 ± 0.097
0.724SerTrp: 0.724 ± 0.04
1.807SerTyr: 1.807 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
6.188ThrAla: 6.188 ± 0.136
0.122ThrCys: 0.122 ± 0.018
4.016ThrAsp: 4.016 ± 0.091
2.957ThrGlu: 2.957 ± 0.078
2.705ThrPhe: 2.705 ± 0.079
5.063ThrGly: 5.063 ± 0.138
1.354ThrHis: 1.354 ± 0.046
4.64ThrIle: 4.64 ± 0.098
3.069ThrLys: 3.069 ± 0.08
6.667ThrLeu: 6.667 ± 0.114
1.517ThrMet: 1.517 ± 0.055
2.84ThrAsn: 2.84 ± 0.085
3.497ThrPro: 3.497 ± 0.098
2.938ThrGln: 2.938 ± 0.084
2.211ThrArg: 2.211 ± 0.065
3.668ThrSer: 3.668 ± 0.103
4.586ThrThr: 4.586 ± 0.13
5.652ThrVal: 5.652 ± 0.14
0.718ThrTrp: 0.718 ± 0.037
2.246ThrTyr: 2.246 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
7.544ValAla: 7.544 ± 0.12
0.197ValCys: 0.197 ± 0.02
4.547ValAsp: 4.547 ± 0.099
3.368ValGlu: 3.368 ± 0.086
2.898ValPhe: 2.898 ± 0.079
5.475ValGly: 5.475 ± 0.12
1.326ValHis: 1.326 ± 0.053
5.304ValIle: 5.304 ± 0.104
3.588ValLys: 3.588 ± 0.084
7.148ValLeu: 7.148 ± 0.112
1.97ValMet: 1.97 ± 0.068
3.258ValAsn: 3.258 ± 0.081
3.319ValPro: 3.319 ± 0.072
2.918ValGln: 2.918 ± 0.075
2.651ValArg: 2.651 ± 0.081
4.83ValSer: 4.83 ± 0.106
5.75ValThr: 5.75 ± 0.124
6.117ValVal: 6.117 ± 0.107
0.799ValTrp: 0.799 ± 0.036
2.197ValTyr: 2.197 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.758TrpAla: 0.758 ± 0.034
0.031TrpCys: 0.031 ± 0.008
0.486TrpAsp: 0.486 ± 0.03
0.372TrpGlu: 0.372 ± 0.025
0.605TrpPhe: 0.605 ± 0.037
0.657TrpGly: 0.657 ± 0.034
0.304TrpHis: 0.304 ± 0.025
0.699TrpIle: 0.699 ± 0.037
0.351TrpLys: 0.351 ± 0.032
1.793TrpLeu: 1.793 ± 0.071
0.283TrpMet: 0.283 ± 0.026
0.447TrpAsn: 0.447 ± 0.03
0.474TrpPro: 0.474 ± 0.029
0.851TrpGln: 0.851 ± 0.039
0.624TrpArg: 0.624 ± 0.031
0.634TrpSer: 0.634 ± 0.041
0.615TrpThr: 0.615 ± 0.035
0.825TrpVal: 0.825 ± 0.043
0.276TrpTrp: 0.276 ± 0.026
0.428TrpTyr: 0.428 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.847TyrAla: 2.847 ± 0.066
0.098TyrCys: 0.098 ± 0.011
1.954TyrAsp: 1.954 ± 0.067
1.435TyrGlu: 1.435 ± 0.047
1.686TyrPhe: 1.686 ± 0.058
2.321TyrGly: 2.321 ± 0.064
0.835TyrHis: 0.835 ± 0.041
1.709TyrIle: 1.709 ± 0.052
1.122TyrLys: 1.122 ± 0.049
3.493TyrLeu: 3.493 ± 0.072
0.711TyrMet: 0.711 ± 0.037
1.307TyrAsn: 1.307 ± 0.054
1.426TyrPro: 1.426 ± 0.05
2.177TyrGln: 2.177 ± 0.077
1.798TyrArg: 1.798 ± 0.061
1.693TyrSer: 1.693 ± 0.054
2.155TyrThr: 2.155 ± 0.089
2.275TyrVal: 2.275 ± 0.065
0.4TyrTrp: 0.4 ± 0.027
1.288TyrTyr: 1.288 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1863 proteins (572218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski