Amino acid dipepetide frequency for Prevotella sp. tf2-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.662AlaAla: 5.662 ± 0.097
1.053AlaCys: 1.053 ± 0.037
4.515AlaAsp: 4.515 ± 0.075
4.574AlaGlu: 4.574 ± 0.071
3.069AlaPhe: 3.069 ± 0.062
4.801AlaGly: 4.801 ± 0.081
1.349AlaHis: 1.349 ± 0.035
4.849AlaIle: 4.849 ± 0.082
4.375AlaLys: 4.375 ± 0.077
6.093AlaLeu: 6.093 ± 0.087
2.073AlaMet: 2.073 ± 0.046
3.161AlaAsn: 3.161 ± 0.051
2.331AlaPro: 2.331 ± 0.056
3.016AlaGln: 3.016 ± 0.053
3.0AlaArg: 3.0 ± 0.068
3.876AlaSer: 3.876 ± 0.06
4.105AlaThr: 4.105 ± 0.065
4.802AlaVal: 4.802 ± 0.064
0.915AlaTrp: 0.915 ± 0.024
2.855AlaTyr: 2.855 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.85CysAla: 0.85 ± 0.029
0.257CysCys: 0.257 ± 0.017
0.771CysAsp: 0.771 ± 0.029
0.832CysGlu: 0.832 ± 0.029
0.572CysPhe: 0.572 ± 0.022
1.226CysGly: 1.226 ± 0.037
0.402CysHis: 0.402 ± 0.018
0.877CysIle: 0.877 ± 0.031
0.67CysLys: 0.67 ± 0.028
1.119CysLeu: 1.119 ± 0.034
0.37CysMet: 0.37 ± 0.018
0.63CysAsn: 0.63 ± 0.027
0.582CysPro: 0.582 ± 0.028
0.505CysGln: 0.505 ± 0.024
0.663CysArg: 0.663 ± 0.027
0.793CysSer: 0.793 ± 0.026
0.716CysThr: 0.716 ± 0.031
0.879CysVal: 0.879 ± 0.024
0.193CysTrp: 0.193 ± 0.014
0.646CysTyr: 0.646 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.437AspAla: 4.437 ± 0.075
0.755AspCys: 0.755 ± 0.028
3.54AspAsp: 3.54 ± 0.076
4.293AspGlu: 4.293 ± 0.084
3.0AspPhe: 3.0 ± 0.059
4.691AspGly: 4.691 ± 0.079
1.122AspHis: 1.122 ± 0.034
4.446AspIle: 4.446 ± 0.075
3.776AspLys: 3.776 ± 0.07
4.702AspLeu: 4.702 ± 0.069
1.684AspMet: 1.684 ± 0.04
2.953AspAsn: 2.953 ± 0.059
2.007AspPro: 2.007 ± 0.046
1.646AspGln: 1.646 ± 0.039
2.459AspArg: 2.459 ± 0.051
3.11AspSer: 3.11 ± 0.06
2.92AspThr: 2.92 ± 0.047
3.839AspVal: 3.839 ± 0.065
0.913AspTrp: 0.913 ± 0.034
3.223AspTyr: 3.223 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.694GluAla: 4.694 ± 0.07
0.731GluCys: 0.731 ± 0.03
3.596GluAsp: 3.596 ± 0.064
5.164GluGlu: 5.164 ± 0.094
2.368GluPhe: 2.368 ± 0.046
4.343GluGly: 4.343 ± 0.069
1.494GluHis: 1.494 ± 0.042
4.219GluIle: 4.219 ± 0.074
4.698GluLys: 4.698 ± 0.08
5.568GluLeu: 5.568 ± 0.086
2.162GluMet: 2.162 ± 0.047
3.238GluAsn: 3.238 ± 0.06
1.912GluPro: 1.912 ± 0.045
3.068GluGln: 3.068 ± 0.056
3.392GluArg: 3.392 ± 0.066
2.93GluSer: 2.93 ± 0.057
3.484GluThr: 3.484 ± 0.054
4.177GluVal: 4.177 ± 0.057
0.89GluTrp: 0.89 ± 0.028
2.73GluTyr: 2.73 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
2.913PheAla: 2.913 ± 0.054
0.769PheCys: 0.769 ± 0.028
2.856PheAsp: 2.856 ± 0.048
2.444PheGlu: 2.444 ± 0.046
2.032PhePhe: 2.032 ± 0.053
3.14PheGly: 3.14 ± 0.064
0.944PheHis: 0.944 ± 0.03
2.779PheIle: 2.779 ± 0.062
2.283PheLys: 2.283 ± 0.055
3.657PheLeu: 3.657 ± 0.065
1.195PheMet: 1.195 ± 0.033
2.087PheAsn: 2.087 ± 0.044
1.486PhePro: 1.486 ± 0.04
1.315PheGln: 1.315 ± 0.037
1.997PheArg: 1.997 ± 0.045
3.057PheSer: 3.057 ± 0.057
2.684PheThr: 2.684 ± 0.057
2.914PheVal: 2.914 ± 0.059
0.587PheTrp: 0.587 ± 0.026
1.85PheTyr: 1.85 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.557GlyAla: 4.557 ± 0.083
1.066GlyCys: 1.066 ± 0.035
3.952GlyAsp: 3.952 ± 0.062
4.228GlyGlu: 4.228 ± 0.073
3.02GlyPhe: 3.02 ± 0.057
5.148GlyGly: 5.148 ± 0.129
1.565GlyHis: 1.565 ± 0.038
5.104GlyIle: 5.104 ± 0.086
5.13GlyLys: 5.13 ± 0.074
5.711GlyLeu: 5.711 ± 0.08
2.215GlyMet: 2.215 ± 0.057
3.354GlyAsn: 3.354 ± 0.075
1.366GlyPro: 1.366 ± 0.036
2.329GlyGln: 2.329 ± 0.049
3.046GlyArg: 3.046 ± 0.055
3.976GlySer: 3.976 ± 0.07
4.399GlyThr: 4.399 ± 0.086
4.684GlyVal: 4.684 ± 0.069
1.113GlyTrp: 1.113 ± 0.032
3.249GlyTyr: 3.249 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.306HisAla: 1.306 ± 0.034
0.339HisCys: 0.339 ± 0.017
1.203HisAsp: 1.203 ± 0.033
1.243HisGlu: 1.243 ± 0.034
1.102HisPhe: 1.102 ± 0.032
1.463HisGly: 1.463 ± 0.039
0.734HisHis: 0.734 ± 0.03
1.523HisIle: 1.523 ± 0.043
1.064HisLys: 1.064 ± 0.033
2.042HisLeu: 2.042 ± 0.043
0.445HisMet: 0.445 ± 0.02
0.924HisAsn: 0.924 ± 0.029
1.145HisPro: 1.145 ± 0.036
0.914HisGln: 0.914 ± 0.028
1.065HisArg: 1.065 ± 0.028
1.121HisSer: 1.121 ± 0.033
1.137HisThr: 1.137 ± 0.036
1.359HisVal: 1.359 ± 0.034
0.294HisTrp: 0.294 ± 0.018
1.055HisTyr: 1.055 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.016IleAla: 5.016 ± 0.066
1.051IleCys: 1.051 ± 0.035
4.548IleAsp: 4.548 ± 0.07
4.31IleGlu: 4.31 ± 0.069
2.477IlePhe: 2.477 ± 0.053
4.776IleGly: 4.776 ± 0.089
1.41IleHis: 1.41 ± 0.039
4.667IleIle: 4.667 ± 0.084
3.947IleLys: 3.947 ± 0.066
5.664IleLeu: 5.664 ± 0.094
1.587IleMet: 1.587 ± 0.044
3.271IleAsn: 3.271 ± 0.05
3.036IlePro: 3.036 ± 0.06
2.382IleGln: 2.382 ± 0.047
3.259IleArg: 3.259 ± 0.058
4.178IleSer: 4.178 ± 0.066
4.017IleThr: 4.017 ± 0.062
4.502IleVal: 4.502 ± 0.067
0.711IleTrp: 0.711 ± 0.024
2.654IleTyr: 2.654 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.846LysAla: 4.846 ± 0.074
0.589LysCys: 0.589 ± 0.027
4.16LysAsp: 4.16 ± 0.068
5.161LysGlu: 5.161 ± 0.089
2.005LysPhe: 2.005 ± 0.041
4.466LysGly: 4.466 ± 0.068
1.178LysHis: 1.178 ± 0.031
3.773LysIle: 3.773 ± 0.057
4.85LysLys: 4.85 ± 0.087
4.764LysLeu: 4.764 ± 0.075
2.243LysMet: 2.243 ± 0.048
3.232LysAsn: 3.232 ± 0.061
2.203LysPro: 2.203 ± 0.051
2.509LysGln: 2.509 ± 0.058
3.04LysArg: 3.04 ± 0.05
3.178LysSer: 3.178 ± 0.057
3.7LysThr: 3.7 ± 0.07
4.213LysVal: 4.213 ± 0.062
0.839LysTrp: 0.839 ± 0.026
2.761LysTyr: 2.761 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
5.989LeuAla: 5.989 ± 0.082
1.343LeuCys: 1.343 ± 0.039
4.745LeuAsp: 4.745 ± 0.069
4.689LeuGlu: 4.689 ± 0.071
4.052LeuPhe: 4.052 ± 0.074
5.372LeuGly: 5.372 ± 0.08
1.897LeuHis: 1.897 ± 0.045
5.071LeuIle: 5.071 ± 0.077
5.477LeuLys: 5.477 ± 0.069
8.238LeuLeu: 8.238 ± 0.119
2.752LeuMet: 2.752 ± 0.052
4.167LeuAsn: 4.167 ± 0.074
3.73LeuPro: 3.73 ± 0.07
3.323LeuGln: 3.323 ± 0.056
4.515LeuArg: 4.515 ± 0.083
6.047LeuSer: 6.047 ± 0.076
5.529LeuThr: 5.529 ± 0.087
5.197LeuVal: 5.197 ± 0.084
1.077LeuTrp: 1.077 ± 0.038
3.493LeuTyr: 3.493 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.412MetAla: 2.412 ± 0.054
0.292MetCys: 0.292 ± 0.018
1.517MetAsp: 1.517 ± 0.038
1.899MetGlu: 1.899 ± 0.04
1.007MetPhe: 1.007 ± 0.029
1.982MetGly: 1.982 ± 0.04
0.53MetHis: 0.53 ± 0.023
1.683MetIle: 1.683 ± 0.042
2.469MetLys: 2.469 ± 0.05
2.589MetLeu: 2.589 ± 0.055
1.212MetMet: 1.212 ± 0.036
1.595MetAsn: 1.595 ± 0.038
1.263MetPro: 1.263 ± 0.043
1.18MetGln: 1.18 ± 0.028
1.639MetArg: 1.639 ± 0.041
1.675MetSer: 1.675 ± 0.044
2.005MetThr: 2.005 ± 0.048
1.8MetVal: 1.8 ± 0.038
0.286MetTrp: 0.286 ± 0.018
0.849MetTyr: 0.849 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.435AsnAla: 3.435 ± 0.07
0.609AsnCys: 0.609 ± 0.025
2.785AsnAsp: 2.785 ± 0.053
2.874AsnGlu: 2.874 ± 0.049
1.942AsnPhe: 1.942 ± 0.051
4.034AsnGly: 4.034 ± 0.081
1.046AsnHis: 1.046 ± 0.036
3.639AsnIle: 3.639 ± 0.067
2.899AsnLys: 2.899 ± 0.048
3.793AsnLeu: 3.793 ± 0.064
1.314AsnMet: 1.314 ± 0.036
2.56AsnAsn: 2.56 ± 0.06
2.371AsnPro: 2.371 ± 0.043
1.63AsnGln: 1.63 ± 0.038
2.169AsnArg: 2.169 ± 0.047
2.669AsnSer: 2.669 ± 0.055
2.739AsnThr: 2.739 ± 0.059
3.126AsnVal: 3.126 ± 0.061
0.636AsnTrp: 0.636 ± 0.024
2.272AsnTyr: 2.272 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.627ProAla: 2.627 ± 0.054
0.416ProCys: 0.416 ± 0.022
2.532ProAsp: 2.532 ± 0.046
2.984ProGlu: 2.984 ± 0.053
1.674ProPhe: 1.674 ± 0.042
2.163ProGly: 2.163 ± 0.047
0.779ProHis: 0.779 ± 0.027
2.201ProIle: 2.201 ± 0.04
2.089ProLys: 2.089 ± 0.044
3.084ProLeu: 3.084 ± 0.061
1.055ProMet: 1.055 ± 0.036
1.636ProAsn: 1.636 ± 0.037
0.789ProPro: 0.789 ± 0.032
1.693ProGln: 1.693 ± 0.043
1.346ProArg: 1.346 ± 0.039
2.27ProSer: 2.27 ± 0.045
2.12ProThr: 2.12 ± 0.044
2.866ProVal: 2.866 ± 0.054
0.521ProTrp: 0.521 ± 0.023
1.754ProTyr: 1.754 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.484GlnAla: 2.484 ± 0.055
0.422GlnCys: 0.422 ± 0.019
1.805GlnAsp: 1.805 ± 0.037
2.564GlnGlu: 2.564 ± 0.052
1.591GlnPhe: 1.591 ± 0.042
2.365GlnGly: 2.365 ± 0.048
0.851GlnHis: 0.851 ± 0.028
2.405GlnIle: 2.405 ± 0.043
2.596GlnLys: 2.596 ± 0.056
3.9GlnLeu: 3.9 ± 0.058
1.44GlnMet: 1.44 ± 0.041
1.674GlnAsn: 1.674 ± 0.04
1.447GlnPro: 1.447 ± 0.04
2.293GlnGln: 2.293 ± 0.05
2.051GlnArg: 2.051 ± 0.047
2.024GlnSer: 2.024 ± 0.041
2.197GlnThr: 2.197 ± 0.05
2.348GlnVal: 2.348 ± 0.054
0.612GlnTrp: 0.612 ± 0.025
1.707GlnTyr: 1.707 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.731ArgAla: 2.731 ± 0.052
0.542ArgCys: 0.542 ± 0.022
2.483ArgAsp: 2.483 ± 0.047
3.033ArgGlu: 3.033 ± 0.061
2.163ArgPhe: 2.163 ± 0.052
2.46ArgGly: 2.46 ± 0.051
1.228ArgHis: 1.228 ± 0.039
3.461ArgIle: 3.461 ± 0.063
3.224ArgLys: 3.224 ± 0.055
4.529ArgLeu: 4.529 ± 0.078
1.584ArgMet: 1.584 ± 0.048
2.284ArgAsn: 2.284 ± 0.05
1.643ArgPro: 1.643 ± 0.044
2.43ArgGln: 2.43 ± 0.053
2.55ArgArg: 2.55 ± 0.059
2.353ArgSer: 2.353 ± 0.045
2.348ArgThr: 2.348 ± 0.05
2.674ArgVal: 2.674 ± 0.052
0.725ArgTrp: 0.725 ± 0.028
2.311ArgTyr: 2.311 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.781SerAla: 3.781 ± 0.061
0.803SerCys: 0.803 ± 0.028
3.481SerAsp: 3.481 ± 0.063
3.522SerGlu: 3.522 ± 0.061
2.823SerPhe: 2.823 ± 0.052
4.122SerGly: 4.122 ± 0.072
1.298SerHis: 1.298 ± 0.037
3.908SerIle: 3.908 ± 0.068
3.36SerLys: 3.36 ± 0.057
5.276SerLeu: 5.276 ± 0.081
1.573SerMet: 1.573 ± 0.047
2.613SerAsn: 2.613 ± 0.061
2.102SerPro: 2.102 ± 0.044
2.213SerGln: 2.213 ± 0.046
2.456SerArg: 2.456 ± 0.05
3.66SerSer: 3.66 ± 0.069
3.238SerThr: 3.238 ± 0.062
4.009SerVal: 4.009 ± 0.067
0.839SerTrp: 0.839 ± 0.029
2.575SerTyr: 2.575 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.308ThrAla: 4.308 ± 0.072
0.645ThrCys: 0.645 ± 0.023
3.528ThrAsp: 3.528 ± 0.063
3.421ThrGlu: 3.421 ± 0.058
2.711ThrPhe: 2.711 ± 0.055
4.296ThrGly: 4.296 ± 0.076
1.116ThrHis: 1.116 ± 0.032
4.562ThrIle: 4.562 ± 0.078
3.204ThrLys: 3.204 ± 0.066
5.475ThrLeu: 5.475 ± 0.078
1.506ThrMet: 1.506 ± 0.041
2.582ThrAsn: 2.582 ± 0.055
2.724ThrPro: 2.724 ± 0.053
1.849ThrGln: 1.849 ± 0.04
2.152ThrArg: 2.152 ± 0.044
3.396ThrSer: 3.396 ± 0.07
3.701ThrThr: 3.701 ± 0.086
4.106ThrVal: 4.106 ± 0.082
0.748ThrTrp: 0.748 ± 0.024
2.505ThrTyr: 2.505 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.624ValAla: 4.624 ± 0.067
1.052ValCys: 1.052 ± 0.037
3.808ValAsp: 3.808 ± 0.071
4.239ValGlu: 4.239 ± 0.066
2.837ValPhe: 2.837 ± 0.06
4.236ValGly: 4.236 ± 0.075
1.099ValHis: 1.099 ± 0.034
4.609ValIle: 4.609 ± 0.073
4.252ValLys: 4.252 ± 0.073
5.537ValLeu: 5.537 ± 0.086
1.919ValMet: 1.919 ± 0.045
3.393ValAsn: 3.393 ± 0.062
2.495ValPro: 2.495 ± 0.046
1.929ValGln: 1.929 ± 0.044
3.075ValArg: 3.075 ± 0.058
4.103ValSer: 4.103 ± 0.068
4.185ValThr: 4.185 ± 0.091
4.641ValVal: 4.641 ± 0.077
0.783ValTrp: 0.783 ± 0.029
2.76ValTyr: 2.76 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.85TrpAla: 0.85 ± 0.028
0.181TrpCys: 0.181 ± 0.012
0.765TrpAsp: 0.765 ± 0.028
0.76TrpGlu: 0.76 ± 0.03
0.582TrpPhe: 0.582 ± 0.023
1.025TrpGly: 1.025 ± 0.037
0.333TrpHis: 0.333 ± 0.021
0.815TrpIle: 0.815 ± 0.03
0.875TrpLys: 0.875 ± 0.027
1.344TrpLeu: 1.344 ± 0.039
0.451TrpMet: 0.451 ± 0.023
0.84TrpAsn: 0.84 ± 0.031
0.275TrpPro: 0.275 ± 0.015
0.667TrpGln: 0.667 ± 0.024
0.654TrpArg: 0.654 ± 0.025
0.779TrpSer: 0.779 ± 0.029
0.77TrpThr: 0.77 ± 0.029
0.739TrpVal: 0.739 ± 0.03
0.251TrpTrp: 0.251 ± 0.016
0.625TrpTyr: 0.625 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.953TyrAla: 2.953 ± 0.054
0.638TyrCys: 0.638 ± 0.029
2.926TyrAsp: 2.926 ± 0.059
2.625TyrGlu: 2.625 ± 0.056
1.961TyrPhe: 1.961 ± 0.044
3.101TyrGly: 3.101 ± 0.064
1.1TyrHis: 1.1 ± 0.035
2.871TyrIle: 2.871 ± 0.05
2.474TyrLys: 2.474 ± 0.054
3.619TyrLeu: 3.619 ± 0.066
1.1TyrMet: 1.1 ± 0.031
2.35TyrAsn: 2.35 ± 0.054
1.69TyrPro: 1.69 ± 0.043
1.887TyrGln: 1.887 ± 0.046
2.229TyrArg: 2.229 ± 0.056
2.457TyrSer: 2.457 ± 0.046
2.544TyrThr: 2.544 ± 0.056
2.7TyrVal: 2.7 ± 0.054
0.649TyrTrp: 0.649 ± 0.026
2.272TyrTyr: 2.272 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2923 proteins (1074683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski