Amino acid dipepetide frequency for Vibrio vulnificus (strain YJ016)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.667AlaAla: 7.667 ± 0.093	0.96AlaCys: 0.96 ± 0.026	4.515AlaAsp: 4.515 ± 0.06	5.694AlaGlu: 5.694 ± 0.06	3.562AlaPhe: 3.562 ± 0.05	5.813AlaGly: 5.813 ± 0.067	1.813AlaHis: 1.813 ± 0.036	5.964AlaIle: 5.964 ± 0.065	5.046AlaLys: 5.046 ± 0.065	10.218AlaLeu: 10.218 ± 0.098	2.91AlaMet: 2.91 ± 0.046	3.657AlaAsn: 3.657 ± 0.051	2.811AlaPro: 2.811 ± 0.048	4.512AlaGln: 4.512 ± 0.07	3.716AlaArg: 3.716 ± 0.056	5.445AlaSer: 5.445 ± 0.061	4.563AlaThr: 4.563 ± 0.053	5.912AlaVal: 5.912 ± 0.067	1.035AlaTrp: 1.035 ± 0.031	2.388AlaTyr: 2.388 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.814CysAla: 0.814 ± 0.021	0.181CysCys: 0.181 ± 0.012	0.656CysAsp: 0.656 ± 0.021	0.636CysGlu: 0.636 ± 0.021	0.47CysPhe: 0.47 ± 0.017	0.916CysGly: 0.916 ± 0.026	0.396CysHis: 0.396 ± 0.017	0.551CysIle: 0.551 ± 0.02	0.412CysLys: 0.412 ± 0.015	1.035CysLeu: 1.035 ± 0.029	0.247CysMet: 0.247 ± 0.013	0.375CysAsn: 0.375 ± 0.015	0.445CysPro: 0.445 ± 0.018	0.565CysGln: 0.565 ± 0.021	0.551CysArg: 0.551 ± 0.018	0.748CysSer: 0.748 ± 0.027	0.46CysThr: 0.46 ± 0.019	0.73CysVal: 0.73 ± 0.023	0.146CysTrp: 0.146 ± 0.01	0.355CysTyr: 0.355 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.512AspAla: 4.512 ± 0.059	0.547AspCys: 0.547 ± 0.019	2.843AspAsp: 2.843 ± 0.065	3.788AspGlu: 3.788 ± 0.059	2.436AspPhe: 2.436 ± 0.041	3.677AspGly: 3.677 ± 0.087	1.125AspHis: 1.125 ± 0.026	3.607AspIle: 3.607 ± 0.049	3.107AspLys: 3.107 ± 0.047	5.098AspLeu: 5.098 ± 0.063	1.347AspMet: 1.347 ± 0.032	2.217AspAsn: 2.217 ± 0.037	1.983AspPro: 1.983 ± 0.042	1.925AspGln: 1.925 ± 0.034	2.177AspArg: 2.177 ± 0.042	3.141AspSer: 3.141 ± 0.057	2.424AspThr: 2.424 ± 0.047	3.869AspVal: 3.869 ± 0.052	0.851AspTrp: 0.851 ± 0.021	2.017AspTyr: 2.017 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.286GluAla: 5.286 ± 0.066	0.554GluCys: 0.554 ± 0.02	2.483GluAsp: 2.483 ± 0.051	4.065GluGlu: 4.065 ± 0.068	2.508GluPhe: 2.508 ± 0.044	3.567GluGly: 3.567 ± 0.05	1.669GluHis: 1.669 ± 0.033	3.789GluIle: 3.789 ± 0.047	4.054GluLys: 4.054 ± 0.052	7.158GluLeu: 7.158 ± 0.073	1.883GluMet: 1.883 ± 0.038	2.67GluAsn: 2.67 ± 0.046	2.038GluPro: 2.038 ± 0.04	4.398GluGln: 4.398 ± 0.063	3.579GluArg: 3.579 ± 0.052	3.809GluSer: 3.809 ± 0.064	3.124GluThr: 3.124 ± 0.046	4.356GluVal: 4.356 ± 0.059	0.832GluTrp: 0.832 ± 0.024	1.827GluTyr: 1.827 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.889PheAla: 3.889 ± 0.051	0.548PheCys: 0.548 ± 0.018	2.705PheAsp: 2.705 ± 0.045	2.613PheGlu: 2.613 ± 0.041	1.757PhePhe: 1.757 ± 0.036	3.207PheGly: 3.207 ± 0.049	0.937PheHis: 0.937 ± 0.023	2.594PheIle: 2.594 ± 0.045	1.907PheLys: 1.907 ± 0.035	3.507PheLeu: 3.507 ± 0.045	1.038PheMet: 1.038 ± 0.024	1.938PheAsn: 1.938 ± 0.034	1.485PhePro: 1.485 ± 0.038	1.343PheGln: 1.343 ± 0.029	1.649PheArg: 1.649 ± 0.035	3.4PheSer: 3.4 ± 0.047	2.337PheThr: 2.337 ± 0.042	3.03PheVal: 3.03 ± 0.048	0.563PheTrp: 0.563 ± 0.02	1.388PheTyr: 1.388 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.153GlyAla: 5.153 ± 0.068	0.891GlyCys: 0.891 ± 0.028	3.592GlyAsp: 3.592 ± 0.07	4.562GlyGlu: 4.562 ± 0.053	3.267GlyPhe: 3.267 ± 0.048	4.627GlyGly: 4.627 ± 0.072	1.598GlyHis: 1.598 ± 0.033	4.5GlyIle: 4.5 ± 0.062	3.9GlyLys: 3.9 ± 0.051	6.783GlyLeu: 6.783 ± 0.069	2.017GlyMet: 2.017 ± 0.039	2.513GlyAsn: 2.513 ± 0.057	1.522GlyPro: 1.522 ± 0.033	2.946GlyGln: 2.946 ± 0.047	3.079GlyArg: 3.079 ± 0.044	4.016GlySer: 4.016 ± 0.056	3.206GlyThr: 3.206 ± 0.053	5.131GlyVal: 5.131 ± 0.08	0.97GlyTrp: 0.97 ± 0.026	2.636GlyTyr: 2.636 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.817HisAla: 1.817 ± 0.03	0.361HisCys: 0.361 ± 0.014	1.163HisAsp: 1.163 ± 0.031	1.159HisGlu: 1.159 ± 0.03	1.212HisPhe: 1.212 ± 0.026	1.618HisGly: 1.618 ± 0.033	0.818HisHis: 0.818 ± 0.028	1.436HisIle: 1.436 ± 0.034	1.013HisLys: 1.013 ± 0.024	2.402HisLeu: 2.402 ± 0.036	0.536HisMet: 0.536 ± 0.019	0.927HisAsn: 0.927 ± 0.027	1.218HisPro: 1.218 ± 0.031	1.338HisGln: 1.338 ± 0.032	1.176HisArg: 1.176 ± 0.029	1.509HisSer: 1.509 ± 0.031	1.17HisThr: 1.17 ± 0.026	1.36HisVal: 1.36 ± 0.027	0.414HisTrp: 0.414 ± 0.017	0.986HisTyr: 0.986 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.297IleAla: 6.297 ± 0.069	0.693IleCys: 0.693 ± 0.023	3.963IleAsp: 3.963 ± 0.055	4.709IleGlu: 4.709 ± 0.054	2.112IlePhe: 2.112 ± 0.038	4.46IleGly: 4.46 ± 0.063	1.326IleHis: 1.326 ± 0.035	3.16IleIle: 3.16 ± 0.051	2.939IleLys: 2.939 ± 0.049	5.098IleLeu: 5.098 ± 0.062	1.316IleMet: 1.316 ± 0.028	2.758IleAsn: 2.758 ± 0.047	2.476IlePro: 2.476 ± 0.037	2.289IleGln: 2.289 ± 0.038	2.844IleArg: 2.844 ± 0.036	4.255IleSer: 4.255 ± 0.06	3.55IleThr: 3.55 ± 0.046	4.112IleVal: 4.112 ± 0.049	0.641IleTrp: 0.641 ± 0.02	1.675IleTyr: 1.675 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.917LysAla: 4.917 ± 0.064	0.339LysCys: 0.339 ± 0.018	2.379LysAsp: 2.379 ± 0.043	3.53LysGlu: 3.53 ± 0.046	1.552LysPhe: 1.552 ± 0.036	3.323LysGly: 3.323 ± 0.058	1.278LysHis: 1.278 ± 0.03	2.746LysIle: 2.746 ± 0.046	2.831LysLys: 2.831 ± 0.044	5.317LysLeu: 5.317 ± 0.062	1.493LysMet: 1.493 ± 0.032	2.073LysAsn: 2.073 ± 0.039	2.403LysPro: 2.403 ± 0.04	3.101LysGln: 3.101 ± 0.049	2.848LysArg: 2.848 ± 0.048	3.016LysSer: 3.016 ± 0.047	2.753LysThr: 2.753 ± 0.043	3.836LysVal: 3.836 ± 0.051	0.581LysTrp: 0.581 ± 0.02	1.378LysTyr: 1.378 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.298LeuAla: 10.298 ± 0.095	1.169LeuCys: 1.169 ± 0.03	5.699LeuAsp: 5.699 ± 0.069	6.254LeuGlu: 6.254 ± 0.063	4.464LeuPhe: 4.464 ± 0.066	6.885LeuGly: 6.885 ± 0.079	2.097LeuHis: 2.097 ± 0.046	5.957LeuIle: 5.957 ± 0.058	5.369LeuLys: 5.369 ± 0.066	10.838LeuLeu: 10.838 ± 0.112	2.872LeuMet: 2.872 ± 0.045	4.631LeuAsn: 4.631 ± 0.057	4.769LeuPro: 4.769 ± 0.055	3.92LeuGln: 3.92 ± 0.066	4.385LeuArg: 4.385 ± 0.059	8.09LeuSer: 8.09 ± 0.075	6.152LeuThr: 6.152 ± 0.063	7.105LeuVal: 7.105 ± 0.077	1.103LeuTrp: 1.103 ± 0.031	2.7LeuTyr: 2.7 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.72MetAla: 2.72 ± 0.042	0.239MetCys: 0.239 ± 0.013	1.318MetAsp: 1.318 ± 0.029	1.416MetGlu: 1.416 ± 0.032	1.028MetPhe: 1.028 ± 0.026	1.788MetGly: 1.788 ± 0.034	0.504MetHis: 0.504 ± 0.018	1.575MetIle: 1.575 ± 0.033	1.605MetLys: 1.605 ± 0.029	2.866MetLeu: 2.866 ± 0.049	0.924MetMet: 0.924 ± 0.025	1.168MetAsn: 1.168 ± 0.028	1.269MetPro: 1.269 ± 0.028	1.163MetGln: 1.163 ± 0.03	1.335MetArg: 1.335 ± 0.031	2.042MetSer: 2.042 ± 0.034	1.664MetThr: 1.664 ± 0.031	2.008MetVal: 2.008 ± 0.04	0.255MetTrp: 0.255 ± 0.013	0.558MetTyr: 0.558 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.592AsnAla: 3.592 ± 0.055	0.376AsnCys: 0.376 ± 0.016	2.201AsnAsp: 2.201 ± 0.037	2.381AsnGlu: 2.381 ± 0.04	1.462AsnPhe: 1.462 ± 0.031	3.092AsnGly: 3.092 ± 0.051	1.045AsnHis: 1.045 ± 0.027	2.517AsnIle: 2.517 ± 0.043	2.166AsnLys: 2.166 ± 0.044	3.832AsnLeu: 3.832 ± 0.048	1.029AsnMet: 1.029 ± 0.027	1.787AsnAsn: 1.787 ± 0.037	2.086AsnPro: 2.086 ± 0.039	2.324AsnGln: 2.324 ± 0.043	2.06AsnArg: 2.06 ± 0.041	2.392AsnSer: 2.392 ± 0.047	2.126AsnThr: 2.126 ± 0.043	2.788AsnVal: 2.788 ± 0.049	0.578AsnTrp: 0.578 ± 0.019	1.333AsnTyr: 1.333 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	3.039ProAla: 3.039 ± 0.047	0.347ProCys: 0.347 ± 0.016	2.146ProAsp: 2.146 ± 0.042	3.029ProGlu: 3.029 ± 0.053	1.792ProPhe: 1.792 ± 0.034	2.022ProGly: 2.022 ± 0.043	0.908ProHis: 0.908 ± 0.026	2.403ProIle: 2.403 ± 0.041	1.902ProLys: 1.902 ± 0.034	4.136ProLeu: 4.136 ± 0.053	1.132ProMet: 1.132 ± 0.03	1.646ProAsn: 1.646 ± 0.033	1.134ProPro: 1.134 ± 0.033	1.811ProGln: 1.811 ± 0.034	1.434ProArg: 1.434 ± 0.031	2.562ProSer: 2.562 ± 0.044	2.219ProThr: 2.219 ± 0.041	3.02ProVal: 3.02 ± 0.052	0.514ProTrp: 0.514 ± 0.02	1.32ProTyr: 1.32 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.752GlnAla: 4.752 ± 0.064	0.434GlnCys: 0.434 ± 0.017	2.082GlnAsp: 2.082 ± 0.039	2.706GlnGlu: 2.706 ± 0.04	1.951GlnPhe: 1.951 ± 0.04	3.234GlnGly: 3.234 ± 0.05	1.379GlnHis: 1.379 ± 0.034	2.696GlnIle: 2.696 ± 0.04	2.219GlnLys: 2.219 ± 0.038	5.531GlnLeu: 5.531 ± 0.073	1.3GlnMet: 1.3 ± 0.037	1.748GlnAsn: 1.748 ± 0.036	1.838GlnPro: 1.838 ± 0.039	3.471GlnGln: 3.471 ± 0.08	2.661GlnArg: 2.661 ± 0.045	2.936GlnSer: 2.936 ± 0.051	2.551GlnThr: 2.551 ± 0.044	3.27GlnVal: 3.27 ± 0.044	0.781GlnTrp: 0.781 ± 0.025	1.465GlnTyr: 1.465 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.559ArgAla: 3.559 ± 0.047	0.547ArgCys: 0.547 ± 0.021	2.485ArgAsp: 2.485 ± 0.041	3.16ArgGlu: 3.16 ± 0.053	2.415ArgPhe: 2.415 ± 0.037	2.579ArgGly: 2.579 ± 0.042	1.239ArgHis: 1.239 ± 0.032	3.017ArgIle: 3.017 ± 0.044	2.406ArgLys: 2.406 ± 0.043	5.035ArgLeu: 5.035 ± 0.059	1.31ArgMet: 1.31 ± 0.026	1.92ArgAsn: 1.92 ± 0.036	1.56ArgPro: 1.56 ± 0.035	2.392ArgGln: 2.392 ± 0.036	2.413ArgArg: 2.413 ± 0.05	2.77ArgSer: 2.77 ± 0.047	2.173ArgThr: 2.173 ± 0.034	3.237ArgVal: 3.237 ± 0.048	0.7ArgTrp: 0.7 ± 0.021	1.902ArgTyr: 1.902 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.608SerAla: 5.608 ± 0.061	0.649SerCys: 0.649 ± 0.023	3.66SerAsp: 3.66 ± 0.055	4.109SerGlu: 4.109 ± 0.054	2.751SerPhe: 2.751 ± 0.047	4.831SerGly: 4.831 ± 0.068	1.673SerHis: 1.673 ± 0.03	3.922SerIle: 3.922 ± 0.05	3.156SerLys: 3.156 ± 0.047	7.257SerLeu: 7.257 ± 0.073	1.741SerMet: 1.741 ± 0.036	2.613SerAsn: 2.613 ± 0.046	2.443SerPro: 2.443 ± 0.042	3.206SerGln: 3.206 ± 0.051	2.927SerArg: 2.927 ± 0.047	4.322SerSer: 4.322 ± 0.064	3.169SerThr: 3.169 ± 0.049	4.619SerVal: 4.619 ± 0.059	0.799SerTrp: 0.799 ± 0.024	2.058SerTyr: 2.058 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.433ThrAla: 4.433 ± 0.05	0.447ThrCys: 0.447 ± 0.019	2.57ThrAsp: 2.57 ± 0.053	3.038ThrGlu: 3.038 ± 0.049	2.193ThrPhe: 2.193 ± 0.043	3.767ThrGly: 3.767 ± 0.053	1.272ThrHis: 1.272 ± 0.031	3.37ThrIle: 3.37 ± 0.066	2.265ThrLys: 2.265 ± 0.046	6.436ThrLeu: 6.436 ± 0.067	1.277ThrMet: 1.277 ± 0.027	2.017ThrAsn: 2.017 ± 0.037	2.659ThrPro: 2.659 ± 0.046	2.703ThrGln: 2.703 ± 0.045	2.318ThrArg: 2.318 ± 0.039	3.309ThrSer: 3.309 ± 0.053	2.93ThrThr: 2.93 ± 0.056	3.634ThrVal: 3.634 ± 0.065	0.621ThrTrp: 0.621 ± 0.02	1.447ThrTyr: 1.447 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	6.601ValAla: 6.601 ± 0.074	0.827ValCys: 0.827 ± 0.023	3.985ValAsp: 3.985 ± 0.06	4.842ValGlu: 4.842 ± 0.064	2.794ValPhe: 2.794 ± 0.039	4.654ValGly: 4.654 ± 0.062	1.3ValHis: 1.3 ± 0.029	4.672ValIle: 4.672 ± 0.061	3.594ValLys: 3.594 ± 0.054	6.846ValLeu: 6.846 ± 0.073	2.09ValMet: 2.09 ± 0.038	2.909ValAsn: 2.909 ± 0.049	2.517ValPro: 2.517 ± 0.045	2.32ValGln: 2.32 ± 0.04	3.095ValArg: 3.095 ± 0.045	4.962ValSer: 4.962 ± 0.065	4.14ValThr: 4.14 ± 0.069	5.624ValVal: 5.624 ± 0.071	0.794ValTrp: 0.794 ± 0.024	1.86ValTyr: 1.86 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.873TrpAla: 0.873 ± 0.027	0.186TrpCys: 0.186 ± 0.012	0.612TrpAsp: 0.612 ± 0.022	0.532TrpGlu: 0.532 ± 0.02	0.647TrpPhe: 0.647 ± 0.02	0.79TrpGly: 0.79 ± 0.026	0.404TrpHis: 0.404 ± 0.015	0.678TrpIle: 0.678 ± 0.021	0.535TrpLys: 0.535 ± 0.019	1.813TrpLeu: 1.813 ± 0.039	0.357TrpMet: 0.357 ± 0.014	0.501TrpAsn: 0.501 ± 0.018	0.474TrpPro: 0.474 ± 0.021	1.016TrpGln: 1.016 ± 0.028	0.735TrpArg: 0.735 ± 0.023	0.746TrpSer: 0.746 ± 0.024	0.525TrpThr: 0.525 ± 0.019	0.878TrpVal: 0.878 ± 0.027	0.225TrpTrp: 0.225 ± 0.012	0.397TrpTyr: 0.397 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.372TyrAla: 2.372 ± 0.044	0.396TyrCys: 0.396 ± 0.017	1.632TyrAsp: 1.632 ± 0.034	1.425TyrGlu: 1.425 ± 0.033	1.463TyrPhe: 1.463 ± 0.032	2.058TyrGly: 2.058 ± 0.042	0.852TyrHis: 0.852 ± 0.02	1.52TyrIle: 1.52 ± 0.032	1.269TyrLys: 1.269 ± 0.032	3.548TyrLeu: 3.548 ± 0.053	0.627TyrMet: 0.627 ± 0.019	1.1TyrAsn: 1.1 ± 0.026	1.385TyrPro: 1.385 ± 0.033	2.262TyrGln: 2.262 ± 0.044	1.837TyrArg: 1.837 ± 0.033	2.043TyrSer: 2.043 ± 0.037	1.472TyrThr: 1.472 ± 0.034	1.911TyrVal: 1.911 ± 0.04	0.519TyrTrp: 0.519 ± 0.02	1.05TyrTyr: 1.05 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4990 proteins (1549674 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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