Amino acid dipepetide frequency for Lactobacillus antri DSM 16041

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.051AlaAla: 10.051 ± 0.233
0.577AlaCys: 0.577 ± 0.033
5.905AlaAsp: 5.905 ± 0.088
4.424AlaGlu: 4.424 ± 0.1
3.281AlaPhe: 3.281 ± 0.082
7.445AlaGly: 7.445 ± 0.136
1.763AlaHis: 1.763 ± 0.05
5.607AlaIle: 5.607 ± 0.099
5.527AlaLys: 5.527 ± 0.118
8.254AlaLeu: 8.254 ± 0.148
2.266AlaMet: 2.266 ± 0.06
4.284AlaAsn: 4.284 ± 0.108
2.996AlaPro: 2.996 ± 0.067
4.257AlaGln: 4.257 ± 0.1
3.804AlaArg: 3.804 ± 0.095
4.727AlaSer: 4.727 ± 0.089
5.319AlaThr: 5.319 ± 0.109
6.851AlaVal: 6.851 ± 0.123
0.8AlaTrp: 0.8 ± 0.037
2.597AlaTyr: 2.597 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.506CysAla: 0.506 ± 0.028
0.093CysCys: 0.093 ± 0.016
0.285CysAsp: 0.285 ± 0.022
0.244CysGlu: 0.244 ± 0.019
0.336CysPhe: 0.336 ± 0.022
0.687CysGly: 0.687 ± 0.037
0.173CysHis: 0.173 ± 0.019
0.319CysIle: 0.319 ± 0.022
0.185CysLys: 0.185 ± 0.016
0.672CysLeu: 0.672 ± 0.037
0.164CysMet: 0.164 ± 0.017
0.214CysAsn: 0.214 ± 0.017
0.319CysPro: 0.319 ± 0.024
0.371CysGln: 0.371 ± 0.027
0.337CysArg: 0.337 ± 0.021
0.369CysSer: 0.369 ± 0.026
0.356CysThr: 0.356 ± 0.027
0.38CysVal: 0.38 ± 0.025
0.122CysTrp: 0.122 ± 0.014
0.273CysTyr: 0.273 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.09AspAla: 4.09 ± 0.099
0.328AspCys: 0.328 ± 0.024
3.45AspAsp: 3.45 ± 0.088
3.817AspGlu: 3.817 ± 0.097
2.641AspPhe: 2.641 ± 0.067
3.951AspGly: 3.951 ± 0.089
1.76AspHis: 1.76 ± 0.053
3.123AspIle: 3.123 ± 0.087
2.879AspLys: 2.879 ± 0.079
5.483AspLeu: 5.483 ± 0.098
1.279AspMet: 1.279 ± 0.044
2.6AspAsn: 2.6 ± 0.071
2.474AspPro: 2.474 ± 0.057
4.149AspGln: 4.149 ± 0.105
2.945AspArg: 2.945 ± 0.073
2.704AspSer: 2.704 ± 0.065
2.567AspThr: 2.567 ± 0.065
3.849AspVal: 3.849 ± 0.083
0.795AspTrp: 0.795 ± 0.042
2.782AspTyr: 2.782 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
3.953GluAla: 3.953 ± 0.086
0.252GluCys: 0.252 ± 0.021
2.626GluAsp: 2.626 ± 0.065
3.124GluGlu: 3.124 ± 0.084
1.835GluPhe: 1.835 ± 0.056
2.436GluGly: 2.436 ± 0.063
1.258GluHis: 1.258 ± 0.05
3.429GluIle: 3.429 ± 0.081
3.365GluLys: 3.365 ± 0.088
5.565GluLeu: 5.565 ± 0.109
1.665GluMet: 1.665 ± 0.055
2.425GluAsn: 2.425 ± 0.068
1.529GluPro: 1.529 ± 0.051
3.1GluGln: 3.1 ± 0.074
2.823GluArg: 2.823 ± 0.073
2.13GluSer: 2.13 ± 0.061
2.41GluThr: 2.41 ± 0.057
3.489GluVal: 3.489 ± 0.087
0.591GluTrp: 0.591 ± 0.027
1.847GluTyr: 1.847 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.804PheAla: 3.804 ± 0.083
0.366PheCys: 0.366 ± 0.021
2.602PheAsp: 2.602 ± 0.064
1.642PheGlu: 1.642 ± 0.056
1.729PhePhe: 1.729 ± 0.054
3.082PheGly: 3.082 ± 0.067
0.856PheHis: 0.856 ± 0.037
2.724PheIle: 2.724 ± 0.07
2.248PheLys: 2.248 ± 0.068
3.483PheLeu: 3.483 ± 0.082
1.056PheMet: 1.056 ± 0.043
2.228PheAsn: 2.228 ± 0.062
1.589PhePro: 1.589 ± 0.052
1.374PheGln: 1.374 ± 0.044
1.46PheArg: 1.46 ± 0.051
2.602PheSer: 2.602 ± 0.067
2.606PheThr: 2.606 ± 0.071
2.718PheVal: 2.718 ± 0.07
0.523PheTrp: 0.523 ± 0.028
1.576PheTyr: 1.576 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
5.476GlyAla: 5.476 ± 0.104
0.521GlyCys: 0.521 ± 0.031
3.7GlyAsp: 3.7 ± 0.078
3.27GlyGlu: 3.27 ± 0.083
2.996GlyPhe: 2.996 ± 0.07
4.581GlyGly: 4.581 ± 0.1
1.857GlyHis: 1.857 ± 0.06
5.257GlyIle: 5.257 ± 0.102
4.39GlyLys: 4.39 ± 0.09
6.707GlyLeu: 6.707 ± 0.12
2.061GlyMet: 2.061 ± 0.058
3.1GlyAsn: 3.1 ± 0.093
1.821GlyPro: 1.821 ± 0.052
3.685GlyGln: 3.685 ± 0.083
3.418GlyArg: 3.418 ± 0.077
3.867GlySer: 3.867 ± 0.073
4.396GlyThr: 4.396 ± 0.099
4.858GlyVal: 4.858 ± 0.085
1.068GlyTrp: 1.068 ± 0.057
2.838GlyTyr: 2.838 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
1.583HisAla: 1.583 ± 0.047
0.194HisCys: 0.194 ± 0.017
1.455HisAsp: 1.455 ± 0.046
1.222HisGlu: 1.222 ± 0.038
1.252HisPhe: 1.252 ± 0.045
1.848HisGly: 1.848 ± 0.053
0.911HisHis: 0.911 ± 0.042
1.143HisIle: 1.143 ± 0.044
0.92HisLys: 0.92 ± 0.039
2.219HisLeu: 2.219 ± 0.055
0.494HisMet: 0.494 ± 0.027
1.023HisAsn: 1.023 ± 0.036
1.267HisPro: 1.267 ± 0.042
1.541HisGln: 1.541 ± 0.049
1.415HisArg: 1.415 ± 0.051
1.18HisSer: 1.18 ± 0.041
1.041HisThr: 1.041 ± 0.043
1.427HisVal: 1.427 ± 0.048
0.354HisTrp: 0.354 ± 0.024
1.217HisTyr: 1.217 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.688IleAla: 5.688 ± 0.098
0.583IleCys: 0.583 ± 0.032
3.982IleAsp: 3.982 ± 0.084
2.806IleGlu: 2.806 ± 0.07
2.526IlePhe: 2.526 ± 0.074
4.619IleGly: 4.619 ± 0.096
1.219IleHis: 1.219 ± 0.044
4.723IleIle: 4.723 ± 0.12
3.945IleLys: 3.945 ± 0.092
5.5IleLeu: 5.5 ± 0.111
1.537IleMet: 1.537 ± 0.047
3.37IleAsn: 3.37 ± 0.088
2.596IlePro: 2.596 ± 0.055
2.208IleGln: 2.208 ± 0.062
2.593IleArg: 2.593 ± 0.069
4.004IleSer: 4.004 ± 0.089
3.894IleThr: 3.894 ± 0.077
4.682IleVal: 4.682 ± 0.105
0.604IleTrp: 0.604 ± 0.032
2.02IleTyr: 2.02 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.26LysAla: 4.26 ± 0.101
0.227LysCys: 0.227 ± 0.018
3.201LysAsp: 3.201 ± 0.08
3.548LysGlu: 3.548 ± 0.084
1.77LysPhe: 1.77 ± 0.058
3.005LysGly: 3.005 ± 0.078
1.315LysHis: 1.315 ± 0.048
3.424LysIle: 3.424 ± 0.073
4.051LysLys: 4.051 ± 0.091
5.505LysLeu: 5.505 ± 0.097
1.955LysMet: 1.955 ± 0.058
2.578LysAsn: 2.578 ± 0.08
2.056LysPro: 2.056 ± 0.06
3.421LysGln: 3.421 ± 0.081
3.029LysArg: 3.029 ± 0.069
2.681LysSer: 2.681 ± 0.069
3.171LysThr: 3.171 ± 0.075
3.945LysVal: 3.945 ± 0.081
0.586LysTrp: 0.586 ± 0.033
2.153LysTyr: 2.153 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
10.303LeuAla: 10.303 ± 0.165
0.643LeuCys: 0.643 ± 0.038
5.322LeuAsp: 5.322 ± 0.103
4.116LeuGlu: 4.116 ± 0.095
3.887LeuPhe: 3.887 ± 0.098
6.764LeuGly: 6.764 ± 0.13
2.079LeuHis: 2.079 ± 0.055
6.241LeuIle: 6.241 ± 0.107
5.256LeuLys: 5.256 ± 0.094
9.614LeuLeu: 9.614 ± 0.199
2.431LeuMet: 2.431 ± 0.065
4.56LeuAsn: 4.56 ± 0.08
4.518LeuPro: 4.518 ± 0.099
3.869LeuGln: 3.869 ± 0.094
4.311LeuArg: 4.311 ± 0.097
5.807LeuSer: 5.807 ± 0.112
6.817LeuThr: 6.817 ± 0.117
7.514LeuVal: 7.514 ± 0.127
0.883LeuTrp: 0.883 ± 0.04
2.739LeuTyr: 2.739 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.582MetAla: 2.582 ± 0.073
0.125MetCys: 0.125 ± 0.013
1.433MetAsp: 1.433 ± 0.049
1.177MetGlu: 1.177 ± 0.044
0.943MetPhe: 0.943 ± 0.048
1.723MetGly: 1.723 ± 0.053
0.453MetHis: 0.453 ± 0.027
1.669MetIle: 1.669 ± 0.059
1.764MetLys: 1.764 ± 0.054
2.266MetLeu: 2.266 ± 0.06
0.86MetMet: 0.86 ± 0.037
1.232MetAsn: 1.232 ± 0.046
1.053MetPro: 1.053 ± 0.043
1.056MetGln: 1.056 ± 0.043
1.083MetArg: 1.083 ± 0.046
1.412MetSer: 1.412 ± 0.05
1.77MetThr: 1.77 ± 0.051
2.028MetVal: 2.028 ± 0.059
0.194MetTrp: 0.194 ± 0.016
0.687MetTyr: 0.687 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.617AsnAla: 3.617 ± 0.092
0.312AsnCys: 0.312 ± 0.022
2.797AsnAsp: 2.797 ± 0.071
2.282AsnGlu: 2.282 ± 0.066
1.764AsnPhe: 1.764 ± 0.053
3.884AsnGly: 3.884 ± 0.105
1.267AsnHis: 1.267 ± 0.049
2.567AsnIle: 2.567 ± 0.075
2.294AsnLys: 2.294 ± 0.067
4.036AsnLeu: 4.036 ± 0.085
1.161AsnMet: 1.161 ± 0.043
2.469AsnAsn: 2.469 ± 0.089
2.207AsnPro: 2.207 ± 0.062
2.778AsnGln: 2.778 ± 0.076
2.349AsnArg: 2.349 ± 0.068
2.558AsnSer: 2.558 ± 0.075
2.273AsnThr: 2.273 ± 0.071
3.156AsnVal: 3.156 ± 0.079
0.658AsnTrp: 0.658 ± 0.033
1.937AsnTyr: 1.937 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
4.616ProAla: 4.616 ± 0.096
0.188ProCys: 0.188 ± 0.016
2.641ProAsp: 2.641 ± 0.073
2.546ProGlu: 2.546 ± 0.064
1.636ProPhe: 1.636 ± 0.049
2.74ProGly: 2.74 ± 0.072
0.865ProHis: 0.865 ± 0.033
2.077ProIle: 2.077 ± 0.06
1.749ProLys: 1.749 ± 0.056
3.819ProLeu: 3.819 ± 0.077
0.723ProMet: 0.723 ± 0.034
1.681ProAsn: 1.681 ± 0.057
0.682ProPro: 0.682 ± 0.035
2.065ProGln: 2.065 ± 0.056
1.525ProArg: 1.525 ± 0.044
1.949ProSer: 1.949 ± 0.056
2.605ProThr: 2.605 ± 0.068
3.543ProVal: 3.543 ± 0.08
0.387ProTrp: 0.387 ± 0.023
1.389ProTyr: 1.389 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
5.033GlnAla: 5.033 ± 0.136
0.172GlnCys: 0.172 ± 0.017
2.281GlnAsp: 2.281 ± 0.052
2.644GlnGlu: 2.644 ± 0.069
1.829GlnPhe: 1.829 ± 0.056
2.74GlnGly: 2.74 ± 0.074
1.271GlnHis: 1.271 ± 0.046
2.962GlnIle: 2.962 ± 0.066
2.623GlnLys: 2.623 ± 0.063
6.297GlnLeu: 6.297 ± 0.135
1.219GlnMet: 1.219 ± 0.041
2.011GlnAsn: 2.011 ± 0.062
2.434GlnPro: 2.434 ± 0.077
3.53GlnGln: 3.53 ± 0.12
2.922GlnArg: 2.922 ± 0.071
2.327GlnSer: 2.327 ± 0.066
3.127GlnThr: 3.127 ± 0.09
3.864GlnVal: 3.864 ± 0.087
0.527GlnTrp: 0.527 ± 0.028
1.729GlnTyr: 1.729 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.646ArgAla: 3.646 ± 0.083
0.288ArgCys: 0.288 ± 0.024
2.412ArgAsp: 2.412 ± 0.061
2.725ArgGlu: 2.725 ± 0.075
2.175ArgPhe: 2.175 ± 0.055
2.787ArgGly: 2.787 ± 0.077
1.332ArgHis: 1.332 ± 0.049
2.79ArgIle: 2.79 ± 0.072
2.389ArgLys: 2.389 ± 0.068
5.25ArgLeu: 5.25 ± 0.105
1.167ArgMet: 1.167 ± 0.045
1.815ArgAsn: 1.815 ± 0.056
2.031ArgPro: 2.031 ± 0.06
3.323ArgGln: 3.323 ± 0.07
2.938ArgArg: 2.938 ± 0.088
2.236ArgSer: 2.236 ± 0.062
2.415ArgThr: 2.415 ± 0.061
3.323ArgVal: 3.323 ± 0.086
0.619ArgTrp: 0.619 ± 0.036
1.979ArgTyr: 1.979 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.736SerAla: 4.736 ± 0.093
0.318SerCys: 0.318 ± 0.021
2.84SerAsp: 2.84 ± 0.068
2.273SerGlu: 2.273 ± 0.063
2.596SerPhe: 2.596 ± 0.066
4.301SerGly: 4.301 ± 0.076
1.223SerHis: 1.223 ± 0.04
3.186SerIle: 3.186 ± 0.077
2.876SerLys: 2.876 ± 0.075
5.545SerLeu: 5.545 ± 0.111
1.265SerMet: 1.265 ± 0.048
2.457SerAsn: 2.457 ± 0.072
2.041SerPro: 2.041 ± 0.057
2.82SerGln: 2.82 ± 0.07
2.716SerArg: 2.716 ± 0.068
3.421SerSer: 3.421 ± 0.091
3.135SerThr: 3.135 ± 0.071
3.594SerVal: 3.594 ± 0.065
0.726SerTrp: 0.726 ± 0.037
1.985SerTyr: 1.985 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
6.21ThrAla: 6.21 ± 0.124
0.297ThrCys: 0.297 ± 0.022
3.521ThrAsp: 3.521 ± 0.075
2.492ThrGlu: 2.492 ± 0.067
2.205ThrPhe: 2.205 ± 0.061
4.909ThrGly: 4.909 ± 0.088
1.124ThrHis: 1.124 ± 0.044
4.32ThrIle: 4.32 ± 0.091
3.338ThrLys: 3.338 ± 0.074
5.276ThrLeu: 5.276 ± 0.104
1.395ThrMet: 1.395 ± 0.043
2.692ThrAsn: 2.692 ± 0.081
2.838ThrPro: 2.838 ± 0.075
1.859ThrGln: 1.859 ± 0.056
2.171ThrArg: 2.171 ± 0.064
3.353ThrSer: 3.353 ± 0.082
4.076ThrThr: 4.076 ± 0.107
5.319ThrVal: 5.319 ± 0.117
0.592ThrTrp: 0.592 ± 0.032
1.863ThrTyr: 1.863 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
7.195ValAla: 7.195 ± 0.124
0.526ValCys: 0.526 ± 0.03
4.557ValAsp: 4.557 ± 0.088
3.457ValGlu: 3.457 ± 0.085
2.594ValPhe: 2.594 ± 0.067
5.075ValGly: 5.075 ± 0.103
1.392ValHis: 1.392 ± 0.045
5.141ValIle: 5.141 ± 0.086
4.278ValLys: 4.278 ± 0.081
6.655ValLeu: 6.655 ± 0.119
1.767ValMet: 1.767 ± 0.064
3.626ValAsn: 3.626 ± 0.082
3.097ValPro: 3.097 ± 0.083
2.841ValGln: 2.841 ± 0.08
2.966ValArg: 2.966 ± 0.076
4.164ValSer: 4.164 ± 0.078
5.253ValThr: 5.253 ± 0.116
5.747ValVal: 5.747 ± 0.114
0.618ValTrp: 0.618 ± 0.032
2.315ValTyr: 2.315 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.803TrpAla: 0.803 ± 0.04
0.089TrpCys: 0.089 ± 0.011
0.542TrpAsp: 0.542 ± 0.029
0.429TrpGlu: 0.429 ± 0.025
0.612TrpPhe: 0.612 ± 0.036
0.78TrpGly: 0.78 ± 0.032
0.434TrpHis: 0.434 ± 0.035
0.622TrpIle: 0.622 ± 0.032
0.453TrpLys: 0.453 ± 0.024
1.58TrpLeu: 1.58 ± 0.062
0.31TrpMet: 0.31 ± 0.023
0.479TrpAsn: 0.479 ± 0.033
0.374TrpPro: 0.374 ± 0.026
0.738TrpGln: 0.738 ± 0.037
0.673TrpArg: 0.673 ± 0.032
0.625TrpSer: 0.625 ± 0.036
0.559TrpThr: 0.559 ± 0.029
0.669TrpVal: 0.669 ± 0.031
0.188TrpTrp: 0.188 ± 0.017
0.407TrpTyr: 0.407 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.585TyrAla: 2.585 ± 0.063
0.306TyrCys: 0.306 ± 0.02
2.117TyrAsp: 2.117 ± 0.056
1.612TyrGlu: 1.612 ± 0.049
1.659TyrPhe: 1.659 ± 0.049
2.51TyrGly: 2.51 ± 0.062
1.155TyrHis: 1.155 ± 0.041
1.773TyrIle: 1.773 ± 0.047
1.351TyrLys: 1.351 ± 0.046
3.948TyrLeu: 3.948 ± 0.075
0.732TyrMet: 0.732 ± 0.035
1.521TyrAsn: 1.521 ± 0.056
1.503TyrPro: 1.503 ± 0.052
2.558TyrGln: 2.558 ± 0.072
2.162TyrArg: 2.162 ± 0.052
1.939TyrSer: 1.939 ± 0.059
2.061TyrThr: 2.061 ± 0.064
2.309TyrVal: 2.309 ± 0.058
0.533TyrTrp: 0.533 ± 0.034
1.488TyrTyr: 1.488 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2224 proteins (663820 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski