Amino acid dipepetide frequency for Streptomonospora alba

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.443AlaAla: 22.443 ± 0.251
1.073AlaCys: 1.073 ± 0.026
9.184AlaAsp: 9.184 ± 0.093
10.641AlaGlu: 10.641 ± 0.112
3.614AlaPhe: 3.614 ± 0.053
13.169AlaGly: 13.169 ± 0.124
2.687AlaHis: 2.687 ± 0.043
3.636AlaIle: 3.636 ± 0.056
2.147AlaLys: 2.147 ± 0.051
13.837AlaLeu: 13.837 ± 0.135
2.673AlaMet: 2.673 ± 0.043
1.877AlaAsn: 1.877 ± 0.041
7.053AlaPro: 7.053 ± 0.088
3.741AlaGln: 3.741 ± 0.06
10.128AlaArg: 10.128 ± 0.103
5.989AlaSer: 5.989 ± 0.061
6.099AlaThr: 6.099 ± 0.064
12.315AlaVal: 12.315 ± 0.118
1.822AlaTrp: 1.822 ± 0.042
2.519AlaTyr: 2.519 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.047CysAla: 1.047 ± 0.026
0.103CysCys: 0.103 ± 0.008
0.473CysAsp: 0.473 ± 0.021
0.435CysGlu: 0.435 ± 0.018
0.224CysPhe: 0.224 ± 0.015
0.993CysGly: 0.993 ± 0.028
0.206CysHis: 0.206 ± 0.012
0.169CysIle: 0.169 ± 0.011
0.085CysLys: 0.085 ± 0.009
0.706CysLeu: 0.706 ± 0.022
0.129CysMet: 0.129 ± 0.011
0.126CysAsn: 0.126 ± 0.01
0.472CysPro: 0.472 ± 0.019
0.153CysGln: 0.153 ± 0.012
0.607CysArg: 0.607 ± 0.022
0.447CysSer: 0.447 ± 0.023
0.464CysThr: 0.464 ± 0.019
0.62CysVal: 0.62 ± 0.022
0.094CysTrp: 0.094 ± 0.008
0.189CysTyr: 0.189 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.939AspAla: 7.939 ± 0.083
0.387AspCys: 0.387 ± 0.019
4.005AspAsp: 4.005 ± 0.063
4.374AspGlu: 4.374 ± 0.065
1.774AspPhe: 1.774 ± 0.035
5.886AspGly: 5.886 ± 0.076
1.431AspHis: 1.431 ± 0.032
2.111AspIle: 2.111 ± 0.047
0.881AspLys: 0.881 ± 0.029
6.428AspLeu: 6.428 ± 0.081
1.023AspMet: 1.023 ± 0.027
0.972AspAsn: 0.972 ± 0.032
4.711AspPro: 4.711 ± 0.07
1.583AspGln: 1.583 ± 0.041
5.263AspArg: 5.263 ± 0.064
3.126AspSer: 3.126 ± 0.05
3.387AspThr: 3.387 ± 0.053
4.987AspVal: 4.987 ± 0.069
0.885AspTrp: 0.885 ± 0.023
1.453AspTyr: 1.453 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.232GluAla: 8.232 ± 0.097
0.419GluCys: 0.419 ± 0.02
3.582GluAsp: 3.582 ± 0.051
4.719GluGlu: 4.719 ± 0.073
1.792GluPhe: 1.792 ± 0.039
5.26GluGly: 5.26 ± 0.067
1.857GluHis: 1.857 ± 0.036
2.583GluIle: 2.583 ± 0.05
1.161GluLys: 1.161 ± 0.035
7.166GluLeu: 7.166 ± 0.086
1.181GluMet: 1.181 ± 0.031
1.229GluAsn: 1.229 ± 0.029
3.871GluPro: 3.871 ± 0.06
2.49GluGln: 2.49 ± 0.042
6.492GluArg: 6.492 ± 0.081
3.326GluSer: 3.326 ± 0.05
3.193GluThr: 3.193 ± 0.048
5.103GluVal: 5.103 ± 0.066
0.866GluTrp: 0.866 ± 0.026
1.226GluTyr: 1.226 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.96PheAla: 3.96 ± 0.062
0.276PheCys: 0.276 ± 0.014
2.123PheAsp: 2.123 ± 0.041
1.514PheGlu: 1.514 ± 0.033
0.856PhePhe: 0.856 ± 0.032
3.122PheGly: 3.122 ± 0.054
0.612PheHis: 0.612 ± 0.021
0.791PheIle: 0.791 ± 0.029
0.371PheLys: 0.371 ± 0.019
2.591PheLeu: 2.591 ± 0.049
0.433PheMet: 0.433 ± 0.018
0.559PheAsn: 0.559 ± 0.024
1.357PhePro: 1.357 ± 0.034
0.658PheGln: 0.658 ± 0.023
1.712PheArg: 1.712 ± 0.034
1.613PheSer: 1.613 ± 0.034
1.96PheThr: 1.96 ± 0.041
2.273PheVal: 2.273 ± 0.051
0.408PheTrp: 0.408 ± 0.019
0.607PheTyr: 0.607 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
12.028GlyAla: 12.028 ± 0.12
0.842GlyCys: 0.842 ± 0.024
5.717GlyAsp: 5.717 ± 0.079
6.136GlyGlu: 6.136 ± 0.066
2.907GlyPhe: 2.907 ± 0.056
9.617GlyGly: 9.617 ± 0.115
2.066GlyHis: 2.066 ± 0.038
3.529GlyIle: 3.529 ± 0.055
1.843GlyLys: 1.843 ± 0.041
9.092GlyLeu: 9.092 ± 0.085
2.309GlyMet: 2.309 ± 0.041
1.615GlyAsn: 1.615 ± 0.041
4.866GlyPro: 4.866 ± 0.067
2.443GlyGln: 2.443 ± 0.043
7.72GlyArg: 7.72 ± 0.075
5.466GlySer: 5.466 ± 0.075
5.696GlyThr: 5.696 ± 0.07
7.903GlyVal: 7.903 ± 0.084
1.483GlyTrp: 1.483 ± 0.035
2.465GlyTyr: 2.465 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.592HisAla: 2.592 ± 0.047
0.213HisCys: 0.213 ± 0.013
1.312HisAsp: 1.312 ± 0.032
1.229HisGlu: 1.229 ± 0.032
0.571HisPhe: 0.571 ± 0.021
2.334HisGly: 2.334 ± 0.044
0.605HisHis: 0.605 ± 0.021
0.694HisIle: 0.694 ± 0.024
0.276HisLys: 0.276 ± 0.016
2.288HisLeu: 2.288 ± 0.042
0.395HisMet: 0.395 ± 0.018
0.4HisAsn: 0.4 ± 0.016
1.676HisPro: 1.676 ± 0.038
0.537HisGln: 0.537 ± 0.019
2.018HisArg: 2.018 ± 0.04
1.077HisSer: 1.077 ± 0.028
1.245HisThr: 1.245 ± 0.028
1.715HisVal: 1.715 ± 0.034
0.315HisTrp: 0.315 ± 0.016
0.491HisTyr: 0.491 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.083IleAla: 5.083 ± 0.065
0.269IleCys: 0.269 ± 0.013
2.484IleAsp: 2.484 ± 0.045
2.146IleGlu: 2.146 ± 0.043
0.728IlePhe: 0.728 ± 0.026
3.709IleGly: 3.709 ± 0.055
0.577IleHis: 0.577 ± 0.023
0.994IleIle: 0.994 ± 0.029
0.545IleLys: 0.545 ± 0.022
2.441IleLeu: 2.441 ± 0.048
0.547IleMet: 0.547 ± 0.022
0.684IleAsn: 0.684 ± 0.026
1.768IlePro: 1.768 ± 0.04
0.67IleGln: 0.67 ± 0.026
2.259IleArg: 2.259 ± 0.039
1.852IleSer: 1.852 ± 0.036
2.25IleThr: 2.25 ± 0.048
2.878IleVal: 2.878 ± 0.054
0.324IleTrp: 0.324 ± 0.015
0.598IleTyr: 0.598 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
2.005LysAla: 2.005 ± 0.045
0.077LysCys: 0.077 ± 0.008
0.913LysAsp: 0.913 ± 0.029
0.975LysGlu: 0.975 ± 0.03
0.327LysPhe: 0.327 ± 0.016
1.347LysGly: 1.347 ± 0.036
0.364LysHis: 0.364 ± 0.016
0.627LysIle: 0.627 ± 0.023
0.45LysLys: 0.45 ± 0.024
1.546LysLeu: 1.546 ± 0.04
0.302LysMet: 0.302 ± 0.015
0.364LysAsn: 0.364 ± 0.017
1.003LysPro: 1.003 ± 0.03
0.56LysGln: 0.56 ± 0.023
1.467LysArg: 1.467 ± 0.037
0.917LysSer: 0.917 ± 0.03
0.904LysThr: 0.904 ± 0.026
1.357LysVal: 1.357 ± 0.037
0.165LysTrp: 0.165 ± 0.011
0.323LysTyr: 0.323 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
14.644LeuAla: 14.644 ± 0.133
0.804LeuCys: 0.804 ± 0.027
6.691LeuAsp: 6.691 ± 0.072
5.553LeuGlu: 5.553 ± 0.081
2.684LeuPhe: 2.684 ± 0.056
9.087LeuGly: 9.087 ± 0.088
2.143LeuHis: 2.143 ± 0.043
3.38LeuIle: 3.38 ± 0.051
1.507LeuLys: 1.507 ± 0.039
10.582LeuLeu: 10.582 ± 0.129
1.833LeuMet: 1.833 ± 0.041
1.711LeuAsn: 1.711 ± 0.04
5.843LeuPro: 5.843 ± 0.073
2.289LeuGln: 2.289 ± 0.047
8.799LeuArg: 8.799 ± 0.101
5.694LeuSer: 5.694 ± 0.068
5.513LeuThr: 5.513 ± 0.073
8.739LeuVal: 8.739 ± 0.101
1.276LeuTrp: 1.276 ± 0.035
1.755LeuTyr: 1.755 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.569MetAla: 2.569 ± 0.043
0.151MetCys: 0.151 ± 0.01
0.996MetAsp: 0.996 ± 0.024
0.959MetGlu: 0.959 ± 0.028
0.534MetPhe: 0.534 ± 0.02
1.6MetGly: 1.6 ± 0.035
0.379MetHis: 0.379 ± 0.016
0.681MetIle: 0.681 ± 0.021
0.314MetLys: 0.314 ± 0.016
1.999MetLeu: 1.999 ± 0.045
0.338MetMet: 0.338 ± 0.016
0.456MetAsn: 0.456 ± 0.019
1.243MetPro: 1.243 ± 0.03
0.527MetGln: 0.527 ± 0.02
1.77MetArg: 1.77 ± 0.036
1.458MetSer: 1.458 ± 0.033
1.352MetThr: 1.352 ± 0.034
1.579MetVal: 1.579 ± 0.035
0.241MetTrp: 0.241 ± 0.012
0.311MetTyr: 0.311 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.176AsnAla: 2.176 ± 0.042
0.132AsnCys: 0.132 ± 0.009
0.978AsnAsp: 0.978 ± 0.028
0.95AsnGlu: 0.95 ± 0.029
0.474AsnPhe: 0.474 ± 0.02
1.755AsnGly: 1.755 ± 0.04
0.36AsnHis: 0.36 ± 0.016
0.636AsnIle: 0.636 ± 0.022
0.294AsnLys: 0.294 ± 0.016
1.631AsnLeu: 1.631 ± 0.038
0.326AsnMet: 0.326 ± 0.017
0.377AsnAsn: 0.377 ± 0.019
1.278AsnPro: 1.278 ± 0.034
0.545AsnGln: 0.545 ± 0.021
1.403AsnArg: 1.403 ± 0.033
0.856AsnSer: 0.856 ± 0.029
1.074AsnThr: 1.074 ± 0.031
1.351AsnVal: 1.351 ± 0.035
0.262AsnTrp: 0.262 ± 0.016
0.411AsnTyr: 0.411 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
7.878ProAla: 7.878 ± 0.095
0.311ProCys: 0.311 ± 0.013
4.516ProAsp: 4.516 ± 0.065
5.137ProGlu: 5.137 ± 0.065
1.495ProPhe: 1.495 ± 0.034
6.328ProGly: 6.328 ± 0.072
1.304ProHis: 1.304 ± 0.03
1.463ProIle: 1.463 ± 0.039
0.815ProLys: 0.815 ± 0.024
5.081ProLeu: 5.081 ± 0.064
1.078ProMet: 1.078 ± 0.029
0.889ProAsn: 0.889 ± 0.028
3.535ProPro: 3.535 ± 0.066
1.825ProGln: 1.825 ± 0.044
4.027ProArg: 4.027 ± 0.07
2.872ProSer: 2.872 ± 0.046
2.765ProThr: 2.765 ± 0.044
4.959ProVal: 4.959 ± 0.063
0.864ProTrp: 0.864 ± 0.026
1.203ProTyr: 1.203 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.665GlnAla: 3.665 ± 0.05
0.172GlnCys: 0.172 ± 0.011
1.272GlnAsp: 1.272 ± 0.031
1.74GlnGlu: 1.74 ± 0.04
0.604GlnPhe: 0.604 ± 0.019
2.398GlnGly: 2.398 ± 0.043
0.6GlnHis: 0.6 ± 0.023
1.041GlnIle: 1.041 ± 0.028
0.43GlnLys: 0.43 ± 0.019
2.632GlnLeu: 2.632 ± 0.052
0.532GlnMet: 0.532 ± 0.018
0.498GlnAsn: 0.498 ± 0.021
1.534GlnPro: 1.534 ± 0.039
1.202GlnGln: 1.202 ± 0.036
2.746GlnArg: 2.746 ± 0.045
1.332GlnSer: 1.332 ± 0.029
1.333GlnThr: 1.333 ± 0.038
2.279GlnVal: 2.279 ± 0.037
0.439GlnTrp: 0.439 ± 0.019
0.504GlnTyr: 0.504 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
9.659ArgAla: 9.659 ± 0.104
0.576ArgCys: 0.576 ± 0.022
4.465ArgAsp: 4.465 ± 0.062
5.256ArgGlu: 5.256 ± 0.07
2.508ArgPhe: 2.508 ± 0.045
6.183ArgGly: 6.183 ± 0.072
1.956ArgHis: 1.956 ± 0.04
3.503ArgIle: 3.503 ± 0.048
1.404ArgLys: 1.404 ± 0.035
9.252ArgLeu: 9.252 ± 0.095
2.155ArgMet: 2.155 ± 0.04
1.432ArgAsn: 1.432 ± 0.032
4.883ArgPro: 4.883 ± 0.07
2.069ArgGln: 2.069 ± 0.042
8.489ArgArg: 8.489 ± 0.11
4.664ArgSer: 4.664 ± 0.06
4.684ArgThr: 4.684 ± 0.063
6.403ArgVal: 6.403 ± 0.087
1.307ArgTrp: 1.307 ± 0.032
1.859ArgTyr: 1.859 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.521SerAla: 7.521 ± 0.077
0.416SerCys: 0.416 ± 0.018
3.04SerAsp: 3.04 ± 0.056
3.193SerGlu: 3.193 ± 0.048
1.485SerPhe: 1.485 ± 0.036
6.75SerGly: 6.75 ± 0.078
1.002SerHis: 1.002 ± 0.027
1.553SerIle: 1.553 ± 0.038
0.825SerLys: 0.825 ± 0.031
4.773SerLeu: 4.773 ± 0.057
1.101SerMet: 1.101 ± 0.028
0.836SerAsn: 0.836 ± 0.024
3.099SerPro: 3.099 ± 0.05
1.321SerGln: 1.321 ± 0.031
3.8SerArg: 3.8 ± 0.052
3.023SerSer: 3.023 ± 0.046
2.991SerThr: 2.991 ± 0.055
4.351SerVal: 4.351 ± 0.059
0.881SerTrp: 0.881 ± 0.027
1.208SerTyr: 1.208 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
8.148ThrAla: 8.148 ± 0.09
0.388ThrCys: 0.388 ± 0.02
3.304ThrAsp: 3.304 ± 0.054
3.35ThrGlu: 3.35 ± 0.05
1.436ThrPhe: 1.436 ± 0.029
6.127ThrGly: 6.127 ± 0.07
1.022ThrHis: 1.022 ± 0.031
1.576ThrIle: 1.576 ± 0.038
0.829ThrLys: 0.829 ± 0.028
5.099ThrLeu: 5.099 ± 0.06
1.023ThrMet: 1.023 ± 0.028
0.856ThrAsn: 0.856 ± 0.029
3.422ThrPro: 3.422 ± 0.045
1.147ThrGln: 1.147 ± 0.028
3.94ThrArg: 3.94 ± 0.066
2.699ThrSer: 2.699 ± 0.04
3.051ThrThr: 3.051 ± 0.054
5.386ThrVal: 5.386 ± 0.062
0.804ThrTrp: 0.804 ± 0.022
1.074ThrTyr: 1.074 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
10.987ValAla: 10.987 ± 0.121
0.8ValCys: 0.8 ± 0.023
5.409ValAsp: 5.409 ± 0.068
5.436ValGlu: 5.436 ± 0.072
2.644ValPhe: 2.644 ± 0.051
6.904ValGly: 6.904 ± 0.075
2.027ValHis: 2.027 ± 0.039
2.693ValIle: 2.693 ± 0.055
1.246ValLys: 1.246 ± 0.033
9.557ValLeu: 9.557 ± 0.104
1.479ValMet: 1.479 ± 0.033
1.601ValAsn: 1.601 ± 0.042
4.891ValPro: 4.891 ± 0.076
2.111ValGln: 2.111 ± 0.038
6.876ValArg: 6.876 ± 0.077
4.643ValSer: 4.643 ± 0.067
4.621ValThr: 4.621 ± 0.065
8.174ValVal: 8.174 ± 0.094
1.173ValTrp: 1.173 ± 0.03
1.648ValTyr: 1.648 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.553TrpAla: 1.553 ± 0.039
0.145TrpCys: 0.145 ± 0.01
0.745TrpAsp: 0.745 ± 0.022
0.777TrpGlu: 0.777 ± 0.021
0.485TrpPhe: 0.485 ± 0.021
1.026TrpGly: 1.026 ± 0.027
0.354TrpHis: 0.354 ± 0.014
0.54TrpIle: 0.54 ± 0.021
0.265TrpLys: 0.265 ± 0.016
1.649TrpLeu: 1.649 ± 0.039
0.308TrpMet: 0.308 ± 0.015
0.417TrpAsn: 0.417 ± 0.019
0.755TrpPro: 0.755 ± 0.023
0.543TrpGln: 0.543 ± 0.021
1.339TrpArg: 1.339 ± 0.036
0.945TrpSer: 0.945 ± 0.027
0.828TrpThr: 0.828 ± 0.025
0.97TrpVal: 0.97 ± 0.027
0.348TrpTrp: 0.348 ± 0.017
0.294TrpTyr: 0.294 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.518TyrAla: 2.518 ± 0.041
0.187TyrCys: 0.187 ± 0.013
1.397TyrAsp: 1.397 ± 0.039
1.226TyrGlu: 1.226 ± 0.028
0.655TyrPhe: 0.655 ± 0.022
2.149TyrGly: 2.149 ± 0.047
0.43TyrHis: 0.43 ± 0.02
0.606TyrIle: 0.606 ± 0.019
0.303TyrLys: 0.303 ± 0.016
2.178TyrLeu: 2.178 ± 0.042
0.291TyrMet: 0.291 ± 0.015
0.372TyrAsn: 0.372 ± 0.018
1.084TyrPro: 1.084 ± 0.029
0.54TyrGln: 0.54 ± 0.02
1.851TyrArg: 1.851 ± 0.035
1.171TyrSer: 1.171 ± 0.031
1.275TyrThr: 1.275 ± 0.028
1.579TyrVal: 1.579 ± 0.033
0.326TyrTrp: 0.326 ± 0.014
0.496TyrTyr: 0.496 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4307 proteins (1345555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski