Amino acid dipepetide frequency for Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.228AlaAla: 20.228 ± 0.242	1.436AlaCys: 1.436 ± 0.034	7.115AlaAsp: 7.115 ± 0.065	6.663AlaGlu: 6.663 ± 0.09	3.954AlaPhe: 3.954 ± 0.067	12.805AlaGly: 12.805 ± 0.156	2.815AlaHis: 2.815 ± 0.044	5.644AlaIle: 5.644 ± 0.079	2.893AlaLys: 2.893 ± 0.064	15.77AlaLeu: 15.77 ± 0.162	3.657AlaMet: 3.657 ± 0.062	2.696AlaAsn: 2.696 ± 0.057	6.883AlaPro: 6.883 ± 0.106	6.17AlaGln: 6.17 ± 0.087	11.182AlaArg: 11.182 ± 0.131	6.345AlaSer: 6.345 ± 0.085	5.859AlaThr: 5.859 ± 0.083	9.296AlaVal: 9.296 ± 0.097	2.08AlaTrp: 2.08 ± 0.052	2.919AlaTyr: 2.919 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.255CysAla: 1.255 ± 0.036	0.125CysCys: 0.125 ± 0.011	0.484CysAsp: 0.484 ± 0.021	0.484CysGlu: 0.484 ± 0.019	0.296CysPhe: 0.296 ± 0.017	1.0CysGly: 1.0 ± 0.032	0.271CysHis: 0.271 ± 0.02	0.371CysIle: 0.371 ± 0.021	0.159CysLys: 0.159 ± 0.012	0.863CysLeu: 0.863 ± 0.032	0.212CysMet: 0.212 ± 0.014	0.243CysAsn: 0.243 ± 0.016	0.505CysPro: 0.505 ± 0.024	0.237CysGln: 0.237 ± 0.014	0.625CysArg: 0.625 ± 0.024	0.415CysSer: 0.415 ± 0.02	0.435CysThr: 0.435 ± 0.02	0.794CysVal: 0.794 ± 0.027	0.129CysTrp: 0.129 ± 0.01	0.196CysTyr: 0.196 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.296AspAla: 7.296 ± 0.097	0.498AspCys: 0.498 ± 0.021	2.818AspAsp: 2.818 ± 0.057	3.117AspGlu: 3.117 ± 0.065	2.002AspPhe: 2.002 ± 0.048	4.943AspGly: 4.943 ± 0.075	1.049AspHis: 1.049 ± 0.034	2.715AspIle: 2.715 ± 0.053	1.452AspLys: 1.452 ± 0.036	5.532AspLeu: 5.532 ± 0.077	1.35AspMet: 1.35 ± 0.034	1.216AspAsn: 1.216 ± 0.041	3.162AspPro: 3.162 ± 0.056	1.785AspGln: 1.785 ± 0.044	3.235AspArg: 3.235 ± 0.057	2.246AspSer: 2.246 ± 0.047	2.69AspThr: 2.69 ± 0.054	4.096AspVal: 4.096 ± 0.062	0.941AspTrp: 0.941 ± 0.033	1.54AspTyr: 1.54 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.43GluAla: 6.43 ± 0.094	0.384GluCys: 0.384 ± 0.019	2.101GluAsp: 2.101 ± 0.05	2.092GluGlu: 2.092 ± 0.052	1.666GluPhe: 1.666 ± 0.036	3.468GluGly: 3.468 ± 0.059	1.354GluHis: 1.354 ± 0.038	2.688GluIle: 2.688 ± 0.059	1.489GluLys: 1.489 ± 0.043	5.671GluLeu: 5.671 ± 0.089	1.199GluMet: 1.199 ± 0.036	1.327GluAsn: 1.327 ± 0.039	2.672GluPro: 2.672 ± 0.055	2.628GluGln: 2.628 ± 0.053	4.705GluArg: 4.705 ± 0.069	2.229GluSer: 2.229 ± 0.044	2.396GluThr: 2.396 ± 0.056	3.693GluVal: 3.693 ± 0.073	0.621GluTrp: 0.621 ± 0.024	1.223GluTyr: 1.223 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.949PheAla: 3.949 ± 0.059	0.374PheCys: 0.374 ± 0.018	2.328PheAsp: 2.328 ± 0.047	1.899PheGlu: 1.899 ± 0.044	1.154PhePhe: 1.154 ± 0.043	3.165PheGly: 3.165 ± 0.069	0.711PheHis: 0.711 ± 0.024	1.413PheIle: 1.413 ± 0.043	0.908PheLys: 0.908 ± 0.032	2.938PheLeu: 2.938 ± 0.059	0.805PheMet: 0.805 ± 0.029	0.943PheAsn: 0.943 ± 0.03	1.469PhePro: 1.469 ± 0.039	1.009PheGln: 1.009 ± 0.031	1.822PheArg: 1.822 ± 0.042	1.997PheSer: 1.997 ± 0.047	1.776PheThr: 1.776 ± 0.042	2.718PheVal: 2.718 ± 0.055	0.506PheTrp: 0.506 ± 0.026	0.862PheTyr: 0.862 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.744GlyAla: 10.744 ± 0.133	0.858GlyCys: 0.858 ± 0.029	4.027GlyAsp: 4.027 ± 0.08	4.271GlyGlu: 4.271 ± 0.071	3.027GlyPhe: 3.027 ± 0.062	7.314GlyGly: 7.314 ± 0.149	2.02GlyHis: 2.02 ± 0.047	4.107GlyIle: 4.107 ± 0.062	3.213GlyLys: 3.213 ± 0.073	9.412GlyLeu: 9.412 ± 0.109	2.547GlyMet: 2.547 ± 0.057	2.135GlyAsn: 2.135 ± 0.056	3.4GlyPro: 3.4 ± 0.066	3.738GlyGln: 3.738 ± 0.059	6.134GlyArg: 6.134 ± 0.085	4.315GlySer: 4.315 ± 0.081	4.262GlyThr: 4.262 ± 0.094	6.944GlyVal: 6.944 ± 0.095	1.456GlyTrp: 1.456 ± 0.041	2.466GlyTyr: 2.466 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	3.146HisAla: 3.146 ± 0.065	0.267HisCys: 0.267 ± 0.017	1.275HisAsp: 1.275 ± 0.042	1.069HisGlu: 1.069 ± 0.034	0.724HisPhe: 0.724 ± 0.03	2.234HisGly: 2.234 ± 0.046	0.582HisHis: 0.582 ± 0.025	1.037HisIle: 1.037 ± 0.033	0.511HisLys: 0.511 ± 0.024	2.055HisLeu: 2.055 ± 0.049	0.467HisMet: 0.467 ± 0.02	0.514HisAsn: 0.514 ± 0.021	1.505HisPro: 1.505 ± 0.037	0.796HisGln: 0.796 ± 0.029	1.576HisArg: 1.576 ± 0.046	0.892HisSer: 0.892 ± 0.029	1.097HisThr: 1.097 ± 0.029	1.536HisVal: 1.536 ± 0.037	0.333HisTrp: 0.333 ± 0.02	0.673HisTyr: 0.673 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.071IleAla: 6.071 ± 0.083	0.402IleCys: 0.402 ± 0.02	3.205IleAsp: 3.205 ± 0.057	3.019IleGlu: 3.019 ± 0.06	1.207IlePhe: 1.207 ± 0.038	4.242IleGly: 4.242 ± 0.067	0.817IleHis: 0.817 ± 0.025	1.643IleIle: 1.643 ± 0.049	1.413IleLys: 1.413 ± 0.04	3.655IleLeu: 3.655 ± 0.073	0.882IleMet: 0.882 ± 0.029	1.263IleAsn: 1.263 ± 0.037	2.046IlePro: 2.046 ± 0.045	1.383IleGln: 1.383 ± 0.038	2.672IleArg: 2.672 ± 0.06	2.365IleSer: 2.365 ± 0.051	2.225IleThr: 2.225 ± 0.052	3.801IleVal: 3.801 ± 0.054	0.513IleTrp: 0.513 ± 0.023	1.01IleTyr: 1.01 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.187LysAla: 3.187 ± 0.063	0.135LysCys: 0.135 ± 0.011	1.342LysAsp: 1.342 ± 0.037	1.218LysGlu: 1.218 ± 0.035	0.718LysPhe: 0.718 ± 0.023	2.026LysGly: 2.026 ± 0.052	0.585LysHis: 0.585 ± 0.024	1.146LysIle: 1.146 ± 0.039	1.041LysLys: 1.041 ± 0.045	3.019LysLeu: 3.019 ± 0.065	0.624LysMet: 0.624 ± 0.027	0.715LysAsn: 0.715 ± 0.027	1.76LysPro: 1.76 ± 0.047	1.129LysGln: 1.129 ± 0.038	1.919LysArg: 1.919 ± 0.044	1.517LysSer: 1.517 ± 0.04	1.513LysThr: 1.513 ± 0.043	2.218LysVal: 2.218 ± 0.049	0.402LysTrp: 0.402 ± 0.019	0.663LysTyr: 0.663 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	16.909LeuAla: 16.909 ± 0.169	1.032LeuCys: 1.032 ± 0.032	6.3LeuAsp: 6.3 ± 0.088	4.981LeuGlu: 4.981 ± 0.08	3.312LeuPhe: 3.312 ± 0.068	9.168LeuGly: 9.168 ± 0.103	2.285LeuHis: 2.285 ± 0.049	4.297LeuIle: 4.297 ± 0.083	2.856LeuLys: 2.856 ± 0.054	11.018LeuLeu: 11.018 ± 0.142	2.323LeuMet: 2.323 ± 0.048	2.623LeuAsn: 2.623 ± 0.05	6.164LeuPro: 6.164 ± 0.087	3.825LeuGln: 3.825 ± 0.068	8.49LeuArg: 8.49 ± 0.101	5.709LeuSer: 5.709 ± 0.081	5.384LeuThr: 5.384 ± 0.086	7.762LeuVal: 7.762 ± 0.083	1.166LeuTrp: 1.166 ± 0.04	2.31LeuTyr: 2.31 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.118MetAla: 3.118 ± 0.06	0.169MetCys: 0.169 ± 0.013	1.02MetAsp: 1.02 ± 0.035	0.955MetGlu: 0.955 ± 0.032	0.718MetPhe: 0.718 ± 0.027	1.793MetGly: 1.793 ± 0.046	0.564MetHis: 0.564 ± 0.022	0.98MetIle: 0.98 ± 0.033	0.896MetLys: 0.896 ± 0.035	2.862MetLeu: 2.862 ± 0.055	0.628MetMet: 0.628 ± 0.024	0.799MetAsn: 0.799 ± 0.029	1.559MetPro: 1.559 ± 0.034	1.203MetGln: 1.203 ± 0.034	1.898MetArg: 1.898 ± 0.038	1.598MetSer: 1.598 ± 0.041	1.482MetThr: 1.482 ± 0.034	1.695MetVal: 1.695 ± 0.042	0.186MetTrp: 0.186 ± 0.014	0.408MetTyr: 0.408 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.979AsnAla: 2.979 ± 0.057	0.223AsnCys: 0.223 ± 0.016	1.221AsnAsp: 1.221 ± 0.037	1.055AsnGlu: 1.055 ± 0.033	0.816AsnPhe: 0.816 ± 0.026	2.24AsnGly: 2.24 ± 0.059	0.468AsnHis: 0.468 ± 0.019	1.21AsnIle: 1.21 ± 0.036	0.68AsnLys: 0.68 ± 0.028	2.608AsnLeu: 2.608 ± 0.053	0.593AsnMet: 0.593 ± 0.025	0.677AsnAsn: 0.677 ± 0.029	1.74AsnPro: 1.74 ± 0.04	0.863AsnGln: 0.863 ± 0.029	1.761AsnArg: 1.761 ± 0.04	1.071AsnSer: 1.071 ± 0.032	1.385AsnThr: 1.385 ± 0.039	1.856AsnVal: 1.856 ± 0.044	0.417AsnTrp: 0.417 ± 0.023	0.656AsnTyr: 0.656 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.142ProAla: 8.142 ± 0.104	0.379ProCys: 0.379 ± 0.021	3.539ProAsp: 3.539 ± 0.058	3.204ProGlu: 3.204 ± 0.055	1.807ProPhe: 1.807 ± 0.041	5.109ProGly: 5.109 ± 0.067	1.223ProHis: 1.223 ± 0.038	1.9ProIle: 1.9 ± 0.044	1.191ProLys: 1.191 ± 0.037	5.127ProLeu: 5.127 ± 0.07	1.325ProMet: 1.325 ± 0.031	1.16ProAsn: 1.16 ± 0.034	2.709ProPro: 2.709 ± 0.062	2.315ProGln: 2.315 ± 0.05	3.353ProArg: 3.353 ± 0.059	2.47ProSer: 2.47 ± 0.047	2.279ProThr: 2.279 ± 0.042	4.364ProVal: 4.364 ± 0.064	0.797ProTrp: 0.797 ± 0.029	1.411ProTyr: 1.411 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	7.291GlnAla: 7.291 ± 0.099	0.304GlnCys: 0.304 ± 0.017	1.79GlnAsp: 1.79 ± 0.044	1.662GlnGlu: 1.662 ± 0.048	1.186GlnPhe: 1.186 ± 0.03	3.365GlnGly: 3.365 ± 0.054	0.9GlnHis: 0.9 ± 0.031	1.66GlnIle: 1.66 ± 0.036	0.828GlnLys: 0.828 ± 0.027	3.947GlnLeu: 3.947 ± 0.065	0.891GlnMet: 0.891 ± 0.031	0.801GlnAsn: 0.801 ± 0.029	2.376GlnPro: 2.376 ± 0.054	1.856GlnGln: 1.856 ± 0.052	3.508GlnArg: 3.508 ± 0.063	1.76GlnSer: 1.76 ± 0.037	1.822GlnThr: 1.822 ± 0.043	3.109GlnVal: 3.109 ± 0.059	0.707GlnTrp: 0.707 ± 0.029	0.873GlnTyr: 0.873 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	9.553ArgAla: 9.553 ± 0.108	0.579ArgCys: 0.579 ± 0.021	4.044ArgAsp: 4.044 ± 0.069	4.234ArgGlu: 4.234 ± 0.066	2.711ArgPhe: 2.711 ± 0.051	5.162ArgGly: 5.162 ± 0.07	1.975ArgHis: 1.975 ± 0.045	3.972ArgIle: 3.972 ± 0.06	2.071ArgLys: 2.071 ± 0.046	8.585ArgLeu: 8.585 ± 0.101	1.953ArgMet: 1.953 ± 0.045	1.949ArgAsn: 1.949 ± 0.042	3.725ArgPro: 3.725 ± 0.058	3.49ArgGln: 3.49 ± 0.058	5.882ArgArg: 5.882 ± 0.093	3.045ArgSer: 3.045 ± 0.053	3.187ArgThr: 3.187 ± 0.054	5.471ArgVal: 5.471 ± 0.078	1.063ArgTrp: 1.063 ± 0.03	2.205ArgTyr: 2.205 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.047SerAla: 6.047 ± 0.085	0.403SerCys: 0.403 ± 0.02	2.265SerAsp: 2.265 ± 0.046	2.182SerGlu: 2.182 ± 0.044	1.761SerPhe: 1.761 ± 0.041	4.95SerGly: 4.95 ± 0.083	1.123SerHis: 1.123 ± 0.033	2.239SerIle: 2.239 ± 0.05	1.242SerLys: 1.242 ± 0.036	5.322SerLeu: 5.322 ± 0.083	1.29SerMet: 1.29 ± 0.039	1.238SerAsn: 1.238 ± 0.03	2.592SerPro: 2.592 ± 0.051	1.804SerGln: 1.804 ± 0.042	3.505SerArg: 3.505 ± 0.056	2.607SerSer: 2.607 ± 0.055	2.442SerThr: 2.442 ± 0.047	3.892SerVal: 3.892 ± 0.07	0.735SerTrp: 0.735 ± 0.025	1.219SerTyr: 1.219 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.492ThrAla: 5.492 ± 0.076	0.371ThrCys: 0.371 ± 0.018	2.478ThrAsp: 2.478 ± 0.054	2.17ThrGlu: 2.17 ± 0.046	1.552ThrPhe: 1.552 ± 0.034	4.482ThrGly: 4.482 ± 0.07	1.132ThrHis: 1.132 ± 0.029	2.15ThrIle: 2.15 ± 0.048	0.916ThrLys: 0.916 ± 0.031	6.366ThrLeu: 6.366 ± 0.098	1.074ThrMet: 1.074 ± 0.029	1.074ThrAsn: 1.074 ± 0.032	3.355ThrPro: 3.355 ± 0.056	1.733ThrGln: 1.733 ± 0.044	3.494ThrArg: 3.494 ± 0.064	2.244ThrSer: 2.244 ± 0.054	2.249ThrThr: 2.249 ± 0.047	4.235ThrVal: 4.235 ± 0.063	0.65ThrTrp: 0.65 ± 0.026	1.139ThrTyr: 1.139 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	10.182ValAla: 10.182 ± 0.122	0.782ValCys: 0.782 ± 0.032	4.227ValAsp: 4.227 ± 0.07	3.936ValGlu: 3.936 ± 0.067	2.7ValPhe: 2.7 ± 0.057	5.641ValGly: 5.641 ± 0.082	1.544ValHis: 1.544 ± 0.038	3.236ValIle: 3.236 ± 0.066	2.092ValLys: 2.092 ± 0.061	8.511ValLeu: 8.511 ± 0.097	1.822ValMet: 1.822 ± 0.047	2.108ValAsn: 2.108 ± 0.05	4.088ValPro: 4.088 ± 0.066	2.886ValGln: 2.886 ± 0.056	5.751ValArg: 5.751 ± 0.079	4.133ValSer: 4.133 ± 0.065	3.987ValThr: 3.987 ± 0.072	6.415ValVal: 6.415 ± 0.09	0.852ValTrp: 0.852 ± 0.029	1.66ValTyr: 1.66 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.29TrpAla: 1.29 ± 0.033	0.147TrpCys: 0.147 ± 0.011	0.627TrpAsp: 0.627 ± 0.024	0.505TrpGlu: 0.505 ± 0.023	0.557TrpPhe: 0.557 ± 0.025	0.9TrpGly: 0.9 ± 0.034	0.407TrpHis: 0.407 ± 0.017	0.606TrpIle: 0.606 ± 0.026	0.373TrpLys: 0.373 ± 0.02	2.185TrpLeu: 2.185 ± 0.053	0.391TrpMet: 0.391 ± 0.021	0.413TrpAsn: 0.413 ± 0.02	0.774TrpPro: 0.774 ± 0.029	0.764TrpGln: 0.764 ± 0.029	1.373TrpArg: 1.373 ± 0.04	0.737TrpSer: 0.737 ± 0.028	0.626TrpThr: 0.626 ± 0.028	0.893TrpVal: 0.893 ± 0.026	0.23TrpTrp: 0.23 ± 0.014	0.348TrpTyr: 0.348 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.102TyrAla: 3.102 ± 0.053	0.23TyrCys: 0.23 ± 0.015	1.476TyrAsp: 1.476 ± 0.041	1.318TyrGlu: 1.318 ± 0.04	0.876TyrPhe: 0.876 ± 0.032	2.382TyrGly: 2.382 ± 0.048	0.463TyrHis: 0.463 ± 0.022	0.82TyrIle: 0.82 ± 0.026	0.655TyrLys: 0.655 ± 0.022	2.47TyrLeu: 2.47 ± 0.049	0.497TyrMet: 0.497 ± 0.022	0.627TyrAsn: 0.627 ± 0.026	1.32TyrPro: 1.32 ± 0.033	1.019TyrGln: 1.019 ± 0.037	1.973TyrArg: 1.973 ± 0.046	1.165TyrSer: 1.165 ± 0.035	1.259TyrThr: 1.259 ± 0.035	1.766TyrVal: 1.766 ± 0.04	0.363TyrTrp: 0.363 ± 0.018	0.682TyrTyr: 0.682 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3258 proteins (1063353 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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